The composition of the gut microbiota following early-life antibiotic exposure affects host health and longevity in later life

Antibiotics at birth and later antibiotic courses: effects on gut microbiota

(2021) Sofia Ainonen et al.   PEDIATRIC RESEARCH

Lysosomal Dysregulation in the Murine App Model of Alzheimer’s Disease

(2020) Lauren S. Whyte et al.   NEUROSCIENCE

PICRUSt2 for prediction of metagenome functions

(2020) Gavin M. Douglas et al.   NATURE BIOTECHNOLOGY

Disrupted Neurogenesis in Germ-Free Mice: Effects of Age and Sex

(2020) Gavin A. Scott et al.   Frontiers in Cell and Developmental Biology

The Gut Microbiota and Unhealthy Aging: Disentangling Cause from Consequence

(2020) Erica N. DeJong et al.   Cell Host & Microbe

Human Gut Microbiome Aging Clock Based on Taxonomic Profiling and Deep Learning

(2020) Fedor Galkin et al.   iScience

Long-term effects of antimicrobial drugs on the composition of the human gut microbiota

(2020) M. Mulder et al.   Gut Microbes

Antibiotics-induced monodominance of a novel gut bacterial order

(2019) Falk Hildebrand et al.   GUT

A Weaning Reaction to Microbiota Is Required for Resistance to Immunopathologies in the Adult

(2019) Ziad Al Nabhani et al.   IMMUNITY

Changes in the gut microbiome and fermentation products concurrent with enhanced longevity in acarbose-treated mice

(2019) Byron J Smith et al.   BMC MICROBIOLOGY

Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2

(2019) Evan Bolyen et al.   NATURE BIOTECHNOLOGY

Healthspan and lifespan extension by fecal microbiota transplantation into progeroid mice

(2019) Clea Bárcena et al.   NATURE MEDICINE

The gut microbiome regulates host glucose homeostasis via peripheral serotonin

(2019) Alyce M. Martin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Age-Related Gene Expression Signature in Rats Demonstrate Early, Late, and Linear Transcriptional Changes from Multiple Tissues

(2019) Tea Shavlakadze et al.   Cell Reports

Recovery of the Gut Microbiota after Antibiotics Depends on Host Diet, Community Context, and Environmental Reservoirs

(2019) Katharine Michelle Ng et al.   Cell Host & Microbe

Neurogenesis and prolongevity signaling in young germ-free mice transplanted with the gut microbiota of old mice

(2019) Parag Kundu et al.   Science Translational Medicine

Antibiotic-modulated microbiome suppresses lethal inflammation and prolongs lifespan in Treg-deficient mice

(2019) Baokun He et al.   Microbiome

Early-Life Antibiotic-Driven Dysbiosis Leads to Dysregulated Vaccine Immune Responses in Mice

(2018) Miriam Anne Lynn et al.   Cell Host & Microbe

Lysosomal LAMP1 immunoreactivity exists in both diffuse and neuritic amyloid plaques in the human hippocampus

(2018) Sofia Hassiotis et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Gut dysbiosis: a potential link between increased cancer risk in ageing and inflammaging

(2018) Arya Biragyn et al.   LANCET ONCOLOGY

Early-life exposure to low-dose oxidants can increase longevity via microbiome remodelling in Drosophila

(2018) Fumiaki Obata et al.   Nature Communications

Improved Immune Responses in Young and Aged Mice with Adjuvanted Vaccines against H1N1 Influenza Infection

(2018) Susan L. Baldwin et al.   Frontiers in Immunology

Recovery of gut microbiota of healthy adults following antibiotic exposure

(2018) Albert Palleja et al.   Nature Microbiology

Inflammatory responses to influenza vaccination at the extremes of age

(2017) Jacqueline U. McDonald et al.   IMMUNOLOGY

Twenty-five years of mTOR: Uncovering the link from nutrients to growth

(2017) David M. Sabatini   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oncogenic MNK signalling regulates the metastasis suppressor NDRG1

(2017) Shuye Tian et al.   Oncotarget

Regulation of life span by the gut microbiota in the short-lived African turquoise killifish

(2017) Patrick Smith et al.   eLife

MultiQC: summarize analysis results for multiple tools and samples in a single report

(2016) Philip Ewels et al.   BIOINFORMATICS

Gut microbiota signatures of longevity

(2016) Fanli Kong et al.   CURRENT BIOLOGY

Gut Microbiota and Extreme Longevity

(2016) Elena Biagi et al.   CURRENT BIOLOGY

Prevention of antibiotic-associated metabolic syndrome in mice by intestinal alkaline phosphatase

(2016) K. P. Economopoulos et al.   DIABETES OBESITY & METABOLISM

DADA2: High-resolution sample inference from Illumina amplicon data

(2016) Benjamin J Callahan et al.   NATURE METHODS

Antibiotics, birth mode, and diet shape microbiome maturation during early life

(2016) Nicholas A. Bokulich et al.   Science Translational Medicine

Cognitive Aging and the Hippocampus in Older Adults

(2016) Andrew O’Shea et al.   Frontiers in Aging Neuroscience

Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice

(2016) Alexandra E. Livanos et al.   Nature Microbiology

Inflammaging decreases adaptive and innate immune responses in mice and humans

(2015) Daniela Frasca et al.   BIOGERONTOLOGY

Comprehensive transcriptional landscape of aging mouse liver

(2015) Ryan R. White et al.   BMC GENOMICS

Reduced Expression of MYC Increases Longevity and Enhances Healthspan

(2015) Jeffrey W. Hofmann et al.   CELL

HISAT: a fast spliced aligner with low memory requirements

(2015) Daehwan Kim et al.   NATURE METHODS

Host microbiota constantly control maturation and function of microglia in the CNS

(2015) Daniel Erny et al.   NATURE NEUROSCIENCE

Metabolic and metagenomic outcomes from early-life pulsed antibiotic treatment

(2015) Yael R. Nobel et al.   Nature Communications

Distinct Shifts in Microbiota Composition during Drosophila Aging Impair Intestinal Function and Drive Mortality

(2015) Rebecca I. Clark et al.   Cell Reports

Is interleukin-1β a culprit in macrophage-adipocyte crosstalk in obesity?

(2015) Chen Bing   Adipocyte

Trimmomatic: a flexible trimmer for Illumina sequence data

(2014) Anthony M. Bolger et al.   BIOINFORMATICS

Altering the Intestinal Microbiota during a Critical Developmental Window Has Lasting Metabolic Consequences

(2014) Laura M. Cox et al.   CELL

Antibiotics in early life and obesity

(2014) Laura M. Cox et al.   Nature Reviews Endocrinology

svaseq: removing batch effects and other unwanted noise from sequencing data

(2014) Jeffrey T. Leek   NUCLEIC ACIDS RESEARCH

Establishment of a General NAFLD Scoring System for Rodent Models and Comparison to Human Liver Pathology

(2014) Wen Liang et al.   PLoS One

Lifespan Extension Conferred by Endoplasmic Reticulum Secretory Pathway Deficiency Requires Induction of the Unfolded Protein Response

(2014) Vyacheslav M. Labunskyy et al.   PLoS Genetics

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

(2013) Y. Liao et al.   BIOINFORMATICS

Anti-CD4 treatment inhibits autoimmunity in scurfy mice through the attenuation of co-stimulatory signals

(2013) C.T. Mayer et al.   JOURNAL OF AUTOIMMUNITY

Natural killer cell development and maturation in aged mice

(2013) Eleni Beli et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Interleukin-1β inhibits insulin signaling and prevents insulin-stimulated system A amino acid transport in primary human trophoblasts

(2013) Irving L.M.H. Aye et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

phyloseq: An R Package for Reproducible Interactive Analysis and Graphics of Microbiome Census Data

(2013) Paul J. McMurdie et al.   PLoS One

Serotonin 2C receptor antagonism ameliorates novelty-induced hypophagia in aged mice

(2013) Miwa Nahata et al.   PSYCHONEUROENDOCRINOLOGY

T Cell Aging: A Review of the Transcriptional Changes Determined from Genome-Wide Analysis

(2013) Guobing Chen et al.   Frontiers in Immunology

Excessive folate synthesis limits lifespan in the C. elegans: E. coli aging model

(2012) Bhupinder Virk et al.   BMC BIOLOGY

Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2

(2012) K. D. Copps et al.   DIABETOLOGIA

Divergent metabolic outcomes arising from targeted manipulation of the gut microbiota in diet-induced obesity

(2012) Eileen F Murphy et al.   GUT

Gut microbiota composition correlates with diet and health in the elderly

(2012) Marcus J. Claesson et al.   NATURE

Antibiotics in early life alter the murine colonic microbiome and adiposity

(2012) Ilseung Cho et al.   NATURE

Molecular signatures database (MSigDB) 3.0

(2011) A. Liberzon et al.   BIOINFORMATICS

FastTree 2 – Approximately Maximum-Likelihood Trees for Large Alignments

(2010) Morgan N. Price et al.   PLoS One

Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation

(2010) L. Dethlefsen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

(2009) David E. Harrison et al.   NATURE

Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet-Induced Obesity and Diabetes in Mice

(2008) P. D. Cani et al.   DIABETES