It Takes Two to Tango: How a Dysregulation of the Innate Immunity, Coupled With Candida Virulence, Triggers VVC Onset

Immune Sensing of Candida albicans

(2021) Ebrima Bojang et al.   Journal of Fungi

Candida pathogens induce protective mitochondria-associated type I interferon signalling and a damage-driven response in vaginal epithelial cells

(2021) Marina Pekmezovic et al.   Nature Microbiology

The Fungal Pathogen Candida albicans Promotes Bladder Colonization of Group B Streptococcus

(2020) Samuel R. Shing et al.   Frontiers in Cellular and Infection Microbiology

Oral health problems among palliative and terminally ill patients: an integrated systematic review

(2020) Munikumar Ramasamy Venkatasalu et al.   BMC Oral Health

Candida albicans and candidalysin in inflammatory disorders and cancer

(2020) Jemima Ho et al.   IMMUNOLOGY

Human Pathogenic Candida Species Respond Distinctively to Lactic Acid Stress

(2020) Isabella Zangl et al.   Journal of Fungi

Current patient perspectives of vulvovaginal candidiasis: incidence, symptoms, management and post-treatment outcomes

(2019) Junko Yano et al.   BMC Womens Health

Vaginal Epithelial Cells discriminate between yeast and hyphae of C. albicans in women who are colonized with or have vaginal candidiasis

(2019) Elena Roselletti et al.   JOURNAL OF INFECTIOUS DISEASES

A systems genomics approach identifies SIGLEC15 as a susceptibility factor in recurrent vulvovaginal candidiasis

(2019) M. Jaeger et al.   Science Translational Medicine

Candidalysin activates innate epithelial immune responses via epidermal growth factor receptor

(2019) Jemima Ho et al.   Nature Communications

Keeping Candida commensal: how lactobacilli antagonize pathogenicity of Candida albicans in an in vitro gut model

(2019) Katja Graf et al.   Disease Models & Mechanisms

A Role for Yeast/Pseudohyphal Cells of Candida albicans in the Correlated Expression of NLRP3 Inflammasome Inducers in Women With Acute Vulvovaginal Candidiasis

(2019) Elena Roselletti et al.   Frontiers in Microbiology

Targeting the Aryl Hydrocarbon Receptor With Indole-3-Aldehyde Protects From Vulvovaginal Candidiasis via the IL-22-IL-18 Cross-Talk

(2019) Monica Borghi et al.   Frontiers in Immunology

The Interleukin (IL) 17R/IL-22R Signaling Axis Is Dispensable for Vulvovaginal Candidiasis Regardless of Estrogen Status

(2019) Brian M Peters et al.   JOURNAL OF INFECTIOUS DISEASES

Coassociation between Group B Streptococcus and Candida albicans Promotes Interactions with Vaginal Epithelium

(2018) Grace R. Pidwill et al.   INFECTION AND IMMUNITY

Candida vaginitis: virulence, host response and vaccine prospects

(2018) Flavia De Bernardis et al.   MEDICAL MYCOLOGY

Candida innate immunity at the mucosa

(2018) Jonathan P. Richardson et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Processing of Candida albicans Ece1p Is Critical for Candidalysin Maturation and Fungal Virulence

(2018) Jonathan P. Richardson et al.   mBio

Vulvovaginal candidiasis: species distribution of Candida and their antifungal susceptibility pattern

(2018) Adane Bitew et al.   BMC Womens Health

A comparative analysis of the capacity of the Candida species to elicit vaginal immunopathology

(2018) Hubertine M. E. Willems et al.   INFECTION AND IMMUNITY

Global burden of recurrent vulvovaginal candidiasis: a systematic review

(2018) David W Denning et al.   LANCET INFECTIOUS DISEASES

Epitope unmasking in vulvovaginal candidiasis is associated with hyphal growth and neutrophilic infiltration

(2018) Eva Pericolini et al.   PLoS One

Randomized clinical trial in women with Recurrent Vulvovaginal Candidiasis: efficacy of probiotics and lactoferrin as maintenance treatment

(2018) Rosario Russo et al.   MYCOSES

The resilience of the intestinal microbiota influences health and disease

(2017) Felix Sommer et al.   NATURE REVIEWS MICROBIOLOGY

Vaginal Heparan Sulfate Linked to Neutrophil Dysfunction in the Acute Inflammatory Response Associated with Experimental Vulvovaginal Candidiasis

(2017) Junko Yano et al.   mBio

NLRP3 inflammasome is a key player in human vulvovaginal disease caused by Candida albicans

(2017) Elena Roselletti et al.   Scientific Reports

Recurrent vulvovaginal candidiasis

(2016) Jack D. Sobel   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Association of a variable number tandem repeat in the NLRP3 gene in women with susceptibility to RVVC

(2016) M. Jaeger et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Candida albicans Pathogenesis: Fitting within the Host-Microbe Damage Response Framework

(2016) Mary Ann Jabra-Rizk et al.   INFECTION AND IMMUNITY

Experimental Models of Vaginal Candidiasis and Their Relevance to Human Candidiasis

(2016) Antonio Cassone et al.   INFECTION AND IMMUNITY

Streptococcus oralisandCandida albicansSynergistically Activate μ-Calpain to Degrade E-cadherin From Oral Epithelial Junctions

(2016) Hongbin Xu et al.   JOURNAL OF INFECTIOUS DISEASES

Interaction of Candida albicans with host cells: virulence factors, host defense, escape strategies, and the microbiota

(2016) Sarah Höfs et al.   JOURNAL OF MICROBIOLOGY

The vaginal microbiota, host defence and reproductive physiology

(2016) Steven B Smith et al.   JOURNAL OF PHYSIOLOGY-LONDON

Lactic acid bacteria differentially regulate filamentation in two heritable cell types of the human fungal pathogenCandida albicans

(2016) Weihong Liang et al.   MOLECULAR MICROBIOLOGY

Candidalysin is a fungal peptide toxin critical for mucosal infection

(2016) David L. Moyes et al.   NATURE

A tale of two yeasts: Saccharomyces cerevisiae as a therapeutic against candidiasis

(2016) Duncan Wilson   Virulence

In vivoinduction of neutrophil chemotaxis by secretory aspartyl proteinases ofCandida albicans

(2016) Elena Gabrielli et al.   Virulence

Therapeutic activity of a Saccharomyces cerevisiae-based probiotic and inactivated whole yeast on vaginal candidiasis

(2016) Eva Pericolini et al.   Virulence

Neutrophil Attack Triggers Extracellular Trap-Dependent Candida Cell Wall Remodeling and Altered Immune Recognition

(2016) Alex Hopke et al.   PLoS Pathogens

Lactate signalling regulates fungal β-glucan masking and immune evasion

(2016) Elizabeth R. Ballou et al.   Nature Microbiology

Vaginal colonisation by probiotic lactobacilli and clinical outcome in women conventionally treated for bacterial vaginosis and yeast infection

(2015) Sonal Pendharkar et al.   BMC INFECTIOUS DISEASES

Gynecologic health and disease in relation to the microbiome of the female reproductive tract

(2015) Katherine A. Green et al.   FERTILITY AND STERILITY

Experimental models of vaginal candidiasis and inflammation

(2015) Anna Vecchiarelli et al.   Future Microbiology

New signaling pathways govern the host response toC. albicansinfection in various niches

(2015) Yaoping Liu et al.   GENOME RESEARCH

Induction of Caspase-11 by Aspartyl Proteinases of Candida albicans and Implication in Promoting Inflammatory Response

(2015) Elena Gabrielli et al.   INFECTION AND IMMUNITY

Influence of cancer treatment on the Candida albicans isolated from the oral cavities of cancer patients

(2015) Shilpa Ramla et al.   SUPPORTIVE CARE IN CANCER

Mechanisms of inflammasome activation: recent advances and novel insights

(2015) Sivapriya K. Vanaja et al.   TRENDS IN CELL BIOLOGY

Transcriptomic Analysis of Vulvovaginal Candidiasis Identifies a Role for the NLRP3 Inflammasome

(2015) Vincent M. Bruno et al.   mBio

Secretory Aspartyl Proteinases Cause Vaginitis and Can Mediate Vaginitis Caused by Candida albicans in Mice

(2015) Eva Pericolini et al.   mBio

Candida albicans-epithelial interactions and pathogenicity mechanisms: scratching the surface

(2015) David L Moyes et al.   Virulence

Adaptive immune responses toCandida albicansinfection

(2015) Jonathan P Richardson et al.   Virulence

Turning Up the Heat: Inflammasome Activation by Fungal Pathogens

(2015) Aldo Henrique Tavares et al.   PLoS Pathogens

VulvovaginalCandida albicansinfections: pathogenesis, immunity and vaccine prospects

(2014) A Cassone   BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY

Neutrophils from vasculitis patients exhibit an increased propensity for activation by anti-neutrophil cytoplasmic antibodies

(2014) S. M. Ohlsson et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

PDGF receptor signaling networks in normal and cancer cells

(2014) Jean-Baptiste Demoulin et al.   CYTOKINE & GROWTH FACTOR REVIEWS

In vitro susceptibility profile of 200 recent clinical isolates of Candida spp. to topical antifungal treatments of vulvovaginal candidiasis, the imidazoles and nystatin agents

(2014) F. Choukri et al.   JOURNAL DE MYCOLOGIE MEDICALE

The Vaginal Microbiota: What Have We Learned after a Decade of Molecular Characterization?

(2014) Janneke H. H. M. van de Wijgert et al.   PLoS One

Dysregulation of mucosal immune response in pathogenesis of inflammatory bowel disease

(2014) Xiao-Rong Xu   WORLD JOURNAL OF GASTROENTEROLOGY

Candida albicans Pathogenicity and Epithelial Immunity

(2014) Julian R. Naglik et al.   PLoS Pathogens

Adaptive Prediction As a Strategy in Microbial Infections

(2014) Sascha Brunke et al.   PLoS Pathogens

Candida Vaginitis: When Opportunism Knocks, the Host Responds

(2014) Brian M. Peters et al.   PLoS Pathogens

Genetic susceptibility toCandidainfections

(2013) Sanne P. Smeekens et al.   EMBO Molecular Medicine

Fungal Morphogenetic Pathways Are Required for the Hallmark Inflammatory Response during Candida albicans Vaginitis

(2013) Brian M. Peters et al.   INFECTION AND IMMUNITY

Vaginal Epithelial Cell-Derived S100 Alarmins Induced by Candida albicans via Pattern Recognition Receptor Interactions Are Sufficient but Not Necessary for the Acute Neutrophil Response during Experimental Vaginal Candidiasis

(2013) Junko Yano et al.   INFECTION AND IMMUNITY

An Extracellular Matrix-Based Mechanism of Rapid Neutrophil Extracellular Trap Formation in Response to Candida albicans

(2013) A. S. Byrd et al.   JOURNAL OF IMMUNOLOGY

Disruption of the intestinal mucosal barrier in Candida albicans infections

(2013) Lei Yan et al.   MICROBIOLOGICAL RESEARCH

Development of vaccines for Candida albicans: fighting a skilled transformer

(2013) Antonio Cassone   NATURE REVIEWS MICROBIOLOGY

Diverse Vaginal Microbiomes in Reproductive-Age Women with Vulvovaginal Candidiasis

(2013) Mu-Biao Liu et al.   PLoS One

Candida and candidiasis in HIV-infected patients

(2012) Antonio Cassone et al.   AIDS

Inborn errors of human IL-17 immunity underlie chronic mucocutaneous candidiasis

(2012) Anne Puel et al.   Current Opinion in Allergy and Clinical Immunology

Immunity to fungi

(2012) Salomé LeibundGut-Landmann et al.   CURRENT OPINION IN IMMUNOLOGY

Importance of the Candida albicans cell wall during commensalism and infection

(2012) Neil AR Gow et al.   CURRENT OPINION IN MICROBIOLOGY

Secreted aspartic proteases ofCandida albicansactivate the NLRP3 inflammasome

(2012) Donatella Pietrella et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Growth of Candida albicans Cells on the Physiologically Relevant Carbon Source Lactate Affects Their Recognition and Phagocytosis by Immune Cells

(2012) Iuliana V. Ene et al.   INFECTION AND IMMUNITY

Identification by DNA microarray of genes involved inCandida albicans-treated gingival epithelial cells

(2012) Tonami Ikuta et al.   JOURNAL OF ORAL PATHOLOGY & MEDICINE

Candida albicans-Epithelial Interactions: Dissecting the Roles of Active Penetration, Induced Endocytosis and Host Factors on the Infection Process

(2012) Betty Wächtler et al.   PLoS One

Regulation of phenotypic transitions in the fungal pathogenCandida albicans

(2012) Guanghua Huang   Virulence

Cytokines in the host response to Candida vaginitis: Identifying a role for non-classical immune mediators, S100 alarmins

(2011) Junko Yano et al.   CYTOKINE

Regulation of Innate Immune Response toCandida albicansInfections by αMβ2-Pra1p Interaction

(2011) Dmitry A. Soloviev et al.   INFECTION AND IMMUNITY

Candida albicans interactions with epithelial cells and mucosal immunity

(2011) Julian R. Naglik et al.   MICROBES AND INFECTION

Growth of Candida albicans hyphae

(2011) Peter E. Sudbery   NATURE REVIEWS MICROBIOLOGY

Th17 Cells and IL-17 in Protective Immunity to Vaginal Candidiasis

(2011) Donatella Pietrella et al.   PLoS One

Inflammasome activation and IL-1β and IL-18 processing during infection

(2011) Frank L. van de Veerdonk et al.   TRENDS IN IMMUNOLOGY

Importance of Candida–bacterial polymicrobial biofilms in disease

(2011) Melphine M. Harriott et al.   TRENDS IN MICROBIOLOGY

Protocols for Vaginal Inoculation and Sample Collection in the Experimental Mouse Model of Candida vaginitis

(2011) Junko Yano et al.   Jove-Journal of Visualized Experiments

A Biphasic Innate Immune MAPK Response Discriminates between the Yeast and Hyphal Forms of Candida albicans in Epithelial Cells

(2010) David L. Moyes et al.   Cell Host & Microbe

Epithelial Cell-Derived S100 Calcium-Binding Proteins as Key Mediators in the Hallmark Acute Neutrophil Response during Candida Vaginitis

(2010) J. Yano et al.   INFECTION AND IMMUNITY

Candida albicans forms biofilms on the vaginal mucosa

(2010) M. M. Harriott et al.   MICROBIOLOGY-SGM

Vaginal microbiome of reproductive-age women

(2010) J. Ravel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vulvovaginal Candidiasis Caused by Non-albicans Candida Species: New Insights

(2010) Melissa A. Kennedy et al.   Current Infectious Disease Reports

Transcriptional Responses ofCandida albicansto Epithelial and Endothelial Cells

(2009) Hyunsook Park et al.   EUKARYOTIC CELL

Prospective Study of Vaginal Bacterial Flora and Other Risk Factors for Vulvovaginal Candidiasis

(2009) R. Scott McClelland et al.   JOURNAL OF INFECTIOUS DISEASES

Human Dectin-1 Deficiency and Mucocutaneous Fungal Infections

(2009) Bart Ferwerda et al.   NEW ENGLAND JOURNAL OF MEDICINE

Processing of predicted substrates of fungal Kex2 proteinases from Candida albicans, C. glabrata, Saccharomyces cerevisiae and Pichia pastoris

(2008) Oliver Bader et al.   BMC MICROBIOLOGY

In vitro effects of selected synbiotics on the human faecal microbiota composition

(2008) Delphine M.A. Saulnier et al.   FEMS MICROBIOLOGY ECOLOGY

An adherent Gardnerella vaginalis biofilm persists on the vaginal epithelium after standard therapy with oral metronidazole

(2007) Alexander Swidsinski et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY