Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness

Artemisinin-resistant K13 mutations rewire Plasmodium falciparum’s intra-erythrocytic metabolic program to enhance survival

(2021) Sachel Mok et al.   Nature Communications

A review of the frequencies of Plasmodium falciparum Kelch 13 artemisinin resistance mutations in Africa

(2021) Leonard Ndwiga et al.   International Journal for Parasitology-Drugs and Drug Resistance

A Kelch13-defined endocytosis pathway mediates artemisinin resistance in malaria parasites

(2020) Jakob Birnbaum et al.   SCIENCE

Role of Plasmodium falciparum Kelch 13 Protein Mutations in P. falciparum Populations from Northeastern Myanmar in Mediating Artemisinin Resistance

(2020) Faiza Amber Siddiqui et al.   mBio

Insights into the intracellular localization, protein associations and artemisinin resistance properties of Plasmodium falciparum K13

(2020) Nina F. Gnädig et al.   PLoS Pathogens

Local emergence in Amazonia of Plasmodium falciparum k13 C580Y mutants associated with in vitro artemisinin resistance

(2020) Luana C Mathieu et al.   eLife

Advances and roadblocks in the treatment of malaria

(2020) Borimas Hanboonkunupakarn et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Molecular epidemiology of resistance to antimalarial drugs in the Greater Mekong subregion: an observational study

(2020) Mallika Imwong et al.   LANCET INFECTIOUS DISEASES

The potential public health consequences of COVID-19 on malaria in Africa

(2020) Ellie Sherrard-Smith et al.   NATURE MEDICINE

Emergence and clonal expansion of in vitro artemisinin-resistant Plasmodium falciparum kelch13 R561H mutant parasites in Rwanda

(2020) Aline Uwimana et al.   NATURE MEDICINE

K13-Mediated Reduced Susceptibility to Artemisinin in Plasmodium falciparum Is Overlaid on a Trait of Enhanced DNA Damage Repair

(2020) Aoli Xiong et al.   Cell Reports

Molecular Mechanisms of Drug Resistance in Plasmodium falciparum Malaria

(2020) Kathryn J. Wicht et al.   Annual Review of Microbiology

Artemisinin susceptibility in the malaria parasite Plasmodium falciparum: propellers, adaptor proteins and the need for cellular healing

(2020) Colin J Sutherland et al.   FEMS MICROBIOLOGY REVIEWS

Emergence of artemisinin-resistant Plasmodium falciparum with kelch13 C580Y mutations on the island of New Guinea

(2020) Olivo Miotto et al.   PLoS Pathogens

Spatial and molecular mapping of Pfkelch13 gene polymorphism in Africa in the era of emerging Plasmodium falciparum resistance to artemisinin: a systematic review

(2020) Nadine K Kayiba et al.   LANCET INFECTIOUS DISEASES

Association of mutations in the Plasmodium falciparum Kelch13 gene (Pf3D7_1343700) with parasite clearance rates after artemisinin-based treatments—a WWARN individual patient data meta-analysis

(2019)   BMC Medicine

Antimalarial drug resistance in Africa: the calm before the storm?

(2019) Melissa D Conrad et al.   LANCET INFECTIOUS DISEASES

Determinants of dihydroartemisinin-piperaquine treatment failure in Plasmodium falciparum malaria in Cambodia, Thailand, and Vietnam: a prospective clinical, pharmacological, and genetic study

(2019) Rob W van der Pluijm et al.   LANCET INFECTIOUS DISEASES

Major subpopulations of Plasmodium falciparum in sub-Saharan Africa

(2019) Alfred Amambua-Ngwa et al.   SCIENCE

Modification of pfap2μ and pfubp1 Markedly Reduces Ring-Stage Susceptibility of Plasmodium falciparum to Artemisinin In Vitro

(2019) Ryan C. Henrici et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Plasmodium falciparum resistance to piperaquine driven by PfCRT

(2019) Satish K Dhingra et al.   LANCET INFECTIOUS DISEASES

Decreased K13 Abundance Reduces Hemoglobin Catabolism and Proteotoxic Stress, Underpinning Artemisinin Resistance

(2019) Tuo Yang et al.   Cell Reports

Do fitness costs explain the rapid spread of kelch13-C580Y substitutions conferring artemisinin resistance?

(2018) Shalini Nair et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Origins of the current outbreak of multidrug-resistant malaria in southeast Asia: a retrospective genetic study

(2018) Roberto Amato et al.   LANCET INFECTIOUS DISEASES

Drug resistance in Plasmodium

(2018) Kasturi Haldar et al.   NATURE REVIEWS MICROBIOLOGY

Prevalence of Plasmodium falciparum delayed clearance associated polymorphisms in adaptor protein complex 2 mu subunit (pfap2mu) and ubiquitin specific protease 1 (pfubp1) genes in Ghanaian isolates

(2018) Tryphena Adams et al.   Parasites & Vectors

Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquine

(2018) Leila S. Ross et al.   Nature Communications

Novel pfkelch13 gene polymorphism associates with artemisinin resistance in eastern India

(2018) Sabyasachi Das et al.   CLINICAL INFECTIOUS DISEASES

Mutations in Plasmodium falciparum actin-binding protein coronin confer reduced artemisinin susceptibility

(2018) Allison R. Demas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification and Mechanistic Understanding of Dihydroorotate Dehydrogenase Point Mutations in Plasmodium falciparum that Confer in Vitro Resistance to the Clinical Candidate DSM265

(2018) John White et al.   ACS Infectious Diseases

Multi-omics Based Identification of Specific Biochemical Changes Associated With PfKelch13-Mutant Artemisinin-Resistant Plasmodium falciparum

(2017) Ghizal Siddiqui et al.   JOURNAL OF INFECTIOUS DISEASES

The spread of artemisinin-resistant Plasmodium falciparum in the Greater Mekong subregion: a molecular epidemiology observational study

(2017) Mallika Imwong et al.   LANCET INFECTIOUS DISEASES

A genetic system to study Plasmodium falciparum protein function

(2017) Jakob Birnbaum et al.   NATURE METHODS

Emergence of Indigenous Artemisinin-Resistant Plasmodium falciparum in Africa

(2017) Feng Lu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Plasmodium falciparum K13 Mutations Differentially Impact Ozonide Susceptibility and Parasite Fitness In Vitro

(2017) Judith Straimer et al.   mBio

Declining Efficacy of Artemisinin Combination Therapy AgainstP. FalciparumMalaria on the Thai–Myanmar Border (2003–2013): The Role of Parasite Genetic Factors

(2016) Aung Pyae Phyo et al.   CLINICAL INFECTIOUS DISEASES

Population Parameters Underlying an Ongoing Soft Sweep in Southeast Asian Malaria Parasites

(2016) Timothy J.C. Anderson et al.   MOLECULAR BIOLOGY AND EVOLUTION

A Worldwide Map ofPlasmodium falciparumK13-Propeller Polymorphisms

(2016) Didier Ménard et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genomic epidemiology of artemisinin resistant malaria

(2016)   eLife

UDP-galactose and acetyl-CoA transporters as Plasmodium multidrug resistance genes

(2016) Michelle Yi-Xiu Lim et al.   Nature Microbiology

Genetic architecture of artemisinin-resistant Plasmodium falciparum

(2015) Olivo Miotto et al.   NATURE GENETICS

Plasmodium falciparum genetic crosses in a humanized mouse model

(2015) Ashley M Vaughan et al.   NATURE METHODS

Directional Selection at the pfmdr1, pfcrt, pfubp1, and pfap2mu Loci of Plasmodium falciparum in Kenyan Children Treated With ACT

(2014) Gisela Henriques et al.   JOURNAL OF INFECTIOUS DISEASES

Return of Widespread Chloroquine-Sensitive Plasmodium falciparum to Malawi

(2014) Anne E. P. Frosch et al.   JOURNAL OF INFECTIOUS DISEASES

Genome editing in the human malaria parasite Plasmodium falciparum using the CRISPR-Cas9 system

(2014) Mehdi Ghorbal et al.   NATURE BIOTECHNOLOGY

Spread of Artemisinin Resistance in Plasmodium falciparum Malaria

(2014) Elizabeth A. Ashley et al.   NEW ENGLAND JOURNAL OF MEDICINE

K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates

(2014) J. Straimer et al.   SCIENCE

Malaria

(2013) Nicholas J White et al.   LANCET

Novel phenotypic assays for the detection of artemisinin-resistant Plasmodium falciparum malaria in Cambodia: in-vitro and ex-vivo drug-response studies

(2013) Benoit Witkowski et al.   LANCET INFECTIOUS DISEASES

A molecular marker of artemisinin-resistant Plasmodium falciparum malaria

(2013) Frédéric Ariey et al.   NATURE

Copy number variation detection in whole-genome sequencing data using the Bayesian information criterion

(2011) R. Xi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased Tolerance to Artemisinin in Plasmodium falciparum Is Mediated by a Quiescence Mechanism

(2010) B. Witkowski et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Artemisinin-based combination therapies: a vital tool in efforts to eliminate malaria

(2009) Richard T. Eastman et al.   NATURE REVIEWS MICROBIOLOGY

Artemisinin-Resistant Malaria in Asia

(2009) Harald Noedl et al.   NEW ENGLAND JOURNAL OF MEDICINE

Evidence of Artemisinin-Resistant Malaria in Western Cambodia

(2008) Harald Noedl et al.   NEW ENGLAND JOURNAL OF MEDICINE