The emerging possibility of the use of geniposide in the treatment of cerebral diseases: a review

Rapid protein evolution, organellar reductions, and invasive intronic elements in the marine aerobic parasite dinoflagellate Amoebophrya spp

(2021) Sarah Farhat et al.   BMC BIOLOGY

Geniposide effectively reverses cognitive impairment and inhibits pathological cerebral damage by regulating the mTOR Signal pathway in APP∕PS1 mice

(2020) Zhihua Zhang et al.   NEUROSCIENCE LETTERS

Natural products for the prevention and treatment of cholestasis: A review

(2020) Xiao Ma et al.   PHYTOTHERAPY RESEARCH

Gardenia jasminoides Enhances CDDP-Induced Apoptosis of Glioblastoma Cells via AKT/mTOR Pathway While Protecting Death of Astrocytes

(2020) Hyo In Kim et al.   Nutrients

Direct inhibition of TLR4/MyD88 pathway by geniposide suppresses HIF1α‐independent VEGF expression and hepatocellular carcinoma angiogenesis

(2020) Cheng Zhang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Protective effects of Huang-Lian-Jie-Du-Tang against Aβ25–35-induced memory deficits and oxidative stress in rats

(2020) Wenbin Wu et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

CREB-mediated Generation and Neuronal Growth Regulates the Behavioral Improvement of Geniposide in Diabetes-Associated Depression Mouse Model

(2020) Bo Sun et al.   NEUROSCIENCE RESEARCH

Paeoniflorin, a Natural Product With Multiple Targets in Liver Diseases—A Mini Review

(2020) Xiao Ma et al.   Frontiers in Pharmacology

Geniposide inhibits NLRP3 inflammasome activation via autophagy in BV-2 microglial cells exposed to oxygen–glucose deprivation/reoxygenation

(2020) Chen Fu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Inhibition of autophagy by geniposide protects against myocardial ischemia/reperfusion injury

(2020) Xuexiu Luo et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Gardenia jasminoides Ellis: Ethnopharmacology, phytochemistry, and pharmacological and industrial applications of an important traditional Chinese medicine

(2020) Liping Chen et al.   JOURNAL OF ETHNOPHARMACOLOGY

Metabolomics coupled with integrative pharmacology reveals the therapeutic effect of l ‐borneolum against cerebral ischaemia in rats

(2020) Yinxiao Jiang et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

A comprehensive review of natural products to fight liver fibrosis: Alkaloids, terpenoids, glycosides, coumarins and other compounds

(2020) Xiao Ma et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

GLP-1R activation alters performance in cognitive tasks in a sex-dependent manner

(2020) Taylor S. Trammell et al.   NEUROLOGICAL SCIENCES

Huang Lian Jie Du Tang attenuates paraquat-induced mitophagy in human SH-SY5Y cells: A traditional decoction with a novel therapeutic potential in treating Parkinson’s disease

(2020) I-Jung Lee et al.   BIOMEDICINE & PHARMACOTHERAPY

Gardenia Decoction Prevent Intestinal Mucosal Injury by Inhibiting Pro-inflammatory Cytokines and NF-κB Signaling

(2019) Yizhe Cui et al.   Frontiers in Pharmacology

Geniposide-mediated protection against amyloid deposition and behavioral impairment correlates with downregulation of mTOR signaling and enhanced autophagy in a mouse model of Alzheimer's disease

(2019) Zhihua Zhang et al.   Aging-US

Geniposide Improves Glucose Homeostasis via Regulating FoxO1/PDK4 in Skeletal Muscle

(2019) Yan Li et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Geniposide protects against hypoxia/reperfusion-induced blood-brain barrier impairment by increasing tight junction protein expression and decreasing inflammation, oxidative stress, and apoptosis in an in vitro system

(2019) Changxiang Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Geniposide protects PC12 cells from lipopolysaccharide-evoked inflammatory injury via up-regulation of miR-145-5p

(2019) Shaolong Ma et al.   Artificial Cells Nanomedicine and Biotechnology

Cathepsin L induced PC-12 cell apoptosis via activation of B-Myb and regulation of cell cycle proteins

(2019) Xiao Shen et al.   ACTA PHARMACOLOGICA SINICA

Network pharmacology identification of mechanisms of cerebral ischemia injury amelioration by Baicalin and Geniposide

(2019) Jie Wu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Role of intestinal microbiota-mediated genipin dialdehyde intermediate formation in geniposide-induced hepatotoxicity in rats

(2019) Yi Li et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Studies on APP metabolism related to age-associated mitochondrial dysfunction in APP/PS1 transgenic mice

(2019) Lizhi Chen et al.   Aging-US

Microglia Biology: One Century of Evolving Concepts

(2019) Marco Prinz et al.   CELL

The cellular and molecular basis of major depressive disorder: towards a unified model for understanding clinical depression

(2019) Eleni Pitsillou et al.   MOLECULAR BIOLOGY REPORTS

Biomimetic carbon nanotubes for neurological disease therapeutics as inherent medication

(2019) Chenyang Xiang et al.   Acta Pharmaceutica Sinica B

Gardenia fructus antidepressant formula for depression in diabetes patients: A systematic review and meta-analysis

(2019) Kuang-Dai Li et al.   COMPLEMENTARY THERAPIES IN MEDICINE

Lithium chloride reduced the level of oxidative stress in brains and serums of APP/PS1 double transgenic mice via the regulation of GSK3β/Nrf2/HO-1 pathway

(2019) Jie Xiang et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Second Primary Malignancies in Patients with Well-differentiated/Dedifferentiated Liposarcoma

(2018) ERIC JUNG et al.   ANTICANCER RESEARCH

Mechanisms of Action and Therapeutic Application of Glucagon-like Peptide-1

(2018) Daniel J. Drucker   Cell Metabolism

Depression and cardiovascular disease in elderly: Current understanding

(2018) Yaxin Zhang et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Oral chronic toxicity study of geniposide in rats

(2018) Jingzhuo Tian et al.   JOURNAL OF ETHNOPHARMACOLOGY

Geniposide Increases Unfolded Protein Response-Mediating HRD1 Expression to Accelerate APP Degradation in Primary Cortical Neurons

(2018) Huaqing Cui et al.   NEUROCHEMICAL RESEARCH

Enfermedad cerebral, conectividad, plasticidad y terapia cognitiva. Una visión neurológica del trastorno mental

(2018) G. Lubrini et al.   NEUROLOGIA

Geniposide improves repeated restraint stress-induced depression-like behavior in mice by ameliorating neuronal apoptosis via regulating GLP-1R/AKT signaling pathway

(2018) Yinghua Zhao et al.   NEUROSCIENCE LETTERS

Targeting GLP-1 receptor trafficking to improve agonist efficacy

(2018) Ben Jones et al.   Nature Communications

Do glucagon-like peptide-1 receptor (GLP-1R) agonists have potential as adjuncts in the treatment of type 1 diabetes?

(2018) Sheila A. Doggrell   EXPERT OPINION ON PHARMACOTHERAPY

Angelica polysaccharide protects PC-12 cells from lipopolysaccharide-induced injury via down-regulating microRNA-223

(2018) Ran Li et al.   BIOMEDICINE & PHARMACOTHERAPY

Geniposide protects PC-12 cells against oxygen and glucose deprivation-induced injury by up-regulation of long-noncoding RNA H19

(2018) Yanran Yuan et al.   LIFE SCIENCES

Chronic Unpredictable Mild Stress for Modeling Depression in Rodents:Meta-analysis of Model Reliability

(2018) Svitlana Antoniuk et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Chemistry and bioactivity of Gardenia jasminoides

(2017) Wenping Xiao et al.   JOURNAL OF FOOD AND DRUG ANALYSIS

Alzheimer’s Disease: Past, Present, and Future

(2017) Mark W. Bondi et al.   JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY

Gardenia jasminoides has therapeutic effects on L-NNA-induced hypertension in vivo

(2017) Shaocheng Chen et al.   Molecular Medicine Reports

A direct test of the diathesis–stress model for depression

(2017) L Colodro-Conde et al.   MOLECULAR PSYCHIATRY

A Review on the Phytochemistry, Pharmacology, Pharmacokinetics and Toxicology of Geniposide, a Natural Product

(2017) Mingqiu Shan et al.   MOLECULES

Geniposide ameliorates cognitive deficits by attenuating the cholinergic defect and amyloidosis in middle-aged Alzheimer model mice

(2017) Chunhui Zhao et al.   NEUROPHARMACOLOGY

Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness

(2017) Michiru Nishita et al.   Scientific Reports

Geniposide reduces α-synuclein by blocking microRNA-21/lysosome-associated membrane protein 2A interaction in Parkinson disease models

(2016) Chunhe Su et al.   BRAIN RESEARCH

Geniposide attenuates inflammatory response by suppressing P2Y14 receptor and downstream ERK1/2 signaling pathway in oxygen and glucose deprivation-induced brain microvascular endothelial cells

(2016) Fanghe Li et al.   JOURNAL OF ETHNOPHARMACOLOGY

Geniposide alleviates depression-like behavior via enhancing BDNF expression in hippocampus of streptozotocin-evoked mice

(2016) Junming Wang et al.   METABOLIC BRAIN DISEASE

Geniposide Attenuates the Phosphorylation of Tau Protein in Cellular and Insulin-deficient APP/PS1 Transgenic Mouse Model of Alzheimer's Disease

(2015) Yonglan Zhang et al.   Chemical Biology & Drug Design

Neuroprotective effects of geniposide in the MPTP mouse model of Parkinson's disease

(2015) YiMei Chen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Antidepressant-like effect of geniposide on chronic unpredictable mild stress-induced depressive rats by regulating the hypothalamus–pituitary–adrenal axis

(2015) Li Cai et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Geniposide attenuates insulin-deficiency-induced acceleration of β-amyloidosis in an APP/PS1 transgenic model of Alzheimer’s disease

(2015) Yonglan Zhang et al.   NEUROCHEMISTRY INTERNATIONAL

Ameliorating effects of traditional Chinese medicine preparation, Chinese materia medica and active compounds on ischemia/reperfusion-induced cerebral microcirculatory disturbances and neuron damage

(2015) Kai Sun et al.   Acta Pharmaceutica Sinica B

Study on Integrated Pharmacokinetics of Gardenia Acid and Geniposide: Time-Antioxidant Efficacy after Oral Administration of Huanglian–Zhizi Couplet Medicine from Huang–Lian–Jie–Du–Tang in MCAO Rats

(2014) Linmei Pan et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Microglia Development and Function

(2014) Debasis Nayak et al.   Annual Review of Immunology

Lifestyle medicine for depression

(2014) Jerome Sarris et al.   BMC Psychiatry

Geniposide Attenuates Mitochondrial Dysfunction and Memory Deficits in APP/PS1 Transgenic Mice

(2014) Cui Lv et al.   Current Alzheimer Research

Geniposide decreases the level of A 1-42 in the hippocampus of streptozotocin-induced diabetic rats

(2013) J. Liu et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Geniposide Ameliorates Learning Memory Deficits, Reduces Tau Phosphorylation and Decreases Apoptosis via GSK3β Pathway in Streptozotocin-Induced Alzheimer Rat Model

(2013) Chong Gao et al.   BRAIN PATHOLOGY

Exploratory Pharmacokinetics of Geniposide in Rat Model of Cerebral Ischemia Orally Administered with or without Baicalin and/or Berberine

(2013) Linmei Pan et al.   Evidence-based Complementary and Alternative Medicine

The links between complex coronary disease, cerebrovascular disease, and degenerative brain disease

(2012) Jason C. Kovacic et al.   Annals of the New York Academy of Sciences

Role of metabolism by human intestinal microflora in geniposide-induced toxicity in HepG2 cells

(2012) Mi Jeong Kang et al.   ARCHIVES OF PHARMACAL RESEARCH

Geniposide Reduces Inflammatory Responses of Oxygen-Glucose Deprived Rat Microglial Cells via Inhibition of the TLR4 Signaling Pathway

(2012) Jun Wang et al.   NEUROCHEMICAL RESEARCH

Neuroprotection of geniposide against hydrogen peroxide induced PC12 cells injury: involvement of PI3 kinase signal pathway

(2009) Jian-hui Liu et al.   ACTA PHARMACOLOGICA SINICA