Utility of CSF in translational neuroscience

Penetration of doripenem in human brain: an observational microdialysis study in patients with acute brain injury

(2012) Wolfgang Poeppl et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Direct venous spinal reabsorption of cerebrospinal fluid: a new concept with serial magnetic resonance cisternography in rabbits

(2012) Huseyin Biceroglu et al.   JOURNAL OF NEUROSURGERY-SPINE

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid  

(2012) J. J. Iliff et al.   Science Translational Medicine

Overton's Rule Helps To Estimate the Penetration of Anti-Infectives into Patients' Cerebrospinal Fluid

(2011) Marija Djukic et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Blood–arachnoid barrier disruption in experimental rat meningitis detected using gadolinium-enhancement ratio imaging

(2011) Hiroyuki Ichikawa et al.   BRAIN RESEARCH

Preclinical Prediction of Human Brain Target Site Concentrations: Considerations in Extrapolating to the Clinical Setting

(2011) Joost Westerhout et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Quantitative Evaluation of the Impact of Active Efflux by P-Glycoprotein and Breast Cancer Resistance Protein at the Blood-Brain Barrier on the Predictability of the Unbound Concentrations of Drugs in the Brain Using Cerebrospinal Fluid Concentration as a Surrogate

(2011) H. Kodaira et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Associatingin vitrotarget binding andin vivoCNS occupancy of serotonin reuptake inhibitors in rats: The role of free drug concentrations

(2011) Christoffer Bundgaard et al.   XENOBIOTICA

Penetration of Drugs through the Blood-Cerebrospinal Fluid/Blood-Brain Barrier for Treatment of Central Nervous System Infections

(2010) R. Nau et al.   CLINICAL MICROBIOLOGY REVIEWS

Assessing brain free fraction in early drug discovery

(2010) Kevin D Read et al.   Expert Opinion on Drug Metabolism & Toxicology

Active-Site Concentrations of Chemicals - Are They a Better Predictor of Effect than Plasma/Organ/Tissue Concentrations?

(2009) Margareta Hammarlund-Udenaes   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Extracellular fluid concentrations of cisplatin, carboplatin, and oxaliplatin in brain, muscle, and blood measured using microdialysis in nonhuman primates

(2009) Shana Jacobs et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Methodologies to Assess Brain Drug Delivery in Lead Optimization

(2009) Margareta Hammarlund-Udenaes et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Receptor Occupancy and Brain Free Fraction

(2009) J. Watson et al.   DRUG METABOLISM AND DISPOSITION

Structure−Brain Exposure Relationships in Rat and Human Using a Novel Data Set of Unbound Drug Concentrations in Brain Interstitial and Cerebrospinal Fluids

(2009) Markus Fridén et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pharmacokinetic analysis of etoposide distribution after administration directly into the fourth ventricle in a piglet model

(2009) David I. Sandberg et al.   JOURNAL OF NEURO-ONCOLOGY

Assessment of the blood–brain barrier in CNS drug discovery

(2009) Phil Jeffrey et al.   NEUROBIOLOGY OF DISEASE

Blood–brain interfaces and cerebral drug bioavailability

(2009) J.-F. Ghersi-Egea et al.   REVUE NEUROLOGIQUE

Dynamics of distribution of 3H-inulin between the cerebrospinal fluid compartments

(2008) Anton Vladić et al.   BRAIN RESEARCH

CSF as a Surrogate for Assessing CNS Exposure: An Industrial Perspective

(2008) Jiunn Lin   CURRENT DRUG METABOLISM

Unbound Drug Concentration in Brain Homogenate and Cerebral Spinal Fluid at Steady State as a Surrogate for Unbound Concentration in Brain Interstitial Fluid

(2008) X. Liu et al.   DRUG METABOLISM AND DISPOSITION

Microdialysis Evaluation of Atomoxetine Brain Penetration and Central Nervous System Pharmacokinetics in Rats

(2008) W. Kielbasa et al.   DRUG METABOLISM AND DISPOSITION

Pharmacokinetics of moxifloxacin in non-inflamed cerebrospinal fluid of humans: implication for a bactericidal effect

(2008) K. Kanellakopoulou et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

The Use of a Deuterated Calibrator for In Vivo Recovery Estimations in Microdialysis Studies

(2007) Jörgen Bengtsson et al.   JOURNAL OF PHARMACEUTICAL SCIENCES