Interactions of anti-COVID-19 drug candidates with hepatic transporters may cause liver toxicity and affect pharmacokinetics

Interactions of Potential Anti-COVID-19 Compounds with Multispecific ABC and OATP Drug Transporters

(2021) Ágnes Telbisz et al.   Pharmaceutics

Clinical Management of COVID-19: A Review of Pharmacological Treatment Options

(2021) Ashli Heustess et al.   Pharmaceuticals

Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro

(2020) Manli Wang et al.   CELL RESEARCH

Fluorescent probes for the dual investigation of MRP2 and OATP1B1 function and drug interactions

(2020) Virág Székely et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Pharmacologic Treatments for Coronavirus Disease 2019 (COVID-19)

(2020) James M. Sanders et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Remdesivir for 5 or 10 Days in Patients with Severe Covid-19

(2020) Jason D. Goldman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Remdesivir for the Treatment of Covid-19 — Preliminary Report

(2020) John H. Beigel et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Trial of Lopinavir–Ritonavir in Adults Hospitalized with Severe Covid-19

(2020) Bin Cao et al.   NEW ENGLAND JOURNAL OF MEDICINE

Remdesivir: Review of pharmacology, pre‐clinical data and emerging clinical experience for COVID‐19

(2020) Sarah CJ Jorgensen et al.   PHARMACOTHERAPY

In vitro activity of lopinavir/ritonavir and hydroxychloroquine against severe acute respiratory syndrome coronavirus 2 at concentrations achievable by usual doses

(2020) Chang Kyung Kang et al.   KOREAN JOURNAL OF INTERNAL MEDICINE

The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro

(2020) Leon Caly et al.   ANTIVIRAL RESEARCH

Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitro

(2020) Ka-Tim Choy et al.   ANTIVIRAL RESEARCH

Abnormal laboratory findings and plasma concentration monitoring of lopinavir and ritonavir in COVID‐19

(2020) Benjamin Batteux et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Role of OATP1B1 and OATP1B3 in Drug-Drug Interactions Mediated by Tyrosine Kinase Inhibitors

(2020) Dominique A. Garrison et al.   Pharmaceutics

Repurposed Antiviral Drugs for Covid-19 — Interim WHO Solidarity Trial Results

(2020)   NEW ENGLAND JOURNAL OF MEDICINE

High rate of major drug–drug interactions of lopinavir–ritonavir for COVID-19 treatment

(2020) Juan Macías et al.   Scientific Reports

Organic Anion Transporting Polypeptides: Emerging Roles in Cancer Pharmacology

(2019) Rachael R. Schulte et al.   MOLECULAR PHARMACOLOGY

A systematic in vitro investigation of the inhibitor preincubation effect on multiple classes of clinically relevant transporters

(2019) Peter Tatrai et al.   DRUG METABOLISM AND DISPOSITION

Involvement of human and canine MRP1 and MRP4 in benzylpenicillin transport

(2019) Xiaofen Zhao et al.   PLoS One

Organic Cation Transporters in Health and Disease

(2019) Hermann Koepsell   PHARMACOLOGICAL REVIEWS

Identification of novel cell-impermeant fluorescent substrates for testing the function and drug interaction of Organic Anion-Transporting Polypeptides, OATP1B1/1B3 and 2B1

(2018) Izabel Patik et al.   Scientific Reports

Investigation of the Importance of Multidrug Resistance-Associated Protein 4 (Mrp4/ Abcc4 ) in the Active Efflux of Anionic Drugs Across the Blood–Brain Barrier

(2017) Kayoko Kanamitsu et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Transporters Involved in Metformin Pharmacokinetics and Treatment Response

(2017) Xiaomin Liang et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

The role of organic anion transporting polypeptides in drug absorption, distribution, excretion and drug-drug interactions

(2016) Daniella Kovacsics et al.   Expert Opinion on Drug Metabolism & Toxicology

Organic Anion Transporting Polypeptide (OATP)1B1 and OATP1B3 as Important Regulators of the Pharmacokinetics of Substrate Drugs

(2015) Kazuya Maeda   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Contribution of Abcc4-Mediated Gastric Transport to the Absorption and Efficacy of Dasatinib

(2013) B. D. Furmanski et al.   CLINICAL CANCER RESEARCH

A Mechanistic Framework for In Vitro–In Vivo Extrapolation of Liver Membrane Transporters: Prediction of Drug–Drug Interaction Between Rosuvastatin and Cyclosporine

(2013) M. Jamei et al.   CLINICAL PHARMACOKINETICS

Early Identification of Clinically Relevant Drug Interactions With the Human Bile Salt Export Pump (BSEP/ABCB11)

(2013) Jenny M. Pedersen et al.   TOXICOLOGICAL SCIENCES

Importance of the multidrug and toxin extrusion MATE/SLC47A family to pharmacokinetics, pharmacodynamics/toxicodynamics and pharmacogenomics

(2011) Atsushi Yonezawa et al.   BRITISH JOURNAL OF PHARMACOLOGY

Ivermectin Interacts With Human ABCG2

(2010) Márton Jani et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Membrane transporters in drug development

(2010)   NATURE REVIEWS DRUG DISCOVERY

Interaction of HIV protease inhibitors with OATP1B1, 1B3, and 2B1

(2010) P. Annaert et al.   XENOBIOTICA

Impact of OATP transporters on pharmacokinetics

(2009) A Kalliokoski et al.   BRITISH JOURNAL OF PHARMACOLOGY

Substrates and Inhibitors of Human Multidrug Resistance Associated Proteins and the Implications in Drug Development

(2008) Shu-Feng Zhou et al.   CURRENT MEDICINAL CHEMISTRY

Multidrug resistance protein 4 (MRP4/ABCC4): a versatile efflux transporter for drugs and signalling molecules

(2008) F RUSSEL et al.   TRENDS IN PHARMACOLOGICAL SCIENCES