Adeno-associated virus-mediated delivery of anti-miR-199a tough decoys attenuates cardiac hypertrophy by targeting PGC-1alpha

MicroRNA-20b Promotes Cardiac Hypertrophy by the Inhibition of Mitofusin 2-Mediated Inter-organelle Ca2+ Cross-Talk

(2020) Yue Qiu et al.   Molecular Therapy-Nucleic Acids

Extracellular vesicular MicroRNA-27a* contributes to cardiac hypertrophy in chronic heart failure

(2020) Changhai Tian et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Longterm Exercise-Derived Exosomal miR-342-5p: A Novel Exerkine for Cardioprotection

(2019) Zuoxu Hou et al.   CIRCULATION RESEARCH

Therapeutic role of miR-19a/19b in cardiac regeneration and protection from myocardial infarction

(2019) Feng Gao et al.   Nature Communications

Nuclear miR-320 Mediates Diabetes-Induced Cardiac Dysfunction by Activating Transcription of Fatty Acid Metabolic Genes to Cause Lipotoxicity in the Heart

(2019) Huaping Li et al.   CIRCULATION RESEARCH

Heart specific PGC-1α deletion identifies metabolome of cardiac restricted metabolic heart failure

(2018) Olli Kärkkäinen et al.   CARDIOVASCULAR RESEARCH

Overexpression of miR-135b attenuates pathological cardiac hypertrophy by targeting CACNA1C

(2018) Qun Chu et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Mechanisms of physiological and pathological cardiac hypertrophy

(2018) Michinari Nakamura et al.   Nature Reviews Cardiology

miR-217 Promotes Cardiac Hypertrophy and Dysfunction by Targeting PTEN

(2018) Xiang Nie et al.   Molecular Therapy-Nucleic Acids

miR-146a Suppresses SUMO1 Expression and Induces Cardiac Dysfunction in Maladaptive Hypertrophy

(2018) Jae Gyun Oh et al.   CIRCULATION RESEARCH

Overexpression of miR-142-3p improves mitochondrial function in cardiac hypertrophy

(2018) Bei-lei Liu et al.   BIOMEDICINE & PHARMACOTHERAPY

Content of mitochondrial calcium uniporter (MCU) in cardiomyocytes is regulated by microRNA-1 in physiologic and pathologic hypertrophy

(2017) Tania Zaglia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

miR-199-sponge transgenic mice develop physiological cardiac hypertrophy

(2016) Zhenhua Li et al.   CARDIOVASCULAR RESEARCH

Contrary microRNA Expression Pattern Between Fetal and Adult Cardiac Remodeling: Therapeutic Value for Heart Failure

(2016) Hualin Yan et al.   Cardiovascular Toxicology

miR-199a impairs autophagy and induces cardiac hypertrophy through mTOR activation

(2015) Z Li et al.   CELL DEATH AND DIFFERENTIATION

Adeno-Associated Virus-Mediated MicroRNA Delivery and Therapeutics

(2015) Jun Xie et al.   SEMINARS IN LIVER DISEASE

Promoting PGC-1α-driven mitochondrial biogenesis is detrimental in pressure-overloaded mouse hearts

(2014) Georgios Karamanlidis et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Adeno-Associated Virus Vectors as Therapeutic and Investigational Tools in the Cardiovascular System

(2014) Serena Zacchigna et al.   CIRCULATION RESEARCH

Maintaining PGC-1α expression following pressure overload-induced cardiac hypertrophy preserves angiogenesis but not contractile or mitochondrial function

(2014) Renata O. Pereira et al.   FASEB JOURNAL

The Hypoxia-Inducible MicroRNA Cluster miR-199a∼214 Targets Myocardial PPARδ and Impairs Mitochondrial Fatty Acid Oxidation

(2013) Hamid el Azzouzi et al.   Cell Metabolism

MicroRNA-22 Regulates Cardiac Hypertrophy and Remodeling in Response to Stress

(2013) Zhan-Peng Huang et al.   CIRCULATION RESEARCH

Cardiac Insulin-Resistance and Decreased Mitochondrial Energy Production Precede the Development of Systolic Heart Failure After Pressure-Overload Hypertrophy

(2013) Liyan Zhang et al.   Circulation-Heart Failure

Long-term, efficient inhibition of microRNA function in mice using rAAV vectors

(2012) Jun Xie et al.   NATURE METHODS

PPARα-Sirt1 Complex Mediates Cardiac Hypertrophy and Failure through Suppression of the ERR Transcriptional Pathway

(2011) Shinichi Oka et al.   Cell Metabolism

Mitochondrial Oxidative Stress Mediates Angiotensin II–Induced Cardiac Hypertrophy and Gαq Overexpression–Induced Heart Failure

(2011) Dao-Fu Dai et al.   CIRCULATION RESEARCH

Differential Roles of GSK-3β During Myocardial Ischemia and Ischemia/Reperfusion

(2011) Peiyong Zhai et al.   CIRCULATION RESEARCH

Exercise Increases Mitochondrial PGC-1α Content and Promotes Nuclear-Mitochondrial Cross-talk to Coordinate Mitochondrial Biogenesis

(2011) Adeel Safdar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MicroRNAs are dynamically regulated in hypertrophic hearts, and miR-199a is essential for the maintenance of cell size in cardiomyocytes

(2010) Xiao-Wei Song et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The PGC-1 cascade as a therapeutic target for heart failure

(2010) Joel Schilling et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

MicroRNA-199b targets the nuclear kinase Dyrk1a in an auto-amplification loop promoting calcineurin/NFAT signalling

(2010) Paula A. da Costa Martins et al.   NATURE CELL BIOLOGY

Activation of a HIF1α-PPARγ Axis Underlies the Integration of Glycolytic and Lipid Anabolic Pathways in Pathologic Cardiac Hypertrophy

(2009) Jaya Krishnan et al.   Cell Metabolism

Downregulation of MiR-199a Derepresses Hypoxia-Inducible Factor-1α and Sirtuin 1 and Recapitulates Hypoxia Preconditioning in Cardiac Myocytes

(2009) Shweta Rane et al.   CIRCULATION RESEARCH