SARS-CoV-2/ACE2 Interaction Suppresses IRAK-M Expression and Promotes Pro-Inflammatory Cytokine Production in Macrophages

SARS-CoV-2 induces human plasmacytoid predendritic cell diversification via UNC93B and IRAK4

(2021) Fanny Onodi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Development and Clinical Application of A Rapid IgM‐IgG Combined Antibody Test for SARS‐CoV‐2 Infection Diagnosis

(2020) Zhengtu Li et al.   JOURNAL OF MEDICAL VIROLOGY

Receptor recognition by novel coronavirus from Wuhan: An analysis based on decade-long structural studies of SARS

(2020) Yushun Wan et al.   JOURNAL OF VIROLOGY

Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding

(2020) Roujian Lu et al.   LANCET

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

Clinical Characteristics of Coronavirus Disease 2019 in China

(2020) Wei-jie Guan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses

(2020) Michael Letko et al.   Nature Microbiology

SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues

(2020) Carly G.K. Ziegler et al.   CELL

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

(2020) Alexandra C. Walls et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Heightened Innate Immune Responses in the Respiratory Tract of COVID-19 Patients

(2020) Zhuo Zhou et al.   Cell Host & Microbe

The pivotal link between ACE2 deficiency and SARS-CoV-2 infection

(2020) Paolo Verdecchia et al.   European Journal of Internal Medicine

COVID-19: A New Virus, but a Familiar Receptor and Cytokine Release Syndrome

(2020) Toshio Hirano et al.   IMMUNITY

Tocilizumab treatment in COVID-19: A single center experience

(2020) Pan Luo et al.   JOURNAL OF MEDICAL VIROLOGY

In silico studies on the comparative characterization of the interactions of SARS‐CoV‐2 spike glycoprotein with ACE‐2 receptor homologs and human TLRs

(2020) Abhigyan Choudhury et al.   JOURNAL OF MEDICAL VIROLOGY

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

(2020) Fei Zhou et al.   LANCET

Enhanced isolation of SARS-CoV-2 by TMPRSS2-expressing cells

(2020) Shutoku Matsuyama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Highlight of Immune Pathogenic Response and Hematopathologic Effect in SARS-CoV, MERS-CoV, and SARS-Cov-2 Infection

(2020) Yanwen Liang et al.   Frontiers in Immunology

Coronavirus membrane fusion mechanism offers a potential target for antiviral development

(2020) Tiffany Tang et al.   ANTIVIRAL RESEARCH

Advances in research on ACE2 as a receptor for 2019-nCoV

(2020) Jie Wu et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Can we use interleukin-6 (IL-6) blockade for coronavirus disease 2019 (COVID-19)-induced cytokine release syndrome (CRS)?

(2020) Bingwen Liu et al.   JOURNAL OF AUTOIMMUNITY

Clinical characteristics of 82 cases of death from COVID-19

(2020) Bicheng Zhang et al.   PLoS One

Intoxication With Endogenous Angiotensin II: A COVID-19 Hypothesis

(2020) Adonis Sfera et al.   Frontiers in Immunology

Angiotensin-(1-7) and Alamandine Promote Anti-inflammatory Response in Macrophages In Vitro and In Vivo

(2019) Melissa de Carvalho Santuchi et al.   MEDIATORS OF INFLAMMATION

Attenuation of pulmonary ACE2 activity impairs inactivation of des-Arg9 bradykinin/BKB1R axis and facilitates LPS-induced neutrophil infiltration

(2018) Chhinder P. Sodhi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Understanding Angiotensin II Type 1 Receptor Signaling in Vascular Pathophysiology

(2018) Satoru Eguchi et al.   HYPERTENSION

Middle east respiratory syndrome corona virus spike glycoprotein suppresses macrophage responses via DPP4-mediated induction of IRAK-M and PPARγ

(2017) Ahmed A. Al-Qahtani et al.   Oncotarget

Activator protein 1 promotes the transcriptional activation of IRAK-M

(2016) Peipei Jin et al.   BIOMEDICINE & PHARMACOTHERAPY

Epigenetic and Transcriptional Regulation of IRAK-M Expression in Macrophages

(2016) Konstantina Lyroni et al.   JOURNAL OF IMMUNOLOGY

Structure, Function, and Evolution of Coronavirus Spike Proteins

(2016) Fang Li   Annual Review of Virology

Angiotensin-converting enzyme 2/angiotensin-(1–7)/Mas axis prevents lipopolysaccharide–induced apoptosis of pulmonary microvascular endothelial cells by inhibiting JNK/NF–κB pathways

(2015) Yingchuan Li et al.   Scientific Reports

Integrin-linked kinase plays a key role in the regulation of angiotensin II-induced renal inflammation

(2014) Matilde Alique et al.   CLINICAL SCIENCE

Diminazene aceturate (Berenil), a new use for an old compound?

(2014) Shiby Kuriakose et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Diminazene Attenuates Pulmonary Hypertension and Improves Angiogenic Progenitor Cell Functions in Experimental Models

(2013) Vinayak Shenoy et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Diminazene aceturate (Berenil) modulates LPS induced pro-inflammatory cytokine production by inhibiting phosphorylation of MAPKs and STAT proteins

(2013) Shiby Kuriakose et al.   Innate Immunity

IL-6 amplifier activation in epithelial regions of bronchi after allogeneic lung transplantation

(2013) Jihye Lee et al.   INTERNATIONAL IMMUNOLOGY

Interleukin-1 Receptor-Associated Kinase-3 Is a Key Inhibitor of Inflammation in Obesity and Metabolic Syndrome

(2012) Maarten Hulsmans et al.   PLoS One

Angiotensin-(1-7) decreases LPS-induced inflammatory response in macrophages

(2011) Laura L. Souza et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Genetic Ace2 Deficiency Accentuates Vascular Inflammation and Atherosclerosis in the ApoE Knockout Mouse

(2010) Merlin C. Thomas et al.   CIRCULATION RESEARCH

Adiponectin Promotes Endotoxin Tolerance in Macrophages by Inducing IRAK-M Expression

(2009) Vassiliki Zacharioudaki et al.   JOURNAL OF IMMUNOLOGY

SARS coronavirus spike protein-induced innate immune response occurs via activation of the NF-κB pathway in human monocyte macrophages in vitro

(2009) Susan F. Dosch et al.   VIRUS RESEARCH