Survival of Long-Lived Plasma Cells (LLPC): Piecing Together the Puzzle

No strict requirement for eosinophils for bone marrow plasma cell survival

(2018) Alexandra Bortnick et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Factors of the bone marrow microniche that support human plasma cell survival and immunoglobulin secretion

(2018) Doan C. Nguyen et al.   Nature Communications

Metabolic and Transcriptional Modules Independently Diversify Plasma Cell Lifespan and Function

(2018) Wing Y. Lam et al.   Cell Reports

Targeting B Cell Maturation Antigen (BCMA) in Multiple Myeloma: Potential Uses of BCMA-Based Immunotherapy

(2018) Shih-Feng Cho et al.   Frontiers in Immunology

Long-Lived Plasma Cells in Mice and Men

(2018) Siggeir F. Brynjolfsson et al.   Frontiers in Immunology

Antibody-secreting plasma cells persist for decades in human intestine

(2017) Ole J.B. Landsverk et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Here, There, and Anywhere? Arguments for and against the Physical Plasma Cell Survival Niche

(2017) Joel R. Wilmore et al.   JOURNAL OF IMMUNOLOGY

Plasma cell survival in the absence of B cell memory

(2017) Erika Hammarlund et al.   Nature Communications

T Regulatory Cells Support Plasma Cell Populations in the Bone Marrow

(2017) Arielle Glatman Zaretsky et al.   Cell Reports

The transcriptional profiling of human in vivo-generated plasma cells identifies selective imbalances in monoclonal gammopathies

(2017) Luis M. Valor et al.   PLoS One

ATP-degrading ENPP1 is required for survival (or persistence) of long-lived plasma cells

(2017) Hongsheng Wang et al.   Scientific Reports

APRIL and BCMA promote human multiple myeloma growth and immunosuppression in the bone marrow microenvironment

(2016) Y.-T. Tai et al.   BLOOD

Persistence of long-lived plasma cells and humoral immunity in individuals responding to CD19-directed CAR T-cell therapy

(2016) V. G. Bhoj et al.   BLOOD

Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming

(2016) Michael D. Buck et al.   CELL

Mitochondrial Pyruvate Import Promotes Long-Term Survival of Antibody-Secreting Plasma Cells

(2016) Wing Y. Lam et al.   IMMUNITY

Blimp-1 controls plasma cell function through the regulation of immunoglobulin secretion and the unfolded protein response

(2016) Julie Tellier et al.   NATURE IMMUNOLOGY

Corrigendum: Long-lived antigen-induced IgM plasma cells demonstrate somatic mutations and contribute to long-term protection

(2016) Caitlin Bohannon et al.   Nature Communications

Whole Transcriptome Profiling Identifies CD93 and Other Plasma Cell Survival Factor Genes Associated with Measles-Specific Antibody Response after Vaccination

(2016) Iana H. Haralambieva et al.   PLoS One

A unique population of IgG-expressing plasma cells lacking CD19 is enriched in human bone marrow

(2015) H. E. Mei et al.   BLOOD

Eosinophils: important players in humoral immunity

(2015) C. Berek   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Differentiation and maintenance of long-lived plasma cells

(2015) Kohei Kometani et al.   CURRENT OPINION IN IMMUNOLOGY

Long-Lived Plasma Cells Are Contained within the CD19−CD38hiCD138+ Subset in Human Bone Marrow

(2015) Jessica L. Halliley et al.   IMMUNITY

CD28 Promotes Plasma Cell Survival, Sustained Antibody Responses, and BLIMP-1 Upregulation through Its Distal PYAP Proline Motif

(2015) Cheryl H. Rozanski et al.   JOURNAL OF IMMUNOLOGY

Long-lived plasma cells are generated in mucosal immune responses and contribute to the bone marrow plasma cell pool in mice

(2015) A Lemke et al.   Mucosal Immunology

Mode of Bioenergetic Metabolism during B Cell Differentiation in the Intestine Determines the Distinct Requirement for Vitamin B 1

(2015) Jun Kunisawa et al.   Cell Reports

CD28-mediated pro-survival signaling induces chemotherapeutic resistance in multiple myeloma

(2014) M. E. Murray et al.   BLOOD

The Tao of myeloma

(2014) L. H. Boise et al.   BLOOD

Eosinophils Promote Generation and Maintenance of Immunoglobulin-A-Expressing Plasma Cells and Contribute to Gut Immune Homeostasis

(2014) Van Trung Chu et al.   IMMUNITY

Memory CD8+ T Cells Use Cell-Intrinsic Lipolysis to Support the Metabolic Programming Necessary for Development

(2014) David O’Sullivan et al.   IMMUNITY

Novel Regulation of CD80/CD86-induced Phosphatidylinositol 3-Kinase Signaling by NOTCH1 Protein in Interleukin-6 and Indoleamine 2,3-Dioxygenase Production by Dendritic Cells

(2014) Chandana Koorella et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cutting Edge: The Dependence of Plasma Cells and Independence of Memory B Cells on BAFF and APRIL

(2014) M. J. Benson et al.   JOURNAL OF IMMUNOLOGY

Survival of Human Circulating Antigen-Induced Plasma Cells Is Supported by Plasma Cell–Niche Cytokines and T Follicular Helper Lymphocytes

(2014) Ana Ramos-Amaya et al.   JOURNAL OF IMMUNOLOGY

Natural IgM Is Produced by CD5−Plasma Cells That Occupy a Distinct Survival Niche in Bone Marrow

(2014) Alexander E. Reynolds et al.   JOURNAL OF IMMUNOLOGY

IL-21 and CD40L Synergistically Promote Plasma Cell Differentiation through Upregulation of Blimp-1 in Human B Cells

(2013) B. B. Ding et al.   JOURNAL OF IMMUNOLOGY

STAT-3 Activation by Differential Cytokines Is Critical for Human In Vivo-Generated Plasma Cell Survival and Ig Secretion

(2013) B. Rodriguez-Bayona et al.   JOURNAL OF IMMUNOLOGY

Plasma cells require autophagy for sustainable immunoglobulin production

(2013) Niccolò Pengo et al.   NATURE IMMUNOLOGY

Mcl-1 is essential for the survival of plasma cells

(2013) Victor Peperzak et al.   NATURE IMMUNOLOGY

The contribution of autophagy to lymphocyte survival and homeostasis

(2012) Ian X. McLeod et al.   IMMUNOLOGICAL REVIEWS

Cutting Edge: IL-21 Derived from Human Follicular Helper T Cells Acts as a Survival Factor for Secondary Lymphoid Organ, but Not for Bone Marrow, Plasma Cells

(2012) B. Rodriguez-Bayona et al.   JOURNAL OF IMMUNOLOGY

CD28-B7 Interaction Modulates Short- and Long-Lived Plasma Cell Function

(2012) M. N. Njau et al.   JOURNAL OF IMMUNOLOGY

Crystal structure of Enpp1, an extracellular glycoprotein involved in bone mineralization and insulin signaling

(2012) K. Kato et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Proteasome in Terminal Plasma Cell Differentiation

(2012) Simone Cenci   SEMINARS IN HEMATOLOGY

Sustained antibody responses depend on CD28 function in bone marrow–resident plasma cells

(2011) Cheryl H. Rozanski et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CD28 Expressed on Malignant Plasma Cells Induces a Prosurvival and Immunosuppressive Microenvironment

(2011) J. R. Nair et al.   JOURNAL OF IMMUNOLOGY

Long-Lived Plasma Cells from Human Small Intestine Biopsies Secrete Immunoglobulins for Many Weeks In Vitro

(2011) L. Mesin et al.   JOURNAL OF IMMUNOLOGY

Eosinophils are required for the maintenance of plasma cells in the bone marrow

(2011) Van Trung Chu et al.   NATURE IMMUNOLOGY

Megakaryocytes constitute a functional component of a plasma cell niche in the bone marrow

(2010) O. Winter et al.   BLOOD

mTOR regulation of autophagy

(2010) Chang Hwa Jung et al.   FEBS LETTERS

B cell–intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans

(2010) Danielle T. Avery et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Basophils Support the Survival of Plasma Cells in Mice

(2010) M. R. Gomez et al.   JOURNAL OF IMMUNOLOGY

Reversible Microbial Colonization of Germ-Free Mice Reveals the Dynamics of IgA Immune Responses

(2010) S. Hapfelmeier et al.   SCIENCE

A T Cell-Dependent Mechanism for the Induction of Human Mucosal Homing Immunoglobulin A-Secreting Plasmablasts

(2009) Melissa Dullaers et al.   IMMUNITY

Analysis of Interleukin-21-Induced Prdm1 Gene Regulation Reveals Functional Cooperation of STAT3 and IRF4 Transcription Factors

(2009) Hyokjoon Kwon et al.   IMMUNITY

Induction of long-lived allergen-specific plasma cells by mucosal allergen challenge

(2009) Elke O. Luger et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Targeted Knock-In Mice Expressing Mutations of CD28 Reveal an Essential Pathway for Costimulation

(2009) L. F. Dodson et al.   MOLECULAR AND CELLULAR BIOLOGY

CD93 is required for maintenance of antibody secretion and persistence of plasma cells in the bone marrow niche

(2009) S. Chevrier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Blood-borne human plasma cells in steady state are derived from mucosal immune responses

(2008) H. E. Mei et al.   BLOOD

CD93 and Related Family Members: Their Role in Innate Immunity

(2008) S. Bohlson et al.   CURRENT DRUG TARGETS

Plasma cell differentiation and survival

(2008) David Tarlinton et al.   CURRENT OPINION IN IMMUNOLOGY

Maintenance of the plasma cell pool is independent of memory B cells

(2008) A. Ahuja et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA