Type I Interferons Induce T Regulatory 1 Responses and Restrict Humoral Immunity during Experimental Malaria

Interleukin-27-Producing CD4 + T Cells Regulate Protective Immunity during Malaria Parasite Infection

(2016) Daisuke Kimura et al.   IMMUNITY

Immunological processes underlying the slow acquisition of humoral immunity to malaria

(2016) VICTORIA RYG-CORNEJO et al.   PARASITOLOGY

Severe Malaria Infections Impair Germinal Center Responses by Inhibiting T Follicular Helper Cell Differentiation

(2016) Victoria Ryg-Cornejo et al.   Cell Reports

Blimp-1-Dependent IL-10 Production by Tr1 Cells Regulates TNF-Mediated Tissue Pathology

(2016) Marcela Montes de Oca et al.   PLoS Pathogens

Blockade of Interferon Beta, but Not Interferon Alpha, Signaling Controls Persistent Viral Infection

(2015) Cherie T. Ng et al.   Cell Host & Microbe

PD-1 Co-inhibitory and OX40 Co-stimulatory Crosstalk Regulates Helper T Cell Differentiation and Anti-Plasmodium Humoral Immunity

(2015) Ryan A. Zander et al.   Cell Host & Microbe

Differentiation and maintenance of long-lived plasma cells

(2015) Kohei Kometani et al.   CURRENT OPINION IN IMMUNOLOGY

The regulation of T follicular helper responses during infection

(2015) Noah S Butler et al.   CURRENT OPINION IN IMMUNOLOGY

The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells

(2015) John P. Ray et al.   IMMUNITY

ICOS Coreceptor Signaling Inactivates the Transcription Factor FOXO1 to Promote Tfh Cell Differentiation

(2015) Erica L. Stone et al.   IMMUNITY

Parasite-Specific CD4+IFN-γ+IL-10+T Cells Distribute within Both Lymphoid and Nonlymphoid Compartments and Are Controlled Systemically by Interleukin-27 and ICOS during Blood-Stage Malaria Infection

(2015) Ana Villegas-Mendez et al.   INFECTION AND IMMUNITY

Quality and quantity of T FH cells are critical for broad antibody development in SHIV AD8 infection

(2015) Takuya Yamamoto et al.   Science Translational Medicine

Circulating Th1-Cell-type Tfh Cells that Exhibit Impaired B Cell Help Are Preferentially Activated during Acute Malaria in Children

(2015) Nyamekye Obeng-Adjei et al.   Cell Reports

Malaria Immunity in Man and Mosquito: Insights into Unsolved Mysteries of a Deadly Infectious Disease

(2014) Peter D. Crompton et al.   Annual Review of Immunology

Transcription Factor STAT3 and Type I Interferons Are Corepressive Insulators for Differentiation of Follicular Helper and T Helper 1 Cells

(2014) John P. Ray et al.   IMMUNITY

Chronic viral infection promotes sustained Th1-derived immunoregulatory IL-10 via BLIMP-1

(2014) Ian A. Parish et al.   JOURNAL OF CLINICAL INVESTIGATION

Type I IFN signaling in CD8– DCs impairs Th1-dependent malaria immunity

(2014) Ashraful Haque et al.   JOURNAL OF CLINICAL INVESTIGATION

Role of Blimp-1 in programing Th effector cells into IL-10 producers

(2014) Christian Neumann et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Type I IFN Induces Binding of STAT1 to Bcl6: Divergent Roles of STAT Family Transcription Factors in the T Follicular Helper Cell Genetic Program

(2014) S. Nakayamada et al.   JOURNAL OF IMMUNOLOGY

A p85α-osteopontin axis couples the receptor ICOS to sustained Bcl-6 expression by follicular helper and regulatory T cells

(2014) Jianmei W Leavenworth et al.   NATURE IMMUNOLOGY

Strain-specific innate immune signaling pathways determine malaria parasitemia dynamics and host mortality

(2014) J. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IFNγ/IL-10 Co-producing Cells Dominate the CD4 Response to Malaria in Highly Exposed Children

(2014) Prasanna Jagannathan et al.   PLoS Pathogens

Type I interferons contribute to experimental cerebral malaria development in response to sporozoite or blood-stagePlasmodium bergheiANKA

(2013) Jennifer Palomo et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

IL-12 and type I interferon prolong the division of activated CD8 T cells by maintaining high-affinity IL-2 signaling in vivo

(2013) Gabriel R. Starbeck-Miller et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IFNAR1 Controls Progression to Cerebral Malaria in Children and CD8+ T Cell Brain Pathology in Plasmodium berghei-Infected Mice

(2013) E. A. Ball et al.   JOURNAL OF IMMUNOLOGY

Young Lives Lost as B Cells Falter: What We Are Learning About Antibody Responses in Malaria

(2013) S. Portugal et al.   JOURNAL OF IMMUNOLOGY

Bcl6 Expressing Follicular Helper CD4 T Cells Are Fate Committed Early and Have the Capacity To Form Memory

(2013) Y. S. Choi et al.   JOURNAL OF IMMUNOLOGY

Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells

(2013) Nicola Gagliani et al.   NATURE MEDICINE

Inadequate T follicular cell help impairs B cell immunity during HIV infection

(2013) Rafael A Cubas et al.   NATURE MEDICINE

Blockade of Chronic Type I Interferon Signaling to Control Persistent LCMV Infection

(2013) E. B. Wilson et al.   SCIENCE

Persistent LCMV Infection Is Controlled by Blockade of Type I Interferon Signaling

(2013) J. R. Teijaro et al.   SCIENCE

T cell-derived IL-10 and its impact on the regulation of host responses during malaria

(2012) Ana Paula Freitas do Rosario et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

A Regulatory Role for IL-10 Receptor Signaling in Development and B Cell Help of T Follicular Helper Cells in Mice

(2012) G. Cai et al.   JOURNAL OF IMMUNOLOGY

Splenic Red Pulp Macrophages Produce Type I Interferons as Early Sentinels of Malaria Infection but Are Dispensable for Control

(2012) Charles C. Kim et al.   PLoS One

Follicular Helper CD4 T Cells (TFH)

(2011) Shane Crotty   Annual Review of Immunology

Superior Antimalarial Immunity after Vaccination with Late Liver Stage-Arresting Genetically Attenuated Parasites

(2011) Noah S. Butler et al.   Cell Host & Microbe

Type I interferons suppress CD4+ T-cell-dependent parasite control during blood-stage Plasmodium infection

(2011) Ashraful Haque et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Innate Immune Recognition of an AT-Rich Stem-Loop DNA Motif in the Plasmodium falciparum Genome

(2011) Shruti Sharma et al.   IMMUNITY

IL-27 Promotes IL-10 Production by Effector Th1 CD4+ T Cells: A Critical Mechanism for Protection from Severe Immunopathology during Malaria Infection

(2011) A. P. Freitas do Rosario et al.   JOURNAL OF IMMUNOLOGY

Quantifying Antigen-Specific CD4 T Cells during a Viral Infection: CD4 T Cell Responses Are Larger Than We Think

(2011) D. S. McDermott et al.   JOURNAL OF IMMUNOLOGY

CD4+ T cell help and innate-derived IL-27 induce Blimp-1-dependent IL-10 production by antiviral CTLs

(2011) Jie Sun et al.   NATURE IMMUNOLOGY

Therapeutic blockade of PD-L1 and LAG-3 rapidly clears established blood-stage Plasmodium infection

(2011) Noah S Butler et al.   NATURE IMMUNOLOGY

A rapid and robust tri-color flow cytometry assay for monitoring malaria parasite development

(2011) Benoît Malleret et al.   Scientific Reports

T-bet-mediated differentiation of the activated CD8+ T cell

(2010) Crystal J. J. Yeo et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Mast Cell-Derived IL-10 Suppresses Germinal Center Formation by Affecting T Follicular Helper Cell Function

(2010) R. Chacon-Salinas et al.   JOURNAL OF IMMUNOLOGY

A Detrimental Effect of Interleukin-10 on Protective Pulmonary Humoral Immunity during Primary Influenza A Virus Infection

(2010) K. Sun et al.   JOURNAL OF VIROLOGY

T helper type 1 and 17 cells determine efficacy of interferon-β in multiple sclerosis and experimental encephalomyelitis

(2010) Robert C Axtell et al.   NATURE MEDICINE

A prospective analysis of the Ab response to Plasmodium falciparum before and after a malaria season by protein microarray

(2010) P. D. Crompton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extreme CD8 T Cell Requirements for Anti-Malarial Liver-Stage Immunity following Immunization with Radiation Attenuated Sporozoites

(2010) Nathan W. Schmidt et al.   PLoS Pathogens

Classical CD11c+ dendritic cells, not plasmacytoid dendritic cells, induce T cell responses to Plasmodium chabaudi malaria

(2009) Cecile Voisine et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Cutting Edge: IL-27 Induces the Transcription Factor c-Maf, Cytokine IL-21, and the Costimulatory Receptor ICOS that Coordinately Act Together to Promote Differentiation of IL-10-Producing Tr1 Cells

(2009) C. Pot et al.   JOURNAL OF IMMUNOLOGY

What you see is not what you get: implications of the brevity of antibody responses to malaria antigens and transmission heterogeneity in longitudinal studies of malaria immunity

(2009) Samson M Kinyanjui et al.   MALARIA JOURNAL

IFNα activates dormant haematopoietic stem cells in vivo

(2009) Marieke A. G. Essers et al.   NATURE

Interferon regulatory factor-2 protects quiescent hematopoietic stem cells from type I interferon–dependent exhaustion

(2009) Taku Sato et al.   NATURE MEDICINE

Immunity to malaria: more questions than answers

(2008) Jean Langhorne et al.   NATURE IMMUNOLOGY

IL-10 from CD4+CD25−Foxp3−CD127− Adaptive Regulatory T Cells Modulates Parasite Clearance and Pathology during Malaria Infection

(2008) Kevin N. Couper et al.   PLoS Pathogens