The importance of detailed epigenomic profiling of different cell types within organs

The safety of human pluripotent stem cells in clinical treatment

(2015) Oscar E Simonson et al.   ANNALS OF MEDICINE

Lessons from modENCODE

(2015) James B. Brown et al.   Annual Review of Genomics and Human Genetics

TERT Polymorphism rs2736100-C Is Associated with EGFR Mutation-Positive Non-Small Cell Lung Cancer

(2015) R. Wei et al.   CLINICAL CANCER RESEARCH

Interindividual methylomic variation across blood, cortex, and cerebellum: implications for epigenetic studies of neurological and neuropsychiatric phenotypes

(2015) Eilis Hannon et al.   Epigenetics

Integrative analysis of 111 reference human epigenomes

(2015) Anshul Kundaje et al.   NATURE

Single-cell chromatin accessibility reveals principles of regulatory variation

(2015) Jason D. Buenrostro et al.   NATURE

Critical Role of Histone Turnover in Neuronal Transcription and Plasticity

(2015) Ian Maze et al.   NEURON

DNA methylation in small cell lung cancer defines distinct disease subtypes and correlates with high expression of EZH2

(2015) J T Poirier et al.   ONCOGENE

A survey of human brain transcriptome diversity at the single cell level

(2015) Spyros Darmanis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transgenerational epigenetic inheritance of diabetes risk as a consequence of early nutritional imbalances

(2015) Josep C. Jimenez-Chillaron et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

Epigenomics of Alzheimer's disease

(2015) David A. Bennett et al.   Translational Research

Making sense of GWAS: using epigenomics and genome engineering to understand the functional relevance of SNPs in non-coding regions of the human genome

(2015) Yu Gyoung Tak et al.   Epigenetics & Chromatin

Genetic alterations of DNA methylation machinery in human diseases

(2015) Tewfik Hamidi et al.   Epigenomics

Systematical analyses of variants in CTCF-binding sites identified a novel lung cancer susceptibility locus among Chinese population

(2015) Juncheng Dai et al.   Scientific Reports

Low-Cell-Number Epigenome Profiling Aids the Study of Lens Aging and Hematopoiesis

(2015) Xiaobin Zheng et al.   Cell Reports

TET proteins and the control of cytosine demethylation in cancer

(2015) Laurianne Scourzic et al.   Genome Medicine

A varying T cell subtype explains apparent tobacco smoking induced single CpG hypomethylation in whole blood

(2015) Mario Bauer et al.   Clinical Epigenetics

Somatic cancer mutations in the MLL3-SET domain alter the catalytic properties of the enzyme

(2015) Sara Weirich et al.   Clinical Epigenetics

DNA methylation changes of whole blood cells in response to active smoking exposure in adults: a systematic review of DNA methylation studies

(2015) Xu Gao et al.   Clinical Epigenetics

GeMes, Clusters of DNA Methylation under Genetic Control, Can Inform Genetic and Epigenetic Analysis of Disease

(2014) Yun Liu et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Relationship of DNA Methylation and Gene Expression in Idiopathic Pulmonary Fibrosis

(2014) Ivana V. Yang et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Control of Cell Identity Genes Occurs in Insulated Neighborhoods in Mammalian Chromosomes

(2014) Jill M. Dowen et al.   CELL

Cigarette smoking reduces DNA methylation levels at multiple genomic loci but the effect is partially reversible upon cessation

(2014) Loukia G Tsaprouni et al.   Epigenetics

Alveolar progenitor and stem cells in lung development, renewal and cancer

(2014) Tushar J. Desai et al.   NATURE

A prostate cancer susceptibility allele at 6q22 increases RFX6 expression by modulating HOXB13 chromatin binding

(2014) Qilai Huang et al.   NATURE GENETICS

Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk

(2014) Kyle M Walsh et al.   NATURE GENETICS

Single-cell genome-wide bisulfite sequencing for assessing epigenetic heterogeneity

(2014) Sébastien A Smallwood et al.   NATURE METHODS

Analytical tools and current challenges in the modern era of neuroepigenomics

(2014) Ian Maze et al.   NATURE NEUROSCIENCE

Aberrant transcriptional regulations in cancers: genome, transcriptome and epigenome analysis of lung adenocarcinoma cell lines

(2014) Ayako Suzuki et al.   NUCLEIC ACIDS RESEARCH

A Novel Functional TagSNP Rs7560488 in the DNMT3A1 Promoter Is Associated with Susceptibility to Gastric Cancer by Modulating Promoter Activity

(2014) Huazhang Wu et al.   PLoS One

DNA Methyl Transferase (DNMT) Gene Polymorphisms Could Be a Primary Event in Epigenetic Susceptibility to Schizophrenia

(2014) Koramannil Radha Saradalekshmi et al.   PLoS One

Chromatin state dynamics during blood formation

(2014) D. Lara-Astiaso et al.   SCIENCE

Functional annotation of colon cancer risk SNPs

(2014) Lijing Yao et al.   Nature Communications

Comprehensive Functional Annotation of 77 Prostate Cancer Risk Loci

(2014) Dennis J. Hazelett et al.   PLoS Genetics

Accounting for cellular heterogeneity is critical in epigenome-wide association studies

(2014) Andrew E Jaffe et al.   GENOME BIOLOGY

Global Analysis of DNA Methylation Variation in Adipose Tissue from Twins Reveals Links to Disease-Associated Variants in Distal Regulatory Elements

(2013) Elin Grundberg et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Animal Models of Fibrotic Lung Disease

(2013) Bethany B. Moore et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

An estimation of the number of cells in the human body

(2013) Eva Bianconi et al.   ANNALS OF HUMAN BIOLOGY

Postnatal stability, tissue, and time specific effects ofAHRRmethylation change in response to maternal smoking in pregnancy

(2013) Boris Novakovic et al.   Epigenetics

Identification of seven loci affecting mean telomere length and their association with disease

(2013) Veryan Codd et al.   NATURE GENETICS

Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis

(2013) Tasha E Fingerlin et al.   NATURE GENETICS

Quantitative assessment of single-cell RNA-sequencing methods

(2013) Angela R Wu et al.   NATURE METHODS

The NHGRI GWAS Catalog, a curated resource of SNP-trait associations

(2013) Danielle Welter et al.   NUCLEIC ACIDS RESEARCH

Isolation and Characterization of a Primary Proximal Tubular Epithelial Cell Model from Human Kidney by CD10/CD13 Double Labeling

(2013) Cynthia Van der Hauwaert et al.   PLoS One

Comprehensive Functional Annotation of Seventy-One Breast Cancer Risk Loci

(2013) Suhn Kyong Rhie et al.   PLoS One

Epigenetic medicine and fetal alcohol spectrum disorders

(2013) Marisol Resendiz et al.   Epigenomics

Integrated Transcriptomic and Epigenomic Analysis of Primary Human Lung Epithelial Cell Differentiation

(2013) Crystal N. Marconett et al.   PLoS Genetics

DNMT1 genetic polymorphisms affect breast cancer risk in the central European Caucasian population

(2013) Kathrin Kullmann et al.   Clinical Epigenetics

The mutational landscape of chromatin regulatory factors across 4,623 tumor samples

(2013) Abel Gonzalez-Perez et al.   GENOME BIOLOGY

Altered DNA Methylation Profile in Idiopathic Pulmonary Fibrosis

(2012) Yan Y. Sanders et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The role of nutrition on epigenetic modifications and their implications on health

(2012) Josep C. Jiménez-Chillarón et al.   BIOCHIMIE

DNA methylation arrays as surrogate measures of cell mixture distribution

(2012) Eugene Houseman et al.   BMC BIOINFORMATICS

Association of polymorphisms inDNMT1,DNMT3A,DNMT3B, MTHFRandMTRRgenes with global DNA methylation levels and prognosis of autoimmune thyroid disease

(2012) Y. Arakawa et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Cell-type-specific nuclei purification from whole animals for genome-wide expression and chromatin profiling

(2012) F. A. Steiner et al.   GENOME RESEARCH

Epigenome-wide association study in the European Prospective Investigation into Cancer and Nutrition (EPIC-Turin) identifies novel genetic loci associated with smoking

(2012) Natalie S. Shenker et al.   HUMAN MOLECULAR GENETICS

Building and maintaining the epithelium of the lung

(2012) Craig R. Rackley et al.   JOURNAL OF CLINICAL INVESTIGATION

The telomere syndromes

(2012) Mary Armanios et al.   NATURE REVIEWS GENETICS

FunciSNP: an R/bioconductor tool integrating functional non-coding data sets with genetic association studies to identify candidate regulatory SNPs

(2012) Simon G. Coetzee et al.   NUCLEIC ACIDS RESEARCH

The DNA methylation landscape of small cell lung cancer suggests a differentiation defect of neuroendocrine cells

(2012) S Kalari et al.   ONCOGENE

The polymorphism rs944289 predisposes to papillary thyroid carcinoma through a large intergenic noncoding RNA gene of tumor suppressor type

(2012) J. Jendrzejewski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell of Origin of Small Cell Lung Cancer: Inactivation of Trp53 and Rb1 in Distinct Cell Types of Adult Mouse Lung

(2011) Kate D. Sutherland et al.   CANCER CELL

Isolation and in vitro expansion of human colonic stem cells

(2011) Peter Jung et al.   NATURE MEDICINE

Regulated gene expression in cultured type II cells of adult human lung

(2010) Philip L. Ballard et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The “LEARn” (Latent Early-life Associated Regulation) model integrates environmental risk factors and the developmental basis of Alzheimer’s disease, and proposes remedial steps

(2010) Debomoy K. Lahiri et al.   EXPERIMENTAL GERONTOLOGY

Cell of origin of lung cancer

(2010) Kate D. Sutherland et al.   Molecular Oncology

The INTACT method for cell type–specific gene expression and chromatin profiling in Arabidopsis thaliana

(2010) Roger B Deal et al.   Nature Protocols

Tissue Distribution of 5-Hydroxymethylcytosine and Search for Active Demethylation Intermediates

(2010) Daniel Globisch et al.   PLoS One

Molecular Signals of Epigenetic States

(2010) Roberto Bonasio et al.   SCIENCE

A Genome-wide Association Study of Lung Cancer Identifies a Region of Chromosome 5p15 Associated with Risk for Adenocarcinoma

(2009) Maria Teresa Landi et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The LEARn model: an epigenetic explanation for idiopathic neurobiological diseases

(2009) D K Lahiri et al.   MOLECULAR PSYCHIATRY

Characterization of human embryonic stem cells with features of neoplastic progression

(2009) Tamra E Werbowetski-Ogilvie et al.   NATURE BIOTECHNOLOGY

Short telomeres are a risk factor for idiopathic pulmonary fibrosis

(2008) J. K. Alder et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA