Diversity matters - heterogeneity of dopaminergic neurons in the ventral mesencephalon and its relation to Parkinson's Disease

Communication in Neural Circuits: Tools, Opportunities, and Challenges

(2016) Talia N. Lerner et al.   CELL

Multiplexed neurochemical signaling by neurons of the ventral tegmental area

(2016) David J. Barker et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Mechanisms and functions of GABA co-release

(2016) Nicolas X. Tritsch et al.   NATURE REVIEWS NEUROSCIENCE

Variation is function: Are single cell differences functionally important?

(2015) Hannah Dueck et al.   BIOESSAYS

Circuit Architecture of VTA Dopamine Neurons Revealed by Systematic Input-Output Mapping

(2015) Kevin T. Beier et al.   CELL

Intact-Brain Analyses Reveal Distinct Information Carried by SNc Dopamine Subcircuits

(2015) Talia N. Lerner et al.   CELL

A Corticostriatal Path Targeting Striosomes Controls Decision-Making under Conflict

(2015) Alexander Friedman et al.   CELL

Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets

(2015) Evan Z. Macosko et al.   CELL

Elevated Mitochondrial Bioenergetics and Axonal Arborization Size Are Key Contributors to the Vulnerability of Dopamine Neurons

(2015) Consiglia Pacelli et al.   CURRENT BIOLOGY

How to make a midbrain dopaminergic neuron

(2015) E. Arenas et al.   DEVELOPMENT

Glutamatergic and dopaminergic neurons in the mouse ventral tegmental area

(2015) Tsuyoshi Yamaguchi et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Molecular heterogeneity of midbrain dopaminergic neurons - Moving toward single cell resolution

(2015) Angela Anderegg et al.   FEBS LETTERS

Establishing diversity in the dopaminergic system

(2015) Gabriela O. Bodea et al.   FEBS LETTERS

Functional disruption of the dystrophin gene in rhesus monkey using CRISPR/Cas9

(2015) Yongchang Chen et al.   HUMAN MOLECULAR GENETICS

Functional Connectome Analysis of Dopamine Neuron Glutamatergic Connections in Forebrain Regions

(2015) S. Mingote et al.   JOURNAL OF NEUROSCIENCE

Substance P Weights Striatal Dopamine Transmission Differently within the Striosome-Matrix Axis

(2015) K. R. Brimblecombe et al.   JOURNAL OF NEUROSCIENCE

Monosynaptic Circuit Tracing with Glycoprotein-Deleted Rabies Viruses

(2015) E. M. Callaway et al.   JOURNAL OF NEUROSCIENCE

Epigenetic mechanisms in Parkinson's disease

(2015) Ya Feng et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Apathy in Parkinson's disease: clinical features, neural substrates, diagnosis, and treatment

(2015) Javier Pagonabarraga et al.   LANCET NEUROLOGY

Beyond knockouts: the International Knockout Mouse Consortium delivers modular and evolving tools for investigating mammalian genes

(2015) B. Rosen et al.   MAMMALIAN GENOME

CRISPR/Cas9: a powerful genetic engineering tool for establishing large animal models of neurodegenerative diseases

(2015) Zhuchi Tu et al.   Molecular Neurodegeneration

Alpha-synuclein propagation: New insights from animal models

(2015) Benjamin Dehay et al.   MOVEMENT DISORDERS

Viral-genetic tracing of the input–output organization of a central noradrenaline circuit

(2015) Lindsay A. Schwarz et al.   NATURE

Integration of electrophysiological recordings with single-cell RNA-seq data identifies neuronal subtypes

(2015) János Fuzik et al.   NATURE BIOTECHNOLOGY

Dopaminergic and glutamatergic microdomains in a subset of rodent mesoaccumbens axons

(2015) Shiliang Zhang et al.   NATURE NEUROSCIENCE

Molecular characterization of neuronal cell types based on patterns of projection with Retro-TRAP

(2015) Alexander R Nectow et al.   Nature Protocols

A WNT1-regulated developmental gene cascade prevents dopaminergic neurodegeneration in adult En1+/− mice

(2015) Jingzhong Zhang et al.   NEUROBIOLOGY OF DISEASE

Animal models of Parkinson's disease: An updated overview

(2015) P. Gubellini et al.   REVUE NEUROLOGIQUE

Aldehyde dehydrogenase 1a1 mediates a GABA synthesis pathway in midbrain dopaminergic neurons

(2015) J.-I. Kim et al.   SCIENCE

Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq

(2015) A. Zeisel et al.   SCIENCE

Somatic mutation in single human neurons tracks developmental and transcriptional history

(2015) M. A. Lodato et al.   SCIENCE

Parkinson’s disease: From human genetics to clinical trials

(2015) Marcel P. van der Brug et al.   Science Translational Medicine

Progress in unraveling the genetic etiology of Parkinson disease in a genomic era

(2015) Aline Verstraeten et al.   TRENDS IN GENETICS

Cre-driven optogenetics in the heterogeneous genetic panorama of the VTA

(2015) Stéfano Pupe et al.   TRENDS IN NEUROSCIENCES

Dopamine neurons projecting to the posterior striatum form an anatomically distinct subclass

(2015) William Menegas et al.   eLife

Deep sequencing reveals cell-type-specific patterns of single-cell transcriptome variation

(2015) Hannah Dueck et al.   GENOME BIOLOGY

Substantia Nigra and Parkinson's Disease: A Brief History of Their Long and Intimate Relationship

(2014) Martin Parent et al.   CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES

Molecular Profiling of Neurons Based on Connectivity

(2014) Mats I. Ekstrand et al.   CELL

Generation of Gene-Modified Cynomolgus Monkey via Cas9/RNA-Mediated Gene Targeting in One-Cell Embryos

(2014) Yuyu Niu et al.   CELL

Molecular mechanisms of dopaminergic subset specification: fundamental aspects and clinical perspectives

(2014) Jesse V. Veenvliet et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Aldehyde dehydrogenase 1 defines and protects a nigrostriatal dopaminergic neuron subpopulation

(2014) Guoxiang Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

Evidence for topographic guidance of dopaminergic axons by differential Netrin-1 expression in the striatum

(2014) Jie Li et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Four pioneers of L-dopa treatment: Arvid Carlsson, Oleh Hornykiewicz, George Cotzias, and Melvin Yahr

(2014) Andrew J. Lees et al.   MOVEMENT DISORDERS

Transcriptome in vivo analysis (TIVA) of spatially defined single cells in live tissue

(2014) Ditte Lovatt et al.   NATURE METHODS

Single rodent mesohabenular axons release glutamate and GABA

(2014) David H Root et al.   NATURE NEUROSCIENCE

Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing

(2014) Dmitry Usoskin et al.   NATURE NEUROSCIENCE

Mobile DNA elements in the generation of diversity and complexity in the brain

(2014) Jennifer A. Erwin et al.   NATURE REVIEWS NEUROSCIENCE

Dopamine Neurons Control Striatal Cholinergic Neurons via Regionally Heterogeneous Dopamine and Glutamate Signaling

(2014) Nao Chuhma et al.   NEURON

The place of dopamine in the cortico-basal ganglia circuit

(2014) S.N. Haber   NEUROSCIENCE

An update on the connections of the ventral mesencephalic dopaminergic complex

(2014) L. Yetnikoff et al.   NEUROSCIENCE

Targeting Wnt signaling at the neuroimmune interface for dopaminergic neuroprotection/repair in Parkinson's disease

(2014) Francesca L'Episcopo et al.   Journal of Molecular Cell Biology

Molecular determinants of selective dopaminergic vulnerability in Parkinson’s disease: an update

(2014) Lars Brichta et al.   Frontiers in Neuroanatomy

Sox6 and Otx2 Control the Specification of Substantia Nigra and Ventral Tegmental Area Dopamine Neurons

(2014) Lia Panman et al.   Cell Reports

Single-Cell, Genome-wide Sequencing Identifies Clonal Somatic Copy-Number Variation in the Human Brain

(2014) Xuyu Cai et al.   Cell Reports

Defining Midbrain Dopaminergic Neuron Diversity by Single-Cell Gene Expression Profiling

(2014) Jean-Francois Poulin et al.   Cell Reports

Gambling Disorder during Dopamine Replacement Treatment in Parkinson’s Disease: A Comprehensive Review

(2014) Domenico Pirritano et al.   Biomed Research International

Aldehyde Dehydrogenase 1 making molecular inroads into the differential vulnerability of nigrostriatal dopaminergic neuron subtypes in Parkinson’s disease

(2014) Huaibin Cai et al.   Translational Neurodegeneration

Disease duration and the integrity of the nigrostriatal system in Parkinson’s disease

(2013) Jeffrey H. Kordower et al.   BRAIN

Variability in neuronal expression of dopamine receptors and transporters in the substantia nigra

(2013) Stefanie Reyes et al.   MOVEMENT DISORDERS

Distribution, recognition and regulation of non-CpG methylation in the adult mammalian brain

(2013) Junjie U Guo et al.   NATURE NEUROSCIENCE

A Unique Population of Ventral Tegmental Area Neurons Inhibits the Lateral Habenula to Promote Reward

(2013) Alice M. Stamatakis et al.   NEURON

Expression Analysis of Lrrk1, Lrrk2 and Lrrk2 Splice Variants in Mice

(2013) Florian Giesert et al.   PLoS One

Mosaic Copy Number Variation in Human Neurons

(2013) M. J. McConnell et al.   SCIENCE

Dissecting the diversity of midbrain dopamine neurons

(2013) Jochen Roeper   TRENDS IN NEUROSCIENCES

Wnt1-regulated genetic networks in midbrain dopaminergic neuron development

(2013) W. Wurst et al.   Journal of Molecular Cell Biology

The search for genetic mouse models of prodromal Parkinson's disease

(2012) Gaynor A. Smith et al.   EXPERIMENTAL NEUROLOGY

GIRK2 expression in dopamine neurons of the substantia nigra and ventral tegmental area

(2012) Stefanie Reyes et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Mouse models of Parkinson's disease associated with mitochondrial dysfunction

(2012) Alicia M. Pickrell et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Dopaminergic neurons inhibit striatal output through non-canonical release of GABA

(2012) Nicolas X. Tritsch et al.   NATURE

Input-specific control of reward and aversion in the ventral tegmental area

(2012) Stephan Lammel et al.   NATURE

Localized microstimulation of primate pregenual cingulate cortex induces negative decision-making

(2012) Ken-ichi Amemori et al.   NATURE NEUROSCIENCE

Trophic factors differentiate dopamine neurons vulnerable to Parkinson's disease

(2012) Stefanie Reyes et al.   NEUROBIOLOGY OF AGING

Whole-Brain Mapping of Direct Inputs to Midbrain Dopamine Neurons

(2012) Mitsuko Watabe-Uchida et al.   NEURON

Dopaminergic axon guidance: which makes what?

(2012) Laetitia Prestoz et al.   Frontiers in Cellular Neuroscience

Longitudinal evolution of compensatory changes in striatal dopamine processing in Parkinson's disease

(2011) Ramachandiran Nandhagopal et al.   BRAIN

A cytoarchitectonic and chemoarchitectonic analysis of the dopamine cell groups in the substantia nigra, ventral tegmental area, and retrorubral field in the mouse

(2011) YuHong Fu et al.   Brain Structure & Function

Functional Connectome of the Striatal Medium Spiny Neuron

(2011) N. Chuhma et al.   JOURNAL OF NEUROSCIENCE

Mesocorticolimbic Glutamatergic Pathway

(2011) T. Yamaguchi et al.   JOURNAL OF NEUROSCIENCE

A Wnt1 regulated Frizzled-1/β-Catenin signaling pathway as a candidate regulatory circuit controlling mesencephalic dopaminergic neuron-astrocyte crosstalk: Therapeutical relevance for neuron survival and neuroprotection

(2011) Francesca L'Episcopo et al.   Molecular Neurodegeneration

From glutamate co-release to vesicular synergy: vesicular glutamate transporters

(2011) Salah El Mestikawy et al.   NATURE REVIEWS NEUROSCIENCE

Projection-Specific Modulation of Dopamine Neuron Synapses by Aversive and Rewarding Stimuli

(2011) Stephan Lammel et al.   NEURON

Inputs to the Dorsal Striatum of the Mouse Reflect the Parallel Circuit Architecture of the Forebrain

(2011) Weixing X. Pan et al.   Frontiers in Neuroanatomy

Basal Ganglia Disorders Associated with Imbalances in the Striatal Striosome and Matrix Compartments

(2011) Jill R. Crittenden et al.   Frontiers in Neuroanatomy

Dopaminergic Terminals in the Nucleus Accumbens But Not the Dorsal Striatum Corelease Glutamate

(2010) G. D. Stuber et al.   JOURNAL OF NEUROSCIENCE

Glutamatergic Signaling by Mesolimbic Dopamine Neurons in the Nucleus Accumbens

(2010) F. Tecuapetla et al.   JOURNAL OF NEUROSCIENCE

Otx2 controls neuron subtype identity in ventral tegmental area and antagonizes vulnerability to MPTP

(2010) Michela Di Salvio et al.   NATURE NEUROSCIENCE

Reactive astrocytes and Wnt/β-catenin signaling link nigrostriatal injury to repair in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease

(2010) F. L'Episcopo et al.   NEUROBIOLOGY OF DISEASE

Genetic Animal Models of Parkinson's Disease

(2010) Ted M. Dawson et al.   NEURON

Selective cell death in neurodegeneration: Why are some neurons spared in vulnerable regions?

(2010) K.L. Double et al.   PROGRESS IN NEUROBIOLOGY

DJ-1-deficient mice show less TH-positive neurons in the ventral tegmental area and exhibit non-motoric behavioural impairments

(2009) T. T. Pham et al.   GENES BRAIN AND BEHAVIOR

Otx2 expression is restricted to dopaminergic neurons of the ventral tegmental area in the adult brain

(2009) Michela Di Salvio et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Single Nigrostriatal Dopaminergic Neurons Form Widely Spread and Highly Dense Axonal Arborizations in the Neostriatum

(2009) W. Matsuda et al.   JOURNAL OF NEUROSCIENCE

Two types of dopamine neuron distinctly convey positive and negative motivational signals

(2009) Masayuki Matsumoto et al.   NATURE

mRNA-Seq whole-transcriptome analysis of a single cell

(2009) Fuchou Tang et al.   NATURE METHODS

Dopamine transporter glycosylation correlates with the vulnerability of midbrain dopaminergic cells in Parkinson's disease

(2009) Domingo Afonso-Oramas et al.   NEUROBIOLOGY OF DISEASE

The description of all four cardinal signs of Parkinson's disease in a Hungarian medical text published in 1690

(2009) Dániel Bereczki   PARKINSONISM & RELATED DISORDERS

Unique Properties of Mesoprefrontal Neurons within a Dual Mesocorticolimbic Dopamine System

(2008) Stephan Lammel et al.   NEURON