The Biology and Pathobiology of Glutamatergic, Cholinergic, and Dopaminergic Signaling in the Aging Brain

α-Synuclein Oligomers Induce Glutamate Release from Astrocytes and Excessive Extrasynaptic NMDAR Activity in Neurons, Thus Contributing to Synapse Loss

(2021) Dorit Trudler et al.   JOURNAL OF NEUROSCIENCE

Dysregulation of mitochondria-lysosome contacts by GBA1 dysfunction in dopaminergic neuronal models of Parkinson’s disease

(2021) Soojin Kim et al.   Nature Communications

Targeting the cholinergic system in Parkinson’s disease

(2020) Changliang Liu   ACTA PHARMACOLOGICA SINICA

Activation of α7 nAChR by PNU-282987 improves synaptic and cognitive functions through restoring the expression of synaptic-associated proteins and the CaM-CaMKII-CREB signaling pathway

(2020) Xiao-Ling Wang et al.   Aging-US

BDNF as a Promising Therapeutic Agent in Parkinson’s Disease

(2020) Ewelina Palasz et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Improving Anti-Neurodegenerative Benefits of Acetylcholinesterase Inhibitors in Alzheimer’s Disease: Are Irreversible Inhibitors the Future?

(2020) Donald E. Moss   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Monkeys (Macaca mulatta) learn two-choice discriminations under displaced reinforcement.

(2020) J. David Smith et al.   JOURNAL OF COMPARATIVE PSYCHOLOGY

Modulation of Human Memory by Deep Brain Stimulation of the Entorhinal-Hippocampal Circuitry

(2020) Emily A. Mankin et al.   NEURON

Aging-related motor function and dopaminergic neuronal loss in C57BL/6 mice

(2020) Sachiko Noda et al.   Molecular Brain

Neurodegenerative Diseases – Is Metabolic Deficiency the Root Cause?

(2020) Vignayanandam Ravindernath Muddapu et al.   Frontiers in Neuroscience

Dopamine and reward hypersensitivity in Parkinson’s disease with impulse control disorder

(2020) Daniel S Drew et al.   BRAIN

Glutamate-induced excitotoxicity in Parkinson's disease: The role of glial cells

(2020) L. Iovino et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

A Quantitative Meta-Analysis of Brain Glutamate Metabolites in Aging

(2020) David R. Roalf et al.   NEUROBIOLOGY OF AGING

The Dual Role of Glutamatergic Neurotransmission in Alzheimer’s Disease: From Pathophysiology to Pharmacotherapy

(2020) Vidyasagar Naik Bukke et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

On the Right Track to Treat Movement Disorders: Promising Therapeutic Approaches for Parkinson’s and Huntington’s Disease

(2020) Paulina Troncoso-Escudero et al.   Frontiers in Aging Neuroscience

Memantine, Donepezil, or Combination Therapy—What is the best therapy for Alzheimer’s Disease? A Network Meta‐Analysis

(2020) Jiaxun Guo et al.   Brain and Behavior

Nucleus basalis of meynert stimulation for lewy body dementia: A phase I randomized clinical trial

(2020) David Maltête et al.   NEUROLOGY

Molecular Mechanisms of Glutamate Toxicity in Parkinson’s Disease

(2020) Ji Wang et al.   Frontiers in Neuroscience

On the Role of Aminochrome in Mitochondrial Dysfunction and Endoplasmic Reticulum Stress in Parkinson's Disease

(2019) Juan Segura-Aguilar   Frontiers in Neuroscience

The Brain NGF Metabolic Pathway in Health and in Alzheimer’s Pathology

(2019) A. Claudio Cuello et al.   Frontiers in Neuroscience

Brain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson’s disease pathogenesis

(2019) Iria Carballo-Carbajal et al.   Nature Communications

Dopamine and Cognitive Control in Prefrontal Cortex

(2019) Torben Ott et al.   TRENDS IN COGNITIVE SCIENCES

The Epistasis Project: A Multi-Cohort Study of the Effects of BDNF, DBH, and SORT1 Epistasis on Alzheimer’s Disease Risk

(2019) Olivia Belbin et al.   JOURNAL OF ALZHEIMERS DISEASE

Cellular, molecular, and clinical mechanisms of action of deep brain stimulation—a systematic review on established indications and outlook on future developments

(2019) Martin Jakobs et al.   EMBO Molecular Medicine

Cholinergic system changes of falls and freezing of gait in Parkinson disease

(2019) Nicolaas I. Bohnen et al.   ANNALS OF NEUROLOGY

Quantitative assessment of oligomeric amyloid β peptide binding to α7 nicotinic receptor

(2019) Erika Cecon et al.   BRITISH JOURNAL OF PHARMACOLOGY

Drug treatment strategies for depression in Parkinson disease

(2019) Melody Ryan et al.   EXPERT OPINION ON PHARMACOTHERAPY

Neuroplasticity and Neuroprotective Effect of Treadmill Training in the Chronic Mouse Model of Parkinson’s Disease

(2019) Ewelina Palasz et al.   NEURAL PLASTICITY

Updates and advances in the treatment of Parkinson disease

(2019) Michael W Hayes et al.   MEDICAL JOURNAL OF AUSTRALIA

Neuromelanin, aging, and neuronal vulnerability in Parkinson's disease

(2019) Miquel Vila   MOVEMENT DISORDERS

Dopamine D2-like receptor stimulation blocks negative feedback in visual and spatial reversal learning in the rat: behavioural and computational evidence

(2019) Johan Alsiö et al.   PSYCHOPHARMACOLOGY

Dopamine and Dopamine Receptors in Alzheimer's Disease: A Systematic Review and Network Meta-Analysis

(2019) Xiongfeng Pan et al.   Frontiers in Aging Neuroscience

Nucleus accumbens medium spiny neurons subtypes signal both reward and aversion

(2019) Carina Soares-Cunha et al.   MOLECULAR PSYCHIATRY

Ageing as a risk factor for neurodegenerative disease

(2019) Yujun Hou et al.   Nature Reviews Neurology

Intracellular and Intercellular Mitochondrial Dynamics in Parkinson’s Disease

(2019) Dario Valdinocci et al.   Frontiers in Neuroscience

Neuroprotective effects of memantine via enhancement of autophagy

(2019) Kazuoki Hirano et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

NMDA Receptor Antagonists: Repositioning of Memantine as a Multitargeting Agent for Alzheimer's Therapy

(2019) Md. Tanvir Kabir et al.   CURRENT PHARMACEUTICAL DESIGN

Oral Monosodium Glutamate Administration Causes Early Onset of Alzheimer’s Disease-Like Pathophysiology in APP/PS1 Mice

(2019) Tanja Fuchsberger et al.   JOURNAL OF ALZHEIMERS DISEASE

Neuronal Representation of Object Choice in the Striatum of the Monkey

(2019) Satoshi Nonomura et al.   Frontiers in Neuroscience

Exercise-Induced Neuroprotection and Recovery of Motor Function in Animal Models of Parkinson's Disease

(2019) Ewelina Palasz et al.   Frontiers in Neurology

Stress-induced plasticity and functioning of ventral tegmental dopamine neurons

(2019) Erik H. Douma et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Regulatory Activities of Dopamine and Its Derivatives toward Metal-Free and Metal-Induced Amyloid-β Aggregation, Oxidative Stress, and Inflammation in Alzheimer’s Disease

(2018) Eunju Nam et al.   ACS Chemical Neuroscience

Memantine ER Maintains Patient Response in Moderate to Severe Alzheimer’s Disease

(2018) George T. Grossberg et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

Synapse Pruning: Mitochondrial ROS with Their Hands on the Shears

(2018) James N. Cobley   BIOESSAYS

The cholinergic system in the pathophysiology and treatment of Alzheimer’s disease

(2018) Harald Hampel et al.   BRAIN

Cognitive correlates of α4β2 nicotinic acetylcholine receptors in mild Alzheimer’s dementia

(2018) Osama Sabri et al.   BRAIN

Differential Effects of Nicotine Exposure on the Hippocampus Across Lifespan

(2018) Dana Zeid et al.   Current Neuropharmacology

Insight into the emerging role of striatal neurotransmitters in the pathophysiology of Parkinson’s disease and Huntington’s disease: A review

(2018) Sumit Jamwal et al.   Current Neuropharmacology

Tau clearance improves astrocytic function and brain glutamate-glutamine cycle

(2018) Michaeline L. Hebron et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Aerobic Exercise: Evidence for a Direct Brain Effect to Slow Parkinson Disease Progression

(2018) J. Eric Ahlskog   MAYO CLINIC PROCEEDINGS

Compromise of cortical proNGF maturation causes selective retrograde atrophy in cholinergic nucleus basalis neurons

(2018) Simon Allard et al.   NEUROBIOLOGY OF AGING

Glutamatergic synaptic plasticity and dysfunction in Alzheimer disease

(2018) Eduardo E. Benarroch   NEUROLOGY

Regional Heterogeneity of D2-Receptor Signaling in the Dorsal Striatum and Nucleus Accumbens

(2018) Pamela F. Marcott et al.   NEURON

Glutamatergic Signaling in the Central Nervous System: Ionotropic and Metabotropic Receptors in Concert

(2018) Andreas Reiner et al.   NEURON

Muscarinic receptor subtype distribution in the central nervous system and relevance to aging and Alzheimer's disease

(2018) E.P. Lebois et al.   NEUROPHARMACOLOGY

The role of dopaminergic midbrain in Alzheimer’s disease: Translating basic science into clinical practice

(2018) Marcello D’Amelio et al.   PHARMACOLOGICAL RESEARCH

Normal aging induces A1-like astrocyte reactivity

(2018) Laura E. Clarke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anatomy, Physiology, and Clinical Syndromes of the Basal Ganglia: A Brief Review

(2018) Arash Fazl et al.   Seminars in Pediatric Neurology

Noradrenergic Dysfunction in Alzheimer's and Parkinson's Diseases—An Overview of Imaging Studies

(2018) Andrew C. Peterson et al.   Frontiers in Aging Neuroscience

Dopamine and reward

(2018) Bolton K.H. Chau et al.   BEHAVIOURAL PHARMACOLOGY

Alteration in NMDA Receptor Mediated Glutamatergic Neurotransmission in the Hippocampus During Senescence

(2018) Ashok Kumar et al.   NEUROCHEMICAL RESEARCH

D2 receptors and cognitive flexibility in marmosets: tri-phasic dose–response effects of intra-striatal quinpirole on serial reversal performance

(2018) Nicole K. Horst et al.   NEUROPSYCHOPHARMACOLOGY

Comparative safety and effectiveness of cholinesterase inhibitors and memantine for Alzheimer’s disease: a network meta-analysis of 41 randomized controlled trials

(2018) Kai-Xin Dou et al.   Alzheimers Research & Therapy

Astrocytes and Aging

(2018) Alexandra L. Palmer et al.   Frontiers in Aging Neuroscience

Identification of the optimal cognitive drugs among Alzheimer’s disease: a Bayesian meta-analytic review

(2018) Jinghong Liang et al.   Clinical Interventions in Aging

Role of 4-hydroxy-2-nonenal (HNE) in the pathogenesis of alzheimer disease and other selected age-related neurodegenerative disorders

(2017) Fabio Di Domenico et al.   FREE RADICAL BIOLOGY AND MEDICINE

Longitudinal imaging reveals subhippocampal dynamics in glutamate levels associated with histopathologic events in a mouse model of tauopathy and healthy mice

(2017) Rachelle Crescenzi et al.   HIPPOCAMPUS

Memantine for Alzheimer’s Disease: An Updated Systematic Review and Meta-analysis

(2017) Taro Kishi et al.   JOURNAL OF ALZHEIMERS DISEASE

Role of Glutamate and NMDA Receptors in Alzheimer’s Disease

(2017) Rui Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

Microtubule dynamics and the neurodegenerative triad of Alzheimer's disease: The hidden connection

(2017) Roland Brandt et al.   JOURNAL OF NEUROCHEMISTRY

Detection of phasic dopamine by D1 and D2 striatal medium spiny neurons

(2017) Cedric Yapo et al.   JOURNAL OF PHYSIOLOGY-LONDON

Channel opening and gating mechanism in AMPA-subtype glutamate receptors

(2017) Edward C. Twomey et al.   NATURE

Reduced dopamine receptors and transporters but not synthesis capacity in normal aging adults: a meta-analysis

(2017) Teresa M. Karrer et al.   NEUROBIOLOGY OF AGING

Unconventional neurotrophic factors CDNF and MANF: Structure, physiological functions and therapeutic potential

(2017) Maria Lindahl et al.   NEUROBIOLOGY OF DISEASE

Astrocyte transport of glutamate and neuronal activity reciprocally modulate tau pathology in Drosophila

(2017) Jason G. Kilian et al.   NEUROSCIENCE

Reward Circuitry in Addiction

(2017) Sarah Cooper et al.   Neurotherapeutics

Metabotropic glutamate receptors and neurodegenerative diseases

(2017) Fabiola M. Ribeiro et al.   PHARMACOLOGICAL RESEARCH

The role of trophic factors and inflammatory processes in physical activity-induced neuroprotection in Parkinson’s disease

(2017) Ewelina Pałasz et al.   Postepy Higieny I Medycyny Doswiadczalnej

Interactions of iron, dopamine and neuromelanin pathways in brain aging and Parkinson's disease

(2017) Fabio A. Zucca et al.   PROGRESS IN NEUROBIOLOGY

Cholinergic Modulation of Cortical Microcircuits Is Layer-Specific: Evidence from Rodent, Monkey and Human Brain

(2017) Joshua Obermayer et al.   Frontiers in Neural Circuits

Dopamine neuronal loss contributes to memory and reward dysfunction in a model of Alzheimer’s disease

(2017) Annalisa Nobili et al.   Nature Communications

Alzheimer's disease: Targeting the Cholinergic System

(2016) Talita H. Ferreira-Vieira et al.   Current Neuropharmacology

Glutamate-glutamine and GABA in brain of normal aged and patients with cognitive impairment

(2016) Dandan Huang et al.   EUROPEAN RADIOLOGY

Oligomers of Amyloid β Prevent Physiological Activation of the Cellular Prion Protein-Metabotropic Glutamate Receptor 5 Complex by Glutamate in Alzheimer Disease

(2016) Laura T. Haas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Diversity matters - heterogeneity of dopaminergic neurons in the ventral mesencephalon and its relation to Parkinson's Disease

(2016) Daniela Maria Vogt Weisenhorn et al.   JOURNAL OF NEUROCHEMISTRY

Deep brain stimulation mechanisms: the control of network activity via neurochemistry modulation

(2016) Cameron C. McIntyre et al.   JOURNAL OF NEUROCHEMISTRY

Mitochondrial dysfunction in Parkinson's disease

(2016) Anindita Bose et al.   JOURNAL OF NEUROCHEMISTRY

Dopaminergic Neurons Exhibit an Age-Dependent Decline in Electrophysiological Parameters in the MitoPark Mouse Model of Parkinson's Disease

(2016) S. Y. Branch et al.   JOURNAL OF NEUROSCIENCE

Aging Affects Dopaminergic Neural Mechanisms of Cognitive Flexibility

(2016) Anne S. Berry et al.   JOURNAL OF NEUROSCIENCE

Nonmotor symptoms in patients with Parkinson disease

(2016) Tie-mei Zhang et al.   MEDICINE

Age and Alzheimer’s disease gene expression profiles reversed by the glutamate modulator riluzole

(2016) A C Pereira et al.   MOLECULAR PSYCHIATRY

Genome-wide interaction study of brain beta-amyloid burden and cognitive impairment in Alzheimer’s disease

(2016) T Roostaei et al.   MOLECULAR PSYCHIATRY

Physiological neuronal decline in healthy aging human brain — An in vivo study with MRI and short echo-time whole-brain 1 H MR spectroscopic imaging

(2016) Xiao-Qi Ding et al.   NEUROIMAGE

Region-specific changes in presynaptic agmatine and glutamate levels in the aged rat brain

(2016) Y. Jing et al.   NEUROSCIENCE

Memory-enhancing and brain protein expression-stimulating effects of novel calcium antagonist in Alzheimer’s disease transgenic female mice

(2016) Baiba Jansone et al.   PHARMACOLOGICAL RESEARCH

A fixed-dose combination of memantine extended-release and donepezil in the treatment of moderate-to-severe Alzheimer’s disease

(2016) William James Deardorff et al.   Drug Design Development and Therapy

Nucleus basalis of Meynert revisited: anatomy, history and differential involvement in Alzheimer’s and Parkinson’s disease

(2015) Alan King Lun Liu et al.   ACTA NEUROPATHOLOGICA

Impact of Rivastigmine on Cognitive Dysfunction and Falling in Parkinson's Disease Patients

(2015) Zhenguang Li et al.   EUROPEAN NEUROLOGY

Therapeutic potential of the endoplasmic reticulum located and secreted CDNF/MANF family of neurotrophic factors in Parkinson's disease

(2015) Merja H. Voutilainen et al.   FEBS LETTERS

Dementia with Lewy bodies can be well-differentiated from Alzheimer's disease by measurement of brain acetylcholinesterase activity-a [11C]MP4A PET study

(2015) H. Shimada et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

Protection against Brain Atrophy by Anti-dementia Medication in Mild Cognitive Impairment and Alzheimer’s Disease: Meta-Analysis of Longitudinal Randomized Placebo-Controlled Trials

(2015) Taro Kishi et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Abnormal amygdala function in Parkinson's disease patients and its relationship to depression

(2015) Peiyu Huang et al.   JOURNAL OF AFFECTIVE DISORDERS

Riluzole rescues glutamate alterations, cognitive deficits, and tau pathology associated with P301L tau expression

(2015) Holly C. Hunsberger et al.   JOURNAL OF NEUROCHEMISTRY

Age-related gene expression changes in substantia nigra dopamine neurons of the rat

(2015) Gemma M. Parkinson et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Rivastigmine for mild cognitive impairment in Parkinson disease: A placebo-controlled study

(2015) Eugenia Mamikonyan et al.   MOVEMENT DISORDERS

Loss of calbindin-D 28K is associated with the full range of tangle pathology within basal forebrain cholinergic neurons in Alzheimer's disease

(2015) Saman S. Ahmadian et al.   NEUROBIOLOGY OF AGING

Posterior cingulate γ-aminobutyric acid and glutamate/glutamine are reduced in amnestic mild cognitive impairment and are unrelated to amyloid deposition and apolipoprotein E genotype

(2015) Florian Riese et al.   NEUROBIOLOGY OF AGING

Diversity of native nicotinic receptor subtypes in mammalian brain

(2015) Michele Zoli et al.   NEUROPHARMACOLOGY

Chronic Glutamate Toxicity in Neurodegenerative Diseases—What is the Evidence?

(2015) Jan Lewerenz et al.   Frontiers in Neuroscience

Memantine Monotherapy for Alzheimer’s Disease: A Systematic Review and Meta-Analysis

(2015) Shinji Matsunaga et al.   PLoS One

Memantine Attenuates Alzheimer’s Disease-Like Pathology and Cognitive Impairment

(2015) Xiaochuan Wang et al.   PLoS One

Ageing and Parkinson's disease: Why is advancing age the biggest risk factor?

(2014) Amy Reeve et al.   AGEING RESEARCH REVIEWS

Premotor and nonmotor features of Parkinsonʼs disease

(2014) Jennifer G. Goldman et al.   CURRENT OPINION IN NEUROLOGY

P301L tau expression affects glutamate release and clearance in the hippocampal trisynaptic pathway

(2014) Holly C. Hunsberger et al.   JOURNAL OF NEUROCHEMISTRY

Endogenous ACh suppresses LTD induction and nicotine relieves the suppression via different nicotinic ACh receptor subtypes in the mouse hippocampus

(2014) Sakura Nakauchi et al.   LIFE SCIENCES

Deep brain stimulation of the nucleus basalis of Meynert in Alzheimer’s dementia

(2014) J Kuhn et al.   MOLECULAR PSYCHIATRY

Abnormal functional connectivity of the amygdala is associated with depression in Parkinson's disease

(2014) Xiao Hu et al.   MOVEMENT DISORDERS

Estrogen receptors’ neuroprotective effect against glutamate-induced neurotoxicity

(2014) Yu-Long Lan et al.   NEUROLOGICAL SCIENCES

Structural and Molecular Remodeling of Dendritic Spine Substructures during Long-Term Potentiation

(2014) Miquel Bosch et al.   NEURON

Beta-amyloid oligomers induce early loss of presynaptic proteins in primary neurons by caspase-dependent and proteasome-dependent mechanisms

(2014) Bong Geum Jang et al.   NEUROREPORT

What is normal in normal aging? Effects of aging, amyloid and Alzheimer's disease on the cerebral cortex and the hippocampus

(2014) Anders M. Fjell et al.   PROGRESS IN NEUROBIOLOGY

mGlu5 receptors and cellular prion protein mediate amyloid-β-facilitated synaptic long-term depression in vivo

(2014) Neng-Wei Hu et al.   Nature Communications

M1 muscarinic acetylcholine receptor in Alzheimer’s disease

(2014) Shangtong Jiang et al.   Neuroscience Bulletin

Alzheimer’s disease drug-development pipeline: few candidates, frequent failures

(2014) Jeffrey L Cummings et al.   Alzheimers Research & Therapy

“Is dopamine involved in Alzheimer's disease?”

(2014) Alessandro Martorana et al.   Frontiers in Aging Neuroscience

α7 Nicotinic Receptor Agonist Enhances Cognition in Aged 3xTg-AD Mice with Robust Plaques and Tangles

(2013) Rodrigo Medeiros et al.   AMERICAN JOURNAL OF PATHOLOGY

Differential behavioral reinforcement effects of dopamine receptor agonists in the rat with bilateral lesion of the posterior ventral tegmental area

(2013) Omar Ouachikh et al.   BEHAVIOURAL BRAIN RESEARCH

Alterations in α4β2 nicotinic receptors in cognitive decline in Alzheimer’s aetiopathology

(2013) Hiroyuki Okada et al.   BRAIN

The Safety, Tolerability, and Efficacy of Once-Daily Memantine (28 mg): A Multinational, Randomized, Double-Blind, Placebo-Controlled Trial in Patients with Moderate-to-Severe Alzheimer’s Disease Taking Cholinesterase Inhibitors

(2013) George T. Grossberg et al.   CNS DRUGS

Effects of age and sex on the concentrations of glutamate and glutamine in the human brain

(2013) Sven Hädel et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Amyloid- 1-42 Slows Clearance of Synaptically Released Glutamate by Mislocalizing Astrocytic GLT-1

(2013) A. Scimemi et al.   JOURNAL OF NEUROSCIENCE

Control of Basal Ganglia Output by Direct and Indirect Pathway Projection Neurons

(2013) B. S. Freeze et al.   JOURNAL OF NEUROSCIENCE

Neurophysiology of gait: From the spinal cord to the frontal lobe

(2013) Kaoru Takakusaki   MOVEMENT DISORDERS

Calcineurin Inhibition Rescues Early Synaptic Plasticity Deficits in a Mouse Model of Alzheimer’s Disease

(2013) Virve Cavallucci et al.   NEUROMOLECULAR MEDICINE

Predominant loss of glutamatergic terminal markers in a β-amyloid peptide model of Alzheimer's disease

(2013) Paula M. Canas et al.   NEUROPHARMACOLOGY

Enhancement of long-term depression by soluble amyloid β protein in rat hippocampus is mediated by metabotropic glutamate receptor and involves activation of p38MAPK, STEP and caspase-3

(2013) X. Chen et al.   NEUROSCIENCE

Memantine and Cholinesterase Inhibitors: Complementary Mechanisms in the Treatment of Alzheimer’s Disease

(2013) Chris G. Parsons et al.   NEUROTOXICITY RESEARCH

GDNF, NGF and BDNF as therapeutic options for neurodegeneration

(2013) Shelley J. Allen et al.   PHARMACOLOGY & THERAPEUTICS

A  induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss

(2013) M. Talantova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial dysfunction and oxidative stress in Parkinson's disease

(2013) Sudhakar Raja Subramaniam et al.   PROGRESS IN NEUROBIOLOGY

A cholinergic trigger drives learning-induced plasticity at hippocampal synapses

(2013) Dai Mitsushima et al.   Nature Communications

Memantine in patients with Alzheimer's disease receiving donepezil: new analyses of efficacy and safety for combination therapy

(2013) Alireza Atri et al.   Alzheimers Research & Therapy

Neuropathological Alterations in Alzheimer Disease

(2013) A. Serrano-Pozo et al.   Cold Spring Harbor Perspectives in Medicine

Functional Neuroanatomy of the Basal Ganglia

(2013) J. L. Lanciego et al.   Cold Spring Harbor Perspectives in Medicine

Role of metabotropic glutamate receptor 5 signaling and homer in oxygen glucose deprivation-mediated astrocyte apoptosis

(2013) Maryse Paquet et al.   Molecular Brain

A Dual Mechanism Linking NGF/proNGF Imbalance and Early Inflammation to Alzheimer's Disease Neurodegeneration in the AD11 Anti-NGF Mouse Model

(2012) S. Capsoni et al.   CNS & Neurological Disorders-Drug Targets

Endogenously released ACh and exogenous nicotine differentially facilitate long-term potentiation induction in the hippocampal CA1 region of mice

(2012) Sakura Nakauchi et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Cholinergic Deficit and Response to Donepezil Therapy in Parkinson’s Disease with Dementia

(2012) Kotaro Hiraoka et al.   EUROPEAN NEUROLOGY

Impact of the NGF Maturation and Degradation Pathway on the Cortical Cholinergic System Phenotype

(2012) S. Allard et al.   JOURNAL OF NEUROSCIENCE

Glutamate system, amyloid β peptides and tau protein: functional interrelationships and relevance to Alzheimer disease pathology

(2012) Timothy Revett et al.   JOURNAL OF PSYCHIATRY & NEUROSCIENCE

Longitudinal measures of cholinergic forebrain atrophy in the transition from healthy aging to Alzheimer's disease

(2012) Michel Grothe et al.   NEUROBIOLOGY OF AGING

Acetylcholine as a Neuromodulator: Cholinergic Signaling Shapes Nervous System Function and Behavior

(2012) Marina R. Picciotto et al.   NEURON

Synaptic changes in Alzheimer’s disease and its models

(2012) J. Pozueta et al.   NEUROSCIENCE

Thalamic cholinergic innervation is spared in Alzheimer disease compared to parkinsonian disorders

(2012) Vikas Kotagal et al.   NEUROSCIENCE LETTERS

Donepezil and Memantine for Moderate-to-Severe Alzheimer's Disease

(2012) Robert Howard et al.   NEW ENGLAND JOURNAL OF MEDICINE

Defects in Mitochondrial Dynamics and Metabolomic Signatures of Evolving Energetic Stress in Mouse Models of Familial Alzheimer's Disease

(2012) Eugenia Trushina et al.   PLoS One

Postsynaptic signaling during plasticity of dendritic spines

(2012) Hideji Murakoshi et al.   TRENDS IN NEUROSCIENCES

NMDA Receptor-Dependent Long-Term Potentiation and Long-Term Depression (LTP/LTD)

(2012) C. Luscher et al.   Cold Spring Harbor Perspectives in Biology

Nigral pathology and parkinsonian signs in elders without Parkinson disease

(2011) Aron S. Buchman et al.   ANNALS OF NEUROLOGY

Mitochondria and Programmed Cell Death in Parkinson's Disease: Apoptosis and Beyond

(2011) Celine Perier et al.   ANTIOXIDANTS & REDOX SIGNALING

Aβ Oligomers Induce Glutamate Release from Hippocampal Neurons

(2011) J. Brito-Moreira et al.   Current Alzheimer Research

D1 and D2 dopaminergic systems in the rat basolateral amygdala are involved in anxiogenic-like effects induced by histamine

(2011) Maryam Bananej et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Addiction: Beyond dopamine reward circuitry

(2011) N. D. Volkow et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neurotoxicity Induced by Okadaic Acid in the Human Neuroblastoma SH-SY5Y Line Can Be Differentially Prevented by α7 and β2* Nicotinic Stimulation

(2011) Laura del Barrio et al.   TOXICOLOGICAL SCIENCES

Ageing, neurodegeneration and Parkinson's disease

(2010) J. V. Hindle   AGE AND AGEING

Reduction in glutamate uptake is associated with extrasynaptic NMDA and metabotropic glutamate receptor activation at the hippocampal CA1 synapse of aged rats

(2010) Brigitte Potier et al.   AGING CELL

AIF deficiency sensitizes dopaminergic neurons to parkinsonian neurotoxins

(2010) Celine Perier et al.   ANNALS OF NEUROLOGY

Metabotropic Glutamate Receptors: Physiology, Pharmacology, and Disease

(2010) Colleen M. Niswender et al.   Annual Review of Pharmacology and Toxicology

The cholinergic system, nerve growth factor and the cytoskeleton

(2010) Grazyna Niewiadomska et al.   BEHAVIOURAL BRAIN RESEARCH

The cholinergic system and Parkinson disease

(2010) Nicolaas I. Bohnen et al.   BEHAVIOURAL BRAIN RESEARCH

The cholinergic system in aging and neuronal degeneration

(2010) Reinhard Schliebs et al.   BEHAVIOURAL BRAIN RESEARCH

Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models

(2010) Lars M. Ittner et al.   CELL

D2 dopamine receptors interact directly with N-type calcium channels and regulate channel surface expression levels

(2010) Alexandra E. Kisilevsky et al.   Channels

Cholinergic mesencephalic neurons are involved in gait and postural disorders in Parkinson disease

(2010) Carine Karachi et al.   JOURNAL OF CLINICAL INVESTIGATION

Dysregulation of striatal dopamine release in a mouse model of dystonia

(2010) Li Bao et al.   JOURNAL OF NEUROCHEMISTRY

Group II Metabotropic Glutamate Receptor Stimulation Triggers Production and Release of Alzheimer's Amyloid  42 from Isolated Intact Nerve Terminals

(2010) S. H. Kim et al.   JOURNAL OF NEUROSCIENCE

Dopaminergic Terminals in the Nucleus Accumbens But Not the Dorsal Striatum Corelease Glutamate

(2010) G. D. Stuber et al.   JOURNAL OF NEUROSCIENCE

Activation of Extrasynaptic, But Not Synaptic, NMDA Receptors Modifies Amyloid Precursor Protein Expression Pattern and Increases Amyloid-  Production

(2010) K. Bordji et al.   JOURNAL OF NEUROSCIENCE

Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders

(2010) Giles E. Hardingham et al.   NATURE REVIEWS NEUROSCIENCE

Long-term depression in the CNS

(2010) Graham L. Collingridge et al.   NATURE REVIEWS NEUROSCIENCE

Glutamate transporter variants reduce glutamate uptake in Alzheimer's disease

(2010) Heather A. Scott et al.   NEUROBIOLOGY OF AGING

Tau Mislocalization to Dendritic Spines Mediates Synaptic Dysfunction Independently of Neurodegeneration

(2010) Brian R. Hoover et al.   NEURON

Dissecting the involvement of tropomyosin-related kinase A and p75 neurotrophin receptor signaling in NGF deficit-induced neurodegeneration

(2010) S. Capsoni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synaptic degeneration in Alzheimer’s disease

(2009) Thomas Arendt   ACTA NEUROPATHOLOGICA

Early Tau Pathology Involving the Septo-Hippocampal Pathway in a Tau Transgenic Model: Relevance to Alzheimers Disease

(2009) Karim Belarbi et al.   Current Alzheimer Research

Chronic nicotine restores normal Aβ levels and prevents short-term memory and E-LTP impairment in Aβ rat model of Alzheimer's disease

(2009) Marisa Srivareerat et al.   NEUROBIOLOGY OF AGING

Age-related changes in glutamate release in the CA3 and dentate gyrus of the rat hippocampus

(2009) Michelle L. Stephens et al.   NEUROBIOLOGY OF AGING

Network perspectives on the mechanisms of deep brain stimulation

(2009) Cameron C. McIntyre et al.   NEUROBIOLOGY OF DISEASE

Interplay between Cytosolic Dopamine, Calcium, and α-Synuclein Causes Selective Death of Substantia Nigra Neurons

(2009) Eugene V. Mosharov et al.   NEURON

Dopamine Modulates Cholinergic Cortical Excitability in Alzheimer's Disease Patients

(2009) Alessandro Martorana et al.   NEUROPSYCHOPHARMACOLOGY

Memantine treatment decreases levels of secreted Alzheimer's amyloid precursor protein (APP) and amyloid beta (Aβ) peptide in the human neuroblastoma cells

(2009) Balmiki Ray et al.   NEUROSCIENCE LETTERS

Mammalian Nicotinic Acetylcholine Receptors: From Structure to Function

(2009) Edson X. Albuquerque et al.   PHYSIOLOGICAL REVIEWS

Regional analysis of age-related decline in dopamine transporters and dopamine D2-like receptors in human striatum

(2009) Kenji Ishibashi et al.   SYNAPSE

The structural basis for mapping behavior onto the ventral striatum and its subdivisions

(2008) Gloria E. Meredith et al.   Brain Structure & Function

Memantine Treatment in Patients with Mild to Moderate Alzheimers Disease Already Receiving a Cholinesterase Inhibitor: A Randomized, Double-Blind, Placebo-Controlled Trial

(2008) Anton Porsteinsson et al.   Current Alzheimer Research

Memantine protects rat cortical cultured neurons against β-amyloid-induced toxicity by attenuating tau phosphorylation

(2008) M. S. Song et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Neuronal activity in the subthalamic nucleus modulates the release of dopamine in the monkey striatum

(2008) Yasushi Shimo et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Neuronal pigmented autophagic vacuoles: lipofuscin, neuromelanin, and ceroid as macroautophagic responses during aging and disease

(2008) David Sulzer et al.   JOURNAL OF NEUROCHEMISTRY

Cholinergic Neuronal and Axonal Abnormalities Are Present Early in Aging and in Alzheimer Disease

(2008) Changiz Geula et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Preservation of Neuronal Number Despite Age-Related Cortical Brain Atrophy in Elderly Subjects Without Alzheimer Disease

(2008) Stefanie H. Freeman et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Relationship of Striatal Dopamine Synthesis Capacity to Age and Cognition

(2008) M. N. Braskie et al.   JOURNAL OF NEUROSCIENCE

Effects of age and sex on brain glutamate and other metabolites

(2008) Linda Chang et al.   MAGNETIC RESONANCE IMAGING

Age-related decline in nicotinic receptor availability with [123I]5-IA-85380 SPECT

(2008) Effie M. Mitsis et al.   NEUROBIOLOGY OF AGING

Cognitive profiles in dementia: Alzheimer disease vs healthy brain aging

(2008) D. K. Johnson et al.   NEUROLOGY

Specific impairments in visuospatial working and short-term memory following low-dose scopolamine challenge in healthy older adults

(2008) Elizabeth Thomas et al.   NEUROPSYCHOLOGIA

Age-related changes in midbrain dopaminergic regulation of the human reward system

(2008) J.-C. Dreher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid β-peptide activates nuclear factor-κB through an N-methyl-D-aspartate signaling pathway in cultured cerebellar cells

(2007) E. M. Kawamoto et al.   JOURNAL OF NEUROSCIENCE RESEARCH