DNA methylation-based signature of CD8+ tumor-infiltrating lymphocytes enables evaluation of immune response and prognosis in colorectal cancer

Genome-wide analysis identifies critical DNA methylations within NTRKs genes in colorectal cancer

(2021) Zijian Chen et al.   Journal of Translational Medicine

Cancer statistics, 2020

(2020) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Epigenetics of colorectal cancer: biomarker and therapeutic potential

(2020) Gerhard Jung et al.   Nature Reviews Gastroenterology & Hepatology

Nomograms for Prediction of Molecular Phenotypes in Colorectal Cancer

(2020) Zhuojun Yu et al.   OncoTargets and Therapy

Neoadjuvant immunotherapy leads to pathological responses in MMR-proficient and MMR-deficient early-stage colon cancers

(2020) Myriam Chalabi et al.   NATURE MEDICINE

Identification of Aberrantly Methylated Differentially CpG Sites in Hepatocellular Carcinoma and Their Association With Patient Survival

(2020) Renguo Guan et al.   Frontiers in Oncology

Epigenetic inactivation of α-internexin accelerates microtubule polymerization in colorectal cancer

(2020) Yingjie Li et al.   CANCER RESEARCH

Epigenetic Alterations in the Gastrointestinal Tract: Current and Emerging Use for Biomarkers of Cancer

(2020) William M. Grady et al.   GASTROENTEROLOGY

Immunotherapy in colorectal cancer: rationale, challenges and potential

(2019) Karuna Ganesh et al.   Nature Reviews Gastroenterology & Hepatology

Novel Assay for Quantitative Analysis of DNA Methylation at Single-Base Resolution

(2019) Huichuan Yu et al.   CLINICAL CHEMISTRY

Defining UHRF1 Domains that Support Maintenance of Human Colon Cancer DNA Methylation and Oncogenic Properties

(2019) Xiangqian Kong et al.   CANCER CELL

Prognostic Impact of Tumor-Infiltrating Lymphocytes in Primary and Metastatic Colorectal Cancer

(2019) Joseph C. Kong et al.   DISEASES OF THE COLON & RECTUM

Determining cell type abundance and expression from bulk tissues with digital cytometry

(2019) Aaron M. Newman et al.   NATURE BIOTECHNOLOGY

Biomarkers for Predicting Response to Immunotherapy with Immune Checkpoint Inhibitors in Cancer Patients

(2019) Michael J. Duffy et al.   CLINICAL CHEMISTRY

Immune cell concentrations among the primary tumor microenvironment in colorectal cancer patients predicted by clinicopathologic characteristics and blood indexes

(2019) Guifang Guo et al.   Journal for ImmunoTherapy of Cancer

The Immunoscore: Colon Cancer and Beyond

(2019) Helen K Angell et al.   CLINICAL CANCER RESEARCH

Cohort Profile: The Colon Cancer Family Registry Cohort (CCFRC)

(2018) Mark A Jenkins et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

International validation of the consensus Immunoscore for the classification of colon cancer: a prognostic and accuracy study

(2018) Franck Pagès et al.   LANCET

DNA methylation loss in late-replicating domains is linked to mitotic cell division

(2018) Wanding Zhou et al.   NATURE GENETICS

Colorectal cancer: Evading the immune response in metastasis

(2018) Katrina Ray   Nature Reviews Gastroenterology & Hepatology

OUP accepted manuscript

(2018)   NUCLEIC ACIDS RESEARCH

Co-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors

(2018) Thomas Duhen et al.   Nature Communications

Adjusting for Batch Effects in DNA Methylation Microarray Data, a Lesson Learned

(2018) E. M. Price et al.   Frontiers in Genetics

EBV+ and MSI Gastric Cancers Harbor High PD-L1/PD-1 Expression and High CD8+ Intratumoral Lymphocytes

(2018) Simona De Rosa et al.   Cancers

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

A radiomics approach to assess tumour-infiltrating CD8 cells and response to anti-PD-1 or anti-PD-L1 immunotherapy: an imaging biomarker, retrospective multicohort study

(2018) Roger Sun et al.   LANCET ONCOLOGY

ITGAE Defines CD8+ Tumor-Infiltrating Lymphocytes Predicting a better Prognostic Survival in Colorectal Cancer

(2018) Xiang Hu et al.   EBioMedicine

Comprehensive human cell-type methylation atlas reveals origins of circulating cell-free DNA in health and disease

(2018) Joshua Moss et al.   Nature Communications

Immunological differences between colorectal cancer and normal mucosa uncover a prognostically relevant immune cell profile

(2018) Katharina Strasser et al.   OncoImmunology

Genome-wide DNA methylation analysis reveals a prognostic classifier for non-metastatic colorectal cancer (ProMCol classifier)

(2017) Melanie Gündert et al.   GUT

DNA methylation–based immune response signature improves patient diagnosis in multiple cancers

(2017) Jana Jeschke et al.   JOURNAL OF CLINICAL INVESTIGATION

Nivolumab in patients with metastatic DNA mismatch repair-deficient or microsatellite instability-high colorectal cancer (CheckMate 142): an open-label, multicentre, phase 2 study

(2017) Michael J Overman et al.   LANCET ONCOLOGY

Differential intratumoral distributions of CD8 and CD163 immune cells as prognostic biomarkers in breast cancer

(2017) Sotirios P. Fortis et al.   Journal for ImmunoTherapy of Cancer

Abscopal Effects of Radiotherapy Are Enhanced by Combined Immunostimulatory mAbs and Are Dependent on CD8 T Cells and Crosspriming

(2016) M. E. Rodriguez-Ruiz et al.   CANCER RESEARCH

DNA Methylation Dynamics of Human Hematopoietic Stem Cell Differentiation

(2016) Matthias Farlik et al.   Cell Stem Cell

Microsatellite Instability as a Biomarker for PD-1 Blockade

(2016) J. C. Dudley et al.   CLINICAL CANCER RESEARCH

The importance of detailed epigenomic profiling of different cell types within organs

(2016) Theresa Ryan Stueve et al.   Epigenomics

Functional impairment of infiltrating T cells in human colorectal cancer

(2016) Edward S. Taylor et al.   OncoImmunology

Association of the Colorectal CpG Island Methylator Phenotype with Molecular Features, Risk Factors, and Family History

(2015) D. J. Weisenberger et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Correlation between Density of CD8+ T-cell Infiltrate in Microsatellite Unstable Colorectal Cancers and Frameshift Mutations: A Rationale for Personalized Immunotherapy

(2015) P. Maby et al.   CANCER RESEARCH

Extent and Location of Tumor-Infiltrating Lymphocytes in Microsatellite-Stable Colon Cancer Predict Outcome to Adjuvant Active Specific Immunotherapy

(2015) A. W. Turksma et al.   CLINICAL CANCER RESEARCH

Association Between Molecular Subtypes of Colorectal Cancer and Patient Survival

(2015) Amanda I. Phipps et al.   GASTROENTEROLOGY

PD-1 Blockade in Tumors with Mismatch-Repair Deficiency

(2015) Dung T. Le et al.   NEW ENGLAND JOURNAL OF MEDICINE

The evaluation of tumor-infiltrating lymphocytes (TILs) in breast cancer: recommendations by an International TILs Working Group 2014

(2014) R. Salgado et al.   ANNALS OF ONCOLOGY

Differences in DNA Methylation Signatures Reveal Multiple Pathways of Progression From Adenoma to Colorectal Cancer

(2014) Yanxin Luo et al.   GASTROENTEROLOGY

Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts

(2009) Akiko Doi et al.   NATURE GENETICS

The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores

(2009) Rafael A Irizarry et al.   NATURE GENETICS

Tumor-Induced Senescent T Cells with Suppressor Function: A Potential Form of Tumor Immune Evasion

(2008) C. L. Montes et al.   CANCER RESEARCH