Xenogeneic Graft-Versus-Host Disease in Humanized NSG and NSG-HLA-A2/HHD Mice

Unraveling the Mechanisms of Cutaneous Graft-Versus-Host Disease

(2018) Pedro Santos e Sousa et al.   Frontiers in Immunology

Pooled CRISPR screening with single-cell transcriptome readout

(2017) Paul Datlinger et al.   NATURE METHODS

Acute Graft-versus-Host Disease — Biologic Process, Prevention, and Therapy

(2017) Robert Zeiser et al.   NEW ENGLAND JOURNAL OF MEDICINE

Targeting Aurora kinase A and JAK2 prevents GVHD while maintaining Tregand antitumor CTL function

(2017) Brian C. Betts et al.   Science Translational Medicine

Targeting the Human T-Cell Inducible COStimulator Molecule with a Monoclonal Antibody Prevents Graft-vs-Host Disease and Preserves Graft vs Leukemia in a Xenograft Murine Model

(2017) Aude Burlion et al.   Frontiers in Immunology

Graft-versus-Leukemia Effect Following Hematopoietic Stem Cell Transplantation for Leukemia

(2017) Anne M. Dickinson et al.   Frontiers in Immunology

Pathophysiology of GvHD and Other HSCT-Related Major Complications

(2017) Sakhila Ghimire et al.   Frontiers in Immunology

Azacytidine prevents experimental xenogeneic graft-versus-host disease without abrogating graft-versus-leukemia effects

(2017) Grégory Ehx et al.   OncoImmunology

RORγt and RORα signature genes in human Th17 cells

(2017) Glenda Castro et al.   PLoS One

Acute Graft-versus-Host Disease: Novel Biological Insights

(2016) Takanori Teshima et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Control of GVHD by regulatory T cells depends on TNF produced by T cells and TNFR2 expressed by regulatory T cells

(2016) M. Leclerc et al.   BLOOD

Pathogenesis of acute graft-versus-host disease: from intestinal microbiota alterations to donor T cell activation

(2016) Robert Zeiser et al.   BRITISH JOURNAL OF HAEMATOLOGY

Azacytidine mitigates experimental sclerodermic chronic graft-versus-host disease

(2016) Gilles Fransolet et al.   Journal of Hematology & Oncology

Targeting of PI3K/AKT/mTOR pathway to inhibit T cell activation and prevent graft-versus-host disease development

(2016) Mª Carmen Herrero-Sánchez et al.   Journal of Hematology & Oncology

Interleukin-22 in Graft-Versus-Host Disease after Allogeneic Stem Cell Transplantation

(2016) Baptiste Lamarthée et al.   Frontiers in Immunology

The Role of Animal Models in the Study of Hematopoietic Stem Cell Transplantation and GvHD: A Historical Overview

(2016) Margherita Boieri et al.   Frontiers in Immunology

Danger Signals and Graft-versus-host Disease: Current Understanding and Future Perspectives

(2016) Tomomi Toubai et al.   Frontiers in Immunology

Immune Recovery after Allogeneic Hematopoietic Stem Cell Transplantation Following Flu-TBI versus TLI-ATG Conditioning

(2015) M. Hannon et al.   CLINICAL CANCER RESEARCH

Human monocyte-derived suppressor cells control graft-versus-host disease by inducing regulatory forkhead box protein 3–positive CD8+ T lymphocytes

(2015) Nona Janikashvili et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Evaluation of the efficiency of human immune system reconstitution in NSG mice and NSG mice containing a human HLA.A2 transgene using hematopoietic stem cells purified from different sources

(2015) John Patton et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Transcriptome analysis of GVHD reveals aurora kinase A as a targetable pathway for disease prevention

(2015) Scott N. Furlan et al.   Science Translational Medicine

G-CSF mobilizes CD34 + regulatory monocytes that inhibit graft-versus-host disease

(2015) Maud D’Aveni et al.   Science Translational Medicine

Monoclonal antibodies against GARP/TGF-β1 complexes inhibit the immunosuppressive activity of human regulatory T cells in vivo

(2015) Julia Cuende et al.   Science Translational Medicine

Validation of a multicolor staining to monitor phosphoSTAT5 levels in regulatory T-cell subsets

(2015) Grégory Ehx et al.   Oncotarget

HLA-haploidentical transplantation with regulatory and conventional T-cell adoptive immunotherapy prevents acute leukemia relapse

(2014) M. F. Martelli et al.   BLOOD

HLA class II upregulation during viral infection leads to HLA-DP-directed graft-versus-host disease after CD4+ donor lymphocyte infusion

(2013) S. Stevanovi  et al.   BLOOD

Impact of bone marrow-derived mesenchymal stromal cells on experimental xenogeneic graft-versus-host disease

(2013) France Bruck et al.   CYTOTHERAPY

Aldehyde Dehydrogenase Expression Drives Human Regulatory T Cell Resistance to Posttransplantation Cyclophosphamide

(2013) C. G. Kanakry et al.   Science Translational Medicine

Infusion of clinical-grade enriched regulatory T cells delays experimental xenogeneic graft-versus-host disease

(2013) Muriel Hannon et al.   TRANSFUSION

Cyclin-A1 represents a new immunogenic targetable antigen expressed in acute myeloid leukemia stem cells with characteristics of a cancer-testis antigen

(2012) S. Ochsenreither et al.   BLOOD

Human T cells depend on functional calcineurin, tumour necrosis factor-α and CD80/CD86 for expansion and activation in mice

(2012) H. Søndergaard et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Massive ex Vivo Expansion of Human Natural Regulatory T Cells (Tregs) with Minimal Loss of in Vivo Functional Activity

(2011) K. L. Hippen et al.   Science Translational Medicine

Evidence for a Bidirectional Relationship between Cytomegalovirus Replication and acute Graft-versus-Host Disease

(2010) Nathan Cantoni et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Of Mice, Not Men: No Evidence for Graft-versus-Host Disease in Humans Receiving T-Cell Receptor–Transduced Autologous T Cells

(2010) Steven A Rosenberg   MOLECULAR THERAPY

Generation of functional human T-cell subsets with HLA-restricted immune responses in HLA class I expressing NOD/SCID/IL2r null humanized mice

(2010) L. D. Shultz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acute graft-versus-host disease: from the bench to the bedside

(2009) G. Socie et al.   BLOOD

Human peripheral blood leucocyte non-obese diabetic-severe combined immunodeficiency interleukin-2 receptor gamma chain gene mouse model of xenogeneic graft-versus-host-like disease and the role of host major histocompatibility complex

(2009) M. A. King et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Evidence for neo-generation of T cells by the thymus after non-myeloablative conditioning

(2008) E. Castermans et al.   HAEMATOLOGICA

A new Hu-PBL model for the study of human islet alloreactivity based on NOD-scid mice bearing a targeted mutation in the IL-2 receptor gamma chain gene

(2007) Marie King et al.   CLINICAL IMMUNOLOGY