A single genetic locus controls both expression of DPEP1/CHMP1A and kidney disease development via ferroptosis

Kidney disease genetic risk variants alter lysosomal beta-mannosidase (MANBA) expression and disease severity

(2021) Xiangchen Gu et al.   Science Translational Medicine

Single cell regulatory landscape of the mouse kidney highlights cellular differentiation programs and disease targets

(2021) Zhen Miao et al.   Nature Communications

Mapping the genetic architecture of human traits to cell types in the kidney identifies mechanisms of disease and potential treatments

(2021) Xin Sheng et al.   NATURE GENETICS

Dnmt3a and Dnmt3b-Decommissioned Fetal Enhancers are Linked to Kidney Disease

(2020) Yuting Guan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Allele-specific expression changes dynamically during T cell activation in HLA and other autoimmune loci

(2020) Maria Gutierrez-Arcelus et al.   NATURE GENETICS

Oligodendrocytes Provide Antioxidant Defense Function for Neurons by Secreting Ferritin Heavy Chain

(2020) Chaitali Mukherjee et al.   Cell Metabolism

Hnf4a Is Required for the Development of Cdh6-Expressing Progenitors into Proximal Tubules in the Mouse Kidney

(2020) Sierra S. Marable et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Unravelling the complex genetics of common kidney diseases: from variants to mechanisms

(2020) Katie Marie Sullivan et al.   Nature Reviews Nephrology

XJB-5-131 inhibited ferroptosis in tubular epithelial cells after ischemia−reperfusion injury

(2020) Zhi Zhao et al.   Cell Death & Disease

The Emerging Roles of Ferroptosis in Huntington’s Disease

(2019) Yajing Mi et al.   NEUROMOLECULAR MEDICINE

Ferroptosis as a target for protection against cardiomyopathy

(2019) Xuexian Fang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chaperone-mediated autophagy is involved in the execution of ferroptosis

(2019) Zheming Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrative analysis of gene expression, DNA methylation, physiological traits, and genetic variation in human skeletal muscle

(2019) D. Leland Taylor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A catalog of genetic loci associated with kidney function from analyses of a million individuals

(2019) Matthias Wuttke et al.   NATURE GENETICS

Genetic Susceptibility to Chronic Kidney Disease – Some More Pieces for the Heritability Puzzle

(2019) Marisa Cañadas-Garre et al.   Frontiers in Genetics

Dipeptidase-1 Is an Adhesion Receptor for Neutrophil Recruitment in Lungs and Liver

(2019) Saurav Roy Choudhury et al.   CELL

Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis

(2019) Ki Wung Chung et al.   Cell Metabolism

Functional genetic variants can mediate their regulatory effects through alteration of transcription factor binding

(2019) Andrew D. Johnston et al.   Nature Communications

Mapping eGFR loci to the renal transcriptome and phenome in the VA Million Veteran Program

(2019) Jacklyn N. Hellwege et al.   Nature Communications

Prominin2 Drives Ferroptosis Resistance by Stimulating Iron Export

(2019) Caitlin W. Brown et al.   DEVELOPMENTAL CELL

Determination of the Subcellular Localization and Mechanism of Action of Ferrostatins in Suppressing Ferroptosis

(2018) Michael M. Gaschler et al.   ACS Chemical Biology

A Bayesian framework for multiple trait colocalization from summary association statistics

(2018) Claudia Giambartolomei et al.   BIOINFORMATICS

Renal immune surveillance and dipeptidase-1 contribute to contrast-induced acute kidney injury

(2018) Arthur Lau et al.   JOURNAL OF CLINICAL INVESTIGATION

Single-cell transcriptomics of the mouse kidney reveals potential cellular targets of kidney disease

(2018) Jihwan Park et al.   SCIENCE

An eQTL Landscape of Kidney Tissue in Human Nephrotic Syndrome

(2018) Christopher E. Gillies et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Renal compartment–specific genetic variation analyses identify new pathways in chronic kidney disease

(2018) Chengxiang Qiu et al.   NATURE MEDICINE

The ESCRT-III Protein CHMP1A Mediates Secretion of Sonic Hedgehog on a Distinctive Subtype of Extracellular Vesicles

(2018) Michael E. Coulter et al.   Cell Reports

GENCODE reference annotation for the human and mouse genomes

(2018) Adam Frankish et al.   NUCLEIC ACIDS RESEARCH

ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation

(2018) Sebastian Rühl et al.   SCIENCE

Ferroptosis and cell death mechanisms in Parkinson's disease

(2017) Stephanie J. Guiney et al.   NEUROCHEMISTRY INTERNATIONAL

Beneficial Effects ofMyo-Inositol Oxygenase Deficiency in Cisplatin-Induced AKI

(2016) Rajesh K. Dutta et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Tubular proteinuria in patients with HNF1α mutations: HNF1α drives endocytosis in the proximal tubule

(2016) Sara Terryn et al.   KIDNEY INTERNATIONAL

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

(2016) Valerian E Kagan et al.   Nature Chemical Biology

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

(2016) Sebastian Doll et al.   Nature Chemical Biology

Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

(2016) Cristian Pattaro et al.   Nature Communications

Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death

(2015) Scott J. Dixon et al.   ACS Chemical Biology

Function and information content of DNA methylation

(2015) Dirk Schübeler   NATURE

The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans

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Genetic and epigenetic fine mapping of causal autoimmune disease variants

(2014) Kyle Kai-How Farh et al.   NATURE

Synchronized renal tubular cell death involves ferroptosis

(2014) Andreas Linkermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Beyond GWASs: Illuminating the Dark Road from Association to Function

(2013) Stacey L. Edwards et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Common noncoding UMOD gene variants induce salt-sensitive hypertension and kidney damage by increasing uromodulin expression

(2013) Matteo Trudu et al.   NATURE MEDICINE

Prioritizing Genetic Variants for Causality on the Basis of Preferential Linkage Disequilibrium

(2012) Qianqian Zhu et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Onco-Nephrology: Renal Toxicities of Chemotherapeutic Agents

(2012) M. A. Perazella   Clinical Journal of the American Society of Nephrology

Cilastatin protects against cisplatin-induced nephrotoxicity without compromising its anticancer efficiency in rats

(2012) Blanca Humanes et al.   KIDNEY INTERNATIONAL

Chromatin marks identify critical cell types for fine mapping complex trait variants

(2012) Gosia Trynka et al.   NATURE GENETICS

New loci associated with kidney function and chronic kidney disease

(2010) Anna Köttgen et al.   NATURE GENETICS