RTP801/REDD1 contributes to neuroinflammation severity and memory impairments in Alzheimer’s disease

In vivo measurement of widespread synaptic loss in Alzheimer's disease with SV2A PET

(2020) Adam P. Mecca et al.   Alzheimers & Dementia

Function and Mechanisms of Truncated BDNF Receptor TrkB.T1 in Neuropathic Pain

(2020) Tuoxin Cao et al.   Cells

Astrocytes contribute to remote memory formation by modulating hippocampal–cortical communication during learning

(2020) Adi Kol et al.   NATURE NEUROSCIENCE

Synaptic RTP801 contributes to motor-learning dysfunction in Huntington’s disease

(2020) Núria Martín-Flores et al.   Cell Death & Disease

Mechanisms of NLRP3 priming in inflammaging and age related diseases

(2020) Anna Gritsenko et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Impairments in remote memory caused by the lack of Type 2 IP 3 receptors

(2019) António Pinto‐Duarte et al.   GLIA

Integrating Gene and Protein Expression Reveals Perturbed Functional Networks in Alzheimer’s Disease

(2019) Saranya Canchi et al.   Cell Reports

Porphyromonas gingivalis PgFur Is a Member of a Novel Fur Subfamily With Non-canonical Function

(2019) Michał Śmiga et al.   Frontiers in Cellular and Infection Microbiology

The neuropathological diagnosis of Alzheimer’s disease

(2019) Michael A. DeTure et al.   Molecular Neurodegeneration

Astrocyte morphogenesis is dependent on BDNF signaling via astrocytic TrkB.T1

(2019) Leanne M Holt et al.   eLife

Alzheimer Disease: An Update on Pathobiology and Treatment Strategies

(2019) Justin M. Long et al.   CELL

Principles of inflammasome priming and inhibition: Implications for psychiatric disorders

(2018) Francis J. Herman et al.   BRAIN BEHAVIOR AND IMMUNITY

RTP801 is a critical factor in the neurodegeneration process of A53T α-synuclein in a mouse model of Parkinson's disease under chronic restraint stress

(2018) Zhao Zhang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Tau-mediated synaptic and neuronal dysfunction in neurodegenerative disease

(2018) Tara E Tracy et al.   CURRENT OPINION IN NEUROBIOLOGY

PTK2B/Pyk2 overexpression improves a mouse model of Alzheimer's disease

(2018) Albert Giralt et al.   EXPERIMENTAL NEUROLOGY

Spatial navigation deficits — overlooked cognitive marker for preclinical Alzheimer disease?

(2018) Gillian Coughlan et al.   Nature Reviews Neurology

Developmental Heterogeneity of Microglia and Brain Myeloid Cells Revealed by Deep Single-Cell RNA Sequencing

(2018) Qingyun Li et al.   NEURON

Regulated in development and DNA damage responses 1 (REDD1) links stress with IL-1β–mediated familial Mediterranean fever attack through autophagy-driven neutrophil extracellular traps

(2017) Panagiotis Skendros et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Truncated TrkB.T1-Mediated Astrocyte Dysfunction Contributes to Impaired Motor Function and Neuropathic Pain after Spinal Cord Injury

(2017) Jessica J. Matyas et al.   JOURNAL OF NEUROSCIENCE

Alzheimer’s Disease: Past, Present, and Future

(2017) Mark W. Bondi et al.   JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY

Cdk5 Contributes to Huntington’s Disease Learning and Memory Deficits via Modulation of Brain Region-Specific Substrates

(2017) Elena Alvarez-Periel et al.   MOLECULAR NEUROBIOLOGY

Implication of REDD1 in the activation of inflammatory pathways

(2017) Faustine Pastor et al.   Scientific Reports

Dendritic Spines as Tunable Regulators of Synaptic Signals

(2016) Jan Tønnesen et al.   Frontiers in Psychiatry

Neuronal NLRP1 inflammasome activation of Caspase-1 coordinately regulates inflammatory interleukin-1-beta production and axonal degeneration-associated Caspase-6 activation

(2015) V Kaushal et al.   CELL DEATH AND DIFFERENTIATION

Reduction of Glucose Metabolism in Olfactory Bulb is an Earlier Alzheimer's Disease-related Biomarker in 5XFAD Mice

(2015) Xiao-Chun Chen et al.   CHINESE MEDICAL JOURNAL

Lipopolysaccharide induction of REDD1 is mediated by two distinct CREB-dependent mechanisms in macrophages

(2015) Dong-Keon Lee et al.   FEBS LETTERS

Investigating Associative Learning Effects in Patients with Prodromal Alzheimer’s Disease Using the Temporal Context Model

(2015) Lisa Quenon et al.   JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

RTP801 Is Involved in Mutant Huntingtin-Induced Cell Death

(2015) Núria Martín-Flores et al.   MOLECULAR NEUROBIOLOGY

TrkB reduction exacerbates Alzheimer’s disease-like signaling aberrations and memory deficits without affecting β-amyloidosis in 5XFAD mice

(2015) L Devi et al.   Translational Psychiatry

Phloroglucinol Attenuates the Cognitive Deficits of the 5XFAD Mouse Model of Alzheimer’s Disease

(2015) Eun-Jeong Yang et al.   PLoS One

The role of the hippocampus in passive and active spatial learning

(2014) Yutaka Kosaki et al.   HIPPOCAMPUS

REDD1 is essential for stress-induced synaptic loss and depressive behavior

(2014) Kristie T Ota et al.   NATURE MEDICINE

Activity-dependent dendritic spine neck changes are correlated with synaptic strength

(2014) R. Araya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Parkin loss of function contributes to RTP801 elevation and neurodegeneration in Parkinson’s disease

(2014) J Romaní-Aumedes et al.   Cell Death & Disease

Amyloid-β induces NLRP1-dependent neuronal pyroptosis in models of Alzheimer’s disease

(2014) M-S Tan et al.   Cell Death & Disease

TrkB.T1 Contributes to Neuropathic Pain after Spinal Cord Injury through Regulation of Cell Cycle Pathways

(2013) J. Wu et al.   JOURNAL OF NEUROSCIENCE

Neurotoxicity of Amyloid  -Protein: Synaptic and Network Dysfunction

(2013) L. Mucke et al.   Cold Spring Harbor Perspectives in Medicine

Dysfunction of the mTOR pathway is a risk factor for Alzheimer’s disease

(2013) Sharon C Yates et al.   Acta Neuropathologica Communications

Truncated TrkB: Beyond a dominant negative receptor

(2012) Barbara M. Fenner   CYTOKINE & GROWTH FACTOR REVIEWS

Neuroprotective effect of ligustilide against ischaemia-reperfusion injury via up-regulation of erythropoietin and down-regulation of RTP801

(2011) Xiao-mei Wu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Increased PKA signaling disrupts recognition memory and spatial memory: role in Huntington's disease

(2011) Albert Giralt et al.   HUMAN MOLECULAR GENETICS

PKC   Activation Prevents Synaptic Loss, A  Elevation, and Cognitive Deficits in Alzheimer's Disease Transgenic Mice

(2011) J. Hongpaisan et al.   JOURNAL OF NEUROSCIENCE

Impaired TrkB receptor signaling contributes to memory impairment in APP/PS1 mice

(2011) Susanna Kemppainen et al.   NEUROBIOLOGY OF AGING

Detection of Neuritic Plaques in Alzheimer's Disease Mouse Model

(2011) Philip T.T. Ly et al.   Jove-Journal of Visualized Experiments

Differential Requirement for Caspase-1 Autoproteolysis in Pathogen-Induced Cell Death and Cytokine Processing

(2010) Petr Broz et al.   Cell Host & Microbe

Cognitive decline following major surgery is associated with gliosis, β-amyloid accumulation, and τ phosphorylation in old mice

(2010) Yanjie Wan et al.   CRITICAL CARE MEDICINE

Rapamycin Protects against Neuron Death in In Vitro andIn Vivo Models of Parkinson's Disease

(2010) C. Malagelada et al.   JOURNAL OF NEUROSCIENCE

Long-term potentiation depends on release of d-serine from astrocytes

(2010) Christian Henneberger et al.   NATURE

Rtp801, a suppressor of mTOR signaling, is an essential mediator of cigarette smoke–induced pulmonary injury and emphysema

(2010) Toshinori Yoshida et al.   NATURE MEDICINE

Motor deficits, neuron loss, and reduced anxiety coinciding with axonal degeneration and intraneuronal Aβ aggregation in the 5XFAD mouse model of Alzheimer's disease

(2010) Sadim Jawhar et al.   NEUROBIOLOGY OF AGING

PKR, a cognitive decline biomarker, can regulate translationviatwo consecutive molecular targets p53 and Redd1 in lymphocytes of AD patients

(2009) Milena Damjanac et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

RTP801 Is Induced in Parkinson's Disease and Mediates Neuron Death by Inhibiting Akt Phosphorylation/Activation

(2009) C. Malagelada et al.   JOURNAL OF NEUROSCIENCE

Genome-wide association study reveals genetic risk underlying Parkinson's disease

(2009) Javier Simón-Sánchez et al.   NATURE GENETICS

Evidence of molecular links between PKR and mTOR signalling pathways in Aβ neurotoxicity: Role of p53, Redd1 and TSC2

(2009) Milena Morel et al.   NEUROBIOLOGY OF DISEASE

Astrocytic involvement in learning and memory consolidation

(2008) Marie E. Gibbs et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS