Structures of the mycobacterial membrane protein MmpL3 reveal its mechanism of lipid transport
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Title
Structures of the mycobacterial membrane protein MmpL3 reveal its mechanism of lipid transport
Authors
Keywords
Electron cryo-microscopy, Lipids, Membrane proteins, Mycobacterium tuberculosis, Fungal structure, Molecular dynamics, Trehalose, Crystal structure
Journal
PLOS BIOLOGY
Volume 19, Issue 8, Pages e3001370
Publisher
Public Library of Science (PLoS)
Online
2021-08-13
DOI
10.1371/journal.pbio.3001370
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- (2018) Jani Reddy Bolla et al. Nature Chemistry
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- (2018) Wei Tian et al. NUCLEIC ACIDS RESEARCH
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- (2018) Pavel V. Afonine et al. Acta Crystallographica Section D-Structural Biology
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- (2016) Jozef Stec et al. JOURNAL OF MEDICINAL CHEMISTRY
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- (2016) Kai Zhang JOURNAL OF STRUCTURAL BIOLOGY
- Tuberculosis—advances in development of new drugs, treatment regimens, host-directed therapies, and biomarkers
- (2016) Robert S Wallis et al. LANCET INFECTIOUS DISEASES
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- (2012) A. V. Vargiu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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- MolProbity: all-atom structure validation for macromolecular crystallography
- (2009) Vincent B. Chen et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
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