Pharmacologic targeting of Cdc42 GTPase by a small molecule Cdc42 activity-specific inhibitor prevents platelet activation and thrombosis

Adaptive responses tomTORgene targeting in hematopoietic stem cells reveal a proliferative mechanism evasive to mTOR inhibition

(2020) Cuiqing Fan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Small molecule targeting the Rac1-NOX2 interaction prevents collagen-related peptide and thrombin induced reactive oxygen species generation and platelet activation

(2018) H. Akbar et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Rational identification of a Cdc42 inhibitor presents a new regimen for long-term hematopoietic stem cell mobilization

(2018) Wei Liu et al.   LEUKEMIA

Glucagon-Like Peptide 1 Receptor Activation Attenuates Platelet Aggregation and Thrombosis

(2016) Alison Cameron-Vendrig et al.   DIABETES

The Phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) Binder Rasa3 Regulates Phosphoinositide 3-kinase (PI3K)-dependent Integrin αIIbβ3Outside-in Signaling

(2016) Anthony M. Battram et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RhoA and Rac1 GTPases Differentially Regulate Agonist-Receptor Mediated Reactive Oxygen Species Generation in Platelets

(2016) Huzoor Akbar et al.   PLoS One

Platelet Rho GTPases–a focus on novel players, roles and relationships

(2015) Robert Goggs et al.   BIOCHEMICAL JOURNAL

Plasma fibronectin supports hemostasis and regulates thrombosis

(2014) Yiming Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

The PAK system links Rho GTPase signaling to thrombin-mediated platelet activation

(2013) Joseph E. Aslan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Defective tubulin organization and proplatelet formation in murine megakaryocytes lacking Rac1 and Cdc42

(2013) I. Pleines et al.   BLOOD

Characterization of a Cdc42 Protein Inhibitor and Its Use as a Molecular Probe

(2013) Lin Hong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting Cdc42 with the small molecule drug AZA197 suppresses primary colon cancer growth and prolongs survival in a preclinical mouse xenograft model by downregulation of PAK1 activity

(2013) Karin Zins et al.   Journal of Translational Medicine

A canonical to non-canonical Wnt signalling switch in haematopoietic stem-cell ageing

(2013) Maria Carolina Florian et al.   NATURE

Small molecule targeting Cdc42–intersectin interaction disrupts Golgi organization and suppresses cell motility

(2013) Amy Friesland et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ADP-Stimulated Activation of Akt During Integrin Outside-In Signaling Promotes Platelet Spreading by Inhibiting Glycogen Synthase Kinase-3β

(2012) Kelly A. O’Brien et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Cdc42 Activity Regulates Hematopoietic Stem Cell Aging and Rejuvenation

(2012) Maria Carolina Florian et al.   Cell Stem Cell

Rational Design of Small Molecule Inhibitors Targeting RhoA Subfamily Rho GTPases

(2012) Xun Shang et al.   CHEMISTRY & BIOLOGY

Rho GTPases in platelet function

(2012) J. E. ASLAN et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Cdc42: An important regulator of neuronal morphology

(2011) Chen Chen et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Platelet adhesion and activation mechanisms in arterial thrombosis and ischaemic stroke

(2011) B. NIESWANDT et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Gene Targeting Implicates Cdc42 GTPase in GPVI and Non-GPVI Mediated Platelet Filopodia Formation, Secretion and Aggregation

(2011) Huzoor Akbar et al.   PLoS One

Signaling During Platelet Adhesion and Activation

(2010) Zhenyu Li et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Multiple alterations of platelet functions dominated by increased secretion in mice lacking Cdc42 in platelets

(2010) I. Pleines et al.   BLOOD

Signaling Role of Cdc42 in Regulating Mammalian Physiology

(2010) Jaime Melendez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rho GTPases in hematopoiesis and hemopathies

(2009) J. C. Mulloy et al.   BLOOD

Non-redundant Roles of Phosphoinositide 3-Kinase Isoforms α and β in Glycoprotein VI-induced Platelet Signaling and Thrombus Formation

(2009) Karen Gilio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of Phosphoinositide 3-Kinase β in Glycoprotein VI-mediated Akt Activation in Platelets

(2009) Soochong Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential Phosphorylation of RhoGDI Mediates the Distinct Cycling of Cdc42 and Rac1 to Regulate Second-phase Insulin Secretion

(2009) Zhanxiang Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Plasma fibronectin depletion enhances platelet aggregation and thrombus formation in mice lacking fibrinogen and von Willebrand factor

(2008) A. Reheman et al.   BLOOD

PAK1-mediated activation of ERK1/2 regulates lamellipodial dynamics

(2008) S. D. Smith et al.   JOURNAL OF CELL SCIENCE

Critical roles for the actin cytoskeleton and cdc42 in regulating platelet integrinα2β1

(2008) Giordano Pula et al.   PLATELETS