Review
Immunology
Linda Abou Chacra, Florence Fenollar, Khoudia Diop
Summary: The vaginal microbiome is an important part of the human microbiome, characterized by unique conditions. Increased diversity in the microbiota can lead to dysbiosis such as bacterial vaginosis, with significant health consequences. Diagnosis and treatment methods are evolving, and research on this topic is becoming increasingly important.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Microbiology
Linda Abou Chacra, Claudia Ly, Alissa Hammoud, Rim Iwaza, Oleg Mediannikov, Florence Bretelle, Florence Fenollar
Summary: This study found a possible association between bacterial vaginosis (BV) and sexually transmitted infections (STIs). Women with BV had a higher prevalence of STIs, including co-infections with multiple STI-causing microorganisms. Women without BV had lower rates of monoinfections and polyinfections with STI-causing microorganisms. Further research is needed to better understand the relationship between BV and STIs.
Article
Immunology
Jane R. Schwebke, Shelly Y. Lensing, Jeannette Lee, Christina A. Muzny, Angela Pontius, Nicole Woznicki, Tina Aguin, Jack D. Sobel
Summary: This study aimed to determine if treating male sexual partners of women with recurrent BV with multidose metronidazole could decrease BV recurrence rates in females. The results showed no significant difference in BV recurrence rates between treatment arms, but women with partners adhering to the medication were less likely to fail treatment.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Sampada Bangar, Pratiksha Sonar, Arati Mane, Suvarna Sane, Abhijit Kadam, Tuman Lal Katendra, Girish Rahane, Anju Sinha, Seema Sahay
Summary: The effectiveness of lactobacilli-containing vaginal tablets in preventing bacterial vaginosis recurrence among women infected with HIV treated with standard oral metronidazole in Pune, India was studied. The study found that lactobacilli-containing vaginal tablets did not provide any additional benefit in preventing bacterial vaginosis recurrence in women infected with HIV.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Review
Immunology
Andile Mtshali, Sinaye Ngcapu, Adrian Mindel, Nigel Garrett, Lenine Liebenberg
Summary: Understanding the biological mechanisms associated with HIV risk in the female genital tract is crucial for epidemic control. Pro-inflammatory cytokines in the FGT may increase the risk of HIV. STIs and BV are potential contributors to genital inflammation in the FGT, highlighting the importance of effective treatment for women's health.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2021)
Review
Obstetrics & Gynecology
Jacques Ravel, Inmaculada Moreno, Carlos Simon
Summary: Bacterial vaginosis, pelvic inflammatory disease, and endometritis can lead to infertility due to factors such as inflammation, immune response, bacterial toxins, and increased risk of sexually transmitted infections. Diagnosing and treating these conditions before attempting conception may improve outcomes of natural and assisted reproduction for symptomatic women.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Elise Smith, Lindi Masson, Jo-Ann S. Passmore, Edina Sinanovic
Summary: This study evaluates the cost-effectiveness of a new rapid point-of-care test (POC) called Genital InFlammation Test (GIFT) compared to other screening and diagnostic strategies for the management of STIs and BV in women in South Africa. The results suggest that screening with GIFT and treating positive cases according to syndromic management guidelines is the most cost-effective strategy.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Microbiology
Supriya D. Mehta, Walter Agingu, Garazi Zulaika, Elizabeth Nyothach, Runa Bhaumik, Stefan J. Green, Anna Maria van Eijk, Fredrick O. Otieno, Penelope A. Phillips-Howard, John Schneider
Summary: A non-optimal vaginal microbiome (VMB) is associated with bacterial vaginosis (BV) and sexually transmitted infections (STIs). This study compared the VMB of Kenyan girls with incident STIs to those who remained negative, and found that VMB networks of those with STI had less connectedness. Key taxa differed between those with and without STI and were not correlated with abundance. Sociodemographic and behavioral factors contribute to microbial network structure.
Article
Immunology
James A. Johnson, Lydia F. Delaney, Vaishali Ojha, Medha Rudraraju, Kaylie R. Hintze, Nazema Y. Siddiqui, Tatyana A. Sysoeva
Summary: This study assessed the functional abilities of urinary lactobacilli in postmenopausal women and found that they strongly inhibit gram-negative Escherichia coli and Klebsiella pneumoniae, but have less inhibition against gram-positive Enterococcus faecalis. These findings suggest a potential interaction between urinary lactobacilli and the urinary microbiome.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Infectious Diseases
George Mtove, R. Matthew Chico, Mwayiwawo Madanitsa, Hellen C. Barsosio, Omari Abdul Msemo, Queen Saidi, Georgia R. Gore-Langton, Daniel T. R. Minja, Crispin Mukerebe, Samwel Gesase, Victor Mwapasa, Kamija S. Phiri, Helle Hansson, James Dodd, Pascal Magnussen, Reginald A. Kavishe, Franklin Mosha, Simon Kariuki, John P. A. Lusingu, Julie R. Gutman, Michael Alifrangis, Feiko O. ter Kuile, Christentze Schmiegelow
Summary: This study conducted in Kenya, Tanzania, and Malawi found that malaria and curable STIs/RTIs have a negative impact on fetal growth, with a greater effect on primigravidae.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Public, Environmental & Occupational Health
Sze Long Chung, Ngai Sze Wong, King Man Ho, Shui Shan Lee
Summary: This study investigated the prevalence and factors associated with bacterial sexually transmitted infection (STI) coinfection among male patients attending public STI clinics in Hong Kong from 2009 to 2019. The study found an increasing prevalence of coinfection over the years, with chlamydia/gonorrhoea coinfection being the most common. Young age, HIV-positive status, and a history of concurrent genital warts/herpes were associated with coinfection in 2014/15. Additionally, male patients aged 30-49 and self-reported as men who have sex with men (MSM) were more likely to have repeat infections. The findings support the implementation of regular multi-STI testing as a control strategy for selected communities.
EPIDEMIOLOGY AND INFECTION
(2023)
Article
Microbiology
Soo-Im Choi, GaYeong Won, YongGyeong Kim, Chang-Ho Kang, Gun-Hee Kim
Summary: This study investigated the effects of a mixture of five lactobacilli strains on bacterial vaginitis (BV) in HeLa cells and GV-infected BV mice. The findings suggest that this mixture can inhibit the growth of GV, reduce inflammation, and suppress the exfoliation of vaginal epithelial cells.
Article
Biology
Mahima Sharma, Chitrakshi Chopra, Malvika Mehta, Varun Sharma, Sharada Mallubhotla, Srinivas Sistla, Jyothi C. Sistla, Indu Bhushan
Summary: The vaginal microbiota plays a significant role in women's health, and understanding its composition is crucial for accurate diagnosis and better treatment of vaginal disorders. Modern techniques can help study variations in the vaginal microbiota, improving diagnostic and treatment capabilities for vaginal diseases.
Article
Pharmacology & Pharmacy
Margaret O. Ilomuanya, Peace O. Bassey, Deborah A. Ogundemuren, Uloma N. Ubani-Ukoma, Alkiviadis Tsamis, Yuwei Fan, Konstantinos Michalakis, Pavimol Angsantikul, Abdulrahman Usman, Andrew N. Amenaghawon
Summary: This study aimed to develop a novel mucoadhesive polyvinyl alcohol and polycaprolactone electrospun nanofibrous scaffolds for vaginal delivery, incorporating metronidazole, a tenside, and Lactobacilli. The electrospun scaffolds provide a new tool for the treatment and management of recurrent bacterial vaginosis.
Review
Immunology
Xiaodi Chen, Yune Lu, Tao Chen, Rongguo Li
Summary: The vaginal microbiome is crucial for women's health, with bacterial vaginosis (BV) associated with various adverse gynecologic and obstetric outcomes. Research on diagnosis and treatment strategies for BV is making progress.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)