A small molecule inhibitor of Nox2 and Nox4 improves contractile function after ischemia–reperfusion in the mouse heart

Hyperglycemia Acutely Increases Cytosolic Reactive Oxygen Species via O -linked GlcNAcylation and CaMKII Activation in Mouse Ventricular Myocytes

(2020) Shan Lu et al.   CIRCULATION RESEARCH

A closer look into NADPH oxidase inhibitors: Validation and insight into their mechanism of action

(2020) Joana Reis et al.   Redox Biology

NADPH oxidases: Current aspects and tools

(2020) Katrin Schröder   Redox Biology

Pharmacological characterization of the seven human NOX isoforms and their inhibitors

(2019) Fiona Augsburger et al.   Redox Biology

Isoform-selective NADPH oxidase inhibitor panel for pharmacological target validation

(2019) Vu Thao-Vi Dao et al.   FREE RADICAL BIOLOGY AND MEDICINE

Vascular smooth muscle contraction in hypertension

(2018) Rhian M Touyz et al.   CARDIOVASCULAR RESEARCH

Megakaryocytic Leukemia 1 (MKL1) Bridges Epigenetic Activation of NADPH Oxidase in Macrophages to Cardiac Ischemia-Reperfusion Injury

(2018) Yu Liming et al.   CIRCULATION

ROS and redox signaling in myocardial ischemia-reperfusion injury and cardioprotection

(2018) Susana Cadenas   FREE RADICAL BIOLOGY AND MEDICINE

The novel NADPH oxidase 4 selective inhibitor GLX7013114 counteracts human islet cell death in vitro

(2018) Xuan Wang et al.   PLoS One

NADPH oxidase in brain injury and neurodegenerative disorders

(2017) Merry W. Ma et al.   Molecular Neurodegeneration

ZYZ-772 Prevents Cardiomyocyte Injury by Suppressing Nox4-Derived ROS Production and Apoptosis

(2017) Ying Wang et al.   MOLECULES

NOX4-dependent neuronal autotoxicity and BBB breakdown explain the superior sensitivity of the brain to ischemic damage

(2017) Ana I. Casas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NOX Inhibitors - A Promising Avenue for Ischemic Stroke

(2017) Jong Youl Kim et al.   Experimental Neurobiology

NF2 Activates Hippo Signaling and Promotes Ischemia/Reperfusion Injury in the HeartNovelty and Significance

(2016) Takahisa Matsuda et al.   CIRCULATION RESEARCH

NOX2 Antisense Attenuates Hypoxia-Induced Oxidative Stress and Apoptosis in Cardiomyocyte

(2016) Bo Yu et al.   International Journal of Medical Sciences

NADPH oxidase inhibitor improves outcome of mechanical reperfusion by suppressing hemorrhagic transformation

(2016) Yong-Hua Tuo et al.   Journal of NeuroInterventional Surgery

Evolution of NADPH Oxidase Inhibitors: Selectivity and Mechanisms for Target Engagement

(2015) Sebastian Altenhöfer et al.   ANTIOXIDANTS & REDOX SIGNALING

A subset of N-substituted phenothiazines inhibits NADPH oxidases

(2015) Tamara Seredenina et al.   FREE RADICAL BIOLOGY AND MEDICINE

The novel NADPH oxidase 4 inhibitor GLX351322 counteracts glucose intolerance in high-fat diet-treated C57BL/6 mice

(2015) E. Anvari et al.   FREE RADICAL RESEARCH

Reperfusion injury and reactive oxygen species: The evolution of a concept

(2015) D. Neil Granger et al.   Redox Biology

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS

(2014) Edward T. Chouchani et al.   NATURE

Cellular mechanisms and physiological consequences of redox-dependent signalling

(2014) Kira M. Holmström et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Physiological and pathological functions of NADPH oxidases during myocardial ischemia–reperfusion

(2014) Shouji Matsushima et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Elimination of NADPH Oxidase Activity Promotes Reductive Stress and Sensitizes the Heart to Ischemic Injury

(2014) Qiujun Yu et al.   Journal of the American Heart Association

Broad Suppression of NADPH Oxidase Activity Exacerbates Ischemia/Reperfusion Injury Through Inadvertent Downregulation of Hypoxia-inducible Factor-1α and Upregulation of Peroxisome Proliferator–activated Receptor-α

(2013) Shouji Matsushima et al.   CIRCULATION RESEARCH

Activation of NADPH Oxidase 4 in the Endoplasmic Reticulum Promotes Cardiomyocyte Autophagy and Survival During Energy Stress Through the Protein Kinase RNA-Activated-Like Endoplasmic Reticulum Kinase/Eukaryotic Initiation Factor 2α/Activating Transcription Factor 4 Pathway

(2013) Sebastiano Sciarretta et al.   CIRCULATION RESEARCH

Characterization of NADPH oxidase 5 expression in human tumors and tumor cell lines with a novel mouse monoclonal antibody

(2013) Smitha Antony et al.   FREE RADICAL BIOLOGY AND MEDICINE

A Model of Hypoxia-Reoxygenation on Isolated Adult Mouse Cardiomyocytes

(2013) Lolita Portal et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS

Role of NADPH oxidase isoforms NOX1, NOX2 and NOX4 in myocardial ischemia/reperfusion injury

(2013) Vincent Braunersreuther et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Neuroprotection After Stroke by Targeting NOX4 As a Source of Oxidative Stress

(2012) Kim A. Radermacher et al.   ANTIOXIDANTS & REDOX SIGNALING

NADPH Oxidases in Heart Failure: Poachers or Gamekeepers?

(2012) Min Zhang et al.   ANTIOXIDANTS & REDOX SIGNALING

VAS2870 is a pan-NADPH oxidase inhibitor

(2012) Kirstin Wingler et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Biochemistry, Physiology, and Pathophysiology of NADPH Oxidases in the Cardiovascular System

(2012) Bernard Lassègue et al.   CIRCULATION RESEARCH

Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010

(2012) Rafael Lozano et al.   LANCET

Endothelial Nox4 NADPH Oxidase Enhances Vasodilatation and Reduces Blood Pressure In Vivo

(2011) Robin Ray et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

NADPH oxidases in cardiovascular disease: insights from in vivo models and clinical studies

(2011) Alexander Sirker et al.   BASIC RESEARCH IN CARDIOLOGY

High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq

(2011) J. Schodel et al.   BLOOD

NADPH oxidase (NOX) isoforms are inhibited by celastrol with a dual mode of action

(2011) Vincent Jaquet et al.   BRITISH JOURNAL OF PHARMACOLOGY

Measuring reactive oxygen and nitrogen species with fluorescent probes: challenges and limitations

(2011) Balaraman Kalyanaraman et al.   FREE RADICAL BIOLOGY AND MEDICINE

PrimerBank: a PCR primer database for quantitative gene expression analysis, 2012 update

(2011) X. Wang et al.   NUCLEIC ACIDS RESEARCH

The cellular and molecular origin of reactive oxygen species generation during myocardial ischemia and reperfusion

(2011) Koen Raedschelders et al.   PHARMACOLOGY & THERAPEUTICS

A Novel and Specific NADPH Oxidase-1 (Nox1) Small-Molecule Inhibitor Blocks the Formation of Functional Invadopodia in Human Colon Cancer Cells

(2010) Davide Gianni et al.   ACS Chemical Biology

Constitutive NADPH-Dependent Electron Transferase Activity of the Nox4 Dehydrogenase Domain

(2010) Yukio Nisimoto et al.   BIOCHEMISTRY

Extracellular hydrogen peroxide contributes to oxidative glutamate toxicity

(2010) Jong Seong Ha et al.   BRAIN RESEARCH

Nox4-dependent H2O2 production contributes to chronic glutamate toxicity in primary cortical neurons

(2010) Jong Seong Ha et al.   EXPERIMENTAL CELL RESEARCH

NADPH oxidases in cardiovascular disease

(2010) Ralf P. Brandes et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nox4-Derived H2O2 Mediates Endoplasmic Reticulum Signaling through Local Ras Activation

(2010) R.-F. Wu et al.   MOLECULAR AND CELLULAR BIOLOGY

Post-Stroke Inhibition of Induced NADPH Oxidase Type 4 Prevents Oxidative Stress and Neurodegeneration

(2010) Christoph Kleinschnitz et al.   PLOS BIOLOGY

Role of NADPH oxidase in H9c2 cardiac muscle cells exposed to simulated ischaemia-reperfusion

(2008) Elisabetta Borchi et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE