The CNS-Penetrant Soluble Guanylate Cyclase Stimulator CY6463 Reveals its Therapeutic Potential in Neurodegenerative Diseases

Neuroimaging Biomarkers in SCA2 Gene Carriers

(2020) Mario Mascalchi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Metabolism and Pharmacokinetic Drug–Drug Interaction Profile of Vericiguat, A Soluble Guanylate Cyclase Stimulator: Results From Preclinical and Phase I Healthy Volunteer Studies

(2020) Michael Boettcher et al.   CLINICAL PHARMACOKINETICS

From single drug targets to synergistic network pharmacology in ischemic stroke

(2019) Ana I. Casas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Calcium-dependent blood-brain barrier breakdown by NOX5 limits postreperfusion benefit in stroke

(2019) Ana I. Casas et al.   JOURNAL OF CLINICAL INVESTIGATION

Neuron-Glia Signaling in Synapse Elimination

(2019) Daniel K. Wilton et al.   Annual Review of Neuroscience

Developing Effective Alzheimer’s Disease Therapies: Clinical Experience and Future Directions

(2019) David R. Elmaleh et al.   JOURNAL OF ALZHEIMERS DISEASE

BOLD signal physiology: Models and applications

(2018) C.J. Gauthier et al.   NEUROIMAGE

Discovery and development of next generation sGC stimulators with diverse multidimensional pharmacology and broad therapeutic potential

(2018) E.S. Buys et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Riociguat versus sildenafil on hypoxic pulmonary vasoconstriction and ventilation/perfusion matching

(2018) Virginia Chamorro et al.   PLoS One

The role of brain vasculature in neurodegenerative disorders

(2018) Melanie D. Sweeney et al.   NATURE NEUROSCIENCE

NO as a multimodal transmitter in the brain: discovery and current status

(2018) John Garthwaite   BRITISH JOURNAL OF PHARMACOLOGY

Pharmacological manipulation of cGMP and NO/cGMP in CNS drug discovery

(2018) Michael A. Hollas et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Investigational phosphodiesterase inhibitors in phase I and phase II clinical trials for Alzheimer’s disease

(2017) Jos Prickaerts et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Neurovascular-neuroenergetic coupling axis in the brain: master regulation by nitric oxide and consequences in aging and neurodegeneration

(2017) Cátia F. Lourenço et al.   FREE RADICAL BIOLOGY AND MEDICINE

A phase I, randomized, proof-of-clinical-mechanism study assessing the pharmacokinetics and pharmacodynamics of the oral PDE9A inhibitor BI 409306 in healthy male volunteers

(2017) Katja Boland et al.   HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL

Discovery of the Soluble Guanylate Cyclase Stimulator Vericiguat (BAY 1021189) for the Treatment of Chronic Heart Failure

(2017) Markus Follmann et al.   JOURNAL OF MEDICINAL CHEMISTRY

The 5-HT 6 receptor antagonist idalopirdine potentiates the effects of donepezil on gamma oscillations in the frontal cortex of anesthetized and awake rats without affecting sleep-wake architecture

(2017) Maria Amat-Foraster et al.   NEUROPHARMACOLOGY

Sensitivity to Sevoflurane anesthesia is decreased in mice with a congenital deletion of Guanylyl Cyclase-1 alpha

(2017) Yasuko Nagasaka et al.   BMC Anesthesiology

Cardiovascular Disease, the Nitric Oxide Pathway and Risk of Cognitive Impairment and Dementia

(2017) Blossom C. M. Stephan et al.   Current Cardiology Reports

Oxidative Stress in Vascular Dementia and Alzheimer's Disease: A Common Pathology

(2017) Stuart Bennett et al.   JOURNAL OF ALZHEIMERS DISEASE

Central Nervous System Multiparameter Optimization Desirability: Application in Drug Discovery

(2016) Travis T. Wager et al.   ACS Chemical Neuroscience

Targeting NO/cGMP Signaling in the CNS for Neurodegeneration and Alzheimer’s Disease

(2016) Manel Aissa et al.   CURRENT MEDICINAL CHEMISTRY

Role of neuroinflammation in neurodegenerative diseases (Review)

(2016) WEI-WEI CHEN et al.   Molecular Medicine Reports

Assessment of disease-related cognitive impairments using the novel object recognition (NOR) task in rodents

(2015) Ben Grayson et al.   BEHAVIOURAL BRAIN RESEARCH

Effect of acute NR2B antagonist treatment on long-term potentiation in the rat hippocampus

(2015) John D Graef et al.   BRAIN RESEARCH

Phosphodiesterase 9A controls nitric-oxide-independent cGMP and hypertrophic heart disease

(2015) Dong I. Lee et al.   NATURE

Leptin resistance in diet-induced obesity: the role of hypothalamic inflammation

(2015) K. C. G. de Git et al.   Obesity Reviews

Diet-induced obesity attenuates cytokine production following an immune challenge

(2014) Katherine M. Baumgarner et al.   BEHAVIOURAL BRAIN RESEARCH

Acute Hemodynamic Effects of Riociguat in Patients With Pulmonary Hypertension Associated With Diastolic Heart Failure (DILATE-1)

(2014) Diana Bonderman et al.   CHEST

A Multicenter, Double-Blind, Placebo-Controlled Trial of the PDE9A Inhibitor, PF-04447943, in Alzheimer’s Disease

(2014) Elias Schwam et al.   Current Alzheimer Research

The Novel Object Recognition Test in Rodents in Relation to Cognitive Impairment in Schizophrenia

(2014) Lakshmi Rajagopal et al.   CURRENT PHARMACEUTICAL DESIGN

Phosphodiesterase Inhibitors as a Target for Cognition Enhancement in Aging and Alzheimer’s Disease: A Translational Overview

(2014) P.R.A. Heckman et al.   CURRENT PHARMACEUTICAL DESIGN

Astrocytes contribute to gamma oscillations and recognition memory

(2014) H. S. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Utility of CSF in translational neuroscience

(2013) Elizabeth C. M. de Lange   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Magnetic Resonance Spectroscopy in Common Dementias

(2013) Kejal Kantarci   NEUROIMAGING CLINICS OF NORTH AMERICA

The role of phosphodiesterases in hippocampal synaptic plasticity

(2013) Thomas M. Sanderson et al.   NEUROPHARMACOLOGY

Structure and Regulation of Soluble Guanylate Cyclase

(2012) Emily R. Derbyshire et al.   Annual Review of Biochemistry

Phosphodiesterases in neurodegenerative disorders

(2012) Eva Bollen et al.   IUBMB LIFE

Demystifying Brain Penetration in Central Nervous System Drug Discovery

(2012) Li Di et al.   JOURNAL OF MEDICINAL CHEMISTRY

Inhibition of acetylcholinesterase and phosphodiesterase-9A has differential effects on hippocampal early and late LTP

(2012) Katja S. Kroker et al.   NEUROPHARMACOLOGY

The selective phosphodiesterase 9 (PDE9) inhibitor PF-04447943 (6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one) enhances synaptic plasticity and cognitive function in rodents

(2011) P.H. Hutson et al.   NEUROPHARMACOLOGY

The cholinergic system in aging and neuronal degeneration

(2010) Reinhard Schliebs et al.   BEHAVIOURAL BRAIN RESEARCH

Age-related changes in metabolic profiles of rat hippocampus and cortices

(2010) Véronique Paban et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Brain function with complex decision making using electroencephalography

(2010) C. Ervin Davis et al.   INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY

High-fat diets impair spatial learning in the radial-arm maze in mice

(2010) I. Valladolid-Acebes et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Olfactory system gamma oscillations: the physiological dissection of a cognitive neural system

(2008) Daniel Rojas-Líbano et al.   Cognitive Neurodynamics

Validation of a Rapid Equilibrium Dialysis Approach for the Measurement of Plasma Protein Binding

(2008) Nigel J. Waters et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

The novel selective PDE9 inhibitor BAY 73-6691 improves learning and memory in rodents

(2008) F. Josef van der Staay et al.   NEUROPHARMACOLOGY