Anabaenopeptins: What We Know So Far

Current Knowledge on Microviridin from Cyanobacteria

(2021) Samuel Cavalcante do Amaral et al.   Marine Drugs

CyanoMetDB, a comprehensive public database of secondary metabolites from cyanobacteria

(2021) Martin R. Jones et al.   WATER RESEARCH

Cytotoxic and Genotoxic Effects of Cyanobacterial and Algal Extracts—Microcystin and Retinoic Acid Content

(2021) Michal Bittner et al.   Toxins

Symbioses of Cyanobacteria in Marine Environments: Ecological Insights and Biotechnological Perspectives

(2021) Mirko Mutalipassi et al.   Marine Drugs

Comprehensive Analyses of Cytochrome P450 Monooxygenases and Secondary Metabolite Biosynthetic Gene Clusters in Cyanobacteria

(2020) Makhosazana Jabulile Khumalo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Phosphate Limitation Increases Content of Protease Inhibitors in the Cyanobacterium Microcystis aeruginosa

(2020) Christian Burberg et al.   Toxins

Genomic and Metabolomic Analyses of Natural Products in Nodularia spumigena Isolated from a Shrimp Culture Pond

(2020) Rafael Vicentini Popin et al.   Toxins

Nodularin induced oxidative stress contributes to developmental toxicity in zebrafish embryos

(2020) Guoliang Chen et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Cyanopeptide Co-Production Dynamics beyond Mirocystins and Effects of Growth Stages and Nutrient Availability

(2020) Regiane Natumi et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

The Effects of Cyanobacterial Bloom Extracts on the Biomass, Chl-a, MC and Other Oligopeptides Contents in a Natural Planktothrix agardhii Population

(2020) Magdalena Toporowska et al.   International Journal of Environmental Research and Public Health

Blooms of Toxic Cyanobacterium Nodularia spumigena in Norwegian Fjords During Holocene Warm Periods

(2020) Robert Konkel et al.   Toxins

A Mini Review on Microcystins and Bacterial Degradation

(2020) Isaac Yaw Massey et al.   Toxins

Advances in the Biotechnological Potential of Brazilian Marine Microalgae and Cyanobacteria

(2020) Deborah Terra de Oliveira et al.   MOLECULES

Co-Occurrence of Tetrodotoxin and Saxitoxins and Their Intra-Body Distribution in the Pufferfish Canthigaster valentini

(2020) Hongchen Zhu et al.   Toxins

Effects of Harmful Blooms of Large-Sized and Colonial Cyanobacteria on Aquatic Food Webs

(2020) Maria Moustaka-Gouni et al.   Water

The Natural Polypeptides as Significant Elastase Inhibitors

(2020) Shabir Ahmad et al.   Frontiers in Pharmacology

Novel cyanobacterial metabolites, cyanopeptolin 1081 and anabaenopeptin 899, isolated from an enrichment culture dominated by Woronichinia naegeliana (Unger) Elenkin

(2020) Beata Bober et al.   EUROPEAN JOURNAL OF PHYCOLOGY

Cyanobacterial Polyhydroxyalkanoates: A Sustainable Alternative in Circular Economy

(2020) Diana Gomes Gradíssimo et al.   MOLECULES

Discovery of Unusual Cyanobacterial Tryptophan-Containing Anabaenopeptins by MS/MS-Based Molecular Networking

(2020) Subhasish Saha et al.   MOLECULES

Determination of Volatile Organic Compounds and Antibacterial Activity of the Amazonian Cyanobacterium Synechococcus sp. Strain GFB01

(2020) Samuel Cavalcante do Amaral et al.   MOLECULES

High Levels of Anabaenopeptins Detected in a Cyanobacteria Bloom from N.E. Spanish Sau-Susqueda-El Pasteral Reservoirs System by LC–HRMS

(2020) Cintia Flores et al.   Toxins

Insight into Unprecedented Diversity of Cyanopeptides in Eutrophic Ponds Using an MS/MS Networking Approach

(2020) Andreja Kust et al.   Toxins

Cyanobacterial peptides beyond microcystins – A review on co-occurrence, toxicity, and challenges for risk assessment

(2019) Elisabeth M.-L. Janssen   WATER RESEARCH

Effects of secondary metabolites produced by different cyanobacterial populations on the freshwater zooplankters Brachionus calyciflorus and Daphnia pulex

(2019) Barbara Pawlik-Skowrońska et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Unlocking the Spatial Control of Secondary Metabolism Uncovers Hidden Natural Product Diversity in Nostoc punctiforme

(2019) Daniel Dehm et al.   ACS Chemical Biology

Microcystis Chemotype Diversity in the Alimentary Tract of Bigheaded Carp

(2019) Milán Riba et al.   Toxins

Lipopolysaccharides from Microcystis Cyanobacteria-Dominated Water Bloom and from Laboratory Cultures Trigger Human Immune Innate Response

(2019) Zdena Moosová et al.   Toxins

A Data-Independent Methodology for the Structural Characterization of Microcystins and Anabaenopeptins Leading to the Identification of Four New Congeners

(2019) Audrey Roy-Lachapelle et al.   Toxins

Combined Danio rerio embryo morbidity, mortality and photomotor response assay: A tool for developmental risk assessment from chronic cyanoHAB exposure

(2019) Amber Roegner et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Dereplication of Natural Products with Antimicrobial and Anticancer Activity from Brazilian Cyanobacteria

(2019) Tania Keiko Shishido et al.   Toxins

Direct Pathway Cloning (DiPaC) to unlock natural product biosynthetic potential

(2018) Christian Greunke et al.   METABOLIC ENGINEERING

Cyanobacterial blooms

(2018) Jef Huisman et al.   NATURE REVIEWS MICROBIOLOGY

Adaptation of a Chytrid Parasite to Its Cyanobacterial Host Is Hampered by Host Intraspecific Diversity

(2018) Ramsy Agha et al.   Frontiers in Microbiology

Insights into cyanophage-mediated dynamics of nodularin and other non-ribosomal peptides in Nodularia spumigena

(2018) Sigitas Šulčius et al.   HARMFUL ALGAE

Spatial analysis of toxic or otherwise bioactive cyanobacterial peptides in Green Bay, Lake Michigan

(2018) Sarah L. Bartlett et al.   JOURNAL OF GREAT LAKES RESEARCH

Alternative biosynthetic starter units enhance the structural diversity of cyanobacterial lipopeptides

(2018) Jan Mareš et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Anabaenopeptins and cyanopeptolins induce systemic toxicity effects in a model organism the nematode Caenorhabditis elegans

(2018) Kade A. Lenz et al.   CHEMOSPHERE

Namalides B and C and Spumigins K–N from the Cultured Freshwater Cyanobacterium Sphaerospermopsis torques-reginae

(2017) Miriam Sanz et al.   JOURNAL OF NATURAL PRODUCTS

Structural Diversity, Biological Properties and Applications of Natural Products from Cyanobacteria. A Review

(2017) Sayed Shah et al.   Marine Drugs

New Peptides Isolated from Marine Cyanobacteria, an Overview over the Past Decade

(2017) Yue Mi et al.   Marine Drugs

Variable Cyanobacterial Toxin and Metabolite Profiles across Six Eutrophic Lakes of Differing Physiochemical Characteristics

(2017) Lucas Beversdorf et al.   Toxins

Evolution of Anabaenopeptin Peptide Structural Variability in the Cyanobacterium Planktothrix

(2017) Elisabeth Entfellner et al.   Frontiers in Microbiology

Zooming in on the phycosphere: the ecological interface for phytoplankton–bacteria relationships

(2017) Justin R. Seymour et al.   Nature Microbiology

Fungal lifestyle reflected in serine protease repertoire

(2017) Anna Muszewska et al.   Scientific Reports

Discovery of anabaenopeptin 679 from freshwater algal bloom material: Insights into the structure–activity relationship of anabaenopeptin protease inhibitors

(2016) Henrik Harms et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The algicidal activity of Aeromonas sp. strain GLY-2107 against bloom-forming Microcystis aeruginosa is regulated by N -acyl homoserine lactone-mediated quorum sensing

(2016) Xingliang Guo et al.   ENVIRONMENTAL MICROBIOLOGY

Role of toxic and bioactive secondary metabolites in colonization and bloom formation by filamentous cyanobacteria Planktothrix

(2016) Rainer Kurmayer et al.   HARMFUL ALGAE

The interaction between cyanobacteria and zooplankton in a more eutrophic world

(2016) Kemal Ali Ger et al.   HARMFUL ALGAE

Algae as nutritional and functional food sources: revisiting our understanding

(2016) Mark L. Wells et al.   JOURNAL OF APPLIED PHYCOLOGY

Chemical and Genetic Diversity of Nodularia spumigena from the Baltic Sea

(2016) Hanna Mazur-Marzec et al.   Marine Drugs

Morphologic, Phylogenetic and Chemical Characterization of a Brackish Colonial Picocyanobacterium (Coelosphaeriaceae) with Bioactive Properties

(2016) Kerstin Häggqvist et al.   Toxins

Microcystin-LR Biodegradation by Bacillus sp.: Reaction Rates and Possible Genes Involved in the Degradation

(2016) Michelline Kansole et al.   Water

Role of bacteria in the production and degradation ofMicrocystiscyanopeptides

(2016) Enora Briand et al.   MicrobiologyOpen

Isolation, Co-Crystallization and Structure-Based Characterization of Anabaenopeptins as Highly Potent Inhibitors of Activated Thrombin Activatable Fibrinolysis Inhibitor (TAFIa)

(2016) Herman Schreuder et al.   Scientific Reports

Structural Elucidation of the Bispecificity of A Domains as a Basis for Activating Non-natural Amino Acids

(2015) Heidi Kaljunen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Transcriptomic and Proteomic Profiling of Anabaena sp. Strain 90 under Inorganic Phosphorus Stress

(2015) Jonna Teikari et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Changes in secondary metabolic profiles of Microcystis aeruginosa strains in response to intraspecific interactions

(2015) Enora Briand et al.   ENVIRONMENTAL MICROBIOLOGY

Combined LC–MS/MS and Molecular Networking Approach Reveals New Cyanotoxins from the 2014 Cyanobacterial Bloom in Green Lake, Seattle

(2015) Roberta Teta et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Baltic cyanobacteria – a source of biologically active compounds

(2015) Hanna Mazur-Marzec et al.   EUROPEAN JOURNAL OF PHYCOLOGY

Two-tier vessel for photoautotrophic high-density cultures

(2015) Lars Bähr et al.   JOURNAL OF APPLIED PHYCOLOGY

Novel Small Molecule Inhibitors of Activated Thrombin Activatable Fibrinolysis Inhibitor (TAFIa) from Natural Product Anabaenopeptin

(2015) Nis Halland et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural Characterization of New Peptide Variants Produced by Cyanobacteria from the Brazilian Atlantic Coastal Forest Using Liquid Chromatography Coupled to Quadrupole Time-of-Flight Tandem Mass Spectrometry

(2015) Miriam Sanz et al.   Marine Drugs

Cyanobacterial Toxic and Bioactive Peptides in Freshwater Bodies of Greece: Concentrations, Occurrence Patterns, and Implications for Human Health

(2015) Spyros Gkelis et al.   Marine Drugs

Structures and Activity of New Anabaenopeptins Produced by Baltic Sea Cyanobacteria

(2015) Lisa Spoof et al.   Marine Drugs

Cyanobactins from Cyanobacteria: Current Genetic and Chemical State of Knowledge

(2015) Joana Martins et al.   Marine Drugs

New Prenylated Aeruginosin, Microphycin, Anabaenopeptin and Micropeptin Analogues from a Microcystis Bloom Material Collected in Kibbutz Kfar Blum, Israel

(2015) Shira Elkobi-Peer et al.   Marine Drugs

Nodularia spumigena Peptides—Accumulation and Effect on Aquatic Invertebrates

(2015) Hanna Mazur-Marzec et al.   Toxins

The Red Queen Race between Parasitic Chytrids and Their Host, Planktothrix: A Test Using a Time Series Reconstructed from Sediment DNA

(2015) Marcia Kyle et al.   PLoS One

Non-ribosomal peptides produced by Planktothrix agardhii from Siemianówka Dam Reservoir SDR (northeast Poland)

(2014) Magdalena Grabowska et al.   ARCHIVES OF MICROBIOLOGY

Augmenting Anti-Cancer Natural Products with a Small Molecule Adjuvant

(2014) Paul Wahome et al.   Marine Drugs

An environmental bacterial taxon with a large and distinct metabolic repertoire

(2014) Micheal C. Wilson et al.   NATURE

Impact of Environmental Factors on the Regulation of Cyanotoxin Production

(2014) Thangavelu Boopathi et al.   Toxins

Identification of Homophenylalanine Biosynthetic Genes from the Cyanobacterium Nostoc punctiforme PCC73102 and Application to Its Microbial Production by Escherichia coli

(2013) Kento Koketsu et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

From Green to Red: Horizontal Gene Transfer of the Phycoerythrin Gene Cluster between Planktothrix Strains

(2013) Ave Tooming-Klunderud et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Putative Antiparasite Defensive System Involving Ribosomal and Nonribosomal Oligopeptides in Cyanobacteria of the Genus Planktothrix

(2013) Thomas Rohrlack et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Effect of nutrient limitation of cyanobacteria on protease inhibitor production and fitness of Daphnia magna

(2013) A. Schwarzenberger et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Interpreting the Possible Ecological Role(s) of Cyanotoxins: Compounds for Competitive Advantage and/or Physiological Aide?

(2013) Aleicia Holland et al.   Marine Drugs

Thrombin Activatable Fibrinolysis Inhibitor: A Putative Target to Enhance Fibrinolysis

(2013) Ellen Vercauteren et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Appearance of Planktothrix rubescens Bloom with [D-Asp3, Mdha7]MC–RR in Gravel Pit Pond of a Shallow Lake-Dominated Area

(2013) Gábor Vasas et al.   Toxins

Identification and toxigenic potential of a Nostoc sp.

(2013) Bahareh Nowruzi et al.   ALGAE

Effects of harmful cyanobacteria on the freshwater pathogenic free-living amoeba Acanthamoeba castellanii

(2012) Pablo Urrutia-Cordero et al.   AQUATIC TOXICOLOGY

Assessment of microcystin distribution and biomagnification in tissues of aquatic food web compartments from a shallow lake and evaluation of potential risks to public health

(2012) Theodoti Papadimitriou et al.   ECOTOXICOLOGY

Diversity of Peptides Produced by Nodularia spumigena from Various Geographical Regions

(2012) Hanna Mazur-Marzec et al.   Marine Drugs

Profiles of toxic and non-toxic oligopeptides of Radiocystis fernandoii (Cyanobacteria) exposed to three different light intensities

(2012) Daniel A. Pereira et al.   MICROBIOLOGICAL RESEARCH

Genetic Variation of Adenylation Domains of the Anabaenopeptin Synthesis Operon and Evolution of Substrate Promiscuity

(2011) G. Christiansen et al.   JOURNAL OF BACTERIOLOGY

Discovery and Synthesis of Namalide Reveals a New Anabaenopeptin Scaffold and Peptidase Inhibitor

(2011) Pradeep Cheruku et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cyanotoxins: Bioaccumulation and Effects on Aquatic Animals

(2011) Aloysio da S. Ferrão-Filho et al.   Marine Drugs

Lyngbyaureidamides A and B, two anabaenopeptins from the cultured freshwater cyanobacterium Lyngbya sp. (SAG 36.91)

(2011) Jiachen Zi et al.   PHYTOCHEMISTRY

Genome Mining Demonstrates the Widespread Occurrence of Gene Clusters Encoding Bacteriocins in Cyanobacteria

(2011) Hao Wang et al.   PLoS One

Two Alternative Starter Modules for the Non-Ribosomal Biosynthesis of Specific Anabaenopeptin Variants in Anabaena (Cyanobacteria)

(2010) Leo Rouhiainen et al.   CHEMISTRY & BIOLOGY

Molecular Mechanisms of Microcystin Toxicity in Animal Cells

(2010) Alexandre Campos et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Paltolides A−C, Anabaenopeptin-Type Peptides from the Palau SpongeTheonella swinhoei†

(2010) Alberto Plaza et al.   JOURNAL OF NATURAL PRODUCTS

Oligopeptide chemotypes of the toxic freshwater cyanobacterium Planktothrix can form sub-populations with dissimilar ecological traits

(2010) Thomas Rohrlack et al.   LIMNOLOGY AND OCEANOGRAPHY

Quorum-Sensing-Regulated Bactobolin Production byBurkholderia thailandensisE264

(2010) Mohammad R. Seyedsayamdost et al.   ORGANIC LETTERS

Eight novel serine proteases inhibitors from a water bloom of the cyanobacterium Microcystis sp.

(2010) Ella Zafrir-Ilan et al.   TETRAHEDRON

A genome-wide analysis of nonribosomal peptide synthetase gene clusters and their peptides in a Planktothrix rubescens strain

(2009) Trine B Rounge et al.   BMC GENOMICS

A toxic cyanobacterial bloom in an urban coastal lake, Rio Grande do Sul state, Southern Brazil

(2009) Luciana Retz de Carvalho et al.   BRAZILIAN JOURNAL OF MICROBIOLOGY

Protease Inhibitors from a Water Bloom of the CyanobacteriumMicrocystis aeruginosa

(2009) Shiri Gesner-Apter et al.   JOURNAL OF NATURAL PRODUCTS

SylC Catalyzes Ureido-Bond Formation During Biosynthesis of the Proteasome Inhibitor Syringolin A

(2009) Heidi J. Imker et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Antibacterial Activity of 2-(2’,4’-Dibromophenoxy)-4,6-dibromophenol from Dysidea granulosa

(2009) Divya M. Shridhar et al.   Marine Drugs

Targeting Protein Serine/Threonine Phosphatases for Drug Development

(2009) J. L. McConnell et al.   MOLECULAR PHARMACOLOGY

Infrequent marine–freshwater transitions in the microbial world

(2009) Ramiro Logares et al.   TRENDS IN MICROBIOLOGY

Biodegradation of nodularin and effects of the toxin on bacterial isolates from the Gulf of Gdańsk

(2009) Hanna Mazur-Marzec et al.   WATER RESEARCH

Cytotoxic and peptidase inhibitory activities of selected non-hepatotoxic cyclic peptides from cyanobacteria

(2008) Anja Bubik et al.   BIOLOGICAL CHEMISTRY

Production of cyanopeptolins, anabaenopeptins, and microcystins by the harmful cyanobacteria Anabaena 90 and Microcystis PCC 7806

(2008) Linda Tonk et al.   HARMFUL ALGAE

Homotyrosine-Containing Cyanopeptolins 880 and 960 and Anabaenopeptins 908 and 915 fromPlanktothrix agardhiiCYA 126/8

(2008) Hilary S. Okumura et al.   JOURNAL OF NATURAL PRODUCTS

Pompanopeptins A and B, new cyclic peptides from the marine cyanobacterium Lyngbya confervoides

(2008) Susan Matthew et al.   TETRAHEDRON

Three novel anabaenopeptins from the cyanobacterium Anabaena sp.

(2008) Olga Grach-Pogrebinsky et al.   TETRAHEDRON

Natural products genomics

(2008) Roland J. Siezen et al.   Microbial Biotechnology