TPPU treatment of burned mice dampens inflammation and generation of bioactive DHET which impairs neutrophil function

Diversity and versatility of p38 kinase signalling in health and disease

(2021) Begoña Canovas et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Persistent Systemic Inflammation in Patients With Severe Burn Injury Is Accompanied by Influx of Immature Neutrophils and Shifts in T Cell Subsets and Cytokine Profiles

(2021) Patrick P. G. Mulder et al.   Frontiers in Immunology

Burn injury

(2020) Marc G. Jeschke et al.   Nature Reviews Disease Primers

Scald Injury-Induced T Cell Dysfunction Can Be Mitigated by Gr1+ Cell Depletion and Blockage of CD47/CD172a Signaling

(2020) Nadine Beckmann et al.   Frontiers in Immunology

Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 2.0

(2020) Nathalie Percie du Sert et al.   PLOS BIOLOGY

Distinct Neutrophil Populations in the Spleen During PICS

(2020) Satarupa Sengupta et al.   Frontiers in Immunology

Burn Injury Impairs Neutrophil Chemotaxis through Increased Ceramide

(2020) Nadine Beckmann et al.   SHOCK

sEH Inhibitor TPPU Ameliorates Cecal Ligation and Puncture-Induced Sepsis by Regulating Macrophage Functions

(2019) Zhihui Chen et al.   SHOCK

L-selectin: A Major Regulator of Leukocyte Adhesion, Migration and Signaling

(2019) Aleksandar Ivetic et al.   Frontiers in Immunology

Anti- Versus Pro-Inflammatory Metabololipidome Upon Cupping Treatment

(2018) Qi Zhang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

NADPH oxidase activation in neutrophils: Role of the phosphorylation of its subunits

(2018) Sahra A. Belambri et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Epoxide hydrolase 1 (EPHX1) hydrolyzes epoxyeicosanoids and impairs cardiac recovery after ischemia

(2018) Matthew L. Edin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

14, 15-EET induces breast cancer cell EMT and cisplatin resistance by up-regulating integrin αvβ3 and activating FAK/PI3K/AKT signaling

(2018) Jing Luo et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Profiling inflammatory markers in patients with pneumonia on intensive care

(2018) David B. Antcliffe et al.   Scientific Reports

Update on Neutrophil Function in Severe Inflammation

(2018) Esmaeil Mortaz et al.   Frontiers in Immunology

Genetic deletion or pharmacological inhibition of soluble epoxide hydrolase reduces brain damage and attenuates neuroinflammation after intracerebral hemorrhage

(2017) Chun-Hu Wu et al.   Journal of Neuroinflammation

Longitudinal analysis of serum oxylipin profile as a novel descriptor of the inflammatory response to surgery

(2017) Arnaud M. Wolfer et al.   Journal of Translational Medicine

Generation and characterization of epoxide hydrolase 3 (EPHX3)-deficient mice

(2017) Samantha L. Hoopes et al.   PLoS One

Soluble Epoxide Hydrolase Inhibitor Attenuates Lipopolysaccharide-Induced Acute Lung Injury and Improves Survival in Mice

(2017) Yong Zhou et al.   SHOCK

Soluble Epoxide Hydrolase Inhibitor Suppresses the Expression of Triggering Receptor Expressed on Myeloid Cells-1 by Inhibiting NF-kB Activation in Murine Macrophage

(2016) Liang Dong et al.   INFLAMMATION

CXCR1 Regulates Pulmonary Anti-Pseudomonas Host Defense

(2016) M. Carevic et al.   Journal of Innate Immunity

CXCR1-mediated neutrophil degranulation and fungal killing promote Candida clearance and host survival

(2016) Muthulekha Swamydas et al.   Science Translational Medicine

Effects of a Soluble Epoxide Hydrolase Inhibitor on Lipopolysaccharide-Induced Acute Lung Injury in Mice

(2016) Wei Tao et al.   PLoS One

PI3K signalling in inflammation

(2015) P.T. Hawkins et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

ICAM-1-expressing neutrophils exhibit enhanced effector functions in murine models of endotoxemia

(2015) A. Woodfin et al.   BLOOD

Soluble epoxide hydrolase inhibition provides multi-target therapeutic effects in rats after spinal cord injury

(2015) Xiaojing Chen et al.   MOLECULAR NEUROBIOLOGY

Combined anti CXC receptors 1 and 2 therapy is a promising anti-inflammatory treatment for respiratory diseases by reducing neutrophil migration and activation

(2015) A. Planagumà et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

The proinflammatory LTB4/BLT1 signal axis confers resistance to TGF-β1-induced growth inhibition by targeting Smad3 linker region

(2015) Woo-Kwang Jeon et al.   Oncotarget

PPARγ signaling is required for mediating EETs protective effects in neonatal cardiomyocytes exposed to LPS

(2014) Victor Samokhvalov et al.   Frontiers in Pharmacology

The Multifaceted Functions of Neutrophils

(2013) Tanya N. Mayadas et al.   Annual Review of Pathology-Mechanisms of Disease

Pathview: an R/Bioconductor package for pathway-based data integration and visualization

(2013) Weijun Luo et al.   BIOINFORMATICS

Substituted phenyl groups improve the pharmacokinetic profile and anti-inflammatory effect of urea-based soluble epoxide hydrolase inhibitors in murine models

(2013) Jun-Yan Liu et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

The role of 14,15-dihydroxyeicosatrienoic acid levels in inflammation and its relationship to lipoproteins

(2013) Tian Yang et al.   Lipids in Health and Disease

In vitro and in vivo characterization of a novel soluble epoxide hydrolase inhibitor

(2013) Patricia L. Podolin et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Metabolic products of soluble epoxide hydrolase are essential for monocyte chemotaxis to MCP-1 in vitro and in vivo

(2012) Suman Kundu et al.   JOURNAL OF LIPID RESEARCH

Phagosomal proteolysis in dendritic cells is modulated by NADPH oxidase in a pH-independent manner

(2011) Joanna M Rybicka et al.   EMBO JOURNAL

Phagosome dynamics during phagocytosis by neutrophils

(2011) Pontus Nordenfelt et al.   JOURNAL OF LEUKOCYTE BIOLOGY

A simple procedure for estimation of total body surface area and determination of a new value of Meeh's constant in rats

(2011) E Gouma et al.   LABORATORY ANIMALS

PI3K  Plays a Critical Role in Neutrophil Activation by Immune Complexes

(2011) S. Kulkarni et al.   Science Signaling

Injury Induces Early Activation of T-Cell Receptor Signaling Pathways in CD4+ Regulatory T Cells

(2010) Marc Hanschen et al.   SHOCK

Quantitative Profiling Method for Oxylipin Metabolome by Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry

(2009) Jun Yang et al.   ANALYTICAL CHEMISTRY

A crucial role for TNF-α in mediating neutrophil influx induced by endogenously generated or exogenous chemokines, KC/CXCL1 and LIX/CXCL5

(2009) SM Vieira et al.   BRITISH JOURNAL OF PHARMACOLOGY

A non-redundant role for MKP5 in limiting ROS production and preventing LPS-induced vascular injury

(2009) Feng Qian et al.   EMBO JOURNAL

KEGG for representation and analysis of molecular networks involving diseases and drugs

(2009) Minoru Kanehisa et al.   NUCLEIC ACIDS RESEARCH

DIFFERENTIAL IMMUNOLOGICAL PHENOTYPES ARE EXHIBITED AFTER SCALD AND FLAME BURNS

(2009) Johannes Tschöp et al.   SHOCK

Interaction Between P450 Eicosanoids and Nitric Oxide in the Control of Arterial Tone in Mice

(2008) Hantz C. Hercule et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Epoxyeicosatrienoic Acids Function as Selective, Endogenous Antagonists of Native Thromboxane Receptors: Identification of a Novel Mechanism of Vasodilation

(2008) D. J. Behm et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS