Glyoxalase-1-Dependent Methylglyoxal Depletion Sustains PD-L1 Expression in Metastatic Prostate Cancer Cells: A Novel Mechanism in Cancer Immunosurveillance Escape and a Potential Novel Target to Overcome PD-L1 Blockade Resistance

Refining Immuno-Oncology Approaches in Metastatic Prostate Cancer: Transcending Current Limitations

(2021) Risa L. Wong et al.   CURRENT TREATMENT OPTIONS IN ONCOLOGY

Safety and Clinical Activity of Atezolizumab in Patients With Metastatic Castration-Resistant Prostate Cancer: a Phase I Study

(2021) Daniel P. Petrylak et al.   CLINICAL CANCER RESEARCH

Prevalence of Prostate Cancer at Different Clinical Stages in Italy: Estimated Burden of Disease Based on a Modelling Study

(2021) Federico Spandonaro et al.   Biology-Basel

The efficacy of PD-1/PD-L1 blockade in cold cancers and future perspectives

(2021) Jamal Majidpoor et al.   CLINICAL IMMUNOLOGY

Evolution of systemic therapy for stages I–III non-metastatic non-small-cell lung cancer

(2021) Jamie E. Chaft et al.   Nature Reviews Clinical Oncology

Tumor Microenvironment in Prostate Cancer: Toward Identification of Novel Molecular Biomarkers for Diagnosis, Prognosis, and Therapy Development

(2021) Hisham F. Bahmad et al.   Frontiers in Genetics

Immunotherapy Updates in Advanced Hepatocellular Carcinoma

(2021) Amisha Singh et al.   Cancers

Elevated Expression of Glycerol-3-Phosphate Phosphatase as a Biomarker of Poor Prognosis and Aggressive Prostate Cancer

(2021) Mohamed Amine Lounis et al.   Cancers

Oleic acid and oleoylethanolamide decrease interferon-γ-induced expression of PD-L1 and induce apoptosis in human lung carcinoma cells

(2021) Kazuo Yamagata et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Peptide-based and small molecule PD-1 and PD-L1 pharmacological modulators in the treatment of cancer

(2021) Mohammad Kaisarul Islam et al.   PHARMACOLOGY & THERAPEUTICS

PD1/PD-L1 axis in uro-oncology.

(2020) Kerstin Junker et al.   CURRENT DRUG TARGETS

Regulation of PD-L1 expression on cancer cells with ROS-modulating drugs

(2020) Christian Bailly   LIFE SCIENCES

Regulatory myeloid cells paralyze T cells through cell–cell transfer of the metabolite methylglyoxal

(2020) Tobias Baumann et al.   NATURE IMMUNOLOGY

Chemerin Reactivates PTEN and Suppresses PD-L1 in Tumor Cells via Modulation of a Novel CMKLR1-mediated Signaling Cascade

(2020) Keith Rennier et al.   CLINICAL CANCER RESEARCH

PD-L1 inhibitors for the treatment of prostate cancer

(2020) Matteo Santoni et al.   CURRENT DRUG TARGETS

A phase II single-arm study of pembrolizumab with enzalutamide in men with metastatic castration-resistant prostate cancer progressing on enzalutamide alone

(2020) Julie N Graff et al.   Journal for ImmunoTherapy of Cancer

Isosamidin from Peucedanum japonicum Roots Prevents Methylglyoxal-Induced Glucotoxicity in Human Umbilical Vein Endothelial Cells via Suppression of ROS-Mediated Bax/Bcl-2

(2020) Moon Ho Do et al.   Antioxidants

Nivolumab Plus Ipilimumab for Metastatic Castration-Resistant Prostate Cancer: Preliminary Analysis of Patients in the CheckMate 650 Trial

(2020) Padmanee Sharma et al.   CANCER CELL

LncRNA KCNQ1OT1 sponges miR-15a to promote immune evasion and malignant progression of prostate cancer via up-regulating PD-L1

(2020) Qi-Hua Chen et al.   Cancer Cell International

The Mechanisms of PD-L1 Regulation in Non-Small-Cell Lung Cancer (NSCLC): Which Are the Involved Players?

(2020) Giuseppe Lamberti et al.   Cancers

Interactions between androgen receptor signaling and other molecular pathways in prostate cancer progression: Current and future clinical implications

(2020) Chiara Pisano et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Molecular pathology of prostate cancer: a practical approach

(2020) Tatjana Vlajnic et al.   PATHOLOGY

Regulation of PD-L1 Expression by NF-κB in Cancer

(2020) Fabrizio Antonangeli et al.   Frontiers in Immunology

Interplay among Oxidative Stress, Methylglyoxal Pathway and S-Glutathionylation

(2020) Lidia de Bari et al.   Antioxidants

Genomic GLO1 deletion modulates TXNIP expression, glucose metabolism, and redox homeostasis while accelerating human A375 malignant melanoma tumor growth

(2020) Jana Jandova et al.   Redox Biology

Overexpression of SOCS3 mediated by adenovirus vector in mouse and human castration-resistant prostate cancer cells increases the sensitivity to NK cells in vitro and in vivo

(2019) Tomomi Yoneda et al.   CANCER GENE THERAPY

Glycation interferes with natural killer cell function

(2019) Philip Rosenstock et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Increased glycolysis correlates with elevated immune activity in tumor immune microenvironment

(2019) Zehang Jiang et al.   EBioMedicine

Suppression of Exosomal PD-L1 Induces Systemic Anti-tumor Immunity and Memory

(2019) Mauro Poggio et al.   CELL

Methylglyoxal Acts as a Tumor-Promoting Factor in Anaplastic Thyroid Cancer

(2019) Cinzia Antognelli et al.   Cells

Increased indoleamine 2,3-dioxygenase activity and expression in prostate cancer following targeted immunotherapy

(2019) Chris D. Zahm et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

MiR-195/-16 Family Enhances Radiotherapy via T Cell Activation in the Tumor Microenvironment by Blocking the PD-L1 Immune Checkpoint

(2018) Zhen Tao et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

KRIT1 loss-of-function induces a chronic Nrf2-mediated adaptive homeostasis that sensitizes cells to oxidative stress: Implication for Cerebral Cavernous Malformation disease

(2018) Cinzia Antognelli et al.   FREE RADICAL BIOLOGY AND MEDICINE

Glyoxalases in Urological Malignancies

(2018) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Glyoxalase 1 sustains the metastatic phenotype of prostate cancer cells via EMT control

(2018) Cinzia Antognelli et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Combined inhibition of JAK1,2/Stat3‑PD‑L1 signaling pathway suppresses the immune escape of castration‑resistant prostate cancer to NK cells in hypoxia

(2018) Li‑Jun Xu et al.   Molecular Medicine Reports

Immune Checkpoint-Mediated Interactions Between Cancer and Immune Cells in Prostate Adenocarcinoma and Melanoma

(2018) Angela Rita Elia et al.   Frontiers in Immunology

Immunotherapy for Prostate Cancer: Where We Are Headed

(2017) Giuseppe Schepisi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

High-Level Glyoxalase 1 (GLO1) expression is linked to poor prognosis in prostate cancer

(2017) Christoph Burdelski et al.   PROSTATE

The prognostic role of immune checkpoint markers programmed cell death protein 1 (PD-1) and programmed death ligand 1 (PD-L1) in a large, multicenter prostate cancer cohort

(2017) Nora Ness et al.   Oncotarget

A Contemporary Prostate Cancer Grading System: A Validated Alternative to the Gleason Score

(2016) Jonathan I. Epstein et al.   EUROPEAN UROLOGY

The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs—Part B: Prostate and Bladder Tumours

(2016) Peter A. Humphrey et al.   EUROPEAN UROLOGY

Glyoxalase 2 Is Involved in Human Prostate Cancer Progression as Part of a Mechanism Driven By PTEN/PI3K/AKT/mTOR Signaling With Involvement of PKM2 and ERα

(2016) Vincenzo N. Talesa et al.   PROSTATE

The Immune Checkpoint Regulator PD-L1 Is Highly Expressed in Aggressive Primary Prostate Cancer

(2015) H. Gevensleben et al.   CLINICAL CANCER RESEARCH

Peroxynitrite-mediated glyoxalase I epigenetic inhibition drives apoptosis in airway epithelial cells exposed to crystalline silica via a novel mechanism involving argpyrimidine-modified Hsp70, JNK, and NF-κB

(2015) Cinzia Antognelli et al.   FREE RADICAL BIOLOGY AND MEDICINE

Immune evasion in cancer: Mechanistic basis and therapeutic strategies

(2015) Dass S. Vinay et al.   SEMINARS IN CANCER BIOLOGY

Dicarbonyl Induced Structural Perturbations Make Histone H1 Highly Immunogenic and Generate an Auto-Immune Response in Cancer

(2015) Abdul Rouf Mir et al.   PLoS One

Glyoxalase I inhibition induces apoptosis in irradiated MCF-7 cells via a novel mechanism involving Hsp27, p53 and NF-κB

(2014) C Antognelli et al.   BRITISH JOURNAL OF CANCER

Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens

(2014) Matthew M. Gubin et al.   NATURE

Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients

(2014) Roy S. Herbst et al.   NATURE

Oncology Meets Immunology: The Cancer-Immunity Cycle

(2013) Daniel S. Chen et al.   IMMUNITY

A novel mechanism of methylglyoxal cytotoxicity in prostate cancer cells

(2013) Cinzia Antognelli et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Up-regulation of proliferative and migratory genes in regulatory T cells from patients with metastatic castration-resistant prostate cancer

(2013) Ngar-Yee Huen et al.   INTERNATIONAL JOURNAL OF CANCER

Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

(2012) Patrick S. Ward et al.   CANCER CELL

Molecular Pathways: Next-Generation Immunotherapy--Inhibiting Programmed Death-Ligand 1 and Programmed Death-1

(2012) D. S. Chen et al.   CLINICAL CANCER RESEARCH

Targeting the PD-1/B7-H1(PD-L1) pathway to activate anti-tumor immunity

(2012) Suzanne L Topalian et al.   CURRENT OPINION IN IMMUNOLOGY

Changes in lymphocyte oxidant/antioxidant parameters after carbonyl and antioxidant exposure

(2012) A.P. Bolin et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Negative regulatory responses to metabolically triggered inflammation impair renal epithelial immunity in diabetes mellitus

(2012) Nelson K. F. Chen et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Proteomic Analysis of Protease Resistant Proteins in the Diabetic Rat Kidney

(2012) Sneha B. Bansode et al.   MOLECULAR & CELLULAR PROTEOMICS

Role of glyoxalase I in the proliferation and apoptosis control of human LNCaP and PC3 prostate cancer cells

(2012) Cinzia Antognelli et al.   PROSTATE

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Prostate Cancer Immunotherapy: Figure 1.

(2011) Kenneth F. May et al.   CLINICAL CANCER RESEARCH

Methylglyoxal modulates immune responses: relevance to diabetes

(2009) Claire L. Price et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Methylglyoxal induced activation of murine peritoneal macrophages and surface markers of T lymphocytes in Sarcoma-180 bearing mice: Involvement of MAP kinase, NF-κβ signal transduction pathway

(2009) Aparajita Pal et al.   MOLECULAR IMMUNOLOGY

Phenotypic characterization of the infiltrating immune cells in normal prostate, benign nodular prostatic hyperplasia and prostatic adenocarcinoma

(2008) Mahmoud-Rezk A. Hussein et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Activation of macrophages and lymphocytes by methylglyoxal against tumor cells in the host

(2008) Nivedita Bhattacharyya et al.   INTERNATIONAL IMMUNOPHARMACOLOGY