Not Only Immune Escape—The Confusing Role of the TRP Metabolic Pathway in Carcinogenesis

TDO2 Promotes the EMT of Hepatocellular Carcinoma Through Kyn-AhR Pathway

(2021) Lei Li et al.   Frontiers in Oncology

Serotonin Pathway in Cancer

(2021) Pragathi Balakrishna et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Potentiating the Antitumor Activity of Cytotoxic T Cells via the Transmembrane Domain of IGSF4 That Increases TCR Avidity

(2021) Hye-Ran Kim et al.   Frontiers in Immunology

Activation of the GPR35 pathway drives angiogenesis in the tumour microenvironment

(2021) Ester Pagano et al.   GUT

Immune and metabolic checkpoints blockade: Dual wielding against tumors

(2021) Mohammad Hossein Kazemi et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Cancer Associated Fibroblasts Promote Renal Cancer Progression Through a TDO/Kyn/AhR Dependent Signaling Pathway

(2021) Li-bo Chen et al.   Frontiers in Oncology

Phase 1 Study of Epacadostat in Combination With Atezolizumab for Patients With Previously Treated Advanced Non‐Small Cell Lung Cancer

(2020) Matthew D. Hellmann et al.   INTERNATIONAL JOURNAL OF CANCER

Immunosurveillance and Immunoediting of Lung Cancer: Current Perspectives and Challenges

(2020) Kei Kunimasa et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Expression of Tryptophan 2,3-Dioxygenase in Metastatic Uveal Melanoma

(2020) Terai et al.   Cancers

INTRACELLULAR MECHANISMS OF TUMOR CELL IMMUNORESISTANCE

(2020) Justyna Hermanowicz et al.   ACTA BIOCHIMICA POLONICA

Harnessing nanomedicine to overcome the immunosuppressive tumor microenvironment

(2020) Bo Sun et al.   ACTA PHARMACOLOGICA SINICA

Bidirectional signals of PD-L1 in T cells that fraternize with cancer cells

(2020) Rachel M. Gibbons Johnson et al.   NATURE IMMUNOLOGY

Indoleamine 2,3-Dioxygenase 2 Immunohistochemical Expression in Resected Human Non-small Cell Lung Cancer: A Potential New Prognostic Tool

(2020) Martina Mandarano et al.   Frontiers in Immunology

The immune-checkpoint HLA-G/ILT4 is involved in the regulation of VEGF expression in clear cell renal cell carcinoma

(2020) Marcela García et al.   BMC CANCER

The roles of tumor-associated macrophages in tumor angiogenesis and metastasis

(2020) Luo-Qin Fu et al.   CELLULAR IMMUNOLOGY

Discovery of indoximod prodrugs and characterization of clinical candidate NLG802

(2020) Sanjeev Kumar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

M2 macrophage‐derived exosomes facilitate hepatocarcinoma metastasis by transferring α M β 2 integrin to tumor cells

(2020) Jindao Wu et al.   HEPATOLOGY

Important players in carcinogenesis as potential targets in cancer therapy: an update

(2020) Justyna Magdalena Hermanowicz et al.   Oncotarget

Comprehensive Analysis of the Expressionand Prognosis for TDO2 in Breast Cancer

(2020) Qiang Liu et al.   Molecular Therapy-Oncolytics

Functional Metabolomics Reveal the Role of AHR/GPR35 Mediated Kynurenic acid Gradient Sensing in Chemotherapy-induced Intestinal Damage

(2020) Di Wang et al.   Acta Pharmaceutica Sinica B

VCAM1 Promotes Tumor Cell Invasion and Metastasis by Inducing EMT and Transendothelial Migration in Colorectal Cancer

(2020) Dan Zhang et al.   Frontiers in Oncology

Cytotoxic CD8+ T cells in cancer and cancer immunotherapy

(2020) Hans Raskov et al.   BRITISH JOURNAL OF CANCER

Adenosine and adenosine receptors in colorectal cancer

(2020) Farnaz Hajizadeh et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Indoleamine 2,3-Dioxygenase (IDO) Expression Is an Independent Prognostic Marker in Esophageal Adenocarcinoma

(2020) Heike Loeser et al.   Journal of Immunology Research

NAD+ Metabolism Maintains Inducible PD-L1 Expression to Drive Tumor Immune Evasion

(2020) Hongwei Lv et al.   Cell Metabolism

Oxidative Storm Induced by Tryptophan Metabolites: Missing Link between Atherosclerosis and Chronic Kidney Disease

(2020) Iwona Kwiatkowska et al.   Oxidative Medicine and Cellular Longevity

Effect of Taxane Chemotherapy With or Without Indoximod in Metastatic Breast Cancer

(2020) Veronica Mariotti et al.   JAMA Oncology

Effect of a Single Bout of Aerobic Exercise on Kynurenine Pathway Metabolites and Inflammatory Markers in Prostate Cancer Patients—A Pilot Randomized Controlled Trial

(2020) Alexander Schenk et al.   Metabolites

ILT3 promotes tumor cell motility and angiogenesis in non-small cell lung cancer

(2020) Juan Li et al.   CANCER LETTERS

GPR35 promotes glycolysis, proliferation, and oncogenic signaling by engaging with the sodium potassium pump

(2019) Georg Schneditz et al.   Science Signaling

Identification of a peptide antagonist of the FGF1-FGFR1 signaling axis by phage display selection

(2019) Magdalena Lipok et al.   FEBS Open Bio

Clinicopathologic and prognostic significance of tumor-infiltrating CD8+ T cells in patients with hepatocellular carcinoma

(2019) Xuezhong Xu et al.   MEDICINE

2,3,7,8‑tetrachlorodibenzo‑p‑dioxin suppresses the growth of human colorectal cancer cells in vitro: Implication of the aryl hydrocarbon receptor signaling

(2019) Masayoshi Yamaguchi et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Phase I Study of the Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitor Navoximod (GDC-0919) Administered with PD-L1 Inhibitor (Atezolizumab) in Advanced Solid Tumors

(2019) Kyung Hae Jung et al.   CLINICAL CANCER RESEARCH

IDO1 and Kynurenine Pathway Metabolites Activate PI3K-Akt Signaling in the Neoplastic Colon Epithelium to Promote Cancer Cell Proliferation and Inhibit Apoptosis

(2019) Kumar S. Bishnupuri et al.   CANCER RESEARCH

α7-Nicotinic Acetylcholine Receptor Promotes Cholangiocarcinoma Progression and Epithelial–Mesenchymal Transition Process

(2019) Shuhai Chen et al.   DIGESTIVE DISEASES AND SCIENCES

A novel dual inhibitor of IDO and TDO, CMG017, potently suppresses the kynurenine pathway and overcomes resistance to immune checkpoint inhibitors.

(2019) Chan Kim et al.   JOURNAL OF CLINICAL ONCOLOGY

CD73 Promotes Glioblastoma Pathogenesis and Enhances Its Chemoresistance via A2B Adenosine Receptor Signaling

(2019) Angela Yan et al.   JOURNAL OF NEUROSCIENCE

High BIN1 expression has a favorable prognosis in malignant pleural mesothelioma and is associated with tumor infiltrating lymphocytes

(2019) Tamkin Ahmadzada et al.   LUNG CANCER

Cancer metabolomic markers in urine: evidence, techniques and recommendations

(2019) Sarah S. Dinges et al.   Nature Reviews Urology

Tumor-associated macrophages: role in cancer development and therapeutic implications

(2019) Arash Salmaninejad et al.   CELLULAR ONCOLOGY

Circulating markers of cellular immune activation in prediagnostic blood sample and lung cancer risk in the Lung Cancer Cohort Consortium (LC3)

(2019) Joyce Y. Huang et al.   INTERNATIONAL JOURNAL OF CANCER

Adenosine Interaction with Adenosine Receptor A2a Promotes Gastric Cancer Metastasis by Enhancing PI3K–AKT–mTOR Signaling

(2019) Linsen Shi et al.   MOLECULAR BIOLOGY OF THE CELL

Utility of G protein-coupled receptor 35 expression for predicting outcome in colon cancer

(2019) Haytham Ali et al.   TUMOR BIOLOGY

Mechanisms of Action of Novel Drugs Targeting Angiogenesis-Promoting Matrix Metalloproteinases

(2019) Gregg B. Fields   Frontiers in Immunology

M2 macrophage infiltration into tumor islets leads to poor prognosis in non-small-cell lung cancer

(2019) Lili Cao et al.   Cancer Management and Research

MicroRNA-153 Decreases Tryptophan Catabolism and Inhibits Angiogenesis in Bladder Cancer by Targeting Indoleamine 2,3-Dioxygenase 1

(2019) Wentao Zhang et al.   Frontiers in Oncology

Activation of Aryl Hydrocarbon Receptor by Kynurenine Impairs Progression and Metastasis of Neuroblastoma.

(2019) Pei-Yi Wu et al.   CANCER RESEARCH

MYC promotes tryptophan uptake and metabolism by the kynurenine pathway in colon cancer

(2019) Niranjan Venkateswaran et al.   GENES & DEVELOPMENT

Epacadostat plus pembrolizumab versus placebo plus pembrolizumab in patients with unresectable or metastatic melanoma (ECHO-301/KEYNOTE-252): a phase 3, randomised, double-blind study

(2019) Georgina V Long et al.   LANCET ONCOLOGY

The Dark Side of Fibroblasts: Cancer-Associated Fibroblasts as Mediators of Immunosuppression in the Tumor Microenvironment

(2019) Lea Monteran et al.   Frontiers in Immunology

Colorectal cancer cell-derived CCL20 recruits regulatory T cells to promote chemoresistance via FOXO1/CEBPB/NF-κB signaling

(2019) Dan Wang et al.   Journal for ImmunoTherapy of Cancer

Migration of gastric cancer is suppressed by recombinant Newcastle disease virus (rL-RVG) via regulating α7-nicotinic acetylcholine receptors/ERK- EMT

(2019) Xuefeng Bu et al.   BMC CANCER

Kynurenic acid and cancer: facts and controversies

(2019) Katarzyna Walczak et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The therapeutic potential of targeting tryptophan catabolism in cancer

(2019) Christiane A. Opitz et al.   BRITISH JOURNAL OF CANCER

MiR-21 modulates the polarization of macrophages and increases the effects of M2 macrophages on promoting the chemoresistance of ovarian cancer

(2019) Yuanyuan An et al.   LIFE SCIENCES

Myeloid-driven mechanisms as barriers to antitumor CD8+ T cell activity

(2019) Sean H. Colligan et al.   MOLECULAR IMMUNOLOGY

Aryl hydrocarbon receptor enhances the expression of miR-150-5p to suppress in prostate cancer progression by regulating MAP3K12

(2018) Jingsong Yu et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

PD-L1 confers glioblastoma multiforme malignancy via Ras binding and Ras/Erk/EMT activation

(2018) Xin Yao Qiu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Serotonin and human cancer: A critical view

(2018) Denis Sarrouilhe et al.   BIOCHIMIE

Tumor-Repopulating Cells Induce PD-1 Expression in CD8 + T Cells by Transferring Kynurenine and AhR Activation

(2018) Yuying Liu et al.   CANCER CELL

Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease

(2018) Allison Agus et al.   Cell Host & Microbe

IDO1 in cancer: a Gemini of immune checkpoints

(2018) Lijie Zhai et al.   Cellular & Molecular Immunology

Epithelial-mesenchymal transition leads to NK cell–mediated metastasis-specific immunosurveillance in lung cancer

(2018) Peter J. Chockley et al.   JOURNAL OF CLINICAL INVESTIGATION

TCR Signaling: Mechanisms of Initiation and Propagation

(2018) Adam H. Courtney et al.   TRENDS IN BIOCHEMICAL SCIENCES

CREB promotes laryngeal cancer cell migration via MYCT1/NAT10 axis

(2018) Zhao-Xiong Zhang et al.   OncoTargets and Therapy

Tumor-associated macrophages-derived exosomes promote the migration of gastric cancer cells by transfer of functional Apolipoprotein E

(2018) Peiming Zheng et al.   Cell Death & Disease

Phase Ia study of the indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor navoximod (GDC-0919) in patients with recurrent advanced solid tumors

(2018) Asha Nayak-Kapoor et al.   Journal for ImmunoTherapy of Cancer

Upregulation of long non-coding RNA RAB1A-2 induces FGF1 expression worsening lung cancer prognosis

(2018) Di Wu et al.   CANCER LETTERS

Epacadostat Plus Pembrolizumab in Patients With Advanced Solid Tumors: Phase I Results From a Multicenter, Open-Label Phase I/II Trial (ECHO-202/KEYNOTE-037)

(2018) Tara C. Mitchell et al.   JOURNAL OF CLINICAL ONCOLOGY

Expression of ILT3 predicts poor prognosis and is inversely associated with infiltration of CD45RO+ T cells in patients with colorectal cancer

(2018) Jie Liu et al.   PATHOLOGY RESEARCH AND PRACTICE

Durable Clinical Responses and Long-Term Follow-Up of Stage III–IV Non-Small-Cell Lung Cancer (NSCLC) Patients Treated With IDO Peptide Vaccine in a Phase I Study—A Brief Research Report

(2018) Julie Westerlin Kjeldsen et al.   Frontiers in Immunology

Indoximod: An Immunometabolic Adjuvant That Empowers T Cell Activity in Cancer

(2018) Eric Fox et al.   Frontiers in Oncology

M2 Macrophage-Derived Exosomes Promote Cell Migration and Invasion in Colon Cancer

(2018) Jingqin Lan et al.   CANCER RESEARCH

WNK pathways in cancer signaling networks

(2018) Sachith Gallolu Kankanamalage et al.   Cell Communication and Signaling

Contribution of regulatory T cells to cancer: A review

(2018) Masoud Najafi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Metabolomics of Non-muscle Invasive Bladder Cancer: Biomarkers for Early Detection of Bladder Cancer

(2018) Xiangming Cheng et al.   Frontiers in Oncology

Updates in the Clinical Development of Epacadostat and Other Indoleamine 2,3-Dioxygenase 1 Inhibitors (IDO1) for Human Cancers

(2018) Takefumi Komiya et al.   Frontiers in Oncology

Prognostic significance of tumor-associated macrophages in ovarian cancer: A meta-analysis

(2017) Xia Yuan et al.   GYNECOLOGIC ONCOLOGY

A randomised, open-label, phase 2 study of the IDO1 inhibitor epacadostat (INCB024360) versus tamoxifen as therapy for biochemically recurrent (CA-125 relapse)–only epithelial ovarian cancer, primary peritoneal carcinoma, or fallopian tube cancer

(2017) Rebecca Kristeleit et al.   GYNECOLOGIC ONCOLOGY

Gene silencing of indoleamine 2,3-dioxygenase hinders tumor growth through angiogenesis inhibition

(2017) Jinfeng Pan et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

M2-like macrophages induce colon cancer cell invasion via matrix metalloproteinases

(2017) Katyayni Vinnakota et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Inflammation, vitamin B6 and related pathways

(2017) Per Magne Ueland et al.   MOLECULAR ASPECTS OF MEDICINE

Inhibition of Notch signalling has ability to alter the proximal and distal TCR signalling events in human CD3 + αβ T-cells

(2017) Asif A. Dar et al.   MOLECULAR IMMUNOLOGY

Activation of the kynurenine pathway predicts poor outcome in patients with clear cell renal cell carcinoma

(2017) Giuseppe Lucarelli et al.   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

A cytokine signal inhibitor for rheumatoid arthritis enhances cancer metastasis via depletion of NK cells in an experimental lung metastasis mouse model of colon cancer

(2017) Hideki Shimaoka et al.   Oncology Letters

Blockade of IDO-kynurenine-AhR metabolic circuitry abrogates IFN-γ-induced immunologic dormancy of tumor-repopulating cells

(2017) Yuying Liu et al.   Nature Communications

Breast cancer metastasis: Putative therapeutic role of vascular cell adhesion molecule-1

(2017) Rohit Sharma et al.   CELLULAR ONCOLOGY

Soluble PD-1 and PD-L1: predictive and prognostic significance in cancer

(2017) Xinxin Zhu et al.   Oncotarget

Role of NOX2-Derived Reactive Oxygen Species in NK Cell–Mediated Control of Murine Melanoma Metastasis

(2017) Ebru Aydin et al.   Cancer Immunology Research

The immune system in cancer metastasis: friend or foe?

(2017) Louise M.E. Janssen et al.   Journal for ImmunoTherapy of Cancer

Mitochondrial Dysfunction: A Novel Potential Driver of Epithelial-to-Mesenchymal Transition in Cancer

(2017) Flora Guerra et al.   Frontiers in Oncology

Tumor microenvironment-mediated chemoresistance in breast cancer

(2016) Kobra velaei et al.   BREAST

Abstract LB-085: RG70099: A novel, highly potent dual IDO1/TDO inhibitor to reverse metabolic suppression of immune cells in the tumor micro-environment

(2016) Gabor Gyulveszi et al.   CANCER RESEARCH

Tumor-Intrinsic PD-L1 Signals Regulate Cell Growth, Pathogenesis, and Autophagy in Ovarian Cancer and Melanoma

(2016) Curtis A. Clark et al.   CANCER RESEARCH

Dual Faces of IFN  in Cancer Progression: A Role of PD-L1 Induction in the Determination of Pro- and Antitumor Immunity

(2016) M. Mandai et al.   CLINICAL CANCER RESEARCH

Safety, immune and clinical responses in metastatic melanoma patients vaccinated with a long peptide derived from indoleamine 2,3-dioxygenase in combination with ipilimumab

(2016) Jon Bjoern et al.   CYTOTHERAPY

PD-L1 expression is associated with epithelial-to-mesenchymal transition in adenocarcinoma of the lung

(2016) Sehui Kim et al.   HUMAN PATHOLOGY

Sulforaphane prevents quinolinic acid-induced mitochondrial dysfunction in rat striatum

(2016) Erika Rubí Luis-García et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Tumor-associated macrophages correlate with the clinicopathological features and poor outcomes via inducing epithelial to mesenchymal transition in oral squamous cell carcinoma

(2016) Yong Hu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Tolerogenic Phenotype of IFN-γ–Induced IDO+Dendritic Cells Is Maintained via an Autocrine IDO–Kynurenine/AhR–IDO Loop

(2016) Qingsheng Li et al.   JOURNAL OF IMMUNOLOGY

The M2 phenotype of tumor-associated macrophages in the stroma confers a poor prognosis in pancreatic cancer

(2016) Hai Hu et al.   TUMOR BIOLOGY

Targeting the Inhibition of Tryptophan 2,3-Dioxygenase (TDO-2) for Cancer Treatment

(2016) Ahmed F. Abdel-Magid   ACS Medicinal Chemistry Letters

PD-L1 expression is associated with epithelial-mesenchymal transition in head and neck squamous cell carcinoma

(2016) Chan-Young Ock et al.   Oncotarget

Lung cancer-derived galectin-1 contributes to cancer associated fibroblast-mediated cancer progression and immune suppression through TDO2/kynurenine axis

(2016) Ya-Ling Hsu et al.   Oncotarget

A phase I study of indoximod in patients with advanced malignancies

(2016) Hatem H. Soliman et al.   Oncotarget

Role of α7-nicotinic acetylcholine receptor in nicotine-induced invasion and epithelial-to-mesenchymal transition in human non-small cell lung cancer cells

(2016) Chun Zhang et al.   Oncotarget

IDO1 is an Integral Mediator of Inflammatory Neovascularization

(2016) Arpita Mondal et al.   EBioMedicine

IL4 receptor α mediates enhanced glucose and glutamine metabolism to support breast cancer growth

(2015) Katherine T. Venmar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

A TDO2-AhR Signaling Axis Facilitates Anoikis Resistance and Metastasis in Triple-Negative Breast Cancer

(2015) Nicholas C. D'Amato et al.   CANCER RESEARCH

FGF-1/-3/FGFR4 signaling in cancer-associated fibroblasts promotes tumor progression in colon cancer through Erk and MMP-7

(2015) Yu-Pan Bai et al.   CANCER SCIENCE

Targeting of IL-4 and IL-13 receptors for cancer therapy

(2015) Akiko Suzuki et al.   CYTOKINE

Decrease of phosphorylated proto-oncogeneCREBat Ser 133 site inhibits growth and metastatic activity of renal cell cancer

(2015) Xue Wang et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

CD73 and CD39 ectonucleotidases in T cell differentiation: Beyond immunosuppression

(2015) María Rosa Bono et al.   FEBS LETTERS

Clinicopathological significance of fibroblast growth factor 1 in non–small cell lung cancer

(2015) Juan Li et al.   HUMAN PATHOLOGY

Extracellular 2′5′-oligoadenylate synthetase 2 mediates T-cell receptor CD3-ζchain down-regulation via caspase-3 activation in oral cancer

(2015) Asif A. Dar et al.   IMMUNOLOGY

From mice to humans: developments in cancer immunoediting

(2015) Michele W.L. Teng et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of Substituted Naphthotriazolediones as Novel Tryptophan 2,3-Dioxygenase (TDO) Inhibitors through Structure-Based Virtual Screening

(2015) Jian-Sung Wu et al.   JOURNAL OF MEDICINAL CHEMISTRY

PD-L1 induces epithelial-to-mesenchymal transition via activating SREBP-1c in renal cell carcinoma

(2015) Yiwei Wang et al.   MEDICAL ONCOLOGY

Amino acid auxotrophy as a system of immunological control nodes

(2015) Peter J Murray   NATURE IMMUNOLOGY

The pancreatic cancer secreted REG4 promotes macrophage polarization to M2 through EGFR/AKT/CREB pathway

(2015) XIUYING MA et al.   ONCOLOGY REPORTS

The aryl hydrocarbon receptor (AhR) mediates resistance to apoptosis induced in breast cancer cells

(2015) Kanae Bekki et al.   PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY

Activation of FGF receptor signaling promotes invasion of non-small-cell lung cancer

(2015) Deping Zhao et al.   TUMOR BIOLOGY

Tryptophan 2,3-dioxygenase (TDO)-reactive T cells differ in their functional characteristics in health and cancer

(2015) Mads Duus Hjortsø et al.   OncoImmunology

A first in man phase I trial of the oral immunomodulator, indoximod, combined with docetaxel in patients with metastatic solid tumors

(2015) Hatem H. Soliman et al.   Oncotarget

Tumour-infiltrating CD4+ and CD8+ lymphocytes as predictors of clinical outcome in glioma

(2014) S Han et al.   BRITISH JOURNAL OF CANCER

IL4 Receptor ILR4  Regulates Metastatic Colonization by Mammary Tumors through Multiple Signaling Pathways

(2014) K. T. Venmar et al.   CANCER RESEARCH

Immune Escape Mechanisms as a Guide for Cancer Immunotherapy

(2014) G. L. Beatty et al.   CLINICAL CANCER RESEARCH

Inhibitory receptor immunoglobulin-like transcript 4 was highly expressed in primary ductal and lobular breast cancer and significantly correlated with IL-10

(2014) Jie Liu et al.   Diagnostic Pathology

Dopamine and serotonin regulate tumor behavior by affecting angiogenesis

(2014) Marloes A.M. Peters et al.   DRUG RESISTANCE UPDATES

Human fibrocytic myeloid-derived suppressor cells express IDO and promote tolerance via Treg-cell expansion

(2014) Alessia Zoso et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Vascular cell adhesion molecule-1 (VCAM-1)-An increasing insight into its role in tumorigenicity and metastasis

(2014) Martin Schlesinger et al.   INTERNATIONAL JOURNAL OF CANCER

The FGF-1-specific single-chain antibody scFv1C9 effectively inhibits breast cancer tumour growth and metastasis

(2014) Hengliang Shi et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The role of plasma IDO activity as a diagnostic marker of patients with colorectal cancer

(2014) M. Cavia-Saiz et al.   MOLECULAR BIOLOGY REPORTS

Kynurenic acid enhances expression of p21 Waf1/Cip1 in colon cancer HT-29 cells

(2014) Katarzyna Walczak et al.   Pharmacological Reports

Kynurenic acid inhibits proliferation and migration of human glioblastoma T98G cells

(2014) Katarzyna Walczak et al.   Pharmacological Reports

Disruption of CD8+ Treg Activity Results in Expansion of T Follicular Helper Cells and Enhanced Antitumor Immunity

(2014) D. A. Alvarez Arias et al.   Cancer Immunology Research

The indoleamine 2,3-dioxygenase pathway controls complement-dependent enhancement of chemo-radiation therapy against murine glioblastoma

(2014) Minghui Li et al.   Journal for ImmunoTherapy of Cancer

Tumor-Associated Macrophages as Major Players in the Tumor Microenvironment

(2014) Theerawut Chanmee et al.   Cancers

The dioxin receptor has tumor suppressor activity in melanoma growth and metastasis

(2013) María Contador-Troca et al.   CARCINOGENESIS

The tryptophan metabolite 3-hydroxyanthranilic acid suppresses T cell responses by inhibiting dendritic cell activation

(2013) Won-Sik Lee et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Urinary Metabotyping of Bladder Cancer Using Two-Dimensional Gas Chromatography Time-of-Flight Mass Spectrometry

(2013) Kishore Kumar Pasikanti et al.   JOURNAL OF PROTEOME RESEARCH

Tumor Secretion of CCL22 Activates Intratumoral Treg Infiltration and Is Independent Prognostic Predictor of Breast Cancer

(2013) Ya-Qing Li et al.   PLoS One

Kynurenic acid in human renal cell carcinoma: its antiproliferative and antimigrative action on Caki-2 cells

(2012) Katarzyna Walczak et al.   AMINO ACIDS

Cytokine Stimulation of Epithelial Cancer Cells: The Similar and Divergent Functions of IL-4 and IL-13

(2012) M. A. Hallett et al.   CANCER RESEARCH

Importance of direct macrophage - Tumor cell interaction on progression of human glioma

(2012) Yoshihiro Komohara et al.   CANCER SCIENCE

Serotonin activates angiogenic phosphorylation signaling in human endothelial cells

(2012) Ali Zamani et al.   FEBS LETTERS

Expression of immunoglobulin-like transcript (ILT)2 and ILT3 in human gastric cancer and its clinical significance

(2012) YI ZHANG et al.   Molecular Medicine Reports

What are regulatory T cells (Treg) regulating in cancer and why?

(2012) Theresa L. Whiteside   SEMINARS IN CANCER BIOLOGY

Spontaneous Cytotoxic T-Cell Reactivity against Indoleamine 2,3-Dioxygenase-2

(2011) R. B. Sorensen et al.   CANCER RESEARCH

Macrophage infiltration and its prognostic relevance in clear cell renal cell carcinoma

(2011) Yoshihiro Komohara et al.   CANCER SCIENCE

Tyrphostin analogs are GPR35 agonists

(2011) Huayun Deng et al.   FEBS LETTERS

Differential action of 3-hydroxyanthranilic acid on viability and activation of stimulated lymphocytes

(2011) Elisa Piscianz et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

l-Kynurenine-induced apoptosis in human NK cells is mediated by reactive oxygen species

(2011) Hyunkeun Song et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Role of aquaporin-4 in the regulation of migration and invasion of human glioma cells

(2011) Feng Gu   INTERNATIONAL JOURNAL OF ONCOLOGY

Imatinib potentiates antitumor T cell responses in gastrointestinal stromal tumor through the inhibition of Ido

(2011) Vinod P Balachandran et al.   NATURE MEDICINE

Frequency of regulatory T cells in peripheral blood and in tumour-infiltrating lymphocytes correlates with poor prognosis in renal cell carcinoma

(2010) Francesco Liotta et al.   BJU INTERNATIONAL

Aquaporins in tumor growth and angiogenesis

(2010) Beatrice Nico et al.   CANCER LETTERS

Tryptophan metabolite 3-hydroxyanthranilic acid selectively induces activated T cell death via intracellular GSH depletion

(2010) Sun-Mi Lee et al.   IMMUNOLOGY LETTERS

Higher intratumoral infiltrated Foxp3+ Treg numbers and Foxp3+/CD8+ ratio are associated with adverse prognosis in resectable gastric cancer

(2010) Zhengbin Shen et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

An Interaction between Kynurenine and the Aryl Hydrocarbon Receptor Can Generate Regulatory T Cells

(2010) J. D. Mezrich et al.   JOURNAL OF IMMUNOLOGY

Kynurenic Acid Is a Potent Endogenous Aryl Hydrocarbon Receptor Ligand that Synergistically Induces Interleukin-6 in the Presence of Inflammatory Signaling

(2010) Brett C. DiNatale et al.   TOXICOLOGICAL SCIENCES

The Aryl Hydrocarbon Receptor Functions as a Tumor Suppressor of Liver Carcinogenesis

(2009) Y. Fan et al.   CANCER RESEARCH

Unifying roles for regulatory T cells and inflammation in cancer

(2009) Susan E. Erdman et al.   INTERNATIONAL JOURNAL OF CANCER

Tryptophan Deprivation Induces Inhibitory Receptors ILT3 and ILT4 on Dendritic Cells Favoring the Induction of Human CD4+CD25+ Foxp3+ T Regulatory Cells

(2009) M. Brenk et al.   JOURNAL OF IMMUNOLOGY

Interleukin-6 induces an epithelial–mesenchymal transition phenotype in human breast cancer cells

(2009) N J Sullivan et al.   ONCOGENE

Human Leukocyte Antigen Class I, MHC Class I Chain-Related Molecule A, and CD8+/Regulatory T-Cell Ratio: Which Variable Determines Survival of Cervical Cancer Patients?

(2008) E. S. Jordanova et al.   CLINICAL CANCER RESEARCH