Synergy of nanodiamond–doxorubicin conjugates and PD-L1 blockade effectively turns tumor-associated macrophages against tumor cells

Conjugation with nanodiamonds via hydrazone bond fundamentally alters intracellular distribution and activity of doxorubicin

(2021) Shen-Jun Yuan et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Stromal PD-1+ tumor-associated macrophages predict poor prognosis in lung adenocarcinoma

(2020) Lu Chen et al.   HUMAN PATHOLOGY

Macrophage and Tumor Cell Cross-Talk Is Fundamental for Lung Tumor Progression: We Need to Talk

(2020) Poonam Sarode et al.   Frontiers in Oncology

Anti–PD-1 Induces M1 Polarization in the Glioma Microenvironment and Exerts Therapeutic Efficacy in the Absence of CD8 Cytotoxic T Cells

(2020) Ganesh Rao et al.   CLINICAL CANCER RESEARCH

Hepatocellular carcinoma-derived high mobility group box 1 triggers M2 macrophage polarization via a TLR2/NOX2/autophagy axis

(2020) Dong-Jer Shiau et al.   Scientific Reports

Turning up the heat on non-immunoreactive tumours: opportunities for clinical development

(2020) María Ochoa de Olza et al.   LANCET ONCOLOGY

Tumor-Associated Macrophages in Human Breast, Colorectal, Lung, Ovarian and Prostate Cancers

(2020) Irina Larionova et al.   Frontiers in Oncology

Doxorubicin-polyglycerol-nanodiamond composites stimulate glioblastoma cell immunogenicity through activation of autophagy

(2019) Tong-Fei Li et al.   Acta Biomaterialia

Tumor-derived exosomal HMGB1 promotes esophageal squamous cell carcinoma progression through inducing PD1+ TAM expansion

(2019) Bin Li et al.   Oncogenesis

Upregulation of PD-L1 via HMGB1-activated IRF3 and NF-kB contributes to UV radiation-induced immune suppression

(2019) Wei Wang et al.   CANCER RESEARCH

Checkpoint Blockade in Combination With Doxorubicin Augments Tumor Cell Apoptosis in Osteosarcoma

(2019) Jizhuang Wang et al.   JOURNAL OF IMMUNOTHERAPY

M1 Macrophages Induce PD-L1 Expression in Hepatocellular Carcinoma Cells Through IL-1β Signaling

(2019) Zhaoyun Zong et al.   Frontiers in Immunology

Antitumor activity of the PD-1/PD-L1 binding inhibitor BMS-202 in the humanized MHC-double knockout NOG mouse

(2019) Tadashi ASHIZAWA et al.   BIOMEDICAL RESEARCH-TOKYO

Mechanisms Controlling PD-L1 Expression in Cancer

(2019) Jong-Ho Cha et al.   MOLECULAR CELL

Doxorubicin-polyglycerol-nanodiamond conjugate is a cytostatic agent that evades chemoresistance and reverses cancer-induced immunosuppression in triple-negative breast cancer

(2019) Shen-Jun Yuan et al.   JOURNAL OF NANOBIOTECHNOLOGY

Beyond T Cells: Understanding the Role of PD-1/PD-L1 in Tumor-Associated Macrophages

(2019) Di Lu et al.   Journal of Immunology Research

Blocking the PD-1/PD-L1 axis enhanced cisplatin chemotherapy in osteosarcoma in vitro and in vivo

(2019) Xiaoqiang Liu et al.   Environmental Health and Preventive Medicine

Monocyte-mediated chemotherapy drug delivery in glioblastoma

(2018) Chao Wang et al.   Nanomedicine

Programmed Cell Death Ligand 1 (PD-L1) Signaling Regulates Macrophage Proliferation and Activation

(2018) Genevieve P Hartley et al.   Cancer Immunology Research

Dendritic cell-mediated delivery of doxorubicin-polyglycerol-nanodiamond composites elicits enhanced anti-cancer immune response in glioblastoma

(2018) Tong-Fei Li et al.   BIOMATERIALS

Anti-PD-1/PD-L1 Therapy for Non-Small-Cell Lung Cancer: Toward Personalized Medicine and Combination Strategies

(2018) Hongshu Sui et al.   Journal of Immunology Research

Harnessing the cross-talk between tumor cells and tumor-associated macrophages with a nano-drug for modulation of glioblastoma immune microenvironment

(2017) Tong-Fei Li et al.   JOURNAL OF CONTROLLED RELEASE

Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Death-Ligand 1 (PD-1/PD-L1) Interaction via Transiently Induced Protein States and Dimerization of PD-L1

(2017) Katarzyna Guzik et al.   JOURNAL OF MEDICINAL CHEMISTRY

PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity

(2017) Sydney R. Gordon et al.   NATURE

Glycyrrhizin, a Direct HMGB1 Antagonist, Ameliorates Inflammatory Infiltration in a Model of Autoimmune Thyroiditis via Inhibition of TLR2-HMGB1 Signaling

(2017) Chenyan Li et al.   THYROID

PDL1 Signals through Conserved Sequence Motifs to Overcome Interferon-Mediated Cytotoxicity

(2017) Maria Gato-Cañas et al.   Cell Reports

PD-1 and PD-L1 Checkpoint Signaling Inhibition for Cancer Immunotherapy: Mechanism, Combinations, and Clinical Outcome

(2017) Hashem O. Alsaab et al.   Frontiers in Pharmacology

PD-1/PD-L1 blockade in cancer treatment: perspectives and issues

(2016) Junzo Hamanishi et al.   International Journal of Clinical Oncology

Structural basis for small molecule targeting of the programmed death ligand 1 (PD-L1)

(2016) Krzysztof M. Zak et al.   Oncotarget

Periostin secreted by glioblastoma stem cells recruits M2 tumour-associated macrophages and promotes malignant growth

(2015) Wenchao Zhou et al.   NATURE CELL BIOLOGY

Polyglycerol-coated nanodiamond as a macrophage-evading platform for selective drug delivery in cancer cells

(2014) Li Zhao et al.   BIOMATERIALS

Myeloid IKK  Promotes Antitumor Immunity by Modulating CCL11 and the Innate Immune Response

(2014) J. Yang et al.   CANCER RESEARCH

Effect of ammonium pyrrolidine dithiocarbamate (PDTC) on NF-κB activation and CYP2E1 content of rats with immunological liver injury

(2014) Jin-dong Qin et al.   PHARMACEUTICAL BIOLOGY

Tumor-Associated Macrophages as Major Players in the Tumor Microenvironment

(2014) Theerawut Chanmee et al.   Cancers

Ménage à Trois in stress: DAMPs, redox and autophagy

(2013) Guanqiao Li et al.   SEMINARS IN CANCER BIOLOGY

A multimodal RAGE-specific inhibitor reduces amyloid β–mediated brain disorder in a mouse model of Alzheimer disease

(2012) Rashid Deane et al.   JOURNAL OF CLINICAL INVESTIGATION

Tumor-Associated Macrophages Promote Invasion while Retaining Fc-Dependent Anti-Tumor Function

(2012) K. D. Grugan et al.   JOURNAL OF IMMUNOLOGY

Ethyl pyruvate decreases HMGB1 release and ameliorates murine colitis

(2009) Shaival H. Davé et al.   JOURNAL OF LEUKOCYTE BIOLOGY