Murine Blastocysts Release Mature MicroRNAs Into Culture Media That Reflect Developmental Status

Comprehensive profiling of Small RNAs in human embryo-conditioned culture media by improved sequencing and quantitative PCR methods

(2020) Stewart J. Russell et al.   Systems Biology in Reproductive Medicine

Identification and Characterization of Extracellular Vesicles and Its DNA Cargo Secreted During Murine Embryo Development

(2020) Blanca Simon et al.   Genes

Minimally Invasive Cell-Free Human Embryo Aneuploidy Testing (miPGT-A) Utilizing Combined Spent Embryo Culture Medium and Blastocoel Fluid –Towards Development of a Clinical Assay

(2020) Valeriy Kuznyetsov et al.   Scientific Reports

Extracellular vesicles, microRNA and the preimplantation embryo: non-invasive clues of embryo well-being

(2020) David Connor Hawke et al.   REPRODUCTIVE BIOMEDICINE ONLINE

Identification of extracellular vesicles and characterization of miRNA expression profiles in human blastocoel fluid

(2019) R. Battaglia et al.   Scientific Reports

Bovine Embryo-Secreted microRNA-30c Is a Potential Non-invasive Biomarker for Hampered Preimplantation Developmental Competence

(2019) Xiaoyuan Lin et al.   Frontiers in Genetics

Roles of MicroRNAs in Establishing and Modulating Stem Cell Potential

(2019) Zhenwu Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Expression of miR‐Let‐7a, miR‐15a, miR‐16‐1, and their target genes in fresh and vitrified embryos and its surrounding culture media for noninvasive embryo assessment

(2019) Fezzeh Heidari et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Structural Basis for Target-Directed MicroRNA Degradation

(2019) Jessica Sheu-Gruttadauria et al.   MOLECULAR CELL

Bta-miR-10b Secreted by Bovine Embryos Negatively Impacts Preimplantation Embryo Quality

(2019) Xiaoyuan Lin et al.   Frontiers in Genetics

Origin and composition of cell-free DNA in spent medium from human embryo culture during preimplantation development

(2018) M Vera-Rodriguez et al.   HUMAN REPRODUCTION

NGS Analysis of Human Embryo Culture Media Reveals miRNAs of Extra Embryonic Origin

(2018) Immaculada Sánchez-Ribas et al.   Reproductive Sciences

Mechanisms regulating zygotic genome activation

(2018) Katharine N. Schulz et al.   NATURE REVIEWS GENETICS

Characterizing nuclear and mitochondrial DNA in spent embryo culture media: genetic contamination identified

(2017) Elizabeth R. Hammond et al.   FERTILITY AND STERILITY

Rhein Induces Oxidative Stress and Apoptosis in Mouse Blastocysts and Has Immunotoxic Effects during Embryonic Development

(2017) Chien-Hsun Huang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Identification and characteristics of extracellular vesicles from bovine blastocysts produced in vitro

(2017) Edwin A. Mellisho et al.   PLoS One

Sexual Dimorphism of miRNAs Secreted by Bovine In vitro-produced Embryos

(2017) Nicole Gross et al.   Frontiers in Genetics

Secretome of in vitro cultured human embryos contains extracellular vesicles that are uptaken by the maternal side

(2017) Elisa Giacomini et al.   Scientific Reports

Non-invasive pre-implantation aneuploidy screening and diagnosis of beta thalassemia IVSII654 mutation using spent embryo culture medium

(2016) WeiQiang Liu et al.   ANNALS OF MEDICINE

MicroRNAs in spent blastocyst culture medium are derived from trophectoderm cells and can be explored for human embryo reproductive competence assessment

(2016) Antonio Capalbo et al.   FERTILITY AND STERILITY

Degradation dynamics of microRNAs revealed by a novel pulse-chase approach

(2016) Matteo J. Marzi et al.   GENOME RESEARCH

Assessment of human embryo development using morphological criteria in an era of time-lapse, algorithms and ‘OMICS’: is looking good still important?

(2016) David K. Gardner et al.   MOLECULAR HUMAN REPRODUCTION

Y-box protein 1 is required to sort microRNAs into exosomes in cells and in a cell-free reaction

(2016) Matthew J Shurtleff et al.   eLife

MicroRNAs of the miR-290–295 Family Maintain Bivalency in Mouse Embryonic Stem Cells

(2016) Bryony Graham et al.   Stem Cell Reports

MiR-143 and rat embryo implantation

(2015) Shi Tian et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Validating reference microRNAs for normalizing qRT-PCR data in bovine oocytes and preimplantation embryos

(2015) Mahdi Mahdipour et al.   BMC DEVELOPMENTAL BIOLOGY

Embryonic Stem Cell-Derived Exosomes Promote Endogenous Repair Mechanisms and Enhance Cardiac Function Following Myocardial Infarction

(2015) M. Khan et al.   CIRCULATION RESEARCH

Characterization of microRNA in bovine in vitro culture media associated with embryo quality and development

(2015) Jenna Kropp et al.   JOURNAL OF DAIRY SCIENCE

Mmu-miR-126a-3p plays a role in murine embryo implantation by regulating Itga11

(2015) Zhengyu Li et al.   REPRODUCTIVE BIOMEDICINE ONLINE

Human Blastocyst Secreted microRNA Regulate Endometrial Epithelial Cell Adhesion

(2015) Carly Cuman et al.   EBioMedicine

Improvement of Cloned Embryos Development by Co-Culturing with Parthenotes: A Possible Role of Exosomes/Microvesicles for Embryos Paracrine Communication

(2014) Islam M. Saadeldin et al.   Cellular Reprogramming

Human embryos secrete microRNAs into culture media—a potential biomarker for implantation

(2014) Evan M. Rosenbluth et al.   FERTILITY AND STERILITY

The fusion of two worlds: Non-coding RNAs and extracellular vesicles - diagnostic and therapeutic implications (Review)

(2014) YUKIE SATO-KUWABARA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Transactivation of MicroRNA-320 by MicroRNA-383 Regulates Granulosa Cell Functions by Targeting E2F1 and SF-1 Proteins

(2014) Mianmian Yin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adenylation of Maternally Inherited MicroRNAs by Wispy

(2014) Mihye Lee et al.   MOLECULAR CELL

Activity-associated miRNA are packaged in Map1b-enriched exosomes released from depolarized neurons

(2014) Belinda J. Goldie et al.   NUCLEIC ACIDS RESEARCH

Circulating Exosomal microRNAs as Biomarkers of Colon Cancer

(2014) Hiroko Ogata-Kawata et al.   PLoS One

Quantitative and stoichiometric analysis of the microRNA content of exosomes

(2014) J. R. Chevillet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HDL-transferred microRNA-223 regulates ICAM-1 expression in endothelial cells

(2014) Fatiha Tabet et al.   Nature Communications

Expression of microRNAs in bovine and human pre-implantation embryo culture media

(2014) Jenna Kropp et al.   Frontiers in Genetics

Characterization of human plasma-derived exosomal RNAs by deep sequencing

(2013) Xiaoyi Huang et al.   BMC GENOMICS

Neutral Sphingomyelinase 2 (nSMase2)-dependent Exosomal Transfer of Angiogenic MicroRNAs Regulate Cancer Cell Metastasis

(2013) Nobuyoshi Kosaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endometrial Exosomes/Microvesicles in the Uterine Microenvironment: A New Paradigm for Embryo-Endometrial Cross Talk at Implantation

(2013) York Hunt Ng et al.   PLoS One

Discovery of pluripotency-associated microRNAs in rabbit preimplantation embryos and embryonic stem-like cells

(2013) Pouneh Maraghechi et al.   REPRODUCTION

Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs

(2013) Carolina Villarroya-Beltri et al.   Nature Communications

Small RNA Profile of the Cumulus-Oocyte Complex and Early Embryos in the Pig1

(2012) Cai-Xia Yang et al.   BIOLOGY OF REPRODUCTION

Selective extracellular vesicle-mediated export of an overlapping set of microRNAs from multiple cell types

(2012) Jasenka Guduric-Fuchs et al.   BMC GENOMICS

MicroRNA expression in the human blastocyst

(2012) Evan M. Rosenbluth et al.   FERTILITY AND STERILITY

Identification of apolipoprotein A1 in the human embryonic secretome

(2011) Lindsay M. Mains et al.   FERTILITY AND STERILITY

Comparison of DNA apoptosis in mouse and human blastocysts after vitrification and slow freezing

(2011) Lifei Li et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins

(2011) Kasey C. Vickers et al.   NATURE CELL BIOLOGY

Characterization of extracellular circulating microRNA

(2011) Andrey Turchinovich et al.   NUCLEIC ACIDS RESEARCH

Sperm-borne microRNA-34c is required for the first cleavage division in mouse

(2011) W.-M. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mir-290-295 deficiency in mice results in partially penetrant embryonic lethality and germ cell defects

(2011) L. A. Medeiros et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Latent Pro-Survival Function for the Mir-290-295 Cluster in Mouse Embryonic Stem Cells

(2011) Grace X. Y. Zheng et al.   PLoS Genetics

The role of miRNAs and endogenous siRNAs in maternal-to-zygotic reprogramming and the establishment of pluripotency

(2010) Petr Svoboda et al.   EMBO REPORTS

Secretory Mechanisms and Intercellular Transfer of MicroRNAs in Living Cells

(2010) Nobuyoshi Kosaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural basis for 5′-nucleotide base-specific recognition of guide RNA by human AGO2

(2010) Filipp Frank et al.   NATURE

Let-7 MicroRNA Family Is Selectively Secreted into the Extracellular Environment via Exosomes in a Metastatic Gastric Cancer Cell Line

(2010) Keiichi Ohshima et al.   PLoS One

Exosomes – vesicular carriers for intercellular communication

(2009) Mikael Simons et al.   CURRENT OPINION IN CELL BIOLOGY

Connecting microRNA Genes to the Core Transcriptional Regulatory Circuitry of Embryonic Stem Cells

(2008) Alexander Marson et al.   CELL

Embryonic stem cell–specific microRNAs regulate the G1-S transition and promote rapid proliferation

(2008) Yangming Wang et al.   NATURE GENETICS