MFG-E8 regulated by miR-99b-5p protects against osteoarthritis by targeting chondrocyte senescence and macrophage reprogramming via the NF-κB pathway

Macrophages regulate the progression of osteoarthritis

(2020) H. Zhang et al.   OSTEOARTHRITIS AND CARTILAGE

Navitoclax (ABT263) reduces inflammation and promotes chondrogenic phenotype by clearing senescent osteoarthritic chondrocytes in osteoarthritis

(2020) Hao Yang et al.   Aging-US

MicroRNA-99b-5p downregulates protein synthesis in human primary myotubes

(2020) Evelyn Zacharewicz et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Long non‐coding RNA MEG3 inhibits M2 macrophage polarization by activating TRAF6 via microRNA‐223 down‐regulation in viral myocarditis

(2020) Yu‐Long Xue et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Targeted delivery of miR-99b reprograms tumor-associated macrophage phenotype leading to tumor regression

(2020) Liang Wang et al.   Journal for ImmunoTherapy of Cancer

Parthenolide promotes the repair of spinal cord injury by modulating M1/M2 polarization via the NF-κB and STAT 1/3 signaling pathway

(2020) Tao Gaojian et al.   Cell Death Discovery

The regulation of cartilage extracellular matrix homeostasis in joint cartilage degeneration and regeneration

(2020) Zhi Peng et al.   BIOMATERIALS

Transcription factor NF-κB promotes acute lung injury via microRNA-99b-mediated PRDM1 down-regulation

(2020) Jie Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MFG-E8 attenuates inflammation in subarachnoid hemorrhage by driving microglial M2 polarization

(2020) Yong-Yue Gao et al.   EXPERIMENTAL NEUROLOGY

Intraarticular senescent chondrocytes impair the cartilage regeneration capacity of mesenchymal stem cells

(2019) Xu Cao et al.   Stem Cell Research & Therapy

Inhibition of MMPs and ADAM/ADAMTS

(2019) Charles J. Malemud   BIOCHEMICAL PHARMACOLOGY

Osteoarthritis phenotypes and novel therapeutic targets

(2019) Willem Evert Van Spil et al.   BIOCHEMICAL PHARMACOLOGY

Osteoarthritis

(2019) David J Hunter et al.   LANCET

Synovial fluid and plasma levels of milk fat globule–epidermal growth factor 8 are inversely correlated with radiographic severity of knee osteoarthritis

(2019) Feihu Chen et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

NF-B Signaling Pathways in Osteoarthritic Cartilage Destruction

(2019) Choi et al.   Cells

CCL5 deficiency promotes liver repair by improving inflammation resolution and liver regeneration through M2 macrophage polarization

(2019) Meng Li et al.   Cellular & Molecular Immunology

Neurogenesis in Neurodegenerative Diseases: Role of MFG-E8

(2019) Cletus Cheyuo et al.   Frontiers in Neuroscience

An emerging role for Toll-like receptors at the neuroimmune interface in osteoarthritis

(2019) Rachel E. Miller et al.   Seminars in Immunopathology

GRK5 Inhibition Attenuates Cartilage Degradation via Decreased NF‐κB Signalling

(2019) Takuya Sueishi et al.   Arthritis & Rheumatology

Expression of p16INK 4a is a biomarker of chondrocyte aging but does not cause osteoarthritis

(2018) Brian O. Diekman et al.   AGING CELL

Synovial macrophage M1 polarisation exacerbates experimental osteoarthritis partially through R-spondin-2

(2018) Haiyan Zhang et al.   ANNALS OF THE RHEUMATIC DISEASES

Repeated stimulation by LPS promotes the senescence of DPSCs via TLR4/MyD88-NF-κB-p53/p21 signaling

(2018) Guijuan Feng et al.   CYTOTECHNOLOGY

Inflammatory bone loss associated with MFG-E8 deficiency is rescued by teriparatide

(2018) Megan N. Michalski et al.   FASEB JOURNAL

Widespread epigenomic, transcriptomic and proteomic differences between hip osteophytic and articular chondrocytes in osteoarthritis

(2018) Julia Steinberg et al.   RHEUMATOLOGY

Redox and NF-κB signaling in osteoarthritis

(2018) Panagiotis Lepetsos et al.   FREE RADICAL BIOLOGY AND MEDICINE

Recombinant milk fat globule-EGF factor-8 reduces apoptosis via integrin β3/FAK/PI3K/AKT signaling pathway in rats after traumatic brain injury

(2018) Yong-Yue Gao et al.   Cell Death & Disease

Inflammatory molecules produced by meniscus and synovium in early and end-stage osteoarthritis: a coculture study

(2018) Marta Favero et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Targeting of chondrocyte plasticity via connexin43 modulation attenuates cellular senescence and fosters a pro-regenerative environment in osteoarthritis

(2018) Marta Varela-Eirín et al.   Cell Death & Disease

Mesenchymal stem cells-derived MFG-E8 accelerates diabetic cutaneous wound healing

(2017) Akihiko Uchiyama et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

MFG-E8 Reprogramming of Macrophages Promotes Wound Healing by Increased bFGF Production and Fibroblast Functions

(2017) Patrick Laplante et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Treatment with milk fat globule epidermal growth factor-factor 8 (MFG-E8) reduces inflammation and lung injury in neonatal sepsis

(2017) Laura W. Hansen et al.   SURGERY

MicroRNAs: exploring new horizons in osteoarthritis

(2016) M. Nugent   OSTEOARTHRITIS AND CARTILAGE

Spherical nucleic acid targeting microRNA-99b enhances intestinal MFG-E8 gene expression and restores enterocyte migration in lipopolysaccharide-induced septic mice

(2016) Xiao Wang et al.   Scientific Reports

Loss of milk fat globule-epidermal growth factor 8 (MFG-E8) in mice leads to low bone mass and accelerates ovariectomy-associated bone loss by increasing osteoclastogenesis

(2015) Kathrin Sinningen et al.   BONE

Milk Fat Globule-Epidermal Growth Factor 8 (MFG-E8) Is a Novel Anti-inflammatory Factor in Rheumatoid Arthritis in Mice and Humans

(2015) Elise Albus et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Synovitis in knee osteoarthritis: a precursor of disease?

(2014) I Atukorala et al.   ANNALS OF THE RHEUMATIC DISEASES

Antiinflammatory and chondroprotective effects of intraarticular injection of adipose-derived stem cells in experimental osteoarthritis

(2012) Menno ter Huurne et al.   ARTHRITIS AND RHEUMATISM

Molecular differentiation between osteophytic and articular cartilage – clues for a transient and permanent chondrocyte phenotype

(2011) K. Gelse et al.   OSTEOARTHRITIS AND CARTILAGE

The OARSI histopathology initiative – recommendations for histological assessments of osteoarthritis in the mouse

(2010) S.S. Glasson et al.   OSTEOARTHRITIS AND CARTILAGE

MFG-E8 Attenuates Intestinal Inflammation in Murine Experimental Colitis by Modulating Osteopontin-Dependent  v 3 Integrin Signaling

(2009) Md. M. Aziz et al.   JOURNAL OF IMMUNOLOGY

Primary culture and phenotyping of murine chondrocytes

(2008) Marjolaine Gosset et al.   Nature Protocols