Hsp40s play complementary roles in the prevention of tau amyloid formation

J-domain proteins interaction with neurodegenerative disease-related proteins

(2021) Sara María Ayala Mariscal et al.   EXPERIMENTAL CELL RESEARCH

Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice

(2021) Benjamin Caballero et al.   Nature Communications

Electrostatically Driven Complex Coacervation and Amyloid Aggregation of Tau Are Independent Processes with Overlapping Conditions

(2020) Yanxian Lin et al.   ACS Chemical Neuroscience

Disassembly of Tau fibrils by the human Hsp70 disaggregation machinery generates small seeding-competent species

(2020) Eliana Nachman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The mechanism of Hsp90-induced oligomerizaton of Tau

(2020) S. Weickert et al.   Science Advances

Impact of the Hereditary P301L Mutation on the Correlated Conformational Dynamics of Human Tau Protein Revealed by the Paramagnetic Relaxation Enhancement NMR Experiments

(2020) Ryosuke Kawasaki et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Hsp70 chaperone network

(2019) Rina Rosenzweig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Tau local structure shields an amyloid-forming motif and controls aggregation propensity

(2019) Dailu Chen et al.   Nature Communications

Structural basis for client recognition and activity of Hsp40 chaperones

(2019) Yajun Jiang et al.   SCIENCE

Mechanisms of secretion and spreading of pathological tau protein

(2019) Cecilia A. Brunello et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Unraveling the structure and dynamics of the human DNAJB6b chaperone by NMR reveals insights into Hsp40-mediated proteostasis

(2019) Theodoros K. Karamanos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hsp70 Inhibits the Nucleation and Elongation of Tau and Sequesters Tau Aggregates with High Affinity

(2018) Franziska Kundel et al.   ACS Chemical Biology

Measurement of Tau Filament Fragmentation Provides Insights into Prion-like Spreading

(2018) Franziska Kundel et al.   ACS Chemical Neuroscience

HspB1 and Hsc70 chaperones engage distinct tau species and have different inhibitory effects on amyloid formation

(2018) Hannah E. R. Baughman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Mechanism of J-Domain-Triggered ATP Hydrolysis by Hsp70 Chaperones

(2018) Roman Kityk et al.   MOLECULAR CELL

Mapping interactions with the chaperone network reveals factors that protect against tau aggregation

(2018) Sue-Ann Mok et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mapping interactions with the chaperone network reveals factors that protect against tau aggregation

(2018) Sue-Ann Mok et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Inert and seed-competent tau monomers suggest structural origins of aggregation

(2018) Hilda Mirbaha et al.   eLife

Competing protein-protein interactions regulate binding of Hsp27 to its client protein tau

(2018) Rebecca Freilich et al.   Nature Communications

Cryo-EM structures of tau filaments from Alzheimer’s disease

(2017) Anthony W. P. Fitzpatrick et al.   NATURE

Signature of an aggregation-prone conformation of tau

(2017) Neil A. Eschmann et al.   Scientific Reports

Tau Oligomers: Cytotoxicity, Propagation, and Mitochondrial Damage

(2017) Scott S. Shafiei et al.   Frontiers in Aging Neuroscience

Characterization of tau prion seeding activity and strains from formaldehyde-fixed tissue

(2017) Sarah K. Kaufman et al.   Acta Neuropathologica Communications

Molecular mechanisms of protein aggregation from global fitting of kinetic models

(2016) Georg Meisl et al.   Nature Protocols

The active Hsc70/tau complex can be exploited to enhance tau turnover without damaging microtubule dynamics

(2015) Sarah N. Fontaine et al.   HUMAN MOLECULAR GENETICS

Tau post-translational modifications in wild-type and human amyloid precursor protein transgenic mice

(2015) Meaghan Morris et al.   NATURE NEUROSCIENCE

A mechanistic model of tau amyloid aggregation based on direct observation of oligomers

(2015) Sarah L. Shammas et al.   Nature Communications

Acetylation: a new key to unlock tau’s role in neurodegeneration

(2014) Casey Cook et al.   Alzheimers Research & Therapy

A Chaperome Subnetwork Safeguards Proteostasis in Aging and Neurodegenerative Disease

(2014) Marc Brehme et al.   Cell Reports

Biochemistry and Cell Biology of Tau Protein in Neurofibrillary Degeneration

(2013) E.-M. Mandelkow et al.   Cold Spring Harbor Perspectives in Medicine

Hsp70 Alters Tau Function and Aggregation in an Isoform Specific Manner

(2012) Kellen Voss et al.   BIOCHEMISTRY

Imbalance of Hsp70 family variants fosters tau accumulation

(2012) Umesh K. Jinwal et al.   FASEB JOURNAL

DnaJA1 Antagonizes Constitutive Hsp70-Mediated Stabilization of Tau

(2012) Jose F. Abisambra et al.   JOURNAL OF MOLECULAR BIOLOGY

Heat Shock Protein 70 Prevents both Tau Aggregation and the Inhibitory Effects of Preexisting Tau Aggregates on Fast Axonal Transport

(2011) Kristina R. Patterson et al.   BIOCHEMISTRY

Molecular chaperones and regulation of tau quality control: strategies for drug discovery in tauopathies

(2011) Yoshinari Miyata et al.   Future Medicinal Chemistry

Understanding the Kinetic Roles of the Inducer Heparin and of Rod-like Protofibrils during Amyloid Fibril Formation by Tau Protein

(2011) Gayathri Ramachandran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular mechanism of Thioflavin-T binding to amyloid fibrils

(2010) Matthew Biancalana et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

The HSP70 chaperone machinery: J proteins as drivers of functional specificity

(2010) Harm H. Kampinga et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Tau phosphorylation: the therapeutic challenge for neurodegenerative disease

(2009) Diane P. Hanger et al.   TRENDS IN MOLECULAR MEDICINE

Structural Polymorphism of 441-Residue Tau at Single Residue Resolution

(2009) Marco D Mukrasch et al.   PLOS BIOLOGY