Multiple regulatory intrinsically disordered motifs control FOXO4 transcription factor binding and function

Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling

(2021) Bas Ponsioen et al.   NATURE CELL BIOLOGY

Intrinsically Disordered Regions Direct Transcription Factor In Vivo Binding Specificity

(2020) Sagie Brodsky et al.   MOLECULAR CELL

NMR characterization of solvent accessibility and transient structure in intrinsically disordered proteins

(2019) Christoph Hartlmüller et al.   JOURNAL OF BIOMOLECULAR NMR

Promotion of β-catenin/Foxo1 signaling ameliorates renal interstitial fibrosis

(2019) Padmashree Rao et al.   LABORATORY INVESTIGATION

The EMBL-EBI search and sequence analysis tools APIs in 2019

(2019) Fábio Madeira et al.   NUCLEIC ACIDS RESEARCH

Mediator Condensates Localize Signaling Factors to Key Cell Identity Genes

(2019) Alicia V. Zamudio et al.   MOLECULAR CELL

The Human Transcription Factors

(2018) Samuel A. Lambert et al.   CELL

Regulation of cellular senescence via the FOXO4-p53 axis

(2018) Benjamin Bourgeois et al.   FEBS LETTERS

Coactivator condensation at super-enhancers links phase separation and gene control

(2018) Benjamin R. Sabari et al.   SCIENCE

Identification of ICAT as an APC Inhibitor, Revealing Wnt-Dependent Inhibition of APC-Axin Interaction

(2018) Lei Ji et al.   MOLECULAR CELL

Transcription Factors Activate Genes through the Phase-Separation Capacity of Their Activation Domains

(2018) Ann Boija et al.   CELL

Therapeutic potential of targeting the Wnt/β-catenin signaling pathway in colorectal cancer

(2018) Xiaofei Cheng et al.   BIOMEDICINE & PHARMACOTHERAPY

FOXP3 promotes tumor growth and metastasis by activating Wnt/β-catenin signaling pathway and EMT in non-small cell lung cancer

(2017) Shucai Yang et al.   Molecular Cancer

Modulation of Intrinsically Disordered Protein Function by Post-translational Modifications

(2016) Alaji Bah et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FOXO target gene CTDSP2 regulates cell cycle progression through Ras and p21Cip1/Waf1

(2015) David E.A. Kloet et al.   BIOCHEMICAL JOURNAL

Intrinsically disordered proteins in cellular signalling and regulation

(2015) Peter E. Wright et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Redox regulation of FoxO transcription factors

(2015) Lars-Oliver Klotz et al.   Redox Biology

Pathological Unfoldomics of Uncontrolled Chaos: Intrinsically Disordered Proteins and Human Diseases

(2014) Vladimir N. Uversky et al.   CHEMICAL REVIEWS

Physicochemical Properties of Cells and Their Effects on Intrinsically Disordered Proteins (IDPs)

(2014) Francois-Xavier Theillet et al.   CHEMICAL REVIEWS

Introducing Protein Intrinsic Disorder

(2014) Johnny Habchi et al.   CHEMICAL REVIEWS

Classification of Intrinsically Disordered Regions and Proteins

(2014) Robin van der Lee et al.   CHEMICAL REVIEWS

Protein backbone and sidechain torsion angles predicted from NMR chemical shifts using artificial neural networks

(2013) Yang Shen et al.   JOURNAL OF BIOMOLECULAR NMR

Site-specific NMR mapping and time-resolved monitoring of serine and threonine phosphorylation in reconstituted kinase reactions and mammalian cell extracts

(2013) Francois-Xavier Theillet et al.   Nature Protocols

FOXOs: signalling integrators for homeostasis maintenance

(2013) Astrid Eijkelenboom et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Pharmacological Inhibition of the Wnt Acyltransferase PORCN Prevents Growth of WNT-Driven Mammary Cancer

(2012) K. D. Proffitt et al.   CANCER RESEARCH

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

The many faces and functions of β-catenin

(2012) Tomas Valenta et al.   EMBO JOURNAL

β-catenin confers resistance to PI3K and AKT inhibitors and subverts FOXO3a to promote metastasis in colon cancer

(2012) Stephan P Tenbaum et al.   NATURE MEDICINE

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Structures of KIX domain of CBP in complex with two FOXO3a transactivation domains reveal promiscuity and plasticity in coactivator recruitment

(2012) F. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intrinsically disordered proteins: a 10-year recap

(2012) Peter Tompa   TRENDS IN BIOCHEMICAL SCIENCES

An intrinsically labile α-helix abutting the BCL9-binding site of β-catenin is required for its inhibition by carnosic acid

(2012) Marc de la Roche et al.   Nature Communications

FoxO transcription factors; Regulation by AKT and 14-3-3 proteins

(2011) Guri Tzivion et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

FoxM1 Promotes β-Catenin Nuclear Localization and Controls Wnt Target-Gene Expression and Glioma Tumorigenesis

(2011) Nu Zhang et al.   CANCER CELL

Wnt Signaling Regulates Hepatic Metabolism

(2011) H. Liu et al.   Science Signaling

Structure of the human FOXO4-DBD–DNA complex at 1.9 Å resolution reveals new details of FOXO binding to the DNA

(2010) Evzen Boura et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

An Efficient Protocol for NMR-Spectroscopy-Based Structure Determination of Protein Complexes in Solution

(2010) Bernd Simon et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Activation of Forkhead Box O Transcription Factors by Oncogenic BRAF Promotes p21cip1-Dependent Senescence

(2010) P. L. J. de Keizer et al.   CANCER RESEARCH

Biochemical and Structural Characterization of β-Catenin Interactions with Nonphosphorylated and CK2-Phosphorylated Lef-1

(2010) Jinglucy Sun et al.   JOURNAL OF MOLECULAR BIOLOGY

SEDVIEW, Real-time Sedimentation Analysis

(2010) David B. Hayes et al.   MACROMOLECULAR BIOSCIENCE

Protein Phosphatase 2A Reactivates FOXO3a through a Dynamic Interplay with 14-3-3 and AKT

(2010) Amrik Singh et al.   MOLECULAR BIOLOGY OF THE CELL

Cytosolic FoxO1: alive and killing

(2010) René H. Medema et al.   NATURE CELL BIOLOGY

Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity

(2010) Ying Zhao et al.   NATURE CELL BIOLOGY

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

(2009) Bryan T. MacDonald et al.   DEVELOPMENTAL CELL

14-3-3 Protein Masks the DNA Binding Interface of Forkhead Transcription Factor FOXO4

(2009) Jan Silhan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphatidylinositol 3-Kinase Signaling Does Not Activate the Wnt Cascade

(2009) Ser Sue Ng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Searching DNA via a “Monkey Bar” Mechanism: The Significance of Disordered Tails

(2009) Dana Vuzman et al.   JOURNAL OF MOLECULAR BIOLOGY

Universal sample preparation method for proteome analysis

(2009) Jacek R Wiśniewski et al.   NATURE METHODS

The evolution of Fox genes and their role in development and disease

(2009) Sridhar Hannenhalli et al.   NATURE REVIEWS GENETICS

Interaction of FOXO with β-Catenin Inhibits β-Catenin/T Cell Factor Activity

(2008) Diana Hoogeboom et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biochemical and Structural Characterization of an Intramolecular Interaction in FOXO3a and Its Binding with p53

(2008) Feng Wang et al.   JOURNAL OF MOLECULAR BIOLOGY

FOXO-binding partners: it takes two to tango

(2008) K E van der Vos et al.   ONCOGENE

Structural Basis for DNA Recognition by FoxO1 and Its Regulation by Posttranslational Modification

(2008) Michael M. Brent et al.   STRUCTURE