Breast Cancer Drug Resistance: Overcoming the Challenge by Capitalizing on MicroRNA and Tumor Microenvironment Interplay

The immunomodulatory effects of endocrine therapy in breast cancer

(2021) Huanhuan Huang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Cancer-Associated Adipocytes in Breast Cancer: Causes and Consequences

(2021) Ilona Rybinska et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

miRNA-5119 regulates immune checkpoints in dendritic cells to enhance breast cancer immunotherapy

(2020) Meng Zhang et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

miR-149 Suppresses Breast Cancer Metastasis by Blocking Paracrine Interactions with Macrophages

(2020) Ismael Sánchez-González et al.   CANCER RESEARCH

Early Modulation of Circulating MicroRNAs Levels in HER2-Positive Breast Cancer Patients Treated with Trastuzumab-Based Neoadjuvant Therapy

(2020) Serena Di Cosimo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Overexpression of microRNA-155 enhances the efficacy of dendritic cell vaccine against breast cancer

(2020) Johnie Hodge et al.   OncoImmunology

MiR-199b-5p Suppresses Tumor Angiogenesis Mediated by Vascular Endothelial Cells in Breast Cancer by Targeting ALK1

(2020) Xiao Lin et al.   Frontiers in Genetics

Nanoparticle-Based Delivery of Tumor Suppressor microRNA for Cancer Therapy

(2020) Clodagh P. O’Neill et al.   Cells

Adipocytes in Breast Cancer, the Thick and the Thin

(2020) Ilona Rybinska et al.   Cells

MiR ‐3613‐3p from carcinoma‐associated fibroblasts exosomes promoted breast cancer cell proliferation and metastasis by regulating SOCS2 expression

(2020) Yonglei Liu et al.   IUBMB LIFE

Cancer exosome-derived miR-9 and miR-181a promote the development of early-stage MDSCs via interfering with SOCS3 and PIAS3 respectively in breast cancer

(2020) Mengmeng Jiang et al.   ONCOGENE

The Role of Immune Cells in Breast Tissue and Immunotherapy for the Treatment of Breast Cancer

(2020) Stephanie L. Goff et al.   Clinical Breast Cancer

Clinicopathologic Characteristics of Breast Cancer According to the Infiltrating Immune Cell Subtypes

(2020) Hye Min Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

MiR-302b as a Combinatorial Therapeutic Approach to Improve Cisplatin Chemotherapy Efficacy in Human Triple-Negative Breast Cancer

(2020) Alessandra Cataldo et al.   Cancers

Role of Tumor-Associated Myeloid Cells in Breast Cancer

(2020) Yoon Jin Cha et al.   Cells

Concepts of extracellular matrix remodelling in tumour progression and metastasis

(2020) Juliane Winkler et al.   Nature Communications

CD63 + Cancer‐Associated Fibroblasts Confer Tamoxifen Resistance to Breast Cancer Cells through Exosomal miR‐22

(2020) Yuan Gao et al.   Advanced Science

miR-9-Mediated Inhibition of EFEMP1 Contributes to the Acquisition of Pro-Tumoral Properties in Normal Fibroblasts

(2020) Giulia Cosentino et al.   Cells

Chemotherapy induces dynamic immune responses in breast cancers that impact treatment outcome

(2020) Yeon Hee Park et al.   Nature Communications

The Therapeutic Potential of MicroRNAs in Cancer: Illusion or Opportunity?

(2020) Orazio Fortunato et al.   Pharmaceuticals

Apoptotic tumor cell-derived microRNA-375 uses CD36 to alter the tumor-associated macrophage phenotype

(2019) Ann-Christin Frank et al.   Nature Communications

Endothelial miR-30c suppresses tumor growth via inhibition of TGF-β–induced Serpine1

(2019) James V. McCann et al.   JOURNAL OF CLINICAL INVESTIGATION

Genome-wide analysis reveals miR-3184-5p and miR-181c-3p as a critical regulator for adipocytes-associated breast cancer

(2019) Dheeran Rajarajan et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Tumor suppressor microRNA-204-5p regulates growth, metastasis, and immune microenvironment remodeling in breast cancer

(2019) Bok Sil Hong et al.   CANCER RESEARCH

Exosomes from the tumour-adipocyte interplay stimulate beige/brown differentiation and reprogram metabolism in stromal adipocytes to promote tumour progression

(2019) Qi Wu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Breast Cancer Tumor Stroma: Cellular Components, Phenotypic Heterogeneity, Intercellular Communication, Prognostic Implications and Therapeutic Opportunities

(2019) Eiro et al.   Cancers

miR-155 harnesses Phf19 to potentiate cancer immunotherapy through epigenetic reprogramming of CD8+ T cell fate

(2019) Yun Ji et al.   Nature Communications

Cancer-associated adipocytes: key players in breast cancer progression

(2019) Qi Wu et al.   Journal of Hematology & Oncology

Adipocytes and microRNAs Crosstalk: A Key Tile in the Mosaic of Breast Cancer Microenvironment

(2019) Erika Bandini et al.   Cancers

A view on drug resistance in cancer

(2019) Neil Vasan et al.   NATURE

miR-149-3p reverses CD8 + T-cell exhaustion by reducing inhibitory receptors and promoting cytokine secretion in breast cancer cells

(2019) Meng Zhang et al.   Open Biology

MicroRNA—A Tumor Trojan Horse for Tumor-Associated Macrophages

(2019) Shahzad Nawaz Syed et al.   Cells

miR-153 inhibits the migration and the tube formation of endothelial cells by blocking the paracrine of angiopoietin 1 in breast cancer cells

(2018) Huichun Liang et al.   ANGIOGENESIS

Fibroblast Heterogeneity and Immunosuppressive Environment in Human Breast Cancer

(2018) Ana Costa et al.   CANCER CELL

Loss of XIST in Breast Cancer Activates MSN-c-Met and Reprograms Microglia via Exosomal miRNA to Promote Brain Metastasis

(2018) Fei Xing et al.   CANCER RESEARCH

Cancer-cell-secreted exosomal miR-105 promotes tumour growth through the MYC-dependent metabolic reprogramming of stromal cells

(2018) Wei Yan et al.   NATURE CELL BIOLOGY

Angiogenic role of miR-20a in breast cancer

(2018) Gines Luengo-Gil et al.   PLoS One

The dark side of tumor-associated endothelial cells

(2018) Francesco De Sanctis et al.   SEMINARS IN IMMUNOLOGY

MiR-205 as predictive biomarker and adjuvant therapeutic tool in combination with trastuzumab

(2018) Alessandra Cataldo et al.   Oncotarget

MicroRNAs and DNA-Damaging Drugs in Breast Cancer: Strength in Numbers

(2018) Ilaria Plantamura et al.   Frontiers in Oncology

Early immune modulation by single-agent trastuzumab as a marker of trastuzumab benefit

(2018) Tiziana Triulzi et al.   BRITISH JOURNAL OF CANCER

Tumour-originated exosomal miR-155 triggers cancer-associated cachexia to promote tumour progression

(2018) Qi Wu et al.   Molecular Cancer

Spatially and functionally distinct subclasses of breast cancer-associated fibroblasts revealed by single cell RNA sequencing

(2018) Michael Bartoschek et al.   Nature Communications

miR-100 maintains phenotype of tumor-associated macrophages by targeting mTOR to promote tumor metastasis via Stat5a/IL-1ra pathway in mouse breast cancer

(2018) Wei Wang et al.   Oncogenesis

Exosomal miRNAs and miRNA dysregulation in cancer-associated fibroblasts

(2017) Fengming Yang et al.   Molecular Cancer

MicroRNA therapeutics: towards a new era for the management of cancer and other diseases

(2017) Rajesha Rupaimoole et al.   NATURE REVIEWS DRUG DISCOVERY

Exhaustion-associated regulatory regions in CD8+tumor-infiltrating T cells

(2017) Giuliana P. Mognol et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Down-regulation of miR-29b in carcinoma associated fibroblasts promotes cell growth and metastasis of breast cancer

(2017) Yonglei Liu et al.   Oncotarget

Cancer-associated fibroblasts release exosomal microRNAs that dictate an aggressive phenotype in breast cancer

(2017) Elvira Donnarumma et al.   Oncotarget

Tumor Microenvironment and Differential Responses to Therapy

(2017) Eishu Hirata et al.   Cold Spring Harbor Perspectives in Medicine

Trial watch: Dendritic cell-based anticancer immunotherapy

(2017) Abhishek D. Garg et al.   OncoImmunology

Transition into inflammatory cancer-associated adipocytes in breast cancer microenvironment requires microRNA regulatory mechanism

(2017) Jiwoo Lee et al.   PLoS One

Downregulation of microRNA-206 promotes invasion and angiogenesis of triple negative breast cancer

(2016) Zhongxing Liang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Targeted delivery of let-7b to reprogramme tumor-associated macrophages and tumor infiltrating dendritic cells for tumor rejection

(2016) Zhen Huang et al.   BIOMATERIALS

One microenvironment does not fit all: heterogeneity beyond cancer cells

(2016) Ik Sun Kim et al.   CANCER AND METASTASIS REVIEWS

miR-9 and miR-200 Regulate PDGFRβ-Mediated Endothelial Differentiation of Tumor Cells in Triple-Negative Breast Cancer

(2016) Elvira D'Ippolito et al.   CANCER RESEARCH

Interactions between Adipocytes and Breast Cancer Cells Stimulate Cytokine Production and Drive Src/Sox2/miR-302b–Mediated Malignant Progression

(2016) Manuel Picon-Ruiz et al.   CANCER RESEARCH

Distribution of miRNA expression across human tissues

(2016) Nicole Ludwig et al.   NUCLEIC ACIDS RESEARCH

Exosomes miR-126a released from MDSC induced by DOX treatment promotes lung metastasis

(2016) Z Deng et al.   ONCOGENE

Immune infiltrates in the breast cancer microenvironment: detection, characterization and clinical implication

(2016) Samantha Burugu et al.   Breast Cancer

miRNA-205 targets VEGFA and FGF2 and regulates resistance to chemotherapeutics in breast cancer

(2016) Y Hu et al.   Cell Death & Disease

Exosome-mediated delivery of miR-9 induces cancer-associated fibroblast-like properties in human breast fibroblasts

(2016) S Baroni et al.   Cell Death & Disease

Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards

(2016) Vincenzo Bronte et al.   Nature Communications

miR-145 sensitizes breast cancer to doxorubicin by targeting multidrug resistance-associated protein-1

(2016) Man Gao et al.   Oncotarget

Loss of oncogenic miR-155 in tumor cells promotes tumor growth by enhancing C/EBP-β-mediated MDSC infiltration

(2016) Sinae Kim et al.   Oncotarget

Doxorubicin resistant cancer cells activate myeloid-derived suppressor cells by releasing PGE2

(2016) Yuan Rong et al.   Scientific Reports

microRNA-155 deficiency impairs dendritic cell function in breast cancer

(2016) Junfeng Wang et al.   OncoImmunology

Targeting exosomes from preadipocytes inhibits preadipocyte to cancer stem cell signaling in early-stage breast cancer

(2015) Ramkishore Gernapudi et al.   BREAST CANCER RESEARCH AND TREATMENT

Combining miR-10b-Targeted Nanotherapy with Low-Dose Doxorubicin Elicits Durable Regressions of Metastatic Breast Cancer

(2015) B. Yoo et al.   CANCER RESEARCH

VEGF-Induced Expression of miR-17–92 Cluster in Endothelial Cells Is Mediated by ERK/ELK1 Activation and Regulates AngiogenesisNovelty and Significance

(2015) Aránzazu Chamorro-Jorganes et al.   CIRCULATION RESEARCH

MiR-21 controls in situ expansion of CCR6+ regulatory T cells through PTEN/AKT pathway in breast cancer

(2015) Yan Hu et al.   IMMUNOLOGY AND CELL BIOLOGY

miR-302b enhances breast cancer cell sensitivity to cisplatin by regulating E2F1 and the cellular DNA damage response

(2015) Alessandra Cataldo et al.   Oncotarget

Endothelial exosomes contribute to the antitumor response during breast cancer neoadjuvant chemotherapy via microRNA transfer

(2015) Nicolas Bovy et al.   Oncotarget

Functions of miR-146a and miR-222 in Tumor-associated Macrophages in Breast Cancer

(2015) Yanshuang Li et al.   Scientific Reports

MiR-221 promotes trastuzumab-resistance and metastasis in HER2-positive breast cancers by targeting PTEN

(2014) Xingming Ye et al.   BMB Reports

Cancer-Secreted miR-105 Destroys Vascular Endothelial Barriers to Promote Metastasis

(2014) Weiying Zhou et al.   CANCER CELL

Tumor–stroma crosstalk

(2014) Carmen Criscitiello et al.   CURRENT OPINION IN ONCOLOGY

The Vascular Endothelium and Human Diseases

(2014) Peramaiyan Rajendran et al.   International Journal of Biological Sciences

MiR-200c suppresses TGF-β signaling and counteracts trastuzumab resistance and metastasis by targeting ZNF217 and ZEB1 in breast cancer

(2014) Wen-Dong Bai et al.   INTERNATIONAL JOURNAL OF CANCER

Exosome derived from epigallocatechin gallate treated breast cancer cells suppresses tumor growth by inhibiting tumor-associated macrophage infiltration and M2 polarization

(2013) Ji-Young Jang et al.   BMC CANCER

Dendritic Cells, Inflammation, and Breast Cancer

(2013) Karolina Palucka et al.   CANCER JOURNAL

The Function Role of miR-181a in Chemosensitivity to Adriamycin by Targeting Bcl-2 in Low-Invasive Breast Cancer Cells

(2013) Ying Zhu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

MicroRNA-126 regulates the induction and function of CD4+Foxp3+regulatory T cells through PI3K/AKT pathway

(2013) Andong Qin et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Comparisons between different polychemotherapy regimens for early breast cancer: meta-analyses of long-term outcome among 100 000 women in 123 randomised trials

(2013)   LANCET

MicroRNA-19a-3p inhibits breast cancer progression and metastasis by inducing macrophage polarization through downregulated expression of Fra-1 proto-oncogene

(2013) J Yang et al.   ONCOGENE

Biological Characteristics and Genetic Heterogeneity between Carcinoma-Associated Fibroblasts and Their Paired Normal Fibroblasts in Human Breast Cancer

(2013) Qiongle Peng et al.   PLoS One

MicroRNA-mediated control of macrophages and its implications for cancer

(2013) Mario Leonardo Squadrito et al.   TRENDS IN IMMUNOLOGY

Autocrine functions of VEGF in breast tumor cells

(2013) Martine Perrot-Applanat et al.   Cell Adhesion & Migration

Lipid-based carriers of microRNAs and intercellular communication

(2012) Kasey C. Vickers et al.   CURRENT OPINION IN LIPIDOLOGY

MicroRNA-494 Is Required for the Accumulation and Functions of Tumor-Expanded Myeloid-Derived Suppressor Cells via Targeting of PTEN

(2012) Y. Liu et al.   JOURNAL OF IMMUNOLOGY

Re-polarization of tumor-associated macrophages to pro-inflammatory M1 macrophages by microRNA-155

(2012) Xing Cai et al.   Journal of Molecular Cell Biology

Reduced miR-128 in Breast Tumor-Initiating Cells Induces Chemotherapeutic Resistance via Bmi-1 and ABCC5

(2011) Y. Zhu et al.   CLINICAL CANCER RESEARCH

Akt3 controls vascular endothelial growth factor secretion and angiogenesis in ovarian cancer cells

(2011) Tiera A. Liby et al.   INTERNATIONAL JOURNAL OF CANCER

MicroRNA-125b Potentiates Macrophage Activation

(2011) Aadel A. Chaudhuri et al.   JOURNAL OF IMMUNOLOGY

MicroRNA-155 may affect allograft survival by regulating the expression of suppressor of cytokine signaling 1

(2011) Maomao Zhang et al.   MEDICAL HYPOTHESES

A microRNA regulon that mediates endothelial recruitment and metastasis by cancer cells

(2011) Kim J. Png et al.   NATURE

Characterization of extracellular circulating microRNA

(2011) Andrey Turchinovich et al.   NUCLEIC ACIDS RESEARCH

Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma

(2011) J. D. Arroyo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alterations of microRNAs and their targets are associated with acquired resistance of MCF-7 breast cancer cells to cisplatin

(2010) Igor P. Pogribny et al.   INTERNATIONAL JOURNAL OF CANCER

Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm

(2010) Subhra K Biswas et al.   NATURE IMMUNOLOGY

Heterogeneity of gene expression in stromal fibroblasts of human breast carcinomas and normal breast

(2010) M Bauer et al.   ONCOGENE

Role of microRNA in anticancer drug resistance

(2009) Tongsen Zheng et al.   INTERNATIONAL JOURNAL OF CANCER

Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation

(2009) G. Solinas et al.   JOURNAL OF LEUKOCYTE BIOLOGY