Paeoniflorin, a Natural Product With Multiple Targets in Liver Diseases—A Mini Review

Natural products for the prevention and treatment of cholestasis: A review

(2020) Xiao Ma et al.   PHYTOTHERAPY RESEARCH

The Regulatory Effects of Paeoniflorin and Its Derivative Paeoniflorin-6′-O-Benzene Sulfonate CP-25 on Inflammation and Immune Diseases

(2019) Jiajie Tu et al.   Frontiers in Pharmacology

Salvia miltiorrhiza in Treating Cardiovascular Diseases: A Review on Its Pharmacological and Clinical Applications

(2019) Jie Ren et al.   Frontiers in Pharmacology

Paeoniflorin inhibits Rho kinase activation in joint synovial tissues of rats with collagen-induced rheumatoid arthritis

(2018) Wenjing Zhai et al.   BIOMEDICINE & PHARMACOTHERAPY

Low Rates of Retention Into Hepatocellular Carcinoma (HCC) Surveillance Program After Initial HCC Screening

(2018) Ann Robinson et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Endoplasmic Reticulum stress signaling and the pathogenesis of Non-Alcoholic Fatty Liver Disease

(2018) Cynthia Lebeaupin et al.   JOURNAL OF HEPATOLOGY

Paeoniflorin improves cardiac function and decreases adverse postinfarction left ventricular remodeling in a rat model of acute myocardial infarction

(2018) Hengwen Chen et al.   Drug Design Development and Therapy

Paeonia lactiflora Pall. regulates the NF-κB-NLRP3 inflammasome pathway to alleviate cholestasis in rats

(2018) Xiao Ma et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Paeoniflorin protects against liver ischemia/reperfusion injury in mice via inhibiting HMGB1-TLR4 signaling pathway

(2018) Tianjun Xie et al.   PHYTOTHERAPY RESEARCH

Paeoniflorin Ameliorates Fructose-Induced Insulin Resistance and Hepatic Steatosis by Activating LKB1/AMPK and AKT Pathways

(2018) Yu-Cheng Li et al.   Nutrients

Paeoniflorin targets apoptosis and ameliorates fibrosis in murine schistosomiasis mansoni : A novel insight

(2017) Naglaa Fathy Abd El-Aal et al.   EXPERIMENTAL PARASITOLOGY

Drug-induced liver injury: recent advances in diagnosis and risk assessment

(2017) Gerd A Kullak-Ublick et al.   GUT

NLRP3 inflammasome driven liver injury and fibrosis: Roles of IL-17 and TNF in mice

(2017) Alexander Wree et al.   HEPATOLOGY

Modeling the epidemic of nonalcoholic fatty liver disease demonstrates an exponential increase in burden of disease

(2017) Chris Estes et al.   HEPATOLOGY

New therapeutic concepts in bile acid transport and signaling for management of cholestasis

(2017) Michael Trauner et al.   HEPATOLOGY

Paeoniflorin influences breast cancer cell proliferation and invasion via inhibition of the Notch‑1 signaling pathway

(2017) Jing Zhang et al.   Molecular Medicine Reports

Paeoniflorin Attenuates Cerebral Ischemia-Induced Injury by Regulating Ca2+/CaMKII/CREB Signaling Pathway

(2017) Yuqin Zhang et al.   MOLECULES

Mechanisms of hepatic stellate cell activation

(2017) Takuma Tsuchida et al.   Nature Reviews Gastroenterology & Hepatology

Beneficial effects of paeoniflorin on non-alcoholic fatty liver disease induced by high-fat diet in rats

(2017) Zhihong Ma et al.   Scientific Reports

A Mechanistic Review of Cell Death in Alcohol-Induced Liver Injury

(2016) Shaogui Wang et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Optimal staging system for predicting the prognosis of patients with hepatocellular carcinoma in China: a retrospective study

(2016) Lihui Su et al.   BMC CANCER

Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases

(2016) Ajaikumar B Kunnumakkara et al.   BRITISH JOURNAL OF PHARMACOLOGY

Paeoniflorin alleviates non-alcoholic steatohepatitis in rats: Involvement with the ROCK/NF-κB pathway

(2016) Zhihong Ma et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Chemical Components and Pharmacological Activities of Terpene Natural Products from the Genus Paeonia

(2016) Dan-Dan Zhao et al.   MOLECULES

Serum Metabolomic Profiling in a Rat Model Reveals Protective Function of Paeoniflorin Against ANIT Induced Cholestasis

(2016) Zhe Chen et al.   PHYTOTHERAPY RESEARCH

Drug-Induced Liver Toxicity and Prevention by Herbal Antioxidants: An Overview

(2016) Divya Singh et al.   Frontiers in Physiology

The pharmacology of resveratrol in animals and humans

(2015) Eun-Jung Park et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Paeoniflorin Protects against Nonalcoholic Fatty Liver Disease Induced by a High-Fat Diet in Mice

(2015) Lijing Zhang et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Hepatic inflammation and fibrosis: Functional links and key pathways

(2015) Ekihiro Seki et al.   HEPATOLOGY

Fibrates and cholestasis

(2015) Nisanne S. Ghonem et al.   HEPATOLOGY

Liver inflammation abrogates immunological tolerance induced by Kupffer cells

(2015) Felix Heymann et al.   HEPATOLOGY

Paeoniflorin protects against concanavalin A-induced hepatitis in mice

(2015) Mingsheng Chen et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Paeoniflorin diminishes ConA-induced IL-8 production in primary human hepatic sinusoidal endothelial cells in the involvement of ERK1/2 and Akt phosphorylation

(2015) Wen-Guang Gong et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The Role of Oxidative Stress and Antioxidants in Liver Diseases

(2015) Sha Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Recent advancement of molecular mechanisms of liver fibrosis

(2015) Ekihiro Seki et al.   Journal of Hepato-Biliary-Pancreatic Sciences

Current mechanistic insights into the roles of matrix metalloproteinases in tumour invasion and metastasis

(2015) Gordon T Brown et al.   JOURNAL OF PATHOLOGY

Paeoniflorin ameliorates ANIT-induced cholestasis by activating Nrf2 through an PI3K/Akt-dependent pathway in rats

(2015) Zhe Chen et al.   PHYTOTHERAPY RESEARCH

Paeoniflorin attenuates hepatic ischemia/reperfusion injury via anti-oxidative, anti-inflammatory and anti-apoptotic pathways

(2015) YE TAO et al.   Experimental and Therapeutic Medicine

Mitochondrial Dysfunction and Autophagy in Hepatic Ischemia/Reperfusion Injury

(2015) Kristina L. Go et al.   Biomed Research International

Paeoniflorin protects cells from GalN/TNF-α-induced apoptosis via ER stress and mitochondria-dependent pathways in human L02 hepatocytes

(2014) Zequn Jiang et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Paeoniflorin alleviates liver fibrosis by inhibiting HIF-1α through mTOR-dependent pathway

(2014) Yanling Zhao et al.   FITOTERAPIA

Paeoniflorin protects against ANIT-induced cholestasis by ameliorating oxidative stress in rats

(2013) Yanling Zhao et al.   FOOD AND CHEMICAL TOXICOLOGY

Decoding cell death signals in liver inflammation

(2013) Catherine Brenner et al.   JOURNAL OF HEPATOLOGY

Hepatic ischemia and reperfusion injury: Effects on the liver sinusoidal milieu

(2013) Carmen Peralta et al.   JOURNAL OF HEPATOLOGY

Involvement of the prostaglandin E receptor EP2 in paeoniflorin-induced human hepatoma cell apoptosis

(2012) Shanshan Hu et al.   ANTI-CANCER DRUGS

Paeoniflorin regulates macrophage activation in dimethylnitrosamine-induced liver fibrosis in rats

(2012) Xiaorong Chen et al.   BMC Complementary and Alternative Medicine

Bile Acids Induce Inflammatory Genes in Hepatocytes

(2011) Katryn Allen et al.   AMERICAN JOURNAL OF PATHOLOGY

Paeoniflorin attenuates schistosomiasis japonica-associated liver fibrosis through inhibiting alternative activation of macrophages

(2011) DEYONG CHU et al.   PARASITOLOGY

Clinical, laboratory and histological associations in adults with nonalcoholic fatty liver disease

(2010) Brent A. Neuschwander-Tetri et al.   HEPATOLOGY

Paeoniflorin: A Monomer from Traditional Chinese Medical Herb Ameliorates Schistosoma japonicum Egg-Induced Hepatic Fibrosis in Mice

(2010) Xiaoyue Li et al.   JOURNAL OF PARASITOLOGY

Paeoniflorin ameliorates schistosomiasis liver fibrosis through regulating IL-13 and its signalling molecules in mice

(2010) XIAOYUE LI et al.   PARASITOLOGY

Oxidative Stress and the Pathogenesis of Cholestasis

(2010) Bryan Copple et al.   SEMINARS IN LIVER DISEASE