期刊
CELL REPORTS
卷 36, 期 3, 页码 -出版社
CELL PRESS
DOI: 10.1016/j.celrep.2021.109422
关键词
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类别
资金
- USPHS [P30 CA44579, CA78400, CA181794, AI007496, GM007267, CA163177]
- University of Virginia Cancer Center Schiff Foundation
- Farrow Fellowship from the University of Virginia
- Wagner Fellowship from the University of Virginia
The study reveals that the development of tumor-associated tertiary lymphoid structures (TA-TLS) is orchestrated by cancer-associated fibroblasts (CAF) with characteristics of lymphoid tissue organizer cells, mediated by CD8 T cells and CXCL13-mediated recruitment of B cells. The presence and size of TA-TLS are correlated with reduced tumor size and overall response to checkpoint immunotherapy, providing a potential platform for cancer immunotherapy strategy.
Tumor-associated tertiary lymphoid structures (TA-TLS) are associated with enhanced patient survival and responsiveness to cancer therapies, but the mechanisms underlying their development are unknown. We show here that TA-TLS development in murine melanoma is orchestrated by cancer-associated fibroblasts (CAF) with characteristics of lymphoid tissue organizer cells that are induced by tumor necrosis factor receptor signaling. CAF organization into reticular networks is mediated by CD8 T cells, while CAF accumulation and TA-TLS expansion depend on CXCL13-mediated recruitment of B cells expressing lymphotoxin-alpha(1)beta(2). Some of these elements are also overrepresented in human TA-TLS. Additionally, we demonstrate that immunotherapy induces more and larger TA-TLS that are more often organized with discrete T and B cell zones, and that TA-TLS presence, number, and size are correlated with reduced tumor size and overall response to checkpoint immunotherapy. This work provides a platform for manipulating TA-TLS development as a cancer immunotherapy strategy.
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