Article
Biochemistry & Molecular Biology
Jyotsana Pandey, Jennifer L. Larson-Casey, Mallikarjun H. Patil, Rutwij Joshi, Chun-sun Jiang, Yong Zhou, Chao He, A. Brent Carter
Summary: Pulmonary fibrosis is a progressive lung disease characterized by macrophage activation. Asbestos-induced NOX4 expression in lung macrophages mediates fibrotic progression through mitochondrial ROS generation, while the mechanism of NOX4 localization to mitochondria is unknown. This study reveals that NOX4 localizes to the mitochondrial matrix via direct interaction with TIM23 in lung macrophages after asbestos exposure. The interaction between TIM23 and NOX4 is crucial for mitochondrial redox signaling and metabolic reprogramming in lung macrophages.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2023)
Article
Plant Sciences
Zhenhua Wu, Yunpeng Bai, Yujuan Qi, Chao Chang, Yan Jiao, Yaobang Bai, Zhigang Guo
Summary: This study found that metformin has a protective effect against ferroptosis in cardiac ischemia and reperfusion (I/R) injury.
PHARMACEUTICAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Shuai Yuan, Scott A. Hahn, Megan P. Miller, Subramaniam Sanker, Michael J. Calderon, Mara Sullivan, Atinuke M. Dosunmu-Ogunbi, Marco Fazzari, Yao Li, Michael Reynolds, Katherine C. Wood, Claudette M. St Croix, Donna Stolz, Eugenia Cifuentes-Pagano, Placido Navas, Sruti Shiva, Francisco J. Schopfer, Patrick J. Pagano, Adam C. Straub
Summary: The study demonstrates that CYB5R3 assists in NOX4-dependent H2O2 generation via CoQ, mitigating endothelial inflammatory activation. Knockout of CYB5R3 led to endothelial dysfunction in mice and enhanced VCAM-1 expression, which was alleviated by silencing NOX4. Overall, these findings suggest a regulatory role of CYB5R3 in endothelial inflammation through interaction with NOX4 and CoQ.
Article
Pharmacology & Pharmacy
Anantha Harijith, Prathima Basa, Alison Ha, Jaya Thomas, Anjum Jafri, Panfeng Fu, Peter M. MacFarlane, Thomas M. Raffay, Viswanathan Natarajan, Tara Sudhadevi
Summary: This study aimed to determine the possible role of AT2 epithelial cell NOX4 in epithelial cell death from hyperoxic acute lung injury (HALI). The results demonstrated that deletion of the Nox4 gene or silencing NOX4 can attenuate epithelial cell apoptosis and mitochondrial ROS production, thus protecting the lungs from severe lung injury.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Marine & Freshwater Biology
Qiang Luo, Liping Ai, Shuqiong Tang, Hua Zhang, Jinze Ma, Xiaoping Xiao, Keyuan Zhong, Guiyou Tian, Bo Cheng, Cong Xiong, Xiaobei Chen, Huiqiang Lu
Summary: Ethyl 3-(N-butylacetamido) propanoate (EBAAP) is a commonly used mosquito repellent and cosmetic ingredient. It has been detected in surface and groundwater in many countries, and its potential environmental harm is unknown. A study was conducted to investigate the developmental and cardiotoxic effects of EBAAP on zebrafish embryos. The results showed that EBAAP was toxic to zebrafish, causing abnormal morphology, heart defects, and dysregulated gene expression. These effects were attributed to the generation of reactive oxygen species (ROS) and activation of oxidative stress response and apoptosis pathways.
AQUATIC TOXICOLOGY
(2023)
Article
Endocrinology & Metabolism
Kalyn S. Specht, Shashi Kant, Adele K. Addington, Ryan P. McMillan, Matthew W. Hulver, Heather Learnard, Maura Campbell, Sarah R. Donnelly, Amada D. Caliz, Yongmei Pei, Michaella M. Reif, Jacob M. Bond, Anthony DeMarco, Branch Craige, John F. d Keaney Jr, Siobhan M. Craige
Summary: The study reveals the crucial role of Nox4 in exercise-induced skeletal muscle metabolism, influencing glucose and fatty acid oxidation through promoting immediate responses. Global Nox4 deletion resulted in decreased glucose and fatty acid oxidation post-exercise, potentially through regulation of UCP3 expression. Endothelial-Nox4 is similarly crucial for glucose and fatty acid oxidation, suggesting inter-tissue cross-talk between endothelium and skeletal muscle in response to exercise.
MOLECULAR METABOLISM
(2021)
Article
Food Science & Technology
Chongshan Dai, Meng Li, Tun Sun, Yuan Zhang, Yang Wang, Zhangqi Shen, Tony Velkov, Shusheng Tang, Jianzhong Shen
Summary: Colistin therapy can induce oxidative stress, mitochondrial dysfunction, and apoptosis by activating the TGF-beta/NOX4/mtROS pathway while inhibiting the Akt/mTOR pathway in lung tissues.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tae Woo Kim, Seong-Gyu Ko
Summary: The study presents a novel herbal extract, JI017, that induces cell death and ER stress in breast cancer cells, and overcomes paclitaxel resistance by blocking EMT processes. These findings suggest that JI017 may serve as a powerful anti-cancer agent in breast cancer and a potential therapy for paclitaxel-resistant breast cancer.
Article
Pharmacology & Pharmacy
Wenzheng Pan, Lin Zheng, Jiawei Gao, Lin Ye, Zhenzhong Chen, Shijie Liu, Bin Pan, Jiawei Fang, Hehuan Lai, Yejin Zhang, Kainai Ni, Chao Lou, Dengwei He
Summary: SIS3 inhibits osteoclastogenesis by suppressing Smad3 phosphorylation, reducing ROS production, and preventing osteoclast differentiation and maturation, making it a promising alternative therapy for osteoporosis.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Oncology
Xiangsheng Su, Yihang Yang, Qing Yang, Bo Pang, Shicheng Sun, Yanjun Wang, Qiujiang Qiao, Changfa Guo, Huanting Liu, Qi Pang
Summary: The expression of FOXM1 and NOX4 was found to be increased in glioma specimens and correlated with poor clinical outcomes. NOX4 induced FOXM1 expression through aberrant mitochondrial ROS production, promoting aerobic glycolysis. Inhibition of the NOX4-FOXM1 signaling pathway may present a potential therapeutic target for glioblastoma treatment.
Article
Pharmacology & Pharmacy
Youli Tao, Hua Zhou, Lili Huang, Xiaoyin Xu, Yun Huang, Lili Ma, Lingna Li, Xu Yao, Ronghui Zhang, Yuyu Zhang, Weibo Rong, Chaojun Yang, Taotao Yang, Yi Shen, Rixiang Wang
Summary: This study showed that schisandrin B inhibited acute ethanol-induced autophagy and subsequent apoptosis, improving cardiac function in ethanol-treated mice. NOX4 protein expression was increased during acute ethanol exposure, and the upregulation of NOX4 was significantly inhibited by schisandrin B treatment, preventing ROS accumulation, cell autophagy, and apoptosis. These results suggest a potential therapeutic strategy for acute alcoholic cardiomyopathy.
Article
Biochemistry & Molecular Biology
Lukas Gola, Laura Bierhansl, Julia Csatari, Christina B. Schroeter, Lisanne Korn, Venu Narayanan, Manuela Cerina, Sara Abdolahi, Anna Speicher, Alexander M. Hermann, Simone Koenig, Albena T. Dinkova-Kostova, Tawfeeq Shekh-Ahmad, Sven G. Meuth, Heinz Wiendl, Ali Gorji, Matthias Pawlowski, Stjepana Kovac
Summary: Hyperexcitability is associated with neuronal dysfunction, cellular death, and neurodegeneration. NOX4, an NADPH oxidase, is found to regulate reactive oxygen species (ROS) levels and calcium homeostasis, thereby preventing hyperexcitability and neuronal death. These findings suggest that NOX4 might have a crucial role in neurodegenerative diseases by acting as a potential redox regulator.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Taewoo Kim, Seong-Gyu Ko
Summary: JI017 is a potent anti-cancer drug for ovarian cancer treatment, mediating endoplasmic reticulum stress and apoptosis through the Nox4-PERK-CHOP signaling pathway. Combination treatment with radiation can overcome radioresistance in ovarian cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Pedro Garcia-Gomez, Irene Golan, Mahsa S. Dadras, Artur Mezheyeuski, Claudia Bellomo, Kalliopi Tzavlaki, Anita Moren, Jordi Carreras-Puigvert, Laia Caja
Summary: This study investigates the crucial roles of TGF beta and ROS in GSC biology, revealing the key regulatory function of NOX4 in GSCs.
MOLECULAR ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mengxiao Zhang, Huiting Zhong, Ting Cao, Yifan Huang, Xiaoyun Ji, Guo-Chang Fan, Tianqing Peng
Summary: Lipid overload contributes to cardiac complications of diabetes and obesity. This study reveals the protective role of gamma-aminobutyrate transaminase (ABAT) in lipid overload-induced cardiac injury through mechanisms independent of its GABA catabolic activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Guo-Hua Zhu, Lu Liu, Xi-Xi Huang, Da-Jin Li, Yi-Zhun Zhu, Xin Lu, Mei-Rong Du
Summary: This article reviews the impact of novel coronavirus infection on pregnancy, elucidates the mechanisms by which immune-related changes may lead to fetal loss, and discusses the role of SARS-CoV-2 in the female reproductive system and existing evidence of infection in pregnant women.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yun-Yun Li, Yi-Kong Lin, Yue Li, Xin-Hua Liu, Da-Jin Li, Xiao-Lin Wang, Li Wang, Yi-Zhun Zhu, Min Yu, Mei-rong Du
Summary: This study found that Tregs were increased in the peritoneal fluid of EMS patients, accompanied by overactivation of estrogen-ER alpha. SCM-198 could reverse the expansion of Tregs induced by estrogen-ER alpha and reduce their invasion and viability effects on eESCs. In vivo experiments confirmed that SCM-198 significantly retarded the growth of ectopic lesions.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Qiuyan Zhang, Zhuqing Shen, Yaqi Shen, Muye Ma, Hao Jue, Yizhun Zhu, Wei Guo
Summary: Hydrogen sulfide (H2S) plays a role in oxidative stress induced hypoxia by regulating CBS expression through miR-203. miR-203 can protect cells from injury by regulating lipid peroxidation, cell apoptosis, and mitochondrial membrane potential. Overexpression of miR-203 may exacerbate cell injury, while inhibition of miR-203 can provide protection against cell injury induced by oxidative stress.
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
(2022)
Correction
Multidisciplinary Sciences
Lei Miao, Xiaoming Xin, Hong Xin, Xiaoyan Shen, Yi-Zhun Zhu
SCIENTIFIC REPORTS
(2022)
Article
Immunology
Xiaocong Pang, Haitao Liu, Xu He, Tianrong Ji, Yizhun Zhu, Yimin Cui
Summary: Recent reports of rare venous thrombosis associated with the ChAdOx1-S vaccine have led to its suspension in several countries. This condition, known as vaccine-induced thrombotic thrombocytopenia (VITT), is characterized by low platelet count and clot formation in relation to anti-platelet factor 4 (PF4) antibodies. This study proposes five potential anionic substances in the ChAdOx1-S vaccine that can bind with PF4 and trigger VITT, with the negatively charged impurity proteins being considered the most likely trigger. The study also discusses the possible routes of PF4 antibody formation triggered by these impurity proteins, which aligns with the clinical situation. Therefore, individuals who express negatively charged impurity proteins at a high titer may be susceptible to VITT after receiving the ChAdOx1-S vaccine.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Qian Peng, Bingkun Zhao, Jie Lin, Haixia Liu, Rong Zhou, Dongmei Lan, Chao Yao, Shaohua Cong, Shen Tao, Yizhun Zhu, Raorao Wang, Shengcai Qi
Summary: The study found that SPRC can prevent the progression of periodontitis by inhibiting the ERK/CREB signaling pathway and regulating the Th17/Treg balance. This suggests that SPRC may be a novel therapeutic drug for periodontitis.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Zhongxiao Lin, Qian Ding, Xinzhi Li, Yuliang Feng, Hao He, Chuoji Huang, YiZhun Zhu
Summary: Environment, diseases, lack of exercise, and aged tendency of population have become crucial factors that induce vascular aging, which is an unmodifiable risk factor for diseases like diabetes and hypertension. Recent transformative omics approaches have enabled a better understanding of vascular aging mechanisms, making it possible to slow down or reverse the aging process.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Medicine, Research & Experimental
Wei Hu, Guanyu Yan, Qian Ding, Jianghong Cai, Zhongyi Zhang, Ziming Zhao, Heping Lei, Yi Zhun Zhu
Summary: Obesity and metabolic disorders are significant public health problems. Strategies and treatments, including herbal medicines, are needed to reduce the risk of metabolic diseases. Compounds containing indole scaffold have potential in regulating glucose and lipid metabolism and preventing metabolic disorders.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Cardiac & Cardiovascular Systems
Ying Wang, Meimi Zhao, Bing Xu, Sherif M. F. Bahriz, Chaoqun Zhu, Aleksandra Jovanovic, Haibo Ni, Ariel Jacobi, Nina Kaludercic, Fabio Di Lisa, Johannes W. Hell, Jean C. Shih, Nazareno Paolocci, Yang K. Xiang
Summary: In this study, the authors investigate the integrative control of intracellular catecholamine for subcellular beta(1)AR signaling and cardiac function. They identify the role of organic cation transporter 3 (OCT3) and monoamine oxidase A (MAO-A) in regulating beta(1)AR-PKA signaling and cardiac function. The results show that MAO-A deletion or inhibition enhances beta(1)AR-PKA activity and improves cardiac contractile response, while OCT3 deletion or inhibition prevents the effects induced by MAO-A. These findings provide insights into the regulation of cardiac function and suggest a drug contraindication between corticosterone and MAO inhibitors.
BASIC RESEARCH IN CARDIOLOGY
(2022)
Editorial Material
Neurosciences
Haocheng Lu, Chi Zhang, Yueqiu Li, Ying Wang
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Biochemistry & Molecular Biology
Haiyan Xi, Chenye Wang, Qixiu Li, Qing Ye, Yizhun Zhu, Yicheng Mao
Summary: This study aims to investigate the pro-angiogenic ability of S-Propargyl-cysteine (SPRC) and its potential mechanisms in peripheral nerve repair. The effects of SPRC on peripheral nerve repair were examined using animal models and in vitro cell experiments. SPRC was found to accelerate the recovery of injured nerves and promote angiogenesis. It activated the expression of SIRT1 and regulated Notch signaling, resulting in enhanced angiogenesis. This study provides evidence that SPRC could be an effective medical therapy for peripheral nerve injury through microvascular reconstruction.
Article
Nutrition & Dietetics
Meng Liu, Yuhui Wang, Guoqiang Guan, Xi Lu, Yizhun Zhu, Xiaoqun Duan
Summary: This study explores the impact of a complex dietary fiber supplement called Ancientino on ulcerative colitis. The results show that Ancientino alleviates colitis by reducing inflammatory response, suppressing oxidative stress, and repairing intestinal barrier function, indicating its potential as an effective therapeutic resource for ulcerative colitis.
Review
Biochemistry & Molecular Biology
Menglin Zhu, Qian Ding, Zhongxiao Lin, Rong Fu, Fuyuan Zhang, Zhaoyi Li, Mei Zhang, Yizhun Zhu
Summary: Rheumatoid arthritis (RA) is a chronic autoimmune disease that causes joint damage and disability, greatly impacting patients' quality of life. Although a complete cure is not currently possible, measures to relieve symptoms and reduce pain are used. RA can be induced by environmental factors, genes, and gender. Common treatments include non-steroidal anti-inflammatory drugs, disease-modifying anti-rheumatic drugs, and glucocorticoids. Some biological agents have been used but often have side effects. Therefore, the search for new mechanisms and targets for treating RA is crucial.
Review
Biochemistry & Molecular Biology
Asrar Alsaeedi, Simon Welham, Peter Rose, Yi-Zhun Zhu
Summary: Mammalian cells and tissues have the ability to produce hydrogen sulfide gas (H2S) through cysteine metabolism. H2S plays roles in cell signaling cascades essential in many biochemical and physiological processes in various organs and systems of mammals. Reduced levels of H2S are observed in several pathophysiological conditions, and it has been discovered that certain commonly prescribed drugs can affect the enzymes responsible for H2S production. Therefore, this review summarizes the studies on key drugs and their impact on H2S production in mammals.
Review
Biochemistry & Molecular Biology
Mu Guo, Xiangbin Yu, Yi Zhun Zhu, Yue Yu
Summary: This review summarizes the main pharmacological effects and mechanisms of imidazothiazole derivatives, which have biological effects such as antitumor, anti-infection, anti-inflammatory, and antioxidant effects. The contents summarized herein aim to advance the research and rational development of imidazothiazole-based drugs in the future.
