Circadian Clock and Liver Cancer

Circadian hepatocyte clocks keep synchrony in the absence of a master pacemaker in the suprachiasmatic nucleus or other extrahepatic clocks

(2021) Flore Sinturel et al.   GENES & DEVELOPMENT

Stress kinases in the development of liver steatosis and hepatocellular carcinoma

(2021) Beatriz Cicuéndez et al.   Molecular Metabolism

Circadian rhythms in the absence of the clock gene Bmal1

(2020) Sandipan Ray et al.   SCIENCE

Nonalcoholic fatty liver disease in CLOCK mutant mice

(2020) Xiaoyue Pan et al.   JOURNAL OF CLINICAL INVESTIGATION

Scientific evidence underlying contraindications to the ketogenic diet: An update

(2020) Mikiko Watanabe et al.   Obesity Reviews

JNK-mediated disruption of bile acid homeostasis promotes intrahepatic cholangiocarcinoma

(2020) Elisa Manieri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The hepatocyte clock and feeding control chronophysiology of multiple liver cell types

(2020) Dongyin Guan et al.   SCIENCE

The role of stress kinases in metabolic disease

(2020) Ivana Nikolic et al.   Nature Reviews Endocrinology

Neutrophil infiltration regulates clock-gene expression to organize daily hepatic metabolism

(2020) María Crespo et al.   eLife

Coordination between the circadian clock and androgen signaling is required to sustain rhythmic expression of Elovl3 in mouse liver

(2019) Huatao Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FGF15 Activates Hippo Signaling to Suppress Bile Acid Metabolism and Liver Tumorigenesis

(2019) Suyuan Ji et al.   DEVELOPMENTAL CELL

Adiponectin accounts for gender differences in hepatocellular carcinoma incidence

(2019) Elisa Manieri et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Defining the Independence of the Liver Circadian Clock

(2019) Kevin B. Koronowski et al.   CELL

Analysis of miRNA expression profiles in the liver of ClockΔ19 mutant mice

(2019) Yanli Wang et al.   PeerJ

Autophagy Regulates the Liver Clock and Glucose Metabolism by Degrading CRY1

(2018) Miriam Toledo et al.   Cell Metabolism

The hepatic BMAL1/AKT/lipogenesis axis protects against alcoholic liver disease in mice via promoting PPARα pathway

(2018) Deqiang Zhang et al.   HEPATOLOGY

mTOR signaling regulates central and peripheral circadian clock function

(2018) Chidambaram Ramanathan et al.   PLoS Genetics

Deficiency of fibroblast growth factor 21 (FGF21) promotes hepatocellular carcinoma (HCC) in mice on a long term obesogenic diet

(2018) Garima Singhal et al.   Molecular Metabolism

Incompatibility of the circadian protein BMAL1 and HNF4α in hepatocellular carcinoma

(2018) Baharan Fekry et al.   Nature Communications

Circadian Clock Regulation of Hepatic Lipid Metabolism by Modulation of m6A mRNA Methylation

(2018) Xiang Zhong et al.   Cell Reports

Critical cholangiocarcinogenesis control by cryptochrome clock genes

(2017) Ali Mteyrek et al.   INTERNATIONAL JOURNAL OF CANCER

CYCLOPS reveals human transcriptional rhythms in health and disease

(2017) Ron C. Anafi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NPAS2 promotes cell survival of hepatocellular carcinoma by transactivating CDC25A

(2017) Peng Yuan et al.   Cell Death & Disease

Circadian Homeostasis of Liver Metabolism Suppresses Hepatocarcinogenesis

(2016) Nicole M. Kettner et al.   CANCER CELL

Circadian Clock Control of Liver Metabolic Functions

(2016) Hans Reinke et al.   GASTROENTEROLOGY

Genetic and Environmental Models of Circadian Disruption Link SRC-2 Function to Hepatic Pathology

(2016) Tiffany Fleet et al.   JOURNAL OF BIOLOGICAL RHYTHMS

Circadian physiology of metabolism

(2016) Satchidananda Panda   SCIENCE

SREBP1c-CRY1 signalling represses hepatic glucose production by promoting FOXO1 degradation during refeeding

(2016) Hagoon Jang et al.   Nature Communications

Clock gene Per2 as a controller of liver carcinogenesis

(2016) Ali Mteyrek et al.   Oncotarget

The emerging roles of lipids in circadian control

(2015) Yaarit Adamovich et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Hepatic Bmal1 Regulates Rhythmic Mitochondrial Dynamics and Promotes Metabolic Fitness

(2015) David Jacobi et al.   Cell Metabolism

Circadian control of bile acid synthesis by a KLF15-Fgf15 axis

(2015) Shuxin Han et al.   Nature Communications

Circadian rhythms in liver metabolism and disease

(2015) Jessica M. Ferrell et al.   Acta Pharmaceutica Sinica B

Liver Clock Protein BMAL1 Promotesde NovoLipogenesis through Insulin-mTORC2-AKT Signaling

(2014) Deqiang Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A circadian gene expression atlas in mammals: Implications for biology and medicine

(2014) Ray Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear receptor Rev-erbα: up, down, and all around

(2014) Logan J. Everett et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Hepatitis B virus X protein disrupts the balance of the expression of circadian rhythm genes in hepatocellular carcinoma

(2014) SHENG-LI YANG et al.   Oncology Letters

In-Vivo Quantitative Proteomics Reveals a Key Contribution of Post-Transcriptional Mechanisms to the Circadian Regulation of Liver Metabolism

(2014) Maria S. Robles et al.   PLoS Genetics

High-fat diet-induced hyperinsulinemia and tissue-specific insulin resistance in Cry-deficient mice

(2013) Johanna L. Barclay et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Reprogramming of the Circadian Clock by Nutritional Challenge

(2013) Kristin L. Eckel-Mahan et al.   CELL

Sleep duration and quality in relation to non-alcoholic fatty liver disease in middle-aged workers and their spouses

(2013) Chan-Won Kim et al.   JOURNAL OF HEPATOLOGY

PER2 promotes glucose storage to liver glycogen during feeding and acute fasting by inducing Gys2 PTG and GL expression

(2013) Fabio Zani et al.   Molecular Metabolism

Rev-erb  and Rev-erb  coordinately protect the circadian clock and normal metabolic function

(2012) A. Bugge et al.   GENES & DEVELOPMENT

Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists

(2012) Laura A. Solt et al.   NATURE

Cryptochromes mediate rhythmic repression of the glucocorticoid receptor

(2011) Katja A. Lamia et al.   NATURE

Hepatocellular Carcinoma

(2011) Hashem B. El-Serag   NEW ENGLAND JOURNAL OF MEDICINE

Deficient of a Clock Gene, Brain and Muscle Arnt-Like Protein-1 (BMAL1), Induces Dyslipidemia and Ectopic Fat Formation

(2011) Shigeki Shimba et al.   PLoS One

A Circadian Rhythm Orchestrated by Histone Deacetylase 3 Controls Hepatic Lipid Metabolism

(2011) D. Feng et al.   SCIENCE

The Mammalian Circadian Timing System: Organization and Coordination of Central and Peripheral Clocks

(2010) Charna Dibner et al.   Annual Review of Physiology

Circadian Clock-Coordinated 12 Hr Period Rhythmic Activation of the IRE1α Pathway Controls Lipid Metabolism in Mouse Liver

(2010) Gaspard Cretenet et al.   Cell Metabolism

PER2 Controls Lipid Metabolism by Direct Regulation of PPARγ

(2010) Benedetto Grimaldi et al.   Cell Metabolism

CLOCK Regulates Circadian Rhythms of Hepatic Glycogen Synthesis through Transcriptional Activation ofGys2

(2010) Ryosuke Doi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcriptional Repressor E4-binding Protein 4 (E4BP4) Regulates Metabolic Hormone Fibroblast Growth Factor 21 (FGF21) during Circadian Cycles and Feeding

(2010) Xin Tong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Circadian Organization Is Governed by Extra-SCN Pacemakers

(2010) Pinar Pezuk et al.   JOURNAL OF BIOLOGICAL RHYTHMS

Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis

(2010) Eric E Zhang et al.   NATURE MEDICINE

Circadian Integration of Metabolism and Energetics

(2010) J. Bass et al.   SCIENCE

Hepatitis B and C Viruses and Hepatocellular Carcinoma

(2010) Birke Bartosch   Viruses-Basel

Circadian Disruption in Experimental Cancer Processes

(2009) Elisabeth Filipski et al.   INTEGRATIVE CANCER THERAPIES

Circadian disruption accelerates liver carcinogenesis in mice

(2009) Elisabeth Filipski et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Circadian Dysregulation Disrupts Bile Acid Homeostasis

(2009) Ke Ma et al.   PLoS One

Time of feeding and the intrinsic circadian clock drive rhythms in hepatic gene expression

(2009) Christopher Vollmers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AMPK Regulates the Circadian Clock by Cryptochrome Phosphorylation and Degradation

(2009) K. A. Lamia et al.   SCIENCE

REV-ERBα Participates in Circadian SREBP Signaling and Bile Acid Homeostasis

(2009) Gwendal Le Martelot et al.   PLOS BIOLOGY

Sympathetic input modulates, but does not determine, phase of peripheral circadian oscillators

(2008) Nina Vujović et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

The NAD+-Dependent Deacetylase SIRT1 Modulates CLOCK-Mediated Chromatin Remodeling and Circadian Control

(2008) Yasukazu Nakahata et al.   CELL

Regulation of Bile Acid Synthesis by the Nuclear Receptor Rev-erbα

(2008) Hélène Duez et al.   GASTROENTEROLOGY

Disturbance of circadian gene expression in hepatocellular carcinoma

(2008) Yueh-Min Lin et al.   MOLECULAR CARCINOGENESIS

Physiological significance of a peripheral tissue circadian clock

(2008) K. A. Lamia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA