Mesenchymal stem cell-derived microvesicles improve intestinal barrier function by restoring mitochondrial dynamic balance in sepsis rats

Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the Global Burden of Disease Study

(2020) Kristina E Rudd et al.   LANCET

In Vivo Tracking of Mesenchymal Stem Cell-Derived Extracellular Vesicles Improving Mitochondrial Function in Renal Ischemia–Reperfusion Injury

(2020) Hongmei Cao et al.   ACS Nano

SnapShot: Extracellular Vesicles

(2020) Federico Cocozza et al.   CELL

Endothelial Microvesicles Induce Pulmonary Vascular Leakage and Lung Injury During Sepsis

(2020) Danyang Zheng et al.   Frontiers in Cell and Developmental Biology

Mitochondrial dynamics in postmitotic cells regulate neurogenesis

(2020) Ryohei Iwata et al.   SCIENCE

Mesenchymal Stem Cell-Derived Extracellular Vesicles Attenuate Mitochondrial Damage and Inflammation by Stabilizing Mitochondrial DNA

(2020) Meng Zhao et al.   ACS Nano

Adeno-associated virus-mediated delivery of anti-miR-199a tough decoys attenuates cardiac hypertrophy by targeting PGC-1alpha

(2020) Hualin Yan et al.   Molecular Therapy-Nucleic Acids

Cellular and Molecular Therapeutic Targets in Inflammatory Bowel Disease—Focusing on Intestinal Barrier Function

(2019) Ida Schoultz et al.   Cells

HIF1α Suppresses Tumor Cell Proliferation through Inhibition of Aspartate Biosynthesis

(2019) Florinda Meléndez-Rodríguez et al.   Cell Reports

Mitochondria in Sepsis-Induced AKI

(2019) Jian Sun et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

A novel cross-linked haemoglobin-based oxygen carrier is beneficial to sepsis in rats

(2019) Lei Kuang et al.   Artificial Cells Nanomedicine and Biotechnology

Microvesicles derived from human Wharton’s Jelly mesenchymal stem cells ameliorate acute lung injury partly mediated by hepatocyte growth factor

(2019) Wenxia Chen et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Mitochondrial dynamics and their potential as a therapeutic target

(2019) B.N. Whitley et al.   MITOCHONDRION

Extracellular vesicles: a new communication paradigm?

(2019) Graça Raposo et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Challenge to the Intestinal Mucosa During Sepsis

(2019) Felix Haussner et al.   Frontiers in Immunology

Mitochondria and Critical Illness

(2019) Gerald S. Supinski et al.   CHEST

Mesenchymal stem cell–derived extracellular vesicles improve the molecular phenotype of isolated rat lungs during ischemia/reperfusion injury

(2019) Caterina Lonati et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Role of TNF-α in vascular hyporeactivity following endotoxic shock and its mechanism

(2019) HongLiang Zhao et al.   Journal of Trauma and Acute Care Surgery

Role of Resveratrol in Protecting Vasodilatation Function in Septic Shock Rats and its Mechanism

(2019) Zi-sen Zhang et al.   Journal of Trauma and Acute Care Surgery

Mitochondrial Dynamics and Its Involvement in Disease

(2019) David C. Chan   Annual Review of Pathology-Mechanisms of Disease

Metabolic Reprogramming in Mitochondria of Myeloid Cells

(2019) Hao Zuo et al.   Cells

The intestinal barrier in multiple sclerosis: implications for pathophysiology and therapeutics

(2018) Carlos R Camara-Lemarroy et al.   BRAIN

In Inflamed Intestinal Tissues and Epithelial Cells, Interleukin 22 Signaling Increases Expression of H19 Long Noncoding RNA, Which Promotes Mucosal Regeneration

(2018) Hua Geng et al.   GASTROENTEROLOGY

Shedding light on the cell biology of extracellular vesicles

(2018) Guillaume van Niel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Circulating Extracellular Vesicles in Human Disease

(2018) Ravi Shah et al.   NEW ENGLAND JOURNAL OF MEDICINE

Therapeutic effects of human mesenchymal stem cell microvesicles in an ex vivo perfused human lung injured with severeE. colipneumonia

(2018) Jeonghyun Park et al.   THORAX

MiR-494-3p regulates mitochondrial biogenesis and thermogenesis through PGC1-α signalling in beige adipocytes

(2018) Mengistu Lemecha et al.   Scientific Reports

A State-of-the-Art Review of New and Emerging Therapies for the Treatment of IBD

(2018) Kenechukwu O Chudy-Onwugaje et al.   INFLAMMATORY BOWEL DISEASES

Higher Levels of Serum Zonulin May Rather Be Associated with Increased Risk of Obesity and Hyperlipidemia, Than with Gastrointestinal Symptoms or Disease Manifestations

(2017) Bodil Ohlsson et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

MicroRNA-211 Regulates Oxidative Phosphorylation and Energy Metabolism in Human Vitiligo

(2017) Anupama Sahoo et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Mesenchymal Stem Cell-Derived Microvesicles Modulate Lipopolysaccharides-Induced Inflammatory Responses to Microglia Cells

(2017) Yarúa Jaimes et al.   STEM CELLS

Mesenchymal Stem Cell Microvesicles Attenuate Acute Lung Injury in Mice Partly Mediated by Ang-1 mRNA

(2017) Xiao-Dan Tang et al.   STEM CELLS

Concise Review: Mesenchymal Stem (Stromal) Cells: Biology and Preclinical Evidence for Therapeutic Potential for Organ Dysfunction Following Trauma or Sepsis

(2017) Michael A. Matthay et al.   STEM CELLS

Redox regulation in metabolic programming and inflammation

(2017) Helen R. Griffiths et al.   Redox Biology

The intestinal epithelial barrier: a therapeutic target?

(2016) Matthew A. Odenwald et al.   Nature Reviews Gastroenterology & Hepatology

Complementation of mitochondrial electron transport chain by manipulation of the NAD+/NADH ratio

(2016) D. V. Titov et al.   SCIENCE

Microvesicles provide a mechanism for intercellular communication by embryonic stem cells during embryo implantation

(2016) Laura M. Desrochers et al.   Nature Communications

Autocrine IL-10 functions as a rheostat for M1 macrophage glycolytic commitment by tuning nitric oxide production

(2016) Walter A. Baseler et al.   Redox Biology

Sepsis and septic shock

(2016) Richard S. Hotchkiss et al.   Nature Reviews Disease Primers

Mitochondrial diseases

(2016) Gráinne S. Gorman et al.   Nature Reviews Disease Primers

Therapeutic Effects of Human Mesenchymal Stem Cell–derived Microvesicles in Severe Pneumonia in Mice

(2015) Antoine Monsel et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Microvesicles Derived From Human Mesenchymal Stem Cells Restore Alveolar Fluid Clearance in Human Lungs Rejected for Transplantation

(2015) S. Gennai et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Supporting Aspartate Biosynthesis Is an Essential Function of Respiration in Proliferating Cells

(2015) Lucas B. Sullivan et al.   CELL

Mesenchymal Stem Cell-derived Extracellular Vesicles: Toward Cell-free Therapeutic Applications

(2015) Sweta Rani et al.   MOLECULAR THERAPY

Mitochondrial Function and Disturbances in the Septic Kidney

(2015) Samir M. Parikh et al.   SEMINARS IN NEPHROLOGY

Mesenchymal stem cells use extracellular vesicles to outsource mitophagy and shuttle microRNAs

(2015) Donald G. Phinney et al.   Nature Communications

Influence of erythropoietin on microvesicles derived from mesenchymal stem cells protecting renal function of chronic kidney disease

(2015) Yan Wang et al.   Stem Cell Research & Therapy

Extracellular vesicles: biology and emerging therapeutic opportunities

(2013) Samir EL Andaloussi et al.   NATURE REVIEWS DRUG DISCOVERY

Human Mesenchymal Stem Cell Microvesicles for Treatment ofEscherichia coliEndotoxin-Induced Acute Lung Injury in Mice

(2013) Ying-gang Zhu et al.   STEM CELLS

Redefining the gut as the motor of critical illness

(2013) Rohit Mittal et al.   TRENDS IN MOLECULAR MEDICINE

Regulation of mitochondrial dynamics: convergences and divergences between yeast and vertebrates

(2012) Jian Zhao et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mitochondrial transfer from bone-marrow–derived stromal cells to pulmonary alveoli protects against acute lung injury

(2012) Mohammad Naimul Islam et al.   NATURE MEDICINE

Role of Mitofusin 2 in the Renal Stress Response

(2012) Jonathan M. Gall et al.   PLoS One

Role of myosin light chain kinase in regulation of basal blood pressure and maintenance of salt-induced hypertension

(2011) Wei-Qi He et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Pharmacokinetics, pharmacodynamics and safety of a human anti-IL-6 monoclonal antibody (sirukumab) in healthy subjects in a first-in-human study

(2011) Zhenhua Xu et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Mitochondrial Biogenesis in Kidney Disease

(2011) J. M. Weinberg   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Nitric oxide and AMPK cooperatively regulate PGC-1α in skeletal muscle cells

(2010) Vitor A. Lira et al.   JOURNAL OF PHYSIOLOGY-LONDON

Mesenchymal Stem Cell-Derived Microvesicles Protect Against Acute Tubular Injury

(2009) S. Bruno et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY