Tryptophan supplementation and serotonin function: genetic variations in behavioural effects

Nice guys: Homozygocity for the TPH2 -703G/T (rs4570625) minor allele promotes low aggressiveness and low anxiety

(2017) Kariina Laas et al.   JOURNAL OF AFFECTIVE DISORDERS

Secondary to excessive melatonin synthesis, the consumption of tryptophan from outside the blood-brain barrier and melatonin over-signaling in the pars tuberalis may be central to the pathophysiology of winter depression

(2017) José Carlos Pereira et al.   MEDICAL HYPOTHESES

Depression-Related Increases and Decreases in Appetite: Dissociable Patterns of Aberrant Activity in Reward and Interoceptive Neurocircuitry

(2016) W. Kyle Simmons et al.   AMERICAN JOURNAL OF PSYCHIATRY

Bipolar Disorder: The Role of the Kynurenine and Melatonergic Pathways

(2016) George Anderson et al.   CURRENT PHARMACEUTICAL DESIGN

Cortico-limbic connectivity in MAOA -L carriers is vulnerable to acute tryptophan depletion

(2016) Patrick Eisner et al.   HUMAN BRAIN MAPPING

Impact of 5-HTTLPR on SSRI serotonin transporter blockade during emotion regulation: A preliminary fMRI study

(2016) Tim Outhred et al.   JOURNAL OF AFFECTIVE DISORDERS

5-HTTLPR and gender differences in affective disorders: A systematic review

(2016) F. Gressier et al.   JOURNAL OF AFFECTIVE DISORDERS

Sex differences modulating serotonergic polymorphisms implicated in the mechanistic pathways of risk for depression and related disorders:

(2016) LeeAnn M. Perry et al.   JOURNAL OF NEUROSCIENCE RESEARCH

A Perspective on the Safety of Supplemental Tryptophan Based on Its Metabolic Fates

(2016) John D Fernstrom   JOURNAL OF NUTRITION

Tryptophan Intake in the US Adult Population Is Not Related to Liver or Kidney Function but Is Associated with Depression and Sleep Outcomes

(2016) Harris R Lieberman et al.   JOURNAL OF NUTRITION

Gut instincts: microbiota as a key regulator of brain development, ageing and neurodegeneration

(2016) Timothy G. Dinan et al.   JOURNAL OF PHYSIOLOGY-LONDON

Tryptophan supplementation modulates social behavior: A review

(2016) Laura Steenbergen et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Influence of Tryptophan and Serotonin on Mood and Cognition with a Possible Role of the Gut-Brain Axis

(2016) Trisha Jenkins et al.   Nutrients

Effect of L-Tryptophan and L-Leucine on Gut Hormone Secretion, Appetite Feelings and Gastric Emptying Rates in Lean and Non-Diabetic Obese Participants: A Randomized, Double-Blind, Parallel-Group Trial

(2016) Anne Christin Meyer-Gerspach et al.   PLoS One

Amino acid challenge and depletion techniques in human functional neuroimaging studies: an overview

(2015) C. S. Biskup et al.   AMINO ACIDS

Chronic treatment with a tryptophan-rich protein hydrolysate improves emotional processing, mental energy levels and reaction time in middle-aged women

(2015) M. H. Mohajeri et al.   BRITISH JOURNAL OF NUTRITION

What has serotonin to do with depression?

(2015) Philip J. Cowen et al.   World Psychiatry

Etiological classification of depression based on the enzymes of tryptophan metabolism

(2014) Katsuhiko Fukuda   BMC Psychiatry

Emotion and decision-making explained: A précis

(2014) Edmund T. Rolls   CORTEX

Upregulating serotonin transporter expression and downregulating monoamine oxidase-A and indoleamine 2, 3-dioxygenase expression involved in the antidepressant effect of sodium valproate in a rat model

(2014) Hong-Mei Qiu et al.   NEUROREPORT

Effect of sub chronic tryptophan supplementation on stress-induced cortisol and appetite in subjects differing in 5-HTTLPR genotype and trait neuroticism

(2014) Aimée E.M. Capello et al.   PSYCHONEUROENDOCRINOLOGY

Effects of acute treatment with a tryptophan-rich protein hydrolysate on plasma amino acids, mood and emotional functioning in older women

(2014) E. L. Gibson et al.   PSYCHOPHARMACOLOGY

Sucrose preload reduces snacking after mild mental stress in healthy participants as a function of 5-hydroxytryptamine transporter gene promoter polymorphism

(2014) C. Rob Markus et al.   STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS

The ingestion of different dietary proteins by humans induces large changes in the plasma tryptophan ratio, a predictor of brain tryptophan uptake and serotonin synthesis

(2013) John D. Fernstrom et al.   CLINICAL NUTRITION

Serotonergic genes and suicide: A systematic review

(2013) Niki Antypa et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Acute tryptophan depletion in humans: a review of theoretical, practical and ethical aspects

(2013) Simon Young et al.   JOURNAL OF PSYCHIATRY & NEUROSCIENCE

Tryptophan: The key to boosting brain serotonin synthesis in depressive illness

(2013) Abdulla A-B Badawy   JOURNAL OF PSYCHOPHARMACOLOGY

The role of serotonin in the neurocircuitry of negative affective bias: Serotonergic modulation of the dorsal medial prefrontal-amygdala ‘aversive amplification’ circuit

(2013) Oliver J. Robinson et al.   NEUROIMAGE

Food can lift mood by affecting mood-regulating neurocircuits via a serotonergic mechanism

(2013) Marijn C.W. Kroes et al.   NEUROIMAGE

Food-derived serotonergic modulators: effects on mood and cognition

(2013) Sjoerd Hulsken et al.   NUTRITION RESEARCH REVIEWS

The effect of raising and lowering tryptophan levels on human mood and social behaviour

(2013) S. N. Young   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

The 5-HTTLPR genotype and depressiveness link: Contribution of aspects of environment and gender

(2013) Triin Kurrikoff et al.   PSYCHIATRY RESEARCH

Revisiting the serotonin–aggression relation in humans: A meta-analysis.

(2013) Aaron A. Duke et al.   PSYCHOLOGICAL BULLETIN

Advances in tryptophan hydroxylase-2 gene expression regulation: New insights into serotonin-stress interaction and clinical implications

(2012) Guo-Lin Chen et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

The psychobiology of comfort eating

(2012) E. Leigh Gibson   BEHAVIOURAL PHARMACOLOGY

Effects and Side Effects Associated with the Non-Nutritional Use of Tryptophan by Humans

(2012) John D. Fernstrom   JOURNAL OF NUTRITION

Serotonin transporter genotype differentially modulates neural responses to emotional words following tryptophan depletion in patients recovered from depression and healthy volunteers

(2012) Jonathan P Roiser et al.   JOURNAL OF PSYCHOPHARMACOLOGY

The integrated model of serotonin transporter gene variation (5HTTLPR) and the glial cell transporter in stress vulnerability and depression

(2012) Gen Shinozaki   MEDICAL HYPOTHESES

Short-term SSRI treatment normalises amygdala hyperactivity in depressed patients

(2012) B. R. Godlewska et al.   PSYCHOLOGICAL MEDICINE

The effect of tryptophan on the cortisol response to social stress is modulated by the 5-HTTLPR genotype

(2012) Hilâl Cerit et al.   PSYCHONEUROENDOCRINOLOGY

Variations in the Promoter Region of the Serotonin Transporter Gene and Biased Attention for Emotional Information: A Meta-Analysis

(2011) Lee Pergamin-Hight et al.   BIOLOGICAL PSYCHIATRY

Effect of hydrolysed egg protein on brain tryptophan availability

(2011) E. Siobhan Mitchell et al.   BRITISH JOURNAL OF NUTRITION

The truth about genetic variation in the serotonin transporter gene and response to stress and medication

(2011) Peter McGuffin et al.   BRITISH JOURNAL OF PSYCHIATRY

Differential effect of the 5-HTT gene-linked polymorphic region on emotional eating during stress exposure following tryptophan challenge

(2011) C. Rob Markus et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Mechanism of acute tryptophan depletion: is it only serotonin?

(2011) E L van Donkelaar et al.   MOLECULAR PSYCHIATRY

Converging evidence for central 5-HT effects in acute tryptophan depletion

(2011) M J Crockett et al.   MOLECULAR PSYCHIATRY

Effects of an acute α-lactalbumin manipulation on mood and food hedonics in high- and low-trait anxiety individuals

(2010) Ellen Verschoor et al.   BRITISH JOURNAL OF NUTRITION

Effect of tryptophan-rich egg protein hydrolysate on brain tryptophan availability, stress and performance

(2010) C. Rob Markus et al.   CLINICAL NUTRITION

Targeting tryptophan hydroxylase 2 in affective disorder

(2010) Nina K Popova et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Acute tryptophan depletion increases experimental nausea but also induces hunger in healthy female subjects

(2010) N. Rieber et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Differential Effects of 5-HTTLPR Genotypes on Inhibition of Negative Emotional Information Following Acute Stress Exposure and Tryptophan Challenge

(2010) C Rob Markus et al.   NEUROPSYCHOPHARMACOLOGY

The new ‘5-HT’ hypothesis of depression: Cell-mediated immune activation induces indoleamine 2,3-dioxygenase, which leads to lower plasma tryptophan and an increased synthesis of detrimental tryptophan catabolites (TRYCATs), both of which contribute to the onset of depression

(2010) M. Maes et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Impact of Tryptophan Metabolism on the Vulnerability to Alcohol-Related Blackouts and Violent Impulsive Behaviours

(2009) J. Vignau et al.   ALCOHOL AND ALCOHOLISM

Differential Effects of Tri-Allelic 5-HTTLPR Polymorphisms in Healthy Subjects on Mood and Stress Performance After Tryptophan Challenge

(2009) C Rob Markus et al.   NEUROPSYCHOPHARMACOLOGY

Effects of tryptophan loading on human cognition, mood, and sleep

(2009) B.Y. Silber et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

5-HTTLPR and Gender Moderate Changes in Negative Affect Responses to Tryptophan Infusion

(2008) Beverly H. Brummett et al.   BEHAVIOR GENETICS

A Double Dissociation in the Roles of Serotonin and Mood in Healthy Subjects

(2008) Oliver J. Robinson et al.   BIOLOGICAL PSYCHIATRY

Alteration of frontal EEG asymmetry during tryptophan depletion predicts future depression

(2008) John J.B. Allen et al.   JOURNAL OF AFFECTIVE DISORDERS

Effect of different tryptophan sources on amino acids availability to the brain and mood in healthy volunteers

(2008) C. Rob Markus et al.   PSYCHOPHARMACOLOGY

The role of implicit wanting in relation to explicit liking and wanting for food: Implications for appetite control

(2007) Graham Finlayson et al.   APPETITE

Acute effects of macronutrient manipulations on cognitive test performance in healthy young adults: A systematic research review

(2007) Alexa Hoyland et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS