Epoxide hydrolase 1 (EPHX1) hydrolyzes epoxyeicosanoids and impairs cardiac recovery after ischemia

Cytochrome P450-derived eicosanoids and heart function

(2017) K. Lockhart Jamieson et al.   PHARMACOLOGY & THERAPEUTICS

Generation and characterization of epoxide hydrolase 3 (EPHX3)-deficient mice

(2017) Samantha L. Hoopes et al.   PLoS One

Microsomal epoxide hydrolase 1 (EPHX1): Gene, structure, function, and role in human disease

(2015) Radka Václavíková et al.   GENE

Müller glia cells regulate Notch signaling and retinal angiogenesis via the generation of 19,20-dihydroxydocosapentaenoic acid

(2014) Jiong Hu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Effect of soluble epoxide hydrolase polymorphism on substrate and inhibitor selectivity and dimer formation

(2014) Christophe Morisseau et al.   JOURNAL OF LIPID RESEARCH

Epoxyeicosatrienoic acids and cardioprotection: The road to translation

(2014) Akinyemi Oni-Orisan et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Anti-inflammatory Effects of ω-3 Polyunsaturated Fatty Acids and Soluble Epoxide Hydrolase Inhibitors in Angiotensin-II–Dependent Hypertension

(2013) Arzu Ulu et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Impact of Soluble Epoxide Hydrolase and Epoxyeicosanoids on Human Health

(2012) Christophe Morisseau et al.   Annual Review of Pharmacology and Toxicology

EH3 (ABHD9): the first member of a new epoxide hydrolase family with high activity for fatty acid epoxides

(2012) Martina Decker et al.   JOURNAL OF LIPID RESEARCH

Regulation of forskolin-induced cAMP production by cytochrome P450 epoxygenase metabolites of arachidonic acid in HEK293 cells

(2011) Mohamed Abukhashim et al.   CELL BIOLOGY AND TOXICOLOGY

Cytochromes P450 Catalyze Both Steps of the Major Pathway of Clopidogrel Bioactivation, whereas Paraoxonase Catalyzes the Formation of a Minor Thiol Metabolite Isomer

(2011) Patrick M. Dansette et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Endothelial expression of human cytochrome P450 epoxygenase CYP2C8 increases susceptibility to ischemia-reperfusion injury in isolated mouse heart

(2011) Matthew L. Edin et al.   FASEB JOURNAL

Epoxyeicosanoids stimulate multiorgan metastasis and tumor dormancy escape in mice

(2011) Dipak Panigrahy et al.   JOURNAL OF CLINICAL INVESTIGATION

Pharmacokinetics and Pharmacodynamics of AR9281, an Inhibitor of Soluble Epoxide Hydrolase, in Single- and Multiple-Dose Studies in Healthy Human Subjects

(2011) Dawn Chen et al.   JOURNAL OF CLINICAL PHARMACOLOGY

CYP-eicosanoids—A new link between omega-3 fatty acids and cardiac disease?

(2011) Christina Westphal et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Role of cytochrome P450 enzymes in the bioactivation of polyunsaturated fatty acids

(2010) Anne Konkel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Inhibition of Soluble Epoxide Hydrolase by trans-4- [4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid Is Protective Against Ischemia–Reperfusion Injury

(2010) Ketul R Chaudhary et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Review Article: Epoxyeicosatrienoic Acids: Novel Mediators of Cardioprotection

(2010) Kasem Nithipatikom et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS

Naturally occurring monoepoxides of eicosapentaenoic acid and docosahexaenoic acid are bioactive antihyperalgesic lipids

(2010) Christophe Morisseau et al.   JOURNAL OF LIPID RESEARCH

Metabolism and Toxicity of Styrene in Microsomal Epoxide Hydrolase-Deficient Mice

(2010) Gary P. Carlson   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Mammalian epoxide hydrolases in xenobiotic metabolism and signalling

(2009) Martina Decker et al.   ARCHIVES OF TOXICOLOGY

Soluble epoxide hydrolase as a therapeutic target for cardiovascular diseases

(2009) John D. Imig et al.   NATURE REVIEWS DRUG DISCOVERY

Distribution of soluble and microsomal epoxide hydrolase in the mouse brain and its contribution to cerebral epoxyeicosatrienoic acid metabolism

(2009) A. Marowsky et al.   NEUROSCIENCE