Review
Medicine, Research & Experimental
Yi Qin, Zhong-hua Chen, Jun-Jie Wu, Zhen-Yu Zhang, Zheng-Dong Yuan, Dan-Yang Guo, Meng-Nan Chen, Xia Li, Feng-Lai Yuan
Summary: The circadian clock plays a crucial role in regulating bone metabolism, including bone loss. Clock-related genes control signaling pathways and transcription factors in osteoblasts and osteoclasts, while also regulating osteocytes and endothelial cells. Furthermore, the regulation of circadian clock genes by novel modulators presents a potential strategy for preventing and treating bone diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Biochemistry & Molecular Biology
Ana Beatriz Aguiar Sanford, Leidivan Sousa da Cunha, Caio Bezerra Machado, Flavia Melo Cunha de Pinho Pessoa, Abigail Nayara dos Santos Silva, Rodrigo Monteiro Ribeiro, Fabiano Cordeiro Moreira, Manoel Odorico de Moraes Filho, Maria Elisabete Amaral de Moraes, Lucas Eduardo Botelho de Souza, Andre Salim Khayat, Caroline Aquino Moreira-Nunes
Summary: The circadian clock is a system that regulates physiological processes and responds to the external environment, while its disruption can lead to various diseases. Leukemia is a malignancy of the blood and bone marrow caused by alterations in cellular regulatory processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Meng Qu, Guoxin Zhang, Han Qu, Alexander Vu, Raymond Wu, Hidekazu Tsukamoto, Zhenyu Jia, Wendong Huang, Heinz-Josef Lenz, Jeremy N. Rich, Steve A. Kay
Summary: Hepatocellular carcinoma (HCC) is a global health challenge with increasing incidence worldwide. The circadian clock has been shown to play a key role in hepatocarcinogenesis, but the cellular and molecular mechanisms underlying the HCC-clock crosstalk are unknown. In this study, we found that HCC cells rely on the circadian clock transcription factors BMAL1 and CLOCK for cell growth, and down-regulation of these factors induces apoptosis and cell cycle arrest. Mechanistically, inhibiting BMAL1/CLOCK dysregulates cell cycle regulators Wee1 and p21, leading to tumor cell death. Our findings provide insights into the cellular impact of clock proteins in HCC oncogenesis and suggest a potential therapeutic approach based on modulation of the circadian clock.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Biochemistry & Molecular Biology
Tingting Li, Shihua Zhang, Yuxuan Yang, Lingli Zhang, Yu Yuan, Jun Zou
Summary: This paper reviews the progress of research on the co-regulation of bone metabolism by circadian clock genes and microRNAs, aiming to provide new ideas for the prevention and treatment of bone metabolic diseases such as osteoporosis.
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2022)
Article
Multidisciplinary Sciences
Annika F. Barber, Shi Yi Fong, Anna Kolesnik, Michael Fetchko, Amita Sehgal
Summary: Regulation of circadian behavior and physiology by the Drosophila brain clock requires communication from central clock neurons to downstream output regions. Morning and evening clock neurons have time-of-day-dependent connectivity to the pars intercerebralis, which is regulated by specific peptides and fast neurotransmitters. This study provides insights into mechanisms by which clock neurons signal to nonclock cells to drive rhythms of behavior.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Medicine, Research & Experimental
Takashi Iwamoto, Kazumasa Torimoto, Daisuke Gotoh, Sayuri Onishi, Shunta Hori, Yousuke Morizawa, Yasushi Nakai, Makito Miyake, Kiyohide Fujimoto
Summary: This study aims to investigate the circadian expression changes of bladder clock genes in Dahl salt-sensitive rats following high salt intake. The results showed that high salt intake led to lower mRNA levels and reduced amplitude of circadian expression changes in bladder clock genes. However, reducing salt intake partially restored these rhythms.
Article
Genetics & Heredity
Huaifeng Liu, Yu Gao, Shangshang Hu, Zhengran Fan, Xianggang Wang, Shujing Li
Summary: The study identified 563 DERGs in LIHC patients, with some genes significantly associated with survival rate. Consistent results from bioinformatics analysis and cell experiments showed that abnormal expression of CSNK1D, CSNK1E, and NPAS2 genes were closely related to the survival rate of LIHC patients.
FRONTIERS IN GENETICS
(2021)
Article
Biochemistry & Molecular Biology
Maria Savino, Claudio Carmine Guida, Maria Nardella, Emanuele Murgo, Bartolomeo Augello, Giuseppe Merla, Salvatore De Cosmo, Antonio Fernando Savino, Roberto Tarquini, Francesco Cei, Filippo Aucella, Gianluigi Mazzoccoli
Summary: This article investigates the relationship between heme biosynthesis disorders and altered expression of circadian genes, finding that changes in circadian gene expression may be associated with the symptoms and signs of porphyria patients.
Review
Genetics & Heredity
Saiedeh Razi Soofiyani, Hossein Ahangari, Alireza Soleimanian, Ghader Babaei, Tohid Ghasemnejad, Seyed Esmaeil Safavi, Shirin Eyvazi, Vahideh Tarhriz
Summary: Colorectal cancer is the third most common cancer in humans, with unclear development mechanisms but known associations with genetic, environmental, and epigenetic risk factors. The circadian rhythm, controlled by circadian clock genes, cytokines, and hormones, regulates various biological processes and disruptions in this rhythm have been linked to diseases such as cancer. The pathways of circadian genes in the pathogenesis of CRC are still underexplored, but understanding them may lead to new therapeutic approaches.
Article
Oncology
Zhen Zhang, Zicheng Liang, Wenhui Gao, Shuxian Yu, Zongwei Hou, Kexin Li, Puhua Zeng
Summary: This study aimed to investigate the role of circadian clock genes in hepatocellular carcinoma (HCC). The results revealed a correlation between the expression of circadian clock genes and the survival rate and immune infiltration in HCC patients. The findings contribute to the discovery of potential molecular targets for diagnosis and therapy of HCC.
Article
Oncology
Zhenyu Wu, Hao Hu, Qiang Zhang, Tengfei Wang, Huixing Li, Yugang Qin, Xiangnan Ai, Wen Yi, Xiaojun Wei, Wei Gao, Caiguo Ouyang
Summary: This study identified circadian rhythm-related genes and constructed a signature that can assess prognosis for hepatocellular carcinoma patients. The resulting prognosis model proved to be an effective biomarker and could predict immune infiltration sensitivity.
FRONTIERS IN ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Matti Steimer, Sandra Kaiser, Felix Ulbrich, Johannes Kalbhenn, Hartmut Buerkle, Nils Schallner
Summary: This study aimed to quantify circadian disruption by analyzing the expression levels of PER2 and HO1 genes as potential diagnostic tools for ICU-acquired delirium in trauma patients. The expression levels of PER2 and HO1 were significantly correlated with trauma severity and longer ICU length of stay, with high expression levels increasing the odds of delirium occurrence. Patients with traumatic brain injury showed a trend towards elevated PER2 expression but were less likely to develop acute kidney injury compared to non-TBI patients.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Weitian Li, Zixu Wang, Jing Cao, Yulan Dong, Yaoxing Chen
Summary: Lack of sleep time is a threat to modern people, leading to chronic diseases and mental illnesses. This study in mice found that sleep restriction disrupted the circadian rhythm of clock genes and advanced the output signals in the plasma.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Review
Endocrinology & Metabolism
Si-Ke He, Jia-Hao Wang, Tao Li, Shan Yin, Jian-Wei Cui, Yun-Fei Xiao, Yin Tang, Jia Wang, Yun-Jin Bai
Summary: This article reviews the relationship between circadian rhythm disturbance and kidney stone disease (KSD), summarizing the risk factors and treatment methods. The results indicate that KSD is associated with systemic disorders such as metabolic syndrome, inflammatory bowel disease, and microbiome dysbiosis, and some chronotherapies have been proven effective.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biology
Juan Alfonso Redondo, Romain Bibes, Alizee Vercauteren Drubbel, Benjamin Dassy, Xavier Bisteau, Eleonore Maury, Benjamin Beck
Summary: The study focused on the oscillations of the clock-related gene PER2 in esophageal cancer cells and found that chemotherapy is more effective when PER2 expression is low. This suggests that chronotherapy could enhance the impact of current chemotherapy regimens for esophageal cancer. The results indicate that understanding and utilizing the circadian rhythm in cancer treatment may lead to improved therapeutic outcomes.