NaCT/SLC13A5 facilitates citrate import and metabolism under nutrient-limited conditions

CRISPR screens in physiologic medium reveal conditionally essential genes in human cells

(2021) Nicholas J. Rossiter et al.   Cell Metabolism

Structure and inhibition mechanism of the human citrate transporter NaCT

(2021) David B. Sauer et al.   NATURE

Escher-Trace: a web application for pathway-based visualization of stable isotope tracing data

(2020) Avi Kumar et al.   BMC BIOINFORMATICS

Neonatal developmental and epileptic encephalopathy due to autosomal recessive variants in SLC13A5 gene

(2020) Sara Matricardi et al.   EPILEPSIA

Disruption of the sodium-dependent citrate transporter SLC13A5 in mice causes alterations in brain citrate levels and neuronal network excitability in the hippocampus

(2020) Christine Henke et al.   NEUROBIOLOGY OF DISEASE

Extracellular serine and glycine are required for mouse and human skeletal muscle stem and progenitor cell function

(2020) Brandon J. Gheller et al.   Molecular Metabolism

Improving the metabolic fidelity of cancer models with a physiological cell culture medium

(2019) Johan Vande Voorde et al.   Science Advances

Peptide YY (PYY) Is Expressed in Human Skeletal Muscle Tissue and Expanding Human Muscle Progenitor Cells

(2019) Brandon J. Gheller et al.   Frontiers in Physiology

Itaconate modulates tricarboxylic acid and redox metabolism to mitigate reperfusion injury

(2019) Thekla Cordes et al.   Molecular Metabolism

Extracellular Citrate Affects Critical Elements of Cancer Cell Metabolism and Supports Cancer DevelopmentIn Vivo

(2018) Maria E. Mycielska et al.   CANCER RESEARCH

CRISPOR: intuitive guide selection for CRISPR/Cas9 genome editing experiments and screens

(2018) Jean-Paul Concordet et al.   NUCLEIC ACIDS RESEARCH

Combination of Mitochondrial and Plasma Membrane Citrate Transporter Inhibitors Inhibits De Novo Lipogenesis Pathway and Triggers Apoptosis in Hepatocellular Carcinoma Cells

(2018) Wan-angkan Poolsri et al.   Biomed Research International

Suppressed de novo lipogenesis by plasma membrane citrate transporter inhibitor promotes apoptosis in HepG2 cells

(2018) Phornpun Phokrai et al.   FEBS Open Bio

Expansion capacity of human muscle progenitor cells differs by age, sex, and metabolic fuel preference

(2018) Emily S Riddle et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Accumulation of succinate controls activation of adipose tissue thermogenesis

(2018) Evanna L. Mills et al.   NATURE

The human longevity gene homolog INDY and interleukin-6 interact in hepatic lipid metabolism

(2017) Christian von Loeffelholz et al.   HEPATOLOGY

Silencing of solute carrier family 13 member 5 disrupts energy homeostasis and inhibits proliferation of human hepatocarcinoma cells

(2017) Zhihui Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of the mitochondrial pyruvate carrier protects from excitotoxic neuronal death

(2017) Ajit S. Divakaruni et al.   JOURNAL OF CELL BIOLOGY

Quantitative metabolic flux analysis reveals an unconventional pathway of fatty acid synthesis in cancer cells deficient for the mitochondrial citrate transport protein

(2017) Lei Jiang et al.   METABOLIC ENGINEERING

Analyses of SLC13A5 -epilepsy patients reveal perturbations of TCA cycle

(2017) Matthew N. Bainbridge et al.   MOLECULAR GENETICS AND METABOLISM

Plasma Membrane Na+-Coupled Citrate Transporter (SLC13A5) and Neonatal Epileptic Encephalopathy

(2017) Yangzom Bhutia et al.   MOLECULES

Database resources of the National Center for Biotechnology Information

(2017) et al.   NUCLEIC ACIDS RESEARCH

A novel mechanism for the pyruvate protection against zinc-induced cytotoxicity: mediation by the chelating effect of citrate and isocitrate

(2016) Jee-Won Sul et al.   ARCHIVES OF PHARMACAL RESEARCH

Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer

(2016) Shawn M. Davidson et al.   Cell Metabolism

SLC13A5is the second gene associated with Kohlschütter–Tönz syndrome

(2016) Anna Schossig et al.   JOURNAL OF MEDICAL GENETICS

Mutations in the Na+/Citrate Cotransporter NaCT (SLC13A5) in Pediatric Patients with Epilepsy and Developmental Delay

(2016) Jenna Klotz et al.   MOLECULAR MEDICINE

Reductive carboxylation supports redox homeostasis during anchorage-independent growth

(2016) Lei Jiang et al.   NATURE

Recessive mutations inSLC13A5result in a loss of citrate transport and cause neonatal epilepsy, developmental delay and teeth hypoplasia

(2015) Katia Hardies et al.   BRAIN

Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma

(2015) Saverio Tardito et al.   NATURE CELL BIOLOGY

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

Discovery and characterization of novel inhibitors of the sodium-coupled citrate transporter (NaCT or SLC13A5)

(2015) Kim Huard et al.   Scientific Reports

Mutations in SLC13A5 Cause Autosomal-Recessive Epileptic Encephalopathy with Seizure Onset in the First Days of Life

(2014) Julien Thevenon et al.   AMERICAN JOURNAL OF HUMAN GENETICS

INCA: a computational platform for isotopically non-stationary metabolic flux analysis

(2014) J. D. Young   BIOINFORMATICS

IDH1 Mutations Alter Citric Acid Cycle Metabolism and Increase Dependence on Oxidative Mitochondrial Metabolism

(2014) A. R. Grassian et al.   CANCER RESEARCH

Regulation of Substrate Utilization by the Mitochondrial Pyruvate Carrier

(2014) Nathaniel M. Vacanti et al.   MOLECULAR CELL

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

Glutamine-driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxia

(2013) J. Fan et al.   Molecular Systems Biology

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

(2013) Jaekyoung Son et al.   NATURE

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Sodium-coupled dicarboxylate and citrate transporters from the SLC13 family

(2013) Ana M. Pajor   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Glucose-Independent Glutamine Metabolism via TCA Cycling for Proliferation and Survival in B Cells

(2012) Anne Le et al.   Cell Metabolism

Deletion of the Mammalian INDY Homolog Mimics Aspects of Dietary Restriction and Protects against Adiposity and Insulin Resistance in Mice

(2011) Andreas L. Birkenfeld et al.   Cell Metabolism

Reductive carboxylation supports growth in tumour cells with defective mitochondria

(2011) Andrew R. Mullen et al.   NATURE

Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

(2011) Christian M. Metallo et al.   NATURE

Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of  -ketoglutarate to citrate to support cell growth and viability

(2011) D. R. Wise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fatty acid metabolism: target for metabolic syndrome

(2008) Salih J. Wakil et al.   JOURNAL OF LIPID RESEARCH

Zinc toxicity alters mitochondrial metabolism and leads to decreased ATP production in hepatocytes

(2007) Joseph Lemire et al.   JOURNAL OF APPLIED TOXICOLOGY