Structural and biophysical aspects of L-asparaginases: a growing family with amazing diversity

Structural and functional diversity of asparaginases: Overview and recommendations for a revised nomenclature

(2021) Leonardo Schultz da Silva et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

Structural and biochemical properties of L‐asparaginase

(2021) Jacek Lubkowski et al.   FEBS Journal

Heterologous gene expression and characterization of TK2246, a highly active and thermostable plant type l-asparaginase from Thermococcus kodakarensis

(2020) Shahid Mahmood Chohan et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Mechanism of Catalysis by l-Asparaginase

(2020) Jacek Lubkowski et al.   BIOCHEMISTRY

Improving the Treatment of Acute Lymphoblastic Leukemia

(2020) Ashish Radadiya et al.   BIOCHEMISTRY

Highly efficient Pyrococcus furiosus recombinant L-asparaginase with no glutaminase activity: Expression, purification, functional characterization, and cytotoxicity on THP-1, A549 and Caco-2 cell lines

(2020) Hesham Saeed et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

The role of the quaternary structure in the activation of human L-asparaginase

(2020) S.B. Morais et al.   Journal of Proteomics

Generalized enzymatic mechanism of catalysis by tetrameric l-asparaginases from mesophilic bacteria

(2020) Pawel Strzelczyk et al.   Scientific Reports

Recent Strategies and Applications for l-Asparaginase Confinement

(2020) João C. F. Nunes et al.   MOLECULES

Opportunistic complexes of E. coli L-asparaginases with citrate anions

(2019) Jacek Lubkowski et al.   Scientific Reports

Geometric considerations support the double‐displacement catalytic mechanism of l ‐asparaginase

(2019) Jacek Lubkowski et al.   PROTEIN SCIENCE

What makes a good new therapeutic l-asparaginase?

(2019) Angela Beckett et al.   WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY

Asparagine and Glutamine: Co-conspirators Fueling Metastasis

(2018) Ming Luo et al.   Cell Metabolism

Structural basis of potassium activation in plant asparaginases

(2018) Ebenezer Ajewole et al.   FEBS Journal

Characterization of PEGylated Asparaginase: New Opportunities from NMR Analysis of Large PEGylated Therapeutics

(2018) Linda Cerofolini et al.   CHEMISTRY-A EUROPEAN JOURNAL

A protease-resistant Escherichia coli asparaginase with outstanding stability and enhanced anti-leukaemic activity in vitro

(2017) Maristella Maggi et al.   Scientific Reports

Structure and function of the thermostable L-asparaginase from Thermococcus kodakarensis

(2017) Jingxu Guo et al.   Acta Crystallographica Section D-Structural Biology

The differential ability of asparagine and glutamine in promoting the closed/active enzyme conformation rationalizes the Wolinella succinogenes L-asparaginase substrate specificity

(2017) Hien Anh Nguyen et al.   Scientific Reports

Intramolecular Cleavage of the hASRGL1 Homodimer Occurs in Two Stages

(2016) Wenzong Li et al.   BIOCHEMISTRY

Structural Insight into Substrate Selectivity of Erwinia chrysanthemi l-Asparaginase

(2016) Hien Anh Nguyen et al.   BIOCHEMISTRY

Experimental Data in Support of a Direct Displacement Mechanism for Type I/II l-Asparaginases

(2016) Amanda M. Schalk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ultrastructural Characterization of the Lower Motor System in a Mouse Model of Krabbe Disease

(2016) Valentina Cappello et al.   Scientific Reports

Structural and Kinetic Characterization of Guinea Pig l-Asparaginase Type III

(2014) Amanda M. Schalk et al.   BIOCHEMISTRY

Crystal structure of active site mutant of antileukemicl-asparaginase reveals conserved zinc-binding site

(2014) Dominika Borek et al.   FEBS Journal

Identification and Structural Analysis of an l-Asparaginase Enzyme from Guinea Pig with Putative Tumor Cell Killing Properties

(2014) Amanda M. Schalk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Elucidation of the Specific Function of the Conserved Threonine Triad Responsible for Human l-Asparaginase Autocleavage and Substrate Hydrolysis

(2014) Julian Nomme et al.   JOURNAL OF MOLECULAR BIOLOGY

Na+/K+exchange switches the catalytic apparatus of potassium-dependent plantL-asparaginase

(2014) Magdalena Bejger et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Structural and functional insights into an archaealL-asparaginase obtained through the linker-less assembly of constituent domains

(2014) Rachana Tomar et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Distinct physiological roles for the two l-asparaginase isozymes of Escherichia coli

(2013) Yogitha N. Srikhanta et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Free Glycine Accelerates the Autoproteolytic Activation of Human Asparaginase

(2013) Ying Su et al.   CHEMISTRY & BIOLOGY

N-terminal domain ofPyrococcus furiosusl-asparaginase functions as a non-specific, stable, molecular chaperone

(2013) Rachana Tomar et al.   FEBS Journal

TK1656, a thermostable l-asparaginase from Thermococcus kodakaraensis, exhibiting highest ever reported enzyme activity

(2013) Shahid Mahmood Chohan et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Uncoupling Intramolecular Processing and Substrate Hydrolysis in the N-Terminal Nucleophile Hydrolase hASRGL1 by Circular Permutation

(2012) Wenzong Li et al.   ACS Chemical Biology

Structures of Apo and Product-Bound Human l-Asparaginase: Insights into the Mechanism of Autoproteolysis and Substrate Hydrolysis

(2012) Julian Nomme et al.   BIOCHEMISTRY

Validation of a 30-year-old process for the manufacture of l-asparaginase from Erwinia chrysanthemi

(2012) David Gervais et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

Biochemical Characterization of Recombinant L-Asparaginase (AnsA) from Rhizobium etli, a Member of an Increasing Rhizobial-Type Family of L-Asparaginases

(2012) Angelica Moreno-Enriquez   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

Rhizobium etli asparaginase II

(2012) Alejandro Huerta-Saquero et al.   Bioengineered

Hyperthermophilic asparaginase mutants with enhanced substrate affinity and antineoplastic activity: structural insights on their mechanism of action

(2011) Saurabh Bansal et al.   FASEB JOURNAL

Structure ofHelicobacter pyloriL-asparaginase at 1.4 Å resolution

(2009) Prathusha Dhavala et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The Human Asparaginase-like Protein 1 hASRGL1 Is an Ntn Hydrolase with β-Aspartyl Peptidase Activity

(2009) Jason R. Cantor et al.   BIOCHEMISTRY

Engineering thermal stability of l-asparaginase by in vitro directed evolution

(2009) Georgia A. Kotzia et al.   FEBS Journal

Three-dimensional structures ofL-asparaginase fromErwinia carotovoracomplexed with aspartate and glutamate

(2008) O. V. Kravchenko et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Crystal packing of plant-typeL-asparaginase fromEscherichia coli

(2008) Karolina Michalska et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Structural and functional insights into Erwinia carotovora l-asparaginase

(2008) Anastassios C. Papageorgiou et al.   FEBS Journal

The Mechanism of Autocatalytic Activation of Plant-type L-Asparaginases

(2008) Karolina Michalska et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NCBI BLAST: a better web interface

(2008) M. Johnson et al.   NUCLEIC ACIDS RESEARCH