Amino Acid Trp: The Far Out Impacts of Host and Commensal Tryptophan Metabolism

Effects of high-fat diet and intestinal aryl hydrocarbon receptor deletion on colon carcinogenesis

(2020) Erika L. Garcia-Villatoro et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Neuronal programming by microbiota regulates intestinal physiology

(2020) Yuuki Obata et al.   NATURE

Differential activation of human pregnane X receptor PXR by isomeric mono-methylated indoles in intestinal and hepatic in vitro models

(2020) Barbora Vyhlídalová et al.   TOXICOLOGY LETTERS

Serum Metabolic Profiles of the Tryptophan-Kynurenine Pathway in the high risk subjects of major depressive disorder

(2020) Masashi Sakurai et al.   Scientific Reports

Microbial tryptophan metabolites regulate gut barrier function via the aryl hydrocarbon receptor

(2020) Samantha A. Scott et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intestinal microbiota-derived tryptophan metabolites are predictive of Ah receptor activity

(2020) Fangcong Dong et al.   Gut Microbes

Tryptophan Metabolism as a Pharmacological Target

(2020) Morgane Modoux et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Ultrahigh-Performance Liquid Chromatography Tandem Mass Spectrometry with Electrospray Ionization Quantification of Tryptophan Metabolites and Markers of Gut Health in Serum and Plasma—Application to Clinical and Epidemiology Cohorts

(2019) Luke Whiley et al.   ANALYTICAL CHEMISTRY

The Environmental Sensor AHR Protects from Inflammatory Damage by Maintaining Intestinal Stem Cell Homeostasis and Barrier Integrity

(2019) Amina Metidji et al.   IMMUNITY

Limitations and Off-Target Effects of Tryptophan-Related IDO Inhibitors in Cancer Treatment

(2019) Juliane Günther et al.   Frontiers in Immunology

The pregnane X receptor and its microbiota-derived ligand indole 3-propionic acid regulate endothelium-dependent vasodilation

(2019) Vivek Krishna Pulakazhi Venu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Cecal Tumorigenesis in Aryl Hydrocarbon Receptor–Deficient Mice Depends on Cecum-Specific Mitogen-Activated Protein Kinase Pathway Activation and Inflammation

(2019) Hisanori Matoba et al.   AMERICAN JOURNAL OF PATHOLOGY

Microbiota-Derived Indole Metabolites Promote Human and Murine Intestinal Homeostasis through Regulation of Interleukin-10 Receptor

(2018) Erica E. Alexeev et al.   AMERICAN JOURNAL OF PATHOLOGY

Simultaneous determination of tryptophan and its 31 catabolites in mouse tissues by polarity switching UHPLC-SRM-MS

(2018) Guan-yuan Chen et al.   ANALYTICA CHIMICA ACTA

Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease

(2018) Allison Agus et al.   Cell Host & Microbe

Gut Microbiota-Produced Tryptamine Activates an Epithelial G-Protein-Coupled Receptor to Increase Colonic Secretion

(2018) Yogesh Bhattarai et al.   Cell Host & Microbe

Aryl hydrocarbon receptor and intestinal immunity

(2018) Bruno Lamas et al.   Mucosal Immunology

Microglial control of astrocytes in response to microbial metabolites

(2018) Veit Rothhammer et al.   NATURE

Apoptotic cell–induced AhR activity is required for immunological tolerance and suppression of systemic lupus erythematosus in mice and humans

(2018) Rahul Shinde et al.   NATURE IMMUNOLOGY

TPH2 polymorphisms across the spectrum of psychiatric morbidity: A systematic review and meta-analysis

(2018) Koen Willem Ottenhof et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Tryptophan supplementation and serotonin function: genetic variations in behavioural effects

(2018) E. L. Gibson   PROCEEDINGS OF THE NUTRITION SOCIETY

Impact of the Gut Microbiota on Intestinal Immunity Mediated by Tryptophan Metabolism

(2018) Jing Gao et al.   Frontiers in Cellular and Infection Microbiology

Kynurenic Acid: The Janus-Faced Role of an Immunomodulatory Tryptophan Metabolite and Its Link to Pathological Conditions

(2018) Elisa Wirthgen et al.   Frontiers in Immunology

The Role of Indoleamine-2,3-Dioxygenase in Cancer Development, Diagnostics, and Therapy

(2018) Lilla Hornyák et al.   Frontiers in Immunology

Impaired Aryl Hydrocarbon Receptor Ligand Production by the Gut Microbiota Is a Key Factor in Metabolic Syndrome

(2018) Jane M. Natividad et al.   Cell Metabolism

Microbial tryptophan catabolites in health and disease

(2018) Henrik M. Roager et al.   Nature Communications

Aryl Hydrocarbon Receptor Promotes IL-10 Expression in Inflammatory Macrophages Through Src-STAT3 Signaling Pathway

(2018) Junyu Zhu et al.   Frontiers in Immunology

The Role of the Aryl Hydrocarbon Receptor (AHR) in Immune and Inflammatory Diseases

(2018) Drew Neavin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Increased Tryptophan Metabolism Is Associated With Activity of Inflammatory Bowel Diseases

(2017) Susanna Nikolaus et al.   GASTROENTEROLOGY

Aryl Hydrocarbon Receptor Controls Monocyte Differentiation into Dendritic Cells versus Macrophages

(2017) Christel Goudot et al.   IMMUNITY

IDO1: An important immunotherapy target in cancer treatment

(2017) Fangxuan Li et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Aryl hydrocarbon receptor inhibits inflammation in DSS‑induced colitis via the MK2/p‑MK2/TTP pathway

(2017) Qimeng Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Dietary tryptophan alleviates dextran sodium sulfate-induced colitis through aryl hydrocarbon receptor in mice

(2017) Jahidul Islam et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Tryptophan metabolite activation of the aryl hydrocarbon receptor regulates IL-10 receptor expression on intestinal epithelia

(2017) J M Lanis et al.   Mucosal Immunology

Feedback control of AHR signalling regulates intestinal immunity

(2017) Chris Schiering et al.   NATURE

Non-conventional features of peripheral serotonin signalling — the gut and beyond

(2017) Stephanie N. Spohn et al.   Nature Reviews Gastroenterology & Hepatology

Involvement of quinolinic acid in the neuropathogenesis of amyotrophic lateral sclerosis

(2017) Jong-Min Lee et al.   NEUROPHARMACOLOGY

Peripheral kynurenine/tryptophan ratio is not a reliable marker of systemic indoleamine 2,3-dioxygenase: A lesson drawn from patients on hemodialysis

(2017) Yuanhan Chen et al.   Oncotarget

Microbiota alteration is associated with the development of stress-induced despair behavior

(2017) Ioana A. Marin et al.   Scientific Reports

Microbiota-related Changes in Bile Acid & Tryptophan Metabolism are Associated with Gastrointestinal Dysfunction in a Mouse Model of Autism

(2017) Anna V. Golubeva et al.   EBioMedicine

Fecal Indole as a Biomarker of Susceptibility to Cryptosporidium Infection

(2016) Cynthia L. Chappell et al.   INFECTION AND IMMUNITY

A Simple HPLC–MS/MS Method for Determination of Tryptophan, Kynurenine and Kynurenic Acid in Human Serum and its Potential for Monitoring Antidepressant Therapy

(2016) Li-Jun Hu et al.   JOURNAL OF ANALYTICAL TOXICOLOGY

Stable isotope dilution ultra-high performance liquid chromatography–tandem mass spectrometry quantitative profiling of tryptophan-related neuroactive substances in human serum and cerebrospinal fluid

(2016) Eva Hényková et al.   JOURNAL OF CHROMATOGRAPHY A

Indole compounds may be promising medicines for ulcerative colitis

(2016) Shinya Sugimoto et al.   JOURNAL OF GASTROENTEROLOGY

Downregulation of serotonin reuptake transporter gene expression in healing colonic mucosa in presence of remaining low-grade inflammation in ulcerative colitis

(2016) Yasumasa Tada et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Transferring the blues: Depression-associated gut microbiota induces neurobehavioural changes in the rat

(2016) John R. Kelly et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor

(2016) Veit Rothhammer et al.   NATURE MEDICINE

CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands

(2016) Bruno Lamas et al.   NATURE MEDICINE

The serotonin system in autism spectrum disorder: From biomarker to animal models

(2016) C.L. Muller et al.   NEUROSCIENCE

AHR Function in Lymphocytes: Emerging Concepts

(2016) Liang Zhou   TRENDS IN IMMUNOLOGY

Microbial metabolism of dietary components to bioactive metabolites: opportunities for new therapeutic interventions

(2016) Linda S. Zhang et al.   Genome Medicine

The Role of Visceral Hypersensitivity in Irritable Bowel Syndrome: Pharmacological Targets and Novel Treatments

(2016) Mohammad H Farzaei et al.   Journal of Neurogastroenterology and Motility

Pregnane X Receptor (PXR)-Mediated Gene Repression and Cross-Talk of PXR with Other Nuclear Receptors via Coactivator Interactions

(2016) Petr Pavek   Frontiers in Pharmacology

Ablating the aryl hydrocarbon receptor (AhR) in CD11c+ cells perturbs intestinal epithelium development and intestinal immunity

(2016) Song Hui Chng et al.   Scientific Reports

Altered kynurenine pathway metabolism in autism: Implication for immune-induced glutamatergic activity

(2015) Chai K. Lim et al.   Autism Research

Serotonin, tryptophan metabolism and the brain-gut-microbiome axis

(2015) S.M. O’Mahony et al.   BEHAVIOURAL BRAIN RESEARCH

Indigenous Bacteria from the Gut Microbiota Regulate Host Serotonin Biosynthesis

(2015) Jessica M. Yano et al.   CELL

The aryl hydrocarbon receptor/microRNA-212/132 axis in T cells regulates IL-10 production to maintain intestinal homeostasis

(2015) Ichino Chinen et al.   INTERNATIONAL IMMUNOLOGY

The Tryptophan-Derived Endogenous Aryl Hydrocarbon Receptor Ligand 6-Formylindolo[3,2- b ]Carbazole Is a Nanomolar UVA Photosensitizer in Epidermal Keratinocytes

(2015) Sophia L. Park et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Roles of Indole as an Interspecies and Interkingdom Signaling Molecule

(2015) Jin-Hyung Lee et al.   TRENDS IN MICROBIOLOGY

Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles

(2015) Troy D. Hubbard et al.   Scientific Reports

The Aryl Hydrocarbon Receptor: Multitasking in the Immune System

(2014) Brigitta Stockinger et al.   Annual Review of Immunology

Rapidly expanding knowledge on the role of the gut microbiome in health and disease

(2014) M.C. Cénit et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mesenchymal Stem Cells Use IDO to Regulate Immunity in Tumor Microenvironment

(2014) W. Ling et al.   CANCER RESEARCH

Discovery and Characterization of Gut Microbiota Decarboxylases that Can Produce the Neurotransmitter Tryptamine

(2014) Brianna B. Williams et al.   Cell Host & Microbe

Microbiota control of a tryptophan-AhR pathway in disease tolerance to fungi

(2014) Luigina Romani et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Activation of the Aryl Hydrocarbon Receptor Dampens the Severity of Inflammatory Skin Conditions

(2014) Paola Di Meglio et al.   IMMUNITY

Symbiotic Bacterial Metabolites Regulate Gastrointestinal Barrier Function via the Xenobiotic Sensor PXR and Toll-like Receptor 4

(2014) Madhukumar Venkatesh et al.   IMMUNITY

Identification of a probiotic bacteria-derived activator of the aryl hydrocarbon receptor that inhibits colitis

(2014) Suguru Fukumoto et al.   IMMUNOLOGY AND CELL BIOLOGY

Aryl hydrocarbon receptor control of a disease tolerance defence pathway

(2014) Alban Bessede et al.   NATURE

Tryptophan Catabolites from Microbiota Engage Aryl Hydrocarbon Receptor and Balance Mucosal Reactivity via Interleukin-22

(2013) Teresa Zelante et al.   IMMUNITY

Group 3 Innate Lymphoid Cells Inhibit T-Cell-Mediated Intestinal Inflammation through Aryl Hydrocarbon Receptor Signaling and Regulation of Microflora

(2013) Ju Qiu et al.   IMMUNITY

The roles of aryl hydrocarbon receptor in immune responses

(2013) Nam Trung Nguyen et al.   INTERNATIONAL IMMUNOLOGY

Indole production by the tryptophanase TnaA in Escherichia coli is determined by the amount of exogenous tryptophan

(2013) G. Li et al.   MICROBIOLOGY-SGM

Serotonin signalling in the gut—functions, dysfunctions and therapeutic targets

(2013) Gary M. Mawe et al.   Nature Reviews Gastroenterology & Hepatology

Use of natural AhR ligands as potential therapeutic modalities against inflammatory disorders

(2013) Philip B Busbee et al.   NUTRITION REVIEWS

Quinolinic Acid: An Endogenous Neurotoxin with Multiple Targets

(2013) Rafael Lugo-Huitrón et al.   Oxidative Medicine and Cellular Longevity

Commensal Bacteria-Dependent Indole Production Enhances Epithelial Barrier Function in the Colon

(2013) Yosuke Shimada et al.   PLoS One

Aryl hydrocarbon receptor and colitis

(2013) Ivan Monteleone et al.   Seminars in Immunopathology

Dominant Fecal Microbiota in Newly Diagnosed Untreated Inflammatory Bowel Disease Patients

(2013) Lill Therese Thorkildsen et al.   Gastroenterology Research and Practice

Microbial butyrate and its role for barrier function in the gastrointestinal tract

(2012) Svenja Plöger et al.   Annals of the New York Academy of Sciences

The Aryl Hydrocarbon Receptor Complex and the Control of Gene Expression

(2012) Timothy V. Beischlag et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

Neuronal Serotonin Regulates Growth of the Intestinal Mucosa in Mice

(2012) Erica R. Gross et al.   GASTROENTEROLOGY

The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner

(2012) G Clarke et al.   MOLECULAR PSYCHIATRY

Interactions Between the Microbiota and the Immune System

(2012) L. V. Hooper et al.   SCIENCE

The microbiota and the gut-brain axis: insights from the temporal and spatial mucosal alterations during colonisation of the germfree mouse intestine

(2012) S. El Aidy et al.   Beneficial Microbes

Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment

(2012) Xochitl C Morgan et al.   GENOME BIOLOGY

Serotonin and GI Disorders: An Update on Clinical and Experimental Studies

(2012) Marcus Manocha et al.   Clinical and Translational Gastroenterology

Quantitative profiling of tryptophan metabolites in serum, urine, and cell culture supernatants by liquid chromatography–tandem mass spectrometry

(2011) Wentao Zhu et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

You AhR What You Eat: Linking Diet and Immunity

(2011) Lora V. Hooper   CELL

The Tryptophan Hydroxylase Inhibitor LX1031 Shows Clinical Benefit in Patients With Nonconstipating Irritable Bowel Syndrome

(2011) Philip M. Brown et al.   GASTROENTEROLOGY

Aryl Hydrocarbon Receptor-Induced Signals Up-regulate IL-22 Production and Inhibit Inflammation in the Gastrointestinal Tract

(2011) Ivan Monteleone et al.   GASTROENTEROLOGY

Kynurenines and intestinal neurotransmission: the role of N-methyl-d-aspartate receptors

(2011) József Kaszaki et al.   JOURNAL OF NEURAL TRANSMISSION

Essential Roles of Enteric Neuronal Serotonin in Gastrointestinal Motility and the Development/Survival of Enteric Dopaminergic Neurons

(2011) Z. Li et al.   JOURNAL OF NEUROSCIENCE

AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch

(2011) Jacob S Lee et al.   NATURE IMMUNOLOGY

Aryl hydrocarbon receptor deficiency in T cells suppresses the development of collagen-induced arthritis

(2011) T. Nakahama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of the aryl hydrocarbon receptor pathway may ameliorate dextran sodium sulfate-induced colitis in mice

(2010) Takeyuki Takamura et al.   IMMUNOLOGY AND CELL BIOLOGY

Role of the xenobiotic receptor in inflammatory bowel disease

(2010) Razvan Arsenescu et al.   INFLAMMATORY BOWEL DISEASES

Bacterial charity work leads to population-wide resistance

(2010) Henry H. Lee et al.   NATURE

Differential Gene Regulation by the Human and Mouse Aryl Hydrocarbon Receptor

(2010) Colin A. Flaveny et al.   TOXICOLOGICAL SCIENCES

Aryl Hydrocarbon Receptor Activation by TCDD Reduces Inflammation Associated with Crohn's Disease

(2010) Jenna M. Benson et al.   TOXICOLOGICAL SCIENCES

Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

(2009) Ivaylo I. Ivanov et al.   CELL

Role of serotonin in gastrointestinal motility and irritable bowel syndrome

(2009) Arbab Sikander et al.   CLINICA CHIMICA ACTA

Indoleamine 2,3-Dioxygenase, an Emerging Target for Anti-Cancer Therapy

(2009) X. Liu et al.   CURRENT CANCER DRUG TARGETS

The role of chemokines in intestinal inflammation and cancer

(2009) Dingzhi Wang et al.   CURRENT OPINION IN PHARMACOLOGY

The aryl hydrocarbon receptor: a perspective on potential roles in the immune system

(2009) Emily A. Stevens et al.   IMMUNOLOGY

IDO Activates Regulatory T Cells and Blocks Their Conversion into Th17-Like T Cells

(2009) B. Baban et al.   JOURNAL OF IMMUNOLOGY

5-HT4 Receptor-Mediated Neuroprotection and Neurogenesis in the Enteric Nervous System of Adult Mice

(2009) M.-T. Liu et al.   JOURNAL OF NEUROSCIENCE

Identification and characterization of novel variants of the tryptophan 2,3-dioxygenase gene: Differential regulation in the mouse nervous system during development

(2009) Masaaki Kanai et al.   NEUROSCIENCE RESEARCH

Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites

(2009) W. R. Wikoff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aryl hydrocarbon receptor suppresses intestinal carcinogenesis in ApcMin/+ mice with natural ligands

(2009) K. Kawajiri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The bacterial signal indole increases epithelial-cell tight-junction resistance and attenuates indicators of inflammation

(2009) T. Bansal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Of mice, rats and men: Revisiting the quinolinic acid hypothesis of Huntington's disease

(2009) Robert Schwarcz et al.   PROGRESS IN NEUROBIOLOGY

Activation of the aryl hydrocarbon receptor promotes allograft-specific tolerance through direct and dendritic cell-mediated effects on regulatory T cells

(2008) E. Hauben et al.   BLOOD

Effects of 5-Hydroxytryptamine (Serotonin) Type 3 Antagonists on Symptom Relief and Constipation in Nonconstipated Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

(2008) Viola Andresen et al.   Clinical Gastroenterology and Hepatology

IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis

(2008) Ken Sugimoto et al.   JOURNAL OF CLINICAL INVESTIGATION

The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat

(2008) Lieve Desbonnet et al.   JOURNAL OF PSYCHIATRIC RESEARCH

The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins

(2008) Marc Veldhoen et al.   NATURE

Indole and 7-hydroxyindole diminishPseudomonas aeruginosavirulence

(2008) Jintae Lee et al.   Microbial Biotechnology