Jagged1/Notch2 controls kidney fibrosis via Tfam-mediated metabolic reprogramming

Single-cell transcriptomics of the mouse kidney reveals potential cellular targets of kidney disease

(2018) Jihwan Park et al.   SCIENCE

The Role of Peroxisome Proliferator-Activated Receptor γ Coactivator 1α (PGC-1α) in Kidney Disease

(2018) Szu-Yuan Li et al.   SEMINARS IN NEPHROLOGY

PGC-1αProtects from Notch-Induced Kidney Fibrosis Development

(2017) Seung Hyeok Han et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Antagonism of profibrotic microRNA-21 improves outcome of murine chronic renal allograft dysfunction

(2017) Celina Schauerte et al.   KIDNEY INTERNATIONAL

Transgenic expression of human APOL1 risk variants in podocytes induces kidney disease in mice

(2017) Pazit Beckerman et al.   NATURE MEDICINE

Human Kidney Tubule-Specific Gene Expression Based Dissection of Chronic Kidney Disease Traits

(2017) Pazit Beckerman et al.   EBioMedicine

Regulation of Vascular and Renal Function by Metabolite Receptors

(2016) János Peti-Peterdi et al.   Annual Review of Physiology

Kidney tubules

(2016) David A. Ferenbach et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

PGC1α drives NAD biosynthesis linking oxidative metabolism to renal protection

(2016) Mei T. Tran et al.   NATURE

The next generation of therapeutics for chronic kidney disease

(2016) Matthew D. Breyer et al.   NATURE REVIEWS DRUG DISCOVERY

Developmental signalling pathways in renal fibrosis: the roles of Notch, Wnt and Hedgehog

(2016) Maria Edeling et al.   Nature Reviews Nephrology

Epithelial Plasticity versus EMT in Kidney Fibrosis

(2016) Shizheng Huang et al.   TRENDS IN MOLECULAR MEDICINE

Notch-independent RBPJ controls angiogenesis in the adult heart

(2016) Ramón Díaz-Trelles et al.   Nature Communications

Sox9-Positive Progenitor Cells Play a Key Role in Renal Tubule Epithelial Regeneration in Mice

(2016) Hyun Mi Kang et al.   Cell Reports

Whole-transcriptome analysis of UUO mouse model of renal fibrosis reveals new molecular players in kidney diseases

(2016) Eleni Arvaniti et al.   Scientific Reports

Performance benchmarking of four cell-free protein expression systems

(2015) Dejan Gagoski et al.   BIOTECHNOLOGY AND BIOENGINEERING

Notch1 and Notch2 in Podocytes Play Differential Roles During Diabetic Nephropathy Development

(2015) Mariya T. Sweetwyne et al.   DIABETES

Differential effects of targeting Notch receptors in a mouse model of liver cancer

(2015) Erik G. Huntzicker et al.   HEPATOLOGY

RNA Sequencing Identifies Novel Translational Biomarkers of Kidney Fibrosis

(2015) F. L. Craciun et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Migration of smooth muscle cells from the arterial anastomosis of arteriovenous fistulas requires Notch activation to form neointima

(2015) Ming Liang et al.   KIDNEY INTERNATIONAL

Snail1-induced partial epithelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established disease

(2015) M Teresa Grande et al.   NATURE MEDICINE

Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis

(2015) Sara Lovisa et al.   NATURE MEDICINE

Tissue transcriptome-driven identification of epidermal growth factor as a chronic kidney disease biomarker

(2015) Wenjun Ju et al.   Science Translational Medicine

Blocking Notch in Endothelial Cells Prevents Arteriovenous Fistula Failure Despite CKD

(2014) Y. Wang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development

(2014) Hyun Mi Kang et al.   NATURE MEDICINE

Therapeutic modulation of Notch signalling — are we there yet?

(2014) Emma R. Andersson et al.   NATURE REVIEWS DRUG DISCOVERY

Notch2 activation ameliorates nephrosis

(2014) Eriko Tanaka et al.   Nature Communications

Primary proximal tubule injury leads to epithelial cell cycle arrest, fibrosis, vascular rarefaction, and glomerulosclerosis

(2014) Joseph V. Bonventre   Kidney International Supplements

Kick it up a notch: Notch signaling and kidney fibrosis

(2014) Mariya T. Sweetwyne et al.   Kidney International Supplements

Dynamic binding of RBPJ is determined by Notch signaling status

(2013) D. Castel et al.   GENES & DEVELOPMENT

Blockade of individual Notch ligands and receptors controls graft-versus-host disease

(2013) Ivy T. Tran et al.   JOURNAL OF CLINICAL INVESTIGATION

Role of epidermal growth factor receptor in acute and chronic kidney injury

(2013) Jinhua Tang et al.   KIDNEY INTERNATIONAL

For better or worse: a niche for Notch in parietal epithelial cell activation

(2013) Mariya T. Sweetwyne et al.   KIDNEY INTERNATIONAL

Endocardial to Myocardial Notch-Wnt-Bmp Axis Regulates Early Heart Valve Development

(2013) Yidong Wang et al.   PLoS One

Notch signaling in diabetic nephropathy

(2012) Ramon Bonegio et al.   EXPERIMENTAL CELL RESEARCH

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Repair Problems in Podocytes: Wnt, Notch, and Glomerulosclerosis

(2012) Hideki Kato et al.   SEMINARS IN NEPHROLOGY

PGC-1α promotes recovery after acute kidney injury during systemic inflammation in mice

(2011) Mei Tran et al.   JOURNAL OF CLINICAL INVESTIGATION

Notch in the kidney: development and disease

(2011) Yasemin Sirin et al.   JOURNAL OF PATHOLOGY

Tubulointerstitial injury and the progression of chronic kidney disease

(2011) Kavita S. Hodgkins et al.   PEDIATRIC NEPHROLOGY

Activation of Notch signaling pathway in HIV-associated nephropathy

(2010) Madhulika Sharma et al.   AIDS

Temporal trends in the burden of chronic kidney disease in the United States

(2010) Robert N Foley   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

The story of Notch and chronic kidney disease

(2010) Shuchita Sharma et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Patterning a Complex Organ: Branching Morphogenesis and Nephron Segmentation in Kidney Development

(2010) Frank Costantini et al.   DEVELOPMENTAL CELL

Modulation of Notch-1 Signaling Alleviates Vascular Endothelial Growth Factor–Mediated Diabetic Nephropathy

(2010) Chun-Liang Lin et al.   DIABETES

Getting a Notch Closer to Understanding Diabetic Kidney Disease: FIG. 1.

(2010) Seon-Ho Ahn et al.   DIABETES

Epithelial Notch signaling regulates interstitial fibrosis development in the kidneys of mice and humans

(2010) Bernhard Bielesz et al.   JOURNAL OF CLINICAL INVESTIGATION

Expression of Notch pathway proteins correlates with albuminuria, glomerulosclerosis, and renal function

(2010) Mariana Murea et al.   KIDNEY INTERNATIONAL

Chronic kidney disease awareness, screening and prevention: Rationale for the design of a public education program

(2010) ALLAN J COLLINS et al.   NEPHROLOGY

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

(2009) Raphael Kopan et al.   CELL

Expression and function of the Delta-1/Notch-2/Hes-1 pathway during experimental acute kidney injury

(2008) T. Kobayashi et al.   KIDNEY INTERNATIONAL

The Notch pathway in podocytes plays a role in the development of glomerular disease

(2008) Thiruvur Niranjan et al.   NATURE MEDICINE