Mouse Models of Antigen Presentation in Hematopoietic Stem Cell Transplantation

T cell exhaustion and a failure in antigen presentation drive resistance to the graft-versus-leukemia effect

(2020) Meng Zhou et al.   Nature Communications

CD4+CD8+ T-Lymphocytes in Xenogeneic and Human Graft-versus-Host Disease

(2020) Kutaiba Alhaj Hussen et al.   Frontiers in Immunology

T cell receptor gene therapy targeting WT1 prevents acute myeloid leukemia relapse post-transplant

(2019) Aude G. Chapuis et al.   NATURE MEDICINE

MHC Class II Antigen Presentation by the Intestinal Epithelium Initiates Graft-versus-Host Disease and Is Influenced by the Microbiota

(2019) Motoko Koyama et al.   IMMUNITY

The primacy of gastrointestinal tract antigen-presenting cells in lethal graft-versus-host disease

(2019) Motoko Koyama et al.   BLOOD

Comprehensive Analysis of the Activation and Proliferation Kinetics and Effector Functions of Human Lymphocytes, and Antigen Presentation Capacity of Antigen-Presenting Cells in Xenogeneic Graft-Versus-Host Disease

(2018) Yasufumi Kawasaki et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Xenogeneic Graft-Versus-Host Disease in Humanized NSG and NSG-HLA-A2/HHD Mice

(2018) Grégory Ehx et al.   Frontiers in Immunology

Lack of acute xenogeneic graft-versus-host disease, but retention of T-cell function following engraftment of human peripheral blood mononuclear cells in NSG mice deficient in MHC class I and II expression

(2018) Michael A. Brehm et al.   FASEB JOURNAL

Improved multilineage human hematopoietic reconstitution and function in NSGS mice

(2018) Mark Wunderlich et al.   PLoS One

Alloantigen presentation and graft-versus-host disease: fuel for the fire

(2016) M. Koyama et al.   BLOOD

Autosomal Minor Histocompatibility Antigens: How Genetic Variants Create Diversity in Immune Targets

(2016) Marieke Griffioen et al.   Frontiers in Immunology

Donor colonic CD103+dendritic cells determine the severity of acute graft-versus-host disease

(2015) Motoko Koyama et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Selection of Thymocytes Expressing Transgenic TCR Specific for a Minor Histocompatibility Antigen, H60

(2015) Ji-Min Ju et al.   Immune Network

An Immunocompetent Mouse Model for MLL/AF9 Leukemia Reveals the Potential of Spontaneous Cytotoxic T-Cell Response to an Antigen Expressed in Leukemia Cells

(2015) Kana Hasegawa et al.   PLoS One

Development and function of human innate immune cells in a humanized mouse model

(2014) Anthony Rongvaux et al.   NATURE BIOTECHNOLOGY

Minor histocompatibility antigens: past, present, and future

(2014) Eric Spierings   TISSUE ANTIGENS

Donor T Cells Administered Over HLA Class II Barriers Mediate Antitumor Immunity without Broad Off-Target Toxicity in a NOD/Scid Mouse Model of Acute Leukemia

(2013) Sanja Stevanović et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Characterization of Human Antiviral Adaptive Immune Responses during Hepatotropic Virus Infection in HLA-Transgenic Human Immune System Mice

(2013) E. Billerbeck et al.   JOURNAL OF IMMUNOLOGY

Tolerance induction with gene-modified stem cells and immune-preserving conditioning in primed mice: restricting antigen to differentiated antigen-presenting cells permits efficacy

(2012) M. A. Coleman et al.   BLOOD

Effect of MHC and non-MHC donor/recipient genetic disparity on the outcome of allogeneic HCT

(2012) E. H. Warren et al.   BLOOD

Comparative analysis of risk factors for acute graft-versus-host disease and for chronic graft-versus-host disease according to National Institutes of Health consensus criteria

(2011) M. E. D. Flowers et al.   BLOOD

Human peripheral blood CD4 T cell-engrafted non-obese diabetic-scid IL2rγnull H2-Ab1 tm1Gru Tg (human leucocyte antigen D-related 4) mice: a mouse model of human allogeneic graft-versus-host disease

(2011) L. Covassin et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Exploiting T cells specific for human minor histocompatibility antigens for therapy of leukemia

(2011) Marie Bleakley et al.   IMMUNOLOGY AND CELL BIOLOGY

Graft-versus-Leukemia (GVL) against Mouse Blast-Crisis Chronic Myelogenous Leukemia (BC-CML) and Chronic-Phase Chronic Myelogenous Leukemia (CP-CML): Shared Mechanisms of T Cell Killing, but Programmed Death Ligands Render CP-CML and Not BC-CML GVL Resistant

(2011) C. Matte-Martone et al.   JOURNAL OF IMMUNOLOGY

Recipient nonhematopoietic antigen-presenting cells are sufficient to induce lethal acute graft-versus-host disease

(2011) Motoko Koyama et al.   NATURE MEDICINE

Characterization of CTL Clones Specific for Single Antigen, H60 Minor Histocompatibility Antigen

(2011) Ji Yeong Jeon et al.   Immune Network

Parameters for establishing humanized mouse models to study human immunity: Analysis of human hematopoietic stem cell engraftment in three immunodeficient strains of mice bearing the IL2rγnull mutation

(2010) Michael A. Brehm et al.   CLINICAL IMMUNOLOGY

AML xenograft efficiency is significantly improved in NOD/SCID-IL2RG mice constitutively expressing human SCF, GM-CSF and IL-3

(2010) M Wunderlich et al.   LEUKEMIA

Generation of functional human T-cell subsets with HLA-restricted immune responses in HLA class I expressing NOD/SCID/IL2r null humanized mice

(2010) L. D. Shultz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human peripheral blood leucocyte non-obese diabetic-severe combined immunodeficiency interleukin-2 receptor gamma chain gene mouse model of xenogeneic graft-versus-host-like disease and the role of host major histocompatibility complex

(2009) M. A. King et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

T Cell Allorecognition via Molecular Mimicry

(2009) Whitney A. Macdonald et al.   IMMUNITY

New Design of MHC Class II Tetramers to Accommodate Fundamental Principles of Antigen Presentation

(2009) E. Landais et al.   JOURNAL OF IMMUNOLOGY

A New T-Cell Receptor Transgenic Model of the CD4+ Direct Pathway: Level of Priming Determines Acute Versus Chronic Rejection

(2009) Todd V. Brennan et al.   TRANSPLANTATION

Mouse Models of Bone Marrow Transplantation

(2007) Pavan Reddy et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION