Hemozoin-mediated inflammasome activation limits long-lived anti-malarial immunity

Dendritic cell responses to Plasmodium falciparum in a malaria-endemic setting

(2021) Triniti C. Turner et al.   MALARIA JOURNAL

Infection-induced plasmablasts are a nutrient sink that impairs humoral immunity to malaria

(2020) Rahul Vijay et al.   NATURE IMMUNOLOGY

Suppression of Inflammasome Activation by IRF8 and IRF4 in cDCs Is Critical for T Cell Priming

(2020) Margaret M. McDaniel et al.   Cell Reports

Hemozoin in Malarial Complications: More Questions Than Answers

(2020) Thao-Thy Pham et al.   TRENDS IN PARASITOLOGY

Plasmodium-specific antibodies block in vivo parasite growth without clearing infected red blood cells

(2019) Jasmin Akter et al.   PLoS Pathogens

The C-type Lectin Receptor CLEC12A Recognizes Plasmodial Hemozoin and Contributes to Cerebral Malaria Development

(2019) Marie-Kristin Raulf et al.   Cell Reports

Survival of Long-Lived Plasma Cells (LLPC): Piecing Together the Puzzle

(2019) Shivana M. Lightman et al.   Frontiers in Immunology

Single-cell gene expression reveals a landscape of regulatory T cell phenotypes shaped by the TCR

(2018) David Zemmour et al.   NATURE IMMUNOLOGY

Targeting the IL33–NLRP3 axis improves therapy for experimental cerebral malaria

(2018) Patrick Strangward et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evidence of Artemisinin-Resistant Plasmodium falciparum Malaria in Eastern India

(2018) Sabyasachi Das et al.   NEW ENGLAND JOURNAL OF MEDICINE

CCR6 Defines Memory B Cell Precursors in Mouse and Human Germinal Centers, Revealing Light-Zone Location and Predominant Low Antigen Affinity

(2017) Dan Suan et al.   IMMUNITY

Emerging concepts in T follicular helper cell responses to malaria

(2017) Diana S. Hansen et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Differentiation of germinal center B cells into plasma cells is initiated by high-affinity antigen and completed by Tfh cells

(2017) Nike J. Kräutler et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Development of a Novel CD4+TCR Transgenic Line That Reveals a Dominant Role for CD8+Dendritic Cells and CD40 Signaling in the Generation of Helper and CTL Responses to Blood-Stage Malaria

(2017) Daniel Fernandez-Ruiz et al.   JOURNAL OF IMMUNOLOGY

Regulatory T cells impede acute and long-term immunity to blood-stage malaria through CTLA-4

(2017) Samarchith P Kurup et al.   NATURE MEDICINE

Atypical activation of dendritic cells byPlasmodium falciparum

(2017) Anton Götz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Germinal Center B Cell Dynamics

(2016) Luka Mesin et al.   IMMUNITY

A Temporal Switch in the Germinal Center Determines Differential Output of Memory B and Plasma Cells

(2016) Florian J. Weisel et al.   IMMUNITY

Somatically Hypermutated Plasmodium-Specific IgM+ Memory B Cells Are Rapid, Plastic, Early Responders upon Malaria Rechallenge

(2016) Akshay T. Krishnamurty et al.   IMMUNITY

Profoundly Reduced CD1c+Myeloid Dendritic Cell HLA-DR and CD86 Expression and Increased Tumor Necrosis Factor Production in Experimental Human Blood-Stage Malaria Infection

(2016) Jessica R. Loughland et al.   INFECTION AND IMMUNITY

Severe Malaria Infections Impair Germinal Center Responses by Inhibiting T Follicular Helper Cell Differentiation

(2016) Victoria Ryg-Cornejo et al.   Cell Reports

Type I Interferons Induce T Regulatory 1 Responses and Restrict Humoral Immunity during Experimental Malaria

(2016) Ryan A. Zander et al.   PLoS Pathogens

Safety, Immunogenicity and Efficacy of Prime-Boost Vaccination with ChAd63 and MVA Encoding ME-TRAP against Plasmodium falciparum Infection in Adults in Senegal

(2016) Victorine A. Mensah et al.   PLoS One

PD-1 Co-inhibitory and OX40 Co-stimulatory Crosstalk Regulates Helper T Cell Differentiation and Anti-Plasmodium Humoral Immunity

(2015) Ryan A. Zander et al.   Cell Host & Microbe

Replication ofPlasmodiumin reticulocytes can occur without hemozoin formation, resulting in chloroquine resistance

(2015) Jing-wen Lin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

BCL6 orchestrates Tfh cell differentiation via multiple distinct mechanisms

(2015) Katerina Hatzi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Efficacy and safety of RTS,S/AS01 malaria vaccine with or without a booster dose in infants and children in Africa: final results of a phase 3, individually randomised, controlled trial

(2015)   LANCET

Circulating Th1-Cell-type Tfh Cells that Exhibit Impaired B Cell Help Are Preferentially Activated during Acute Malaria in Children

(2015) Nyamekye Obeng-Adjei et al.   Cell Reports

Antigen presentation kinetics control T cell/dendritic cell interactions and follicular helper T cell generation in vivo

(2015) Robert A Benson et al.   eLife

T Follicular Helper Cell Differentiation, Function, and Roles in Disease

(2014) Shane Crotty   IMMUNITY

CCR6-Dependent Positioning of Memory B Cells Is Essential for Their Ability To Mount a Recall Response to Antigen

(2014) Raul Elgueta et al.   JOURNAL OF IMMUNOLOGY

CD80 and PD-L2 define functionally distinct memory B cell subsets that are independent of antibody isotype

(2014) Griselda V Zuccarino-Catania et al.   NATURE IMMUNOLOGY

Dual Engagement of the NLRP3 and AIM2 Inflammasomes by Plasmodium-Derived Hemozoin and DNA during Malaria

(2014) Parisa Kalantari et al.   Cell Reports

Malaria-Induced NLRP12/NLRP3-Dependent Caspase-1 Activation Mediates Inflammation and Hypersensitivity to Bacterial Superinfection

(2014) Marco A. Ataide et al.   PLoS Pathogens

An Intensive Longitudinal Cohort Study of Malian Children and Adults Reveals No Evidence of Acquired Immunity to Plasmodium falciparum Infection

(2013) Tuan M. Tran et al.   CLINICAL INFECTIOUS DISEASES

Pulmonary pathology in pediatric cerebral malaria

(2013) Danny Milner et al.   HUMAN PATHOLOGY

Apoptosis and dysfunction of blood dendritic cells in patients with falciparum and vivax malaria

(2013) Alberto Pinzon-Charry et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Low-Level Plasmodium falciparum Blood-Stage Infection Causes Dendritic Cell Apoptosis and Dysfunction in Healthy Volunteers

(2012) T. Woodberry et al.   JOURNAL OF INFECTIOUS DISEASES

Monocytes and macrophages in malaria: protection or pathology?

(2012) Caroline Lin Lin Chua et al.   TRENDS IN PARASITOLOGY

ICOS Receptor Instructs T Follicular Helper Cell versus Effector Cell Differentiation via Induction of the Transcriptional Repressor Bcl6

(2011) Youn Soo Choi et al.   IMMUNITY

T cell receptor signal strength in Tregand iNKT cell development demonstrated by a novel fluorescent reporter mouse

(2011) Amy E. Moran et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Dendritic Cell-Restricted Antigen Presentation Initiates the Follicular Helper T Cell Program but Cannot Complete Ultimate Effector Differentiation

(2011) R. Goenka et al.   JOURNAL OF IMMUNOLOGY

A rapid and robust tri-color flow cytometry assay for monitoring malaria parasite development

(2011) Benoît Malleret et al.   Scientific Reports

Blood-stage Plasmodium berghei infection leads to short-lived parasite-associated antigen presentation by dendritic cells

(2010) Rachel J. Lundie et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Fast on-rates allow short dwell time ligands to activate T cells

(2010) C. C. Govern et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plasmepsin 4-Deficient Plasmodium berghei Are Virulence Attenuated and Induce Protective Immunity against Experimental Malaria

(2009) Roberta Spaccapelo et al.   AMERICAN JOURNAL OF PATHOLOGY

Migrating monocytes recruited to the spleen play an important role in control of blood stage malaria

(2009) A.-M. Sponaas et al.   BLOOD

Classical CD11c+ dendritic cells, not plasmacytoid dendritic cells, induce T cell responses to Plasmodium chabaudi malaria

(2009) Cecile Voisine et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Malarial Hemozoin Activates the NLRP3 Inflammasome through Lyn and Syk Kinases

(2009) Marina Tiemi Shio et al.   PLoS Pathogens