Cdk5 Contributes to Huntington’s Disease Learning and Memory Deficits via Modulation of Brain Region-Specific Substrates
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Title
Cdk5 Contributes to Huntington’s Disease Learning and Memory Deficits via Modulation of Brain Region-Specific Substrates
Authors
Keywords
Huntingtin, Cdk5, Cognition, NR2B, Rac1, Dendritic spines
Journal
MOLECULAR NEUROBIOLOGY
Volume 55, Issue 8, Pages 6250-6268
Publisher
Springer Nature
Online
2017-12-29
DOI
10.1007/s12035-017-0828-4
References
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Note: Only part of the references are listed.- Dendritic Spine Pathology in Neurodegenerative Diseases
- (2016) Jochen Herms et al. Annual Review of Pathology-Mechanisms of Disease
- Cognitive dysfunction in Huntington's disease: mechanisms and therapeutic strategies beyond BDNF
- (2016) Mar Puigdellívol et al. BRAIN PATHOLOGY
- CDK5 downregulation enhances synaptic plasticity
- (2016) Rafael Andrés Posada-Duque et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Cdk5-mediated mitochondrial fission: A key player in dopaminergic toxicity in Huntington's disease
- (2015) Marta Cherubini et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- A novel phosphorylation site of N-methyl- d -aspartate receptor GluN2B at S1284 is regulated by Cdk5 in neuronal ischemia
- (2015) Wen Lu et al. EXPERIMENTAL NEUROLOGY
- A role for Kalirin-7 in corticostriatal synaptic dysfunction in Huntington's disease
- (2015) Mar Puigdellívol et al. HUMAN MOLECULAR GENETICS
- Cyclin-dependent Kinase 5 (Cdk5)-dependent Phosphorylation of p70 Ribosomal S6 Kinase 1 (S6K) Is Required for Dendritic Spine Morphogenesis
- (2015) Kwok-On Lai et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- CDK5 Knockdown Prevents Hippocampal Degeneration and Cognitive Dysfunction Produced by Cerebral Ischemia
- (2015) Johana A Gutiérrez-Vargas et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- p35 and Rac1 underlie the neuroprotection and cognitive improvement induced by CDK5 silencing
- (2015) Rafael Andres Posada-Duque et al. JOURNAL OF NEUROCHEMISTRY
- CDK5 knockdown in astrocytes provide neuroprotection as a trophic source via Rac1
- (2015) Rafael Andrés Posada-Duque et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- Peptide TFP5/TP5 derived from Cdk5 activator P35 provides neuroprotection in the MPTP model of Parkinson’s disease
- (2015) BK. Binukumar et al. MOLECULAR BIOLOGY OF THE CELL
- Neuronal targets for reducing mutant huntingtin expression to ameliorate disease in a mouse model of Huntington's disease
- (2014) Nan Wang et al. NATURE MEDICINE
- Memory Enhancement by Targeting Cdk5 Regulation of NR2B
- (2014) Florian Plattner et al. NEURON
- Physiological and pathological phosphorylation of tau by Cdk5
- (2014) Taeko Kimura et al. Frontiers in Molecular Neuroscience
- Brain Slice Biotinylation: An Ex Vivo Approach to Measure Region-specific Plasma Membrane Protein Trafficking in Adult Neurons
- (2014) Luke R. Gabriel et al. Jove-Journal of Visualized Experiments
- Dendritic Spine Instability Leads to Progressive Neocortical Spine Loss in a Mouse Model of Huntington's Disease
- (2013) R. P. Murmu et al. JOURNAL OF NEUROSCIENCE
- Prefrontal activity in Huntington's disease reflects cognitive and neuropsychiatric disturbances: The IMAGE-HD study
- (2012) M.A. Gray et al. EXPERIMENTAL NEUROLOGY
- Dysregulation of synaptic proteins, dendritic spine abnormalities and pathological plasticity of synapses as experience-dependent mediators of cognitive and psychiatric symptoms in Huntington’s disease
- (2012) J. Nithianantharajah et al. NEUROSCIENCE
- Hippocampal Neurogenesis, Cognitive Deficits and Affective Disorder in Huntington's Disease
- (2012) Mark I. Ransome et al. NEURAL PLASTICITY
- Cyclin-Dependent Kinases in Brain Development and Disease
- (2011) Susan C. Su et al. Annual Review of Cell and Developmental Biology
- Long-term memory deficits in Huntington's disease are associated with reduced CBP histone acetylase activity
- (2011) A. Giralt et al. HUMAN MOLECULAR GENETICS
- Pathophysiology of Huntington's disease: time-dependent alterations in synaptic and receptor function
- (2011) L.A. Raymond et al. NEUROSCIENCE
- Cdk5 Is Required for Memory Function and Hippocampal Plasticity via the cAMP Signaling Pathway
- (2011) Ji-Song Guan et al. PLoS One
- Cdk5: Multitasking between physiological and pathological conditions
- (2011) Joao P. Lopes et al. PROGRESS IN NEUROBIOLOGY
- Cdk5: a multifaceted kinase in neurodegenerative diseases
- (2011) Zelda H. Cheung et al. TRENDS IN CELL BIOLOGY
- Presynaptic dysfunction in Huntington's disease
- (2010) José L. Rozas et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- The role of Cdk5 in cognition and neuropsychiatric and neurological pathology
- (2010) David G.S. Barnett et al. BRAIN RESEARCH BULLETIN
- Mild cognitive impairment in prediagnosed Huntington disease
- (2010) K. Duff et al. NEUROLOGY
- Recent advances in understanding the roles of Cdk5 in synaptic plasticity
- (2009) Kwok-On Lai et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Regulation of Kalirin by Cdk5
- (2008) X. Xin et al. JOURNAL OF CELL SCIENCE
- Suppression of Mutant Huntingtin Aggregate Formation by Cdk5/p35 through the Effect on Microtubule Stability
- (2008) S. Kaminosono et al. JOURNAL OF NEUROSCIENCE
- Cdk5 Regulates the Phosphorylation of Tyrosine 1472 NR2B and the Surface Expression of NMDA Receptors
- (2008) S. Zhang et al. JOURNAL OF NEUROSCIENCE
- Dopaminergic and Glutamatergic Signaling Crosstalk in Huntington's Disease Neurodegeneration: The Role of p25/Cyclin-Dependent Kinase 5
- (2008) P. Paoletti et al. JOURNAL OF NEUROSCIENCE
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