TRAP1 regulation of mitochondrial life or death decision in cancer cells and mitochondria-targeted TRAP1 inhibitors

Reactive Oxygen Species: Stuck in the Middle of Neurodegeneration

(2017) David A. Patten et al.   JOURNAL OF ALZHEIMERS DISEASE

Mitochondrial oxidative stress drives tumor progression and metastasis: should we use antioxidants as a key component of cancer treatment and prevention?

(2011) Federica Sotgia et al.   BMC Medicine

Targeted inhibition of mitochondrial Hsp90 suppresses localised and metastatic prostate cancer growth in a genetic mouse model of disease

(2011) B H Kang et al.   BRITISH JOURNAL OF CANCER

Developmental Control of Apoptosis by the Immunophilin Aryl Hydrocarbon Receptor-interacting Protein (AIP) Involves Mitochondrial Import of the Survivin Protein

(2011) Byoung Heon Kang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exploiting the mitochondrial unfolded protein response for cancer therapy in mice and human cells

(2011) Markus D. Siegelin et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitochondrial TRAP1 regulates the unfolded protein response in the endoplasmic reticulum

(2011) Kana Takemoto et al.   NEUROCHEMISTRY INTERNATIONAL

Tumor necrosis factor receptor-associated protein 1(TRAP1) regulates genes involved in cell cycle and metastases

(2010) Dongxia Liu et al.   CANCER LETTERS

Preclinical Characterization of Mitochondria-Targeted Small Molecule Hsp90 Inhibitors, Gamitrinibs, in Advanced Prostate Cancer

(2010) B. H. Kang et al.   CLINICAL CANCER RESEARCH

Malignant transformation in a defined genetic background: proteome changes displayed by 2D-PAGE

(2010) Stephanie M Pütz et al.   Molecular Cancer

Targeting mitochondria for cancer therapy

(2010) Simone Fulda et al.   NATURE REVIEWS DRUG DISCOVERY

Common ground for protein translocation: access control for mitochondria and chloroplasts

(2010) Enrico Schleiff et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

HSP90 at the hub of protein homeostasis: emerging mechanistic insights

(2010) Mikko Taipale et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cytoprotective Mitochondrial Chaperone TRAP-1 As a Novel Molecular Target in Localized and Metastatic Prostate Cancer

(2009) Irwin Leav et al.   AMERICAN JOURNAL OF PATHOLOGY

TRAP1, a novel mitochondrial chaperone responsible for multi-drug resistance and protection from apoptotis in human colorectal carcinoma cells

(2009) Eleonora Costantino et al.   CANCER LETTERS

Combinatorial drug design targeting multiple cancer signaling networks controlled by mitochondrial Hsp90

(2009) Byoung Heon Kang et al.   JOURNAL OF CLINICAL INVESTIGATION

Heat Shock Protein 90: Inhibitors in Clinical Trials

(2009) Marco A. Biamonte et al.   JOURNAL OF MEDICINAL CHEMISTRY

Compartmentalized cancer drug discovery targeting mitochondrial Hsp90 chaperones

(2009) B H Kang et al.   ONCOGENE

The ATPase Cycle of the Mitochondrial Hsp90 Analog Trap1

(2008) Adriane Leskovar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Development and application of Hsp90 inhibitors

(2007) D SOLIT   DRUG DISCOVERY TODAY