J-domain proteins interaction with neurodegenerative disease-related proteins

Amyloid-β oligomers are captured by the DNAJB6 chaperone: Direct detection of interactions that can prevent primary nucleation

(2020) Nicklas Österlund et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Disassembly of Tau fibrils by the human Hsp70 disaggregation machinery generates small seeding-competent species

(2020) Eliana Nachman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Two-step mechanism of J-domain action in driving Hsp70 function

(2020) Bartlomiej Tomiczek et al.   PLoS Computational Biology

Structural basis for client recognition and activity of Hsp40 chaperones

(2019) Yajun Jiang et al.   SCIENCE

Exome sequencing in amyotrophic lateral sclerosis implicates a novel gene, DNAJC7, encoding a heat-shock protein

(2019) Sali M. K. Farhan et al.   NATURE NEUROSCIENCE

Hsp110 mitigates α-synuclein pathology in vivo

(2019) Yumiko V. Taguchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unraveling the structure and dynamics of the human DNAJB6b chaperone by NMR reveals insights into Hsp40-mediated proteostasis

(2019) Theodoros K. Karamanos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conserved S/T-residues of the human chaperone DNAJB6 are required for effective inhibition of Aβ42 amyloid fibril formation

(2018) Cecilia Månsson et al.   BIOCHEMISTRY

Mapping interactions with the chaperone network reveals factors that protect against tau aggregation

(2018) Sue-Ann Mok et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The absence of specific yeast heat-shock proteins leads to abnormal aggregation and compromised autophagic clearance of mutant Huntingtin proteins

(2018) Ryan Higgins et al.   PLoS One

Mapping interactions with the chaperone network reveals factors that protect against tau aggregation

(2018) Sue-Ann Mok et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural modelling of the DNAJB6 oligomeric chaperone shows a peptide-binding cleft lined with conserved S/T-residues at the dimer interface

(2018) Christopher A. G. Söderberg et al.   Scientific Reports

DnaJ/Hsp40 Family and Parkinson's Disease

(2018) Takafumi Hasegawa et al.   Frontiers in Neuroscience

DNAJC5 facilitates USP19-dependent unconventional secretion of misfolded cytosolic proteins

(2018) Yue Xu et al.   Cell Discovery

Function, evolution, and structure of J-domain proteins

(2018) Harm H. Kampinga et al.   CELL STRESS & CHAPERONES

DNAJ Proteins in neurodegeneration: essential and protective factors

(2017) Christina Zarouchlioti et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

How Do J-Proteins Get Hsp70 to Do So Many Different Things?

(2017) Elizabeth A. Craig et al.   TRENDS IN BIOCHEMICAL SCIENCES

Evolution of an intricate J-protein network driving protein disaggregation in eukaryotes

(2017) Nadinath B Nillegoda et al.   eLife

The molecular chaperones DNAJB6 and Hsp70 cooperate to suppress α-synuclein aggregation

(2017) Francesco A. Aprile et al.   Scientific Reports

A novel nuclear DnaJ protein, DNAJC8, can suppress the formation of spinocerebellar ataxia 3 polyglutamine aggregation in a J-domain independent manner

(2016) Norie Ito et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The heat shock response plays an important role in TDP-43 clearance: evidence for dysfunction in amyotrophic lateral sclerosis

(2016) Han-Jou Chen et al.   BRAIN

Heat Shock Protein (HSP) Drug Discovery and Development: Targeting Heat Shock Proteins in Disease

(2016) Liza Shrestha et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

DnaJ/Hsc70 chaperone complexes control the extracellular release of neurodegenerative‐associated proteins

(2016) Sarah N Fontaine et al.   EMBO JOURNAL

The S/T-Rich Motif in the DNAJB6 Chaperone Delays Polyglutamine Aggregation and the Onset of Disease in a Mouse Model

(2016) Vaishali Kakkar et al.   MOLECULAR CELL

In vivo aspects of protein folding and quality control

(2016) D. Balchin et al.   SCIENCE

Systematic analysis of genetic variants in Han Chinese patients with sporadic Parkinson’s disease

(2016) Lamei Yuan et al.   Scientific Reports

Versatile members of the DNAJ family show Hsp70 dependent anti-aggregation activity on RING1 mutant parkin C289G

(2016) Vaishali Kakkar et al.   Scientific Reports

The Biology of Proteostasis in Aging and Disease

(2015) Johnathan Labbadia et al.   Annual Review of Biochemistry

Human Hsp70 Disaggregase Reverses Parkinson’s-Linked α-Synuclein Amyloid Fibrils

(2015) Xuechao Gao et al.   MOLECULAR CELL

Crucial HSP70 co-chaperone complex unlocks metazoan protein disaggregation

(2015) Nadinath B. Nillegoda et al.   NATURE

Yeast prions and human prion-like proteins: sequence features and prediction methods

(2014) Sean M. Cascarina et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

J protein mutations and resulting proteostasis collapse

(2014) Carolina Koutras et al.   Frontiers in Cellular Neuroscience

A Chaperome Subnetwork Safeguards Proteostasis in Aging and Neurodegenerative Disease

(2014) Marc Brehme et al.   Cell Reports

Functional Diversification of Hsp40: Distinct J-Protein Functional Requirements for Two Prions Allow for Chaperone-Dependent Prion Selection

(2014) Julia M. Harris et al.   PLoS Genetics

Molecular Chaperone Functions in Protein Folding and Proteostasis

(2013) Yujin E. Kim et al.   Annual Review of Biochemistry

Protective Role of DNJ-27/ERdj5 in Caenorhabditis elegans Models of Human Neurodegenerative Diseases

(2013) Fernando Muñoz-Lobato et al.   ANTIOXIDANTS & REDOX SIGNALING

Chaperone-mediated autophagy: roles in disease and aging

(2013) Ana Maria Cuervo et al.   CELL RESEARCH

DNAJB6 is a peptide-binding chaperone which can suppress amyloid fibrillation of polyglutamine peptides at substoichiometric molar ratios

(2013) Cecilia Månsson et al.   CELL STRESS & CHAPERONES

Molecular Chaperone Mediated Late-Stage Neuroprotection in the SOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis

(2013) Sergey S. Novoselov et al.   PLoS One

Suppression of protein aggregation by chaperone modification of high molecular weight complexes

(2012) John Labbadia et al.   BRAIN

Metazoan Hsp70 machines use Hsp110 to power protein disaggregation

(2012) Heike Rampelt et al.   EMBO JOURNAL

Prions in Yeast

(2012) S. W. Liebman et al.   GENETICS

DnaJA1 Antagonizes Constitutive Hsp70-Mediated Stabilization of Tau

(2012) Jose F. Abisambra et al.   JOURNAL OF MOLECULAR BIOLOGY

Identification of Regions Involved in Substrate Binding and Dimer Stabilization within the Central Domains of Yeast Hsp40 Sis1

(2012) Júlio C. Borges et al.   PLoS One

A rare recessive distal hereditary motor neuropathy with HSJ1 chaperone mutation

(2011) Sergiu C. Blumen et al.   ANNALS OF NEUROLOGY

Hsc70 Protein Interaction with Soluble and Fibrillar α-Synuclein

(2011) Samantha Pemberton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Peptide-Binding Sites As Revealed by the Crystal Structures of the Human Hsp40 Hdj1 C-Terminal Domain in Complex with the Octapeptide from Human Hsp70

(2010) Hironori Suzuki et al.   BIOCHEMISTRY

A DNAJB Chaperone Subfamily with HDAC-Dependent Activities Suppresses Toxic Protein Aggregation

(2010) Jurre Hageman et al.   MOLECULAR CELL

The HSP70 chaperone machinery: J proteins as drivers of functional specificity

(2010) Harm H. Kampinga et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Computational analysis of the human HSPH/HSPA/DNAJ family and cloning of a human HSPH/HSPA/DNAJ expression library

(2008) Jurre Hageman et al.   CELL STRESS & CHAPERONES

Guidelines for the nomenclature of the human heat shock proteins

(2008) Harm H. Kampinga et al.   CELL STRESS & CHAPERONES

The Type I Hsp40 Ydj1 Utilizes a Farnesyl Moiety and Zinc Finger-like Region to Suppress Prion Toxicity

(2008) Daniel W. Summers et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Specificity of the J-protein Sis1 in the propagation of 3 yeast prions

(2008) T. Higurashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chaperone-dependent amyloid assembly protects cells from prion toxicity

(2008) P. M. Douglas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adapting Proteostasis for Disease Intervention

(2008) William E. Balch et al.   SCIENCE

The crystal structure of the putative peptide-binding fragment from the human Hsp40 protein Hdj1

(2008) Junbin Hu et al.   BMC STRUCTURAL BIOLOGY