AICAR, an AMP-Activated Protein Kinase Activator, Ameliorates Acute Pancreatitis-Associated Liver Injury Partially Through Nrf2-Mediated Antioxidant Effects and Inhibition of NLRP3 Inflammasome Activation
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
AICAR, an AMP-Activated Protein Kinase Activator, Ameliorates Acute Pancreatitis-Associated Liver Injury Partially Through Nrf2-Mediated Antioxidant Effects and Inhibition of NLRP3 Inflammasome Activation
Authors
Keywords
-
Journal
Frontiers in Pharmacology
Volume 12, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2021-09-04
DOI
10.3389/fphar.2021.724514
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Acute pancreatitis
- (2021) Eduardo R Argaiz et al. LANCET
- AMPK/SIRT1 Pathway is Involved in Arctigenin-Mediated Protective Effects Against Myocardial Ischemia-Reperfusion Injury
- (2021) Cheng-Yin Liu et al. Frontiers in Pharmacology
- β-Arrestin1 Reduces Oxidative Stress via Nrf2 Activation in the Rostral Ventrolateral Medulla in Hypertension
- (2021) Xing Tan et al. Frontiers in Neuroscience
- NmFGF1-Regulated Glucolipid Metabolism and Angiogenesis Improves Functional Recovery in a Mouse Model of Diabetic Stroke and Acts via the AMPK Signaling Pathway
- (2021) Yeli Zhao et al. Frontiers in Pharmacology
- DsbA-L Ameliorates Renal Injury Through the AMPK/NLRP3 Inflammasome Signaling Pathway in Diabetic Nephropathy
- (2021) Ming Yang et al. Frontiers in Physiology
- Adenylate Kinase 4 Promotes Inflammatory Gene Expression via Hif1α and AMPK in Macrophages
- (2021) Wei-Yao Chin et al. Frontiers in Immunology
- AICAr, a Widely Used AMPK Activator with Important AMPK-Independent Effects: A Systematic Review
- (2021) Dora Višnjić et al. Cells
- hTERT Promotes CRC Proliferation and Migration by Recruiting YBX1 to Increase NRF2 Expression
- (2021) Chunli Gong et al. Frontiers in Cell and Developmental Biology
- Folliculin: A Regulator of Transcription Through AMPK and mTOR Signaling Pathways
- (2021) Josué M. J. Ramirez Reyes et al. Frontiers in Cell and Developmental Biology
- Effects of sildenafil on inflammatory injury of the lung in sodium taurocholate-induced severe acute pancreatitis rats
- (2020) Dazhang Fang et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Energy-stress-mediated AMPK activation inhibits ferroptosis
- (2020) Hyemin Lee et al. NATURE CELL BIOLOGY
- Dapagliflozin and Ticagrelor Have Additive Effects on the Attenuation of the Activation of the NLRP3 Inflammasome and the Progression of Diabetic Cardiomyopathy: an AMPK–mTOR Interplay
- (2020) Huan Chen et al. CARDIOVASCULAR DRUGS AND THERAPY
- Hepatocyte-specific deficiency of Nrf2 exacerbates carbon tetrachloride-induced liver fibrosis via aggravated hepatocyte injury and subsequent inflammatory and fibrogenic responses
- (2020) Hang Lyu et al. FREE RADICAL BIOLOGY AND MEDICINE
- Activation of AMP-activated protein kinase attenuates ethanol-induced ER/oxidative stress and lipid phenotype in human pancreatic acinar cells
- (2020) Mukund P Srinivasan et al. BIOCHEMICAL PHARMACOLOGY
- AMP‐activated protein kinase activator AICAR attenuates hypoxia‐induced murine fetal growth restriction in part by improving uterine artery blood flow
- (2020) Sydney L. Lane et al. JOURNAL OF PHYSIOLOGY-LONDON
- Cordycepin protects against acute pancreatitis by modulating NF-κB and NLRP3 inflammasome activation via AMPK
- (2020) Jing Yang et al. LIFE SCIENCES
- The Implication of Oxidative Stress and AMPK-Nrf2 Antioxidative Signaling in Pneumonia Pathogenesis
- (2020) Weitong Xu et al. Frontiers in Endocrinology
- Piperine protects against pyroptosis in myocardial ischaemia/reperfusion injury by regulating the miR‐383/RP105/AKT signalling pathway
- (2020) Xin Guo et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- An Overview of Nrf2 Signaling Pathway and Its Role in Inflammation
- (2020) Sarmistha Saha et al. MOLECULES
- Regulation of the NLRP3 inflammasome with natural products against chemical-induced liver injury
- (2020) Jian Zou et al. PHARMACOLOGICAL RESEARCH
- Theaflavin 3,3′-digallate reverses the downregulation of connexin 43 and autophagy induced by high glucose via AMPK activation in cardiomyocytes
- (2019) Zhida Shen et al. JOURNAL OF CELLULAR PHYSIOLOGY
- The Relationship between Liver Injury and Serum Levels of C-Reactive Protein and Procalcitonin in Patients with Acute Pancreatitis
- (2019) Xiujiang Li et al. JCPSP-Journal of the College of Physicians and Surgeons Pakistan
- Duration of organ failure impacts mortality in acute pancreatitis
- (2019) Na Shi et al. GUT
- Organ Failure due to Systemic Injury in Acute Pancreatitis
- (2019) Pramod K. Garg et al. GASTROENTEROLOGY
- Ethanol Exposure Impairs AMPK Signaling and Phagocytosis in Human Alveolar Macrophages: Role of Ethanol Metabolism
- (2019) Lata Kaphalia et al. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
- 5-Amino-1-β-D-Ribofuranosyl-Imidazole-4-Carboxamide (AICAR) Reduces Peripheral Inflammation by Macrophage Phenotype Shift
- (2019) Lisa Maria Martin et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Induction of Nrf2 pathway by Dendrobium nobile Lindl. alkaloids protects against carbon tetrachloride induced acute liver injury
- (2019) Shiyue Li et al. BIOMEDICINE & PHARMACOTHERAPY
- NLRP3 inflammasome blockade reduces adipose tissue inflammation and extracellular matrix remodeling
- (2019) Xabier Unamuno et al. Cellular & Molecular Immunology
- Retinoic acid modulates IL-4, IL-10 and MCP-1 pathways in immune mediated hepatitis and interrupts CD4+ T cells infiltration
- (2019) Mahmoud Elshal et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- AMPK leads to phosphorylation of the transcription factor Nrf2, tuning transactivation of selected target genes
- (2019) Manuel Matzinger et al. Redox Biology
- Nrf2 inhibits NLRP3 inflammasome activation through regulating Trx1/TXNIP complex in cerebral ischemia reperfusion injury
- (2018) Yanghao Hou et al. BEHAVIOURAL BRAIN RESEARCH
- AMPK: Sensing Glucose as well as Cellular Energy Status
- (2018) Sheng-Cai Lin et al. Cell Metabolism
- The Crosstalk between Nrf2 and Inflammasomes
- (2018) Paulina Hennig et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Glycogen synthase kinase 3β promotes liver innate immune activation by restraining AMP-activated protein kinase activation
- (2018) Haoming Zhou et al. JOURNAL OF HEPATOLOGY
- AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking System Xc– Activity
- (2018) Xinxin Song et al. CURRENT BIOLOGY
- AMPK/PGC1α activation by melatonin attenuates acute doxorubicin cardiotoxicity via alleviating mitochondrial oxidative damage and apoptosis
- (2018) Dong Liu et al. FREE RADICAL BIOLOGY AND MEDICINE
- RNA sequence analysis reveals pathways and candidate genes associated with liver injury in a rat pancreatitis model
- (2018) Qian Wang et al. PANCREATOLOGY
- FXR Inhibits Endoplasmic Reticulum Stress-Induced NLRP3 Inflammasome in Hepatocytes and Ameliorates Liver Injury
- (2018) Chang Yeob Han et al. Cell Reports
- Magnesium isoglycyrrhizinate alleviates liver injury in obese rats with acute necrotizing pancreatitis
- (2018) Fangchao Mei et al. PATHOLOGY RESEARCH AND PRACTICE
- NLRP3 inflammasome driven liver injury and fibrosis: Roles of IL-17 and TNF in mice
- (2017) Alexander Wree et al. HEPATOLOGY
- NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice
- (2017) Auvro R. Mridha et al. JOURNAL OF HEPATOLOGY
- Isoliquiritigenin alleviates early brain injury after experimental intracerebral hemorrhage via suppressing ROS- and/or NF-κB-mediated NLRP3 inflammasome activation by promoting Nrf2 antioxidant pathway
- (2017) Jun Zeng et al. Journal of Neuroinflammation
- AMPK: Mechanisms of Cellular Energy Sensing and Restoration of Metabolic Balance
- (2017) Daniel Garcia et al. MOLECULAR CELL
- AMPK: guardian of metabolism and mitochondrial homeostasis
- (2017) Sébastien Herzig et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Non-Alcoholic Fatty Liver Disease and Nutritional Implications: Special Focus on Copper
- (2017) Laura Antonucci et al. Nutrients
- Isoliquiritigenin Activates Nuclear Factor Erythroid-2 Related Factor 2 to Suppress the NOD-Like Receptor Protein 3 Inflammasome and Inhibits the NF-κB Pathway in Macrophages and in Acute Lung Injury
- (2017) Qinmei Liu et al. Frontiers in Immunology
- Transcriptional Regulation by Nrf2
- (2017) Claudia Tonelli et al. ANTIOXIDANTS & REDOX SIGNALING
- Nobiletin protects against murine l -arginine-induced acute pancreatitis in association with downregulating p38MAPK and AKT
- (2016) Bing Liu et al. BIOMEDICINE & PHARMACOTHERAPY
- Frontline Science: D1 dopaminergic receptor signaling activates the AMPK-bioenergetic pathway in macrophages and alveolar epithelial cells and reduces endotoxin-induced ALI
- (2016) Nathaniel B. Bone et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Traumatic brain injury decreases AMP-activated protein kinase activity and pharmacological enhancement of its activity improves cognitive outcome
- (2016) Julia L. Hill et al. JOURNAL OF NEUROCHEMISTRY
- AMPK-dependent and independent effects of AICAR and compound C on T-cell responses
- (2016) Enyu Rao et al. Oncotarget
- The carvacrol ameliorates acute pancreatitis-induced liver injury via antioxidant response
- (2015) Murat Bakır et al. CYTOTECHNOLOGY
- Activated AMPK boosts the Nrf2/HO-1 signaling axis—A role for the unfolded protein response
- (2015) Kristin Zimmermann et al. FREE RADICAL BIOLOGY AND MEDICINE
- The AMPK Inhibitor Compound C Is a Potent AMPK-Independent Antiglioma Agent
- (2014) X. Liu et al. MOLECULAR CANCER THERAPEUTICS
- AMPK Inhibition Blocks ROS-NFκB Signaling and Attenuates Endotoxemia-Induced Liver Injury
- (2014) Yuan Guo et al. PLoS One
- Desoxyrhapontigenin up-regulates Nrf2-mediated heme oxygenase-1 expression in macrophages and inflammatory lung injury
- (2014) Ran Joo Choi et al. Redox Biology
- Pharmacological activation of AMPK suppresses inflammatory response evoked by IL-6 signalling in mouse liver and in human hepatocytes
- (2013) Annika Nerstedt et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- AMPK activator AICAR ameliorates ischaemia reperfusion injury in the rat kidney
- (2012) J Lempiäinen et al. BRITISH JOURNAL OF PHARMACOLOGY
- Zerumbone Attenuates the Severity of Acute Necrotizing Pancreatitis and Pancreatitis-Induced Hepatic Injury
- (2012) Deng Wenhong et al. MEDIATORS OF INFLAMMATION
- Compound C Prevents the Unfolded Protein Response during Glucose Deprivation through a Mechanism Independent of AMPK and BMP Signaling
- (2012) Sakae Saito et al. PLoS One
- AMP-activated protein kinase inhibits IL-6-stimulated inflammatory response in human liver cells by suppressing phosphorylation of signal transducer and activator of transcription 3 (STAT3)
- (2010) A. Nerstedt et al. DIABETOLOGIA
- Human hepatocarcinoma-intestine-pancreas/pancreatitis-associated protein cures fas-induced acute liver failure in mice by attenuating free-radical damage in injured livers
- (2010) Nicolas Moniaux et al. HEPATOLOGY
- Hypertonic saline reduces metalloproteinase expression in liver during pancreatitis
- (2009) Ester CS Rios et al. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started